J. Orgiazzi

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Combination of autoantibody markers and risk for development of type 1 diabetes: results from a large french cohort of family members.

B. Estour, P. Chatelain, S. Halimi, 2002, Diabetes & metabolism.

Evaluation of gene expression profiles in thyroid nodule biopsy material to diagnose thyroid cancer.

F. Berger, F. Borson‐Chazot, B. Rousset, 2008, The Journal of clinical endocrinology and metabolism.

Advances in diagnostic practices affect thyroid cancer incidence in France.

M. Schlumberger, J. Orgiazzi, F. de Vathaire, 2004, European journal of endocrinology.

Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume of solitary thyroid nodules and improving extranodular nonpalpable changes: a randomized, double-blind, placebo-controlled trial by the French Thyroid Research Group.

P. Caron, J. Schlienger, J. Orgiazzi, 2002, The Journal of clinical endocrinology and metabolism.

Thyroid autoimmunity.

J. Orgiazzi, 2012, Presse medicale.

Thyroid autoimmunity.

J. Orgiazzi, 2012, Presse medicale.

Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.

Jacques Young, J. Orgiazzi, C. Lukas-Croisier, 2006, European journal of endocrinology.

[Thyroid autoimmunity].

J. Orgiazzi, 1982, Annales de medecine interne.

High voltage orbital radiotherapy and surgical orbital decompression in the management of Graves' ophthalmopathy.

J. Gérard, J. Orgiazzi, R. Mornex, 1987, Hormone Research.

Four IgG anti-islet human monoclonal antibodies isolated from a type 1 diabetes patient recognize distinct epitopes of glutamic acid decarboxylase 65 and are somatically mutated.

S. Ho, S. Lebecque, A. Madec, 1996, Journal of immunology.

Treatment of adult Graves' disease.

B. Corvilain, F. Borson‐Chazot, L. Brunaud, 2018, Annales d'endocrinologie.

Guidelines for TSH-receptor antibody measurements in pregnancy: results of an evidence-based symposium organized by the European Thyroid Association.

P. Laurberg, D. Glinoer, B. Nygaard, 1998, European journal of endocrinology.

Anti-TSH receptor antibodies in clinical practice.

J. Orgiazzi, 2000, Endocrinology and metabolism clinics of North America.

Thyroid Cancers with Nodules of Indeterminate Cytology Have a Specific Distribution of Histologic Types

J. Orgiazzi, 2018, Clinical Thyroidology.

Geographical correlation between incidence of benign disease and that of cancer of the thyroid among the population of the Rhône-Alpes Région of France.

G. Sassolas, F. Borson‐Chazot, A. Schott, 2010, European journal of endocrinology.

Thyroid cancer: is the incidence rise abating?

G. Sassolas, F. Borson‐Chazot, J. Orgiazzi, 2009, European journal of endocrinology.

Recreational Physical Activity and Differentiated Thyroid Cancer Risk: A Pooled Analysis of Two Case-Control Studies

G. Sassolas, M. Schlumberger, F. Borson‐Chazot, 2016, European Thyroid Journal.

The interface between thyroid and diabetes mellitus

G. Brabant, L. Duntas, J. Orgiazzi, 2011, Clinical endocrinology.

Is there a need to redefine the upper normal limit of TSH?

G. Brabant, W. Wiersinga, P. Laurberg, 2006, European journal of endocrinology.

Evaluation of the fructosamine test in obesity: consequences for the assessment of past glycemic control in diabetes.

J. Orgiazzi, C. Broussolle, A. Revol, 1991, Clinical biochemistry.

Effects of diabetes type and treatment on zinc status in diabetes mellitus

J. Honnorat, J. Orgiazzi, C. Broussolle, 2007, Biological Trace Element Research.

Acute effects of corticosteroids on thyroid activity in Graves' disease.

D. Williams, J. Orgiazzi, D. Solomon, 1975, The Journal of clinical endocrinology and metabolism.

Opposite effects of dexamethasone on serum concentrations of 3,3',5'-triiodothyronine (reverse T3) and 3,3'5-triiodothyronine (T3).

D. Williams, J. Orgiazzi, D. Solomon, 1975, The Journal of clinical endocrinology and metabolism.

Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice.

V. Maguer-Satta, C. Thivolet, J. Orgiazzi, 1995, Journal of autoimmunity.

Pregnant French women living in the Lyon area are iodine deficient and have elevated serum thyroglobulin concentrations.

G. Sassolas, M. Zimmermann, F. Borson‐Chazot, 2012, Thyroid : official journal of the American Thyroid Association.

French pregnant women in the Lyon area are iodine deficient and have elevated serum thyroglobulin concentrations.

G. Sassolas, M. Zimmermann, F. Borson‐Chazot, 2012 .

Thyroglobulin measurement in fine-needle aspirates of lymph nodes in patients with differentiated thyroid cancer: a simple definition of the threshold value, with emphasis on potential pitfalls of the method

F. Borson‐Chazot, J. Orgiazzi, C. Bournaud, 2010, Clinical chemistry and laboratory medicine.

Postmenopause hormone treatment in women with NIDDM or impaired glucose tolerance: the MEDIA randomized clinical trial.

J. Riou, J. Boissel, J. Orgiazzi, 2000, Maturitas.

Cinacalcet reduces serum calcium concentrations in patients with intractable primary hyperparathyroidism.

P. Chanson, C. Marcocci, J. Bilezikian, 2009, The Journal of clinical endocrinology and metabolism.

The screening for mutations in the thyroglobulin cDNA from six patients with congenital hypothyroidism.

C. Ris-Stalpers, M. Cammenga, J. Orgiazzi, 1999, Biochimie.

Autoantibodies interacting with purified native thyrotropin receptor.

E. Milgrom, J. Orgiazzi, M. Misrahi, 2001, European journal of biochemistry.

A child with resistance to thyroid hormone without thyroid hormone receptor gene mutation: a 20-year follow-up.

F. Savagner, J. Orgiazzi, P. Rodien, 2008, Thyroid : official journal of the American Thyroid Association.

Kinetics of thyrotropin-stimulating hormone (TSH) and thyroid-stimulating antibody binding and action on the TSH receptor in intact TSH receptor-expressing CHO cells.

S. Swillens, J. Dumont, S. Costagliola, 2003, The Journal of clinical endocrinology and metabolism.

Endocrine side-effects of anti-cancer drugs: the impact of retinoids on the thyroid axis.

S. Dalle, J. Orgiazzi, V. Vlaeminck-Guillem, 2014, European journal of endocrinology.

THE IMPACT OF RETINOIDS ON THE THYROID AXIS Running Head : RETINOIDS AND THYROID AXIS

S. Dalle, J. Orgiazzi, V. Vlaeminck-Guillem, 2014 .

Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient

P. van Endert, J. Banga, J. K. Moore, 2004, Clinical and experimental immunology.

Cost-effectiveness analysis of gestational diabetes mellitus screening in France.

J. Orgiazzi, C. Colin, S. Touzet, 2002, European journal of obstetrics, gynecology, and reproductive biology.

Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies.

A. Madec, J. Orgiazzi, F. Rajas, 1996, The Journal of clinical endocrinology and metabolism.

Octreotide (long-acting release formulation) treatment in patients with graves' orbitopathy: clinical results of a four-month, randomized, placebo-controlled, double-blind study.

V. Rohmer, P. Caron, S. Dejager, 2005, The Journal of clinical endocrinology and metabolism.

Autoantibodies and genetic factors associated with the development of Type 1 (insulin-dependent) diabetes mellitus in first degree relatives of diabetic patients

P. Chatelain, C. Thivolet, J. Orgiazzi, 1991, Diabetologia.

Lymphocyte Function Associated Antigen-1, Integrin α4, and L-Selectin Mediate T-Cell Homing to the Pancreas in the Model of Adoptive Transfer of Diabetes in NOD Mice

C. Thivolet, J. Orgiazzi, N. Fabien, 1996, Diabetes.

Assessment of antibody dependent cell cytotoxicity in autoimmune thyroid disease using porcine thyroid cells.

A. Madec, J. Orgiazzi, Y. Morel, 1992, Autoimmunity.

Insulin prevents adoptive cell transfer of diabetes in the autoimmune non-obese diabetic mouse

E. Goillot, P. Bedossa, M. Bonnard, 1991, Diabetologia.

Human thyroid adenyl cyclase-stimulating activity in immunoglobulin G of patients with Graves' disease.

D. Williams, J. Orgiazzi, D. Solomon, 1976, The Journal of clinical endocrinology and metabolism.

Management of Graves' hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy.

P. Laurberg, J. Orgiazzi, C. Bournaud, 2009, European journal of endocrinology.

Regulation of TSH secretion in rats chronically exposed to heat (34°C)

J. Orgiazzi, M. Cure, G. Ponsin, 1978, Pflügers Archiv.

Increased cyclic AMP‐independent protein kinase activity in thyroid toxic adenomas

J. Orgiazzi, R. Mornex, Y. Munari, 1978, FEBS letters.

THYROID STIMULATING ANTIBODIES: AN AID TO THE STRATEGY OF TREATMENT OF GRAVES' DISEASE?

A. Guerrier, A. Madec, J. Orgiazzi, 1984, Clinical endocrinology.

Anti-tubulin antibodies in autoimmune thyroid disorders.

A. Madec, J. Orgiazzi, J. Monier, 1983, Clinical and experimental immunology.

Predictive value of maternal second-generation thyroid-binding inhibitory immunoglobulin assay for neonatal autoimmune hyperthyroidism.

F. Borson‐Chazot, P. Gaucherand, J. Orgiazzi, 2014, European journal of endocrinology.

Splinter Hemorrhages Associated with An

A. Burette, M. Tobi, J. Orgiazzi, 2017 .

Hyperthyroidism due to selective pituitary resistance to thyroid hormones in a 15-month-old boy: efficacy of D-thyroxine therapy.

J. Orgiazzi, M. Pugeat, D. Peynaud, 1988, The Journal of clinical endocrinology and metabolism.

Repeated plasma cortisol determinations in Cushing's syndrome due to adrenocortical adenoma.

J. Orgiazzi, H. Rousset, J. Tourniaire, 1971, The Journal of clinical endocrinology and metabolism.

Three Consecutive Pregnancies in a Patient with Chronic Autoimmune Thyroid Disease Associated with Hypothyroidism and Extremely High Levels of Anti-Thyrotropin Receptor Antibodies.

R. Bouvier, J. Orgiazzi, C. Schvartz, 2019, Thyroid : official journal of the American Thyroid Association.

Evidence for transcriptional and posttranscriptional alterations of the sodium/iodide symporter expression in hypofunctioning benign and malignant thyroid tumors.

B. Franc, F. Borson‐Chazot, Agnès Perrin, 2004, The American journal of pathology.

Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GO.

M. Nardi, W. Wiersinga, C. Marcocci, 2008, European journal of endocrinology.

A questionnaire survey on the management of Graves' orbitopathy in Europe.

M. Nardi, M. Prummel, W. Wiersinga, 2006, European journal of endocrinology.

Evidence for circadian variations in serum thyrotropin, 3,5,3'-triiodothyronine, and thyroxine in the rat.

B. Rousset, J. Orgiazzi, D. Jordan, 1980, Endocrinology.

Germline mutations in the thyrotropin receptor gene cause non–autoimmune autosomal dominant hyperthyroidism

A. Allgeier, J. Parma, J. Dumont, 1994, Nature Genetics.

Fatal and non-fatal adverse events of glucocorticoid therapy for Graves' orbitopathy: a questionnaire survey among members of the European Thyroid Association.

C. Marcocci, L. Bartalena, J. Orgiazzi, 2012, European journal of endocrinology.

Purified D-thyroxine in athyreotic patients

J. Orgiazzi, B. Dingeon, P. Hamon, 1993, The Lancet.

Normal pregnancies after treatment of hyperprolactinemia with bromoergocryptine, despite suspected pituitary tumors.

B. Claustrat, J. Orgiazzi, R. Mornex, 1978, The Journal of clinical endocrinology and metabolism.

Monoclonal antibody approach to the relationship between immunological structure and biological activity of thyrotropin.

S. Costagliola, A. Madec, J. Orgiazzi, 1988, Molecular endocrinology.

Menstrual and reproductive factors in the risk of differentiated thyroid carcinoma in young women in France: a population-based case-control study.

G. Sassolas, M. Schlumberger, F. Borson‐Chazot, 2014, American journal of epidemiology.

Approach to the mechanism of androgen overproduction in a case of Krukenbery tumor responsible for virilization during pregnancy.

M. Forest, J. Bertrand, J. Orgiazzi, 1978, The Journal of clinical endocrinology and metabolism.

Clinical validity of a new commercial method for detection of TSH-receptor binding antibodies in sera from patients with Graves' disease treated with antithyroid drugs.

J. Orgiazzi, C. Massart, D. Maugendre, 2001, Clinica chimica acta; international journal of clinical chemistry.

Blocking anti-thyrotropin receptor antibodies desensitize cultured human thyroid cells.

A. Madec, J. Orgiazzi, A. Stefanutti, 1988, Endocrinology.

Anti TSH‐receptor antibodies in pregnant patients with autoimmune thyroid disorder

A. Madec, J. Orgiazzi, S. Clavel, 1990, British journal of obstetrics and gynaecology.

0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(5):3028–3035 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1394 Silencing of the Tumor Suppressor Gene SLC5A8 Is Associated with BRAF Mutations

F. Borson‐Chazot, B. Rousset, J. Orgiazzi, 2022 .

The relationship between peripheral T cell reactivity to insulin, clinical remissions and cytokine production in type 1 (insulin-dependent) diabetes mellitus.

A. Madec, C. Thivolet, J. Orgiazzi, 1999, The Journal of clinical endocrinology and metabolism.

Paradoxical response of thyrotropin to L-dopa and presence of dopaminergic receptors in a thyrotropin-secreting pituitary adenoma.

P. Chanson, F. Peillon, J. Orgiazzi, 1984, The Journal of clinical endocrinology and metabolism.

Reduction of the risk of relapse after withdrawal of medical therapy for Graves' disease.

A. Madec, J. Orgiazzi, 2002, Thyroid : official journal of the American Thyroid Association.

Antithyroid drugs and Graves' disease: a prospective randomized evaluation of the efficacy of treatment duration.

R. Fauchet, B. Genetet, A. Madec, 1990, The Journal of clinical endocrinology and metabolism.

Management of Graves' hyperthyroidism.

J. Orgiazzi, 1987, Endocrinology and metabolism clinics of North America.

Characterization of an histone kinase activity specifically found in hyperfunctioning benign thyroid tumors.

J. Orgiazzi, R. Mornex, Y. Munari-Silem, 1981, Biochimie.

Separation of different protein kinase activities in the human thyroid gland. Evidence for an abnormal form in hyperfunctioning adenomas.

J. Orgiazzi, R. Mornex, Y. Munari-Silem, 1979, Biochemical and biophysical research communications.

Lasting remissions in patients treated for Graves' hyperthyroidism with propranolol alone: a pattern of spontaneous evolution of the disease.

P. Blanc, J. Orgiazzi, P. Carayon, 1988, The Journal of clinical endocrinology and metabolism.

Competitive Protein Binding Assay of Camp Using Thyroid Cytosol

Donald E. Williams, J. Orgiazzi, D. Solomon, 1974 .

Abnormalities of hypothalamo-hypophyseal-thyroid axis in patients with Graves' ophthalmopathy.

J. Orgiazzi, I. Chopra, U. Chopra, 1973, The Journal of clinical endocrinology and metabolism.

Management of fetal thyroid goitres: a report of 11 cases in a single perinatal unit

D. Luton, J. Oury, M. Polak, 2000, Prenatal diagnosis.

Embryopathies et anti-thyroïdiens

J. Orgiazzi, C. Bournaud, 2008 .

Multi-center study on the characteristics and treatment strategies of patients with Graves' orbitopathy: the first European Group on Graves' Orbitopathy experience.

M. Nardi, W. Wiersinga, C. Marcocci, 2003, European journal of endocrinology.

Clinical assessment of patients with Graves' orbitopathy: the European Group on Graves' Orbitopathy recommendations to generalists, specialists and clinical researchers.

M. Nardi, M. Prummel, W. Wiersinga, 2006, European journal of endocrinology.

Clinical features of dysthyroid optic neuropathy: a European Group on Graves’ Orbitopathy (EUGOGO) survey

Michele Marinò, M. Nardi, M. Prummel, 2006, British Journal of Ophthalmology.

Consensus statement of the European group on Graves' orbitopathy (EUGOGO) on management of Graves' orbitopathy.

M. Nardi, W. Wiersinga, C. Marcocci, 2008, Thyroid : official journal of the American Thyroid Association.

Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism.

H. Vidal, J. Bienvenu, J. Orgiazzi, 2004, The Journal of clinical endocrinology and metabolism.

Immunological parameters in Graves' disease: are they useful for indication and monitoring of antithyroid drug treatment?

A. Madec, J. Orgiazzi, N. Genetet, 1987, Hormone research.

Familial hyperthyroidism without evidence of autoimmunity.

J. Orgiazzi, J. Duheille, J. Leclère, 1982, Acta endocrinologica.

Adenyl cyclase activity in thyroid carcinomas.

J. Orgiazzi, R. Mornex, N. Dutrieux, 1977, Annales de radiologie.

Oxidative stress parameters in type I, type II and insulin-treated type 2 diabetes mellitus; insulin treatment efficiency.

J. Drai, J. Orgiazzi, Jocelyne Drai, 2002, Clinica chimica acta; international journal of clinical chemistry.

[Hyperthyroidism associated with hypopituitarism during the development of a TSH secreting pituitary tumor].

M. Tommasi, J. Orgiazzi, R. Mornex, 1972, Annales d'endocrinologie.

The role of stimulating, function-blocking and growth-blocking anti-TSH receptor antibodies (TRAbs) in GD, Hashimoto's disease and in atrophic thyroiditis.

A. Madec, J. Orgiazzi, X. Ducottet, 2003, Annales d'endocrinologie.

The spectrum of autoimmune thyroid diseases (AITD).

J. Orgiazzi, 1999, Annales de medecine interne.

Reassessment of antithyroid drug therapy of Graves' disease.

D. Glinoer, J. Orgiazzi, U. Feldt-Rasmussen, 1993, Annual review of medicine.

Thyroid stimulating antibody: an index of thyroid stimulation in Graves' disease?

A. Madec, J. Orgiazzi, C. Jaffiol, 1987, Acta endocrinologica.

Physiopathological Relevance of Thyroid Stimulating Antibody (TSAb) Measurements in Graves’ Disease

A. Madec, J. Orgiazzi, R. Mornex, 1987 .

[Autoimmune diseases of the thyroid gland].

A. Madec, J. Orgiazzi, 1986, La Revue du praticien.

[Synthetic antithyroid drugs and Basedow's disease or the choice of a therapeutic strategy].

A. Madec, J. Orgiazzi, A. Leguerrier, 1991, Presse medicale.

T lymphocyte subsets at various stages of hyperthyroid Graves' disease: effect of carbimazole treatment and relationship with thyroid-stimulating antibody levels or HLA status.

R. Fauchet, A. Madec, J. Orgiazzi, 1986, The Journal of clinical endocrinology and metabolism.

PSEUDOMEMBRANOUS COLITIS PROBABLY DUE TO RIFAMPICIN

J. Orgiazzi, M. Dechavanne, G. Fournier, 1980, The Lancet.

[Status of iodine nutrition in France: prevention of iodine deficiency in pregnant and lactating women].

P. Caron, D. Glinoer, P. Lecomte, 2006, Annales d'endocrinologie.

Iodine excess and thyroid autoimmunity.

J. Orgiazzi, C. Bournaud, 2003, Journal of endocrinological investigation.

Which Factors Predict the Outcome of Ablative Radioactive Iodine Treatment of Hyperthyroid Graves' Disease?

J. Orgiazzi, 2018, Clinical Thyroidology.

TSH Isoforms: About a Case of Hypothyroidism in a Down's Syndrome Young Adult

G. Brabant, J. Orgiazzi, Dany Alcaraz-Galvain, 2010, Journal of thyroid research.

Good practice guide for cervical ultrasound scan and echo-guided techniques in treating differentiated thyroid cancer of vesicular origin.

M. Schlumberger, F. Borson‐Chazot, J. Orgiazzi, 2011, Annales d'endocrinologie.

Specific information about the WHO guidelines for gestational diabetes screening improves clinical practices.

A. Gayet-Ageron, J. Orgiazzi, C. Colin, 2008, Journal of evaluation in clinical practice.

Guidelines for the management of differentiated thyroid carcinomas of vesicular origin.

E. Baudin, N. Berger, M. Schlumberger, 2008, Annales d'endocrinologie.

Anthropometric Risk Factors for Differentiated Thyroid Cancer in Young Men and Women From Eastern France: A Case-Control Study.

G. Sassolas, M. Schlumberger, F. Borson‐Chazot, 2015, American journal of epidemiology.

Vitamin E and thyroid disease: A potential link that kindles hope

L. Duntas, J. Orgiazzi, Leonidas H. Duntas, 2003, BioFactors.

Are dietary reports in a case-control study on thyroid cancer biased by risk perception of Chernobyl fallout?

G. Sassolas, M. Schlumberger, F. Borson‐Chazot, 2017, Revue d'epidemiologie et de sante publique.

Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of Type 1 (insulin-dependent) diabetes mellitus in high risk individuals

W. Scherbaum, J. Petersen, P. Chatelain, 1992, Diabetologia.

Contrasting cellular and humoral autoimmunity associated with latent autoimmune diabetes in adults.

J. Bienvenu, A. Madec, J. Orgiazzi, 2007, European journal of endocrinology.

Concurrent Differentiated Thyroid Carcinoma (DTC) and Graves’ Disease Has Similar Outcome  to DTC Alone

J. Orgiazzi, 2018, Clinical Thyroidology.

[Proceedings: Turner phenotype with menses, leucocytes 45,X and ovarian fibroblasts 45,X-47,XXX (author's transl)].

J. Orgiazzi, J. Mornex, R. Mornex, 1975, Annales d'endocrinologie.

[Antithyroid agents and embryopathies].

J. Orgiazzi, C. Bournaud, 2003, Annales d'endocrinologie.

Evidence for several cell populations in human thyroid with distinct glycosphingolipid patterns.

A. Madec, J. Orgiazzi, J. Portoukalian, 1990, Biochimica et Biophysica Acta.

Selective enrichment of phytosphingosine in glycosphingolipids of isolated human thyrocytes as compared to the whole thyroid.

J. Orgiazzi, J. Portoukalian, H. Bornet, 1987, Biochemical and biophysical research communications.

A New β-Globin Variant: Hb Sainte Eugénie [β104(G6)Arg→Trp] in a French Caucasian Female

J. Orgiazzi, A. Francina, P. Lacan, 2000 .

Evidence for normal thyroidal adenyl cyclase, cyclic AMP-binding and protein-kinase activities in Graves' disease.

D. Williams, J. Orgiazzi, D. Solomon, 1975, The Journal of clinical endocrinology and metabolism.

Double Vision in Moderate-to-Severe Graves’ Orbitopathy Correlates Negatively with Inflammatory Signs and Proptosis

J. Orgiazzi, OrgiazziJacques, 2015 .

Antithyroid Drugs and Congenital Heart Defects: Ventricular Septal Defect (VSD) Is Part of the Methimazole/Carbimazole Embryopathy

J. Orgiazzi, OrgiazziJacques, 2014 .

Predictive value of maternal second-generation thyroid-binding inhibitory immunoglobulin assay for neonatal autoimmune hyperthyroidism.

F. Borson‐Chazot, P. Gaucherand, J. Orgiazzi, 2014, European journal of endocrinology.

Management of Graves' hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy.

P. Laurberg, J. Orgiazzi, C. Bournaud, 2009, European journal of endocrinology.