L. Schäffer

发表

Albumin binding of acylated insulin (NN304) does not deter action to stimulate glucose uptake.

R. Bergman, M. Ader, D. Moore, 2002, Diabetes.

Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks

P. H. Hansen, N. Goldstein, U. Ribel, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Insulin aspart: a novel rapid-acting human insulin analogue.

S. Gammeltoft, B. Hansen, A. Lindholm, 1999, Expert opinion on investigational drugs.

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.

T. Kruse, H. Strauss, S. M. Knudsen, 2015, Journal of medicinal chemistry.

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

U. Ribel, S. Havelund, L. Schäffer, 1996, Diabetologia.

Characterization of the three 125I-iodination isomers of human insulin-like growth factor I (IGF1).

L. Schäffer, L. Skriver, K. Hejnaes, 1993, Biochimica et biophysica acta.

Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.

R. Mirmira, L. Schäffer, A. S. Andersen, 1993, The Journal of biological chemistry.

Stress regulating systems and their role for an intrauterine origin of diseases

L. Schäffer, 2011 .

Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity

L. Schäffer, M. Benoit-Biancamano, J. Paulsson, 2011, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses*

B. Ursø, L. Schäffer, P. De Meyts, 2007, Journal of Biological Chemistry.

Expression and Characterization of a 70-kDa Fragment of the Insulin Receptor That Binds Insulin

L. Schäffer, A. S. Andersen, C. Kristensen, 1998, The Journal of Biological Chemistry.

Insulins with built‐in glucose sensors for glucose responsive insulin release

S. Havelund, L. Schäffer, T. Hoeg-Jensen, 2005, Journal of peptide science : an official publication of the European Peptide Society.

A novel high-affinity peptide antagonist to the insulin receptor.

J. Sturis, U. Ribel, B. Hansen, 2008, Biochemical and biophysical research communications.

Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models

J. Ahnfelt-Rønne, J. Hecksher-Sørensen, L. Schäffer, 2015, Islets.

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site.

N. Møłler, N. Møller, L. Schäffer, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Real-time trafficking and signaling of the glucagon-like peptide-1 receptor

J. M. Mathiesen, A. Secher, N. Kulahin, 2014, Molecular and Cellular Endocrinology.

A new view of the beta cell

J. Ahnfelt-Rønne, O. Madsen, L. Schäffer, 2012, Diabetologia.

Enzymatic determination of 1-14C-glucose in pig plasma

L. Schäffer, B. Tronier, 1989, Diabetologia.

Purification, characterization, and biological activity of insulins from the spotted dogfish, Scyliorhinus canicula, and the hammerhead shark, Sphyrna lewini.

W. G. Anderson, N. Hazon, L. Schäffer, 2002, General and comparative endocrinology.

Identification of determinants that confer ligand specificity on the insulin receptor.

N. Møłler, L. Schäffer, P. De Meyts, 1992, The Journal of biological chemistry.

Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor.

L. Schäffer, L. Ljungqvist, 1992, Biochemical and biophysical research communications.

Immobilized insulin for high capacity affinity chromatography of insulin receptors.

L. Schäffer, J. Markussen, F. Wiberg, 1991, The Journal of biological chemistry.

A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor.

L. Schäffer, A. S. Andersen, C. Kristensen, 1995, The Biochemical journal.

A model for insulin binding to the insulin receptor.

L. Schäffer, 1994, European journal of biochemistry.

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

J. Hecksher-Sørensen, J. Jelsing, A. Secher, 2014, The Journal of clinical investigation.

Alanine Scanning Mutagenesis of Insulin*

Claus Kristensen, Svend Havelund, D. Steiner, 1997, The Journal of Biological Chemistry.

Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant*

L. Schäffer, A. S. Andersen, R. Slaaby, 2006, Journal of Biological Chemistry.

Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use.

L. Schäffer, C. Schmid, C. Kristensen, 2000, Diabetes.

A New Secreted Insect Protein Belonging to the Immunoglobulin Superfamily Binds Insulin and Related Peptides and Inhibits Their Activities*

L. Schäffer, C. Kristensen, Asser Sloth Andersen, 2000, The Journal of Biological Chemistry.

Peptides Identify the Critical Hotspots Involved in the Biological Activation of the Insulin Receptor*

Jakob Brandt, Søren Østergaard, P. H. Hansen, 2002, The Journal of Biological Chemistry.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single‐Chain Precursors

L. Schäffer, T. Hoeg-Jensen, K. Jensen, 2008, Chembiochem : a European journal of chemical biology.

Development of Cagrilintide, a Long-Acting Amylin Analogue.

S. Fulle, T. Kruse, J. L. Hansen, 2021, Journal of medicinal chemistry.

Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography*

E. Johansson, J. L. Hansen, L. Schäffer, 2016, The Journal of Biological Chemistry.

Development of an optimized refolding process for recombinant Ala-Glu-IGF-1.

H. H. Sørensen, A. Wollmer, S. Bayne, 1992, Protein Engineering.

Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts.

L. Schäffer, P. De Meyts, R. Borup, 2008, The Biochemical journal.

Agonism and Antagonism at the Insulin Receptor

B. Blagoev, V. Kiselyov, T. Pedersen, 2012, PloS one.

Oligomerization in vitro of the extracellular domain of the insulin receptor by non-covalent interactions is accompanied by increased binding affinity, decreased binding capacity and curvilinear Scatchard plots

L. Schäffer, J. Markussen, M. Christensen, 1993 .

Metabolism of oral glucose in pancreas transplant recipients with normal and impaired glucose tolerance.

J. Holst, S. Madsbad, A. Vølund, 1997, The Journal of clinical endocrinology and metabolism.