T. Hashimoto

发表

Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease

Lief E. Fenno, D. Holtzman, K. Deisseroth, 2022 .

CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC‐P/collagen type XXV

I. Kanazawa, D. Mann, T. Iwatsubo, 2002, The EMBO journal.

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.

Steven Hou, Matthew P Frosch, David M Holtzman, 2012, Brain : a journal of neurology.

Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy

T. Iwatsubo, T. Hashimoto, S. Liebman, 2021, RNA biology.

RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.

S. Tsuji, T. Iwatsubo, M. Miura, 2013, Human molecular genetics.

Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

S. Tsuji, D. Mann, T. Iwatsubo, 2004, The American journal of pathology.

Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.

T. Iwatsubo, A. Harada, Y. Yamanashi, 2019, Cell reports.

Aβ Immunotherapy: Intracerebral Sequestration of Aβ by an Anti-Aβ Monoclonal Antibody 266 with High Affinity to Soluble Aβ

T. Iwatsubo, Y. Hori, T. Terasaki, 2009, The Journal of Neuroscience.

Molecular Identification of AMY, an Alzheimer Disease Amyloid‐Associated Protein

J. Trojanowski, B. Winblad, V. Lee, 2003, Journal of neuropathology and experimental neurology.

CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils*

T. Iwatsubo, T. Hashimoto, T. Wakabayashi, 2005, Journal of Biological Chemistry.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease

S. Tsuji, T. Iwatsubo, T. Ushijima, 2017, Proceedings of the National Academy of Sciences.

The Tottori (D7N) and English (H6R) Familial Alzheimer Disease Mutations Accelerate Aβ Fibril Formation without Increasing Protofibril Formation*

D. Teplow, T. Iwatsubo, K. Nakashima, 2007, Journal of Biological Chemistry.

A Temperature-sensitive Mechanism That Regulates Post-translational Stability of a Plastidial ω-3 Fatty Acid Desaturase (FAD8) in Arabidopsis Leaf Tissues*

H. Sakamoto, T. Hashimoto, O. Matsuda, 2005, Journal of Biological Chemistry.

Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Y. Kamikubo, T. Iwatsubo, T. Uehara, 2021, bioRxiv.

Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration

T. Iwatsubo, T. Hashimoto, T. Wakabayashi, 2018, Human molecular genetics.

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration

T. Iwatsubo, F. Kametani, M. Hasegawa, 2022, The Journal of biological chemistry.

ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1–40) at the blood–brain barrier

T. Iwatsubo, T. Terasaki, K. Ueda, 2008, Neurochemistry International.

Edinburgh Research Explorer The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

B. Hyman, Hwan‐Ching Tai, M. Frosch, 2018 .

Brain Oligomeric A -Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

B. Hyman, T. Gómez-Isla, A. Serrano‐Pozo, 2011 .

Edinburgh Research Explorer Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation

B. Hyman, T. Spires-Jones, B. Bacskai, 2018 .

Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro.

T. Iwatsubo, Koichi Tanaka, K. Sugimura, 2007, Journal of biochemistry.

Analytical Method for β-Amyloid Fibrils Using CE-Laser Induced Fluorescence and Its Application to Screening for Inhibitors of β-Amyloid Protein Aggregation

T. Iwatsubo, Y. Hori, T. Toyo’oka, 2007 .

Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.

T. Iwatsubo, Y. Hori, T. Toyo’oka, 2007, Analytical chemistry.

Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening*

Stephen T. C. Wong, Jing Fan, Alexei Degterev, 2012, The Journal of Biological Chemistry.

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

Josiah R. Boivin, B. Hyman, B. Bacskai, 2017, Molecular Neurodegeneration.

Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

Tara Spires-Jones, Brian J Bacskai, Kishore Kuchibhotla, 2010, The Journal of Neuroscience.

Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease

B. Hyman, T. Spires-Jones, B. Bacskai, 2012, The Journal of Neuroscience.

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.

B. Hyman, Hwan‐Ching Tai, M. Frosch, 2012, The American journal of pathology.

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

B. Hyman, D. Krainc, C. Lill, 2013, Neurobiology of Disease.

Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver

T. Iwatsubo, T. Terasaki, S. Ohtsuki, 2006, Pharmaceutical Research.

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation

B. Hyman, D. Irimia, Y. Hori, 2013, Scientific Reports.

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis

T. Iwatsubo, V. Buchman, T. Hashimoto, 2015, Molecular Neurodegeneration.

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

T. Iwatsubo, S. Tokuhiro, T. Saido, 1998, The Journal of biological chemistry.

ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity

T. Iwatsubo, Wenbin Wei, V. Buchman, 2021, Neurobiology of Disease.

Compositional analysis of ALS-linked stress granule-like structures reveals factors and cellular pathways dysregulated by mutant FUS under stress

T. Iwatsubo, Wenbin Wei, V. Buchman, 2021, bioRxiv.

Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies

T. Iwatsubo, T. Hashimoto, S. Liebman, 2019, PLoS genetics.

Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43*

T. Iwatsubo, M. Miura, T. Hashimoto, 2016, The Journal of Biological Chemistry.

CLAC-P/Collagen Type XXV Is Required for the Intramuscular Innervation of Motoneurons during Neuromuscular Development

T. Iwatsubo, A. Harada, T. Hashimoto, 2014, The Journal of Neuroscience.

Chronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight

S. Tsuji, T. Iwatsubo, A. Iwata, 2019, Scientific Reports.

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Kristina D. Micheva, Stephen J. Smith, K. Micheva, 2009, Proceedings of the National Academy of Sciences.

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Kenji F. Tanaka, M. Mimura, T. Iwatsubo, 2020, Acta Neuropathologica Communications.

Brain Oligomeric &bgr;-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

Bradley T. Hyman, Mireia Coma, Alberto Serrano-Pozo, 2011, Journal of neuropathology and experimental neurology.

Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain

Phillip B. Jones, B. Hyman, T. Spires-Jones, 2011, PloS one.

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

B. Hyman, Y. Hori, T. Spires-Jones, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS‐1 mutations that lead to exceptionally high amyloid‐β concentrations

A. Paetau, J. Hardy, M. Swash, 2000, Annals of neurology.

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

B. Hyman, P. McLean, C. Glabe, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques

T. Iwatsubo, T. Hashimoto, T. Wakabayashi, 2020, Acta neuropathologica communications.

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

T. Iwatsubo, T. Uehara, T. Saido, 2022, iScience.

Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid-β Revealed by a Novel Fluorescence Resonance Energy Transfer Assay

B. Hyman, Z. Fan, B. Bacskai, 2012, The Journal of Neuroscience.

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

B. Hyman, M. Wolfe, O. Berezovska, 2010, Nature communications.

Characterization of the unique In Vitro effects of unsaturated fatty acids on the formation of amyloid β fibrils

T. Iwatsubo, Takao Shimizu, T. Hashimoto, 2019, PloS one.

The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in an in Vitro Model of the Blood-Brain Barrier Cells*

D. Holtzman, T. Iwatsubo, G. Bu, 2008, Journal of Biological Chemistry.

Patterns and severity of vascular amyloid in Alzheimer’s disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer’s disease

D. Mann, T. Iwatsubo, J. Snowden, 2018, Acta Neuropathologica.

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

T. Iwatsubo, T. Hashimoto, Kaoru Yamada, 2022, The Journal of experimental medicine.

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

B. Hyman, B. Davidson, T. Spires-Jones, 2013, Science Translational Medicine.

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide

D. Holtzman, B. Hyman, M. Frosch, 2012, The Journal of Neuroscience.

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

T. Iwatsubo, T. Kadowaki, N. Kubota, 2019, Molecular neurodegeneration.

Eloise Hudry of Amyloid Deposition and Neurotoxicity in Mouse Brain Isoforms Results in Differential Modulation Apoe Gene Transfer of Human

B. Hyman, B. Davidson, T. Spires-Jones, 2013 .

Characterization of Oligomer Formation of Amyloid-β Peptide Using a Split-luciferase Complementation Assay*

B. Hyman, P. McLean, K. Adams, 2011, The Journal of Biological Chemistry.

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

T. Iwatsubo, T. Kadowaki, N. Kubota, 2019, Molecular Neurodegeneration.

Neurobiology of Disease Apolipoprotein E , Especially Apolipoprotein E 4 , Increases the Oligomerization of Amyloid Peptide

D. Holtzman, B. Hyman, M. Frosch, 2017 .

Amyloid‐β peptide(1‐40) elimination from cerebrospinal fluid involves low‐density lipoprotein receptor‐related protein 1 at the blood‐cerebrospinal fluid barrier

T. Iwatsubo, T. Terasaki, S. Ohtsuki, 2011, Journal of neurochemistry.

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis

T. Iwatsubo, V. Buchman, T. Hashimoto, 2015, Molecular Neurodegeneration.

Role of Apolipoprotein E in β-Amyloidogenesis

B. Hyman, T. Iwatsubo, Y. Hori, 2015, The Journal of Biological Chemistry.

CHRONIC CEREBRAL HYPOPERFUSION INCREASES AMYLOID PLAQUES BY ACCELERATING AMYLOID BETA AGGREGATION IN APP/PS1 TRANSGENIC MICE

T. Iwatsubo, A. Iwata, T. Toda, 2018, Alzheimer's & Dementia.

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-b on Microglial

Y. Hori, T. Hashimoto, Lingzhi Zhao, 2013 .

RNA Aptamer Probes as Optical Imaging Agents for the Detection of Amyloid Plaques

B. Hyman, E. Hudry, C. Farrar, 2014, PloS one.

Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides

T. Iwatsubo, S. Tokuhiro, T. Saido, 1998, The Journal of Biological Chemistry.

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

B. Hyman, T. Gómez-Isla, Z. Fan, 2012, Neurobiology of Disease.

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Kenji F. Tanaka, M. Mimura, T. Iwatsubo, 2020, Acta Neuropathologica Communications.

Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain

Phillip B. Jones, B. Hyman, T. Spires-Jones, 2011, PloS one.

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model

T. Iwatsubo, T. Hashimoto, Yuko Saito, 2023, Stem Cell Reports.

Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease.

K. Deisseroth, O. Yizhar, H. Bito, 2015, Cell reports.

Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ in vitro and brain Aβ deposition in vivo.

B. Hyman, T. Iwatsubo, Y. Hori, 2018, The Journal of Biological Chemistry.