K. Lim

发表

Developmental transcriptome analysis of human erythropoiesis.

J. D. Engel, Y. Guan, Fan Zhu, 2014, Human molecular genetics.

Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT

J. D. Engel, J. Engel, Masayuki Yamamoto, 2008, Genes to cells : devoted to molecular & cellular mechanisms.

Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.

J. D. Engel, A. Prakash, J. Engel, 2014, Gastroenterology.

RED CELLS , IRON , AND ERYTHROPOIESIS The LSD 1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

J. D. Engel, J. Engel, Y. Saunthararajah, 2015 .

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.

J. D. Engel, J. Engel, Y. Saunthararajah, 2015, Blood.

GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies.

J. D. Engel, J. Engel, R. Shimizu, 2000, Blood.

Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect

J. D. Engel, J. Engel, Masayuki Yamamoto, 2016, Molecular and Cellular Biology.

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning.

J. D. Engel, J. Engel, S. Camper, 2012, The Journal of clinical investigation.

Defining the Functional Boundaries of the Gata2 Locus by Rescue with a Linked Bacterial Artificial Chromosome Transgene*

J. D. Engel, J. Engel, Masayuki Yamamoto, 2008, Journal of Biological Chemistry.

Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer.

J. D. Engel, A. Rao, J. Engel, 2007, Developmental biology.

Transcription Factor Networks Specify Sympathetic and Adrenal Chromaffin Cell Differentiation

J. D. Engel, J. Engel, K. Lim, 2007 .

A Snail1/Notch1 Signaling Axis Controls Embryonic Vascular Development

S. Weiss, R. Rowe, Yi Tang, 2014, Nature Communications.

Genomic organization and sequence variation of the human integrin subunit α8 gene (ITGA8)

C. Carlson, R. Samudrala, B. Levy, 2004 .

Soluble triggering receptor expressed on myeloid cells-1 in acute respiratory infections

T. Lim, K. Lim, E. Koay, 2006, European Respiratory Journal.

Transcription factor GATA‐3 is essential for lens development

J. D. Engel, J. Engel, Satoru Takahashi, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

Summary Gata 2 specifies serotonergic neurons downstream of sonic hedgehog

J. D. Engel, S. E. Craven, J. Engel, 2004 .

Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq

J. D. Engel, J. Engel, Ping Zhu, 2022, Cell discovery.

Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3.

J. D. Engel, J. Engel, Bernd Fritzsch, 2011, The International journal of developmental biology.

Mammalian Granulocyte–Macrophage Colony-stimulating Factor Receptor Expressed in Primary Avian Hematopoietic Progenitors: Lineage-specific Regulation of Proliferation and Differentiation

H. Beug, P. Steinlein, O. Wessely, 1998, The Journal of cell biology.

Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation

R. E. Huber, J. D. Engel, A. Rao, 2006, Development.

Graded Levels of GATA-1 Expression Modulate Survival, Proliferation, and Differentiation of Erythroid Progenitors*

J. D. Engel, J. Engel, S. Philipsen, 2005, Journal of Biological Chemistry.

Expression of the chicken GATA factor family during early erythroid development and differentiation.

J. D. Engel, J. Engel, K. Lim, 1993, Development.

An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3 (cid:1) to the Gata3 Structural Gene (cid:1)

J. D. Engel, J. Engel, K. Lim, 2011 .

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.

J. D. Engel, J. Engel, B. Cha, 2016, Developmental biology.

Identification of novel γ-globin inducers among all potential erythroid druggable targets

J. D. Engel, J. Engel, D. Ginsburg, 2022, Blood advances.

Gata3 hypomorphic mutant mice rescued with a YAC transgene suffer a glomerular mesangial cell defect

J. D. Engel, J. Engel, Masayuki Yamamoto, 2016 .

The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision

J. D. Engel, M. Rosenfeld, J. Bushweller, 2021, bioRxiv.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

J. D. Engel, J. Rual, Yukio Nakamura, 2018, Genes & development.

BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesis

J. D. Engel, J. Rual, Yukio Nakamura, 2018, bioRxiv.

Hepatic Erythropoietin Gene Regulation by GATA-4*

J. D. Engel, J. Fandrey, K. Lim, 2004, Journal of Biological Chemistry.

Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

James Douglas Engel, Yuanfang Guan, Osamu Tanabe, 2014, PLoS genetics.

Gata2 specifies serotonergic neurons downstream of sonic hedgehog

James Douglas Engel, J. D. Engel, S. E. Craven, 2004, Development.

Supplementary Figures and Figure Legends

J. D. Engel, S. Camper, B. Cha, 2019 .

Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity

G. Levi, K. Lim, D. Clouthier, 2004, Development.

A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance

J. D. Engel, S. Kalantry, K. Lim, 2015, Genes & development.

GATA-3 is required for early T lineage progenitor development

J. D. Engel, K. Lim, I. Maillard, 2009, The Journal of experimental medicine.

An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene

J. D. Engel, A. Rao, Yu-Hsuan Lin, 2011, Molecular and Cellular Biology.

Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA‐2 in urogenital development

J. D. Engel, S. Orkin, N. Minegishi, 1998, The EMBO journal.

Structure and regulation of vertebrate δ‐aminolevulinate synthases

J. D. Engel, Masayuki Yamamoto, T. Nagai, 1994 .

PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis

Jiandie D. Lin, J. D. Engel, H. Xu, 2014, Molecular and Cellular Biology.

Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system

James Douglas Engel, Frank Grosveld, Susan E. Crawford, 2000, Nature Genetics.

Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner.

J. D. Engel, H. Beug, M. Zenke, 1993, Genes & development.

cis and trans regulation of tissue-specific transcription

J. D. Engel, J. Kornhauser, J. Lavail, 1992, Journal of Cell Science.

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

J. D. Engel, J. Shavit, K. Lim, 1995, Genes & development.

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene

J. D. Engel, Satoru Takahashi, Masayuki Yamamoto, 2005, Molecular and Cellular Biology.

Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq

J. D. Engel, Ping Zhu, Jiaxi Zhou, 2022, Cell Discovery.

Regulation and function of transcription factor GATA-1 during red blood cell differentiation.

J. D. Engel, H. Beug, M. Zenke, 1996, Development.

A Gata2 intronic enhancer confers its pan-endothelia-specific regulation

J. D. Engel, T. Glover, Masayuki Yamamoto, 2007, Development.

GATA-3: an unexpected regulator of cell lineage determination in skin.

C. Kaufman, H. Pasolli, E. Fuchs, 2003, Genes & development.

Localization of Distant Urogenital System-, Central Nervous System-, and Endocardium-Specific Transcriptional Regulatory Elements in the GATA-3 Locus

James Douglas Engel, Frank Grosveld, J. D. Engel, 1999, Molecular and Cellular Biology.

Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human β‐globin locus

K. Lim, J. Bungert, James Douglas Engel, 1998, Genes to cells : devoted to molecular & cellular mechanisms.

Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

J. D. Engel, M. Sierant, Osamu Tanabe, 2015, Blood.

RED CELLS , IRON , AND ERYTHROPOIESIS Compound loss of function of nuclear receptors Tr 2 and Tr 4 leads to induction of murine embryonic b-type globin genes

J. D. Engel, M. Sierant, Osamu Tanabe, 2015 .

A Gata3 3′ Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression

J. D. Engel, A. Rao, Masayuki Yamamoto, 2018, Molecular and Cellular Biology.

UG4 Enhancer-Driven GATA-2 and Bone Morphogenetic Protein 4 Complementation Remedies the CAKUT Phenotype in Gata2 Hypomorphic Mutant Mice

J. D. Engel, Masayuki Yamamoto, R. Shimizu, 2012, Molecular and Cellular Biology.

GATA3 is essential for separating patterning domains during facial morphogenesis.

J. D. Engel, T. Cox, K. Lim, 2021, Development.

Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder.

M. McInnis, D. Schill, K. Lim, 2020, Advances in neurobiology.

Erratum: GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene (Molecular and Cellular Biology (2005) 25, 16 (7005-7020))

J. D. Engel, Satoru Takahashi, Masayuki Yamamoto, 2005 .

GATA3 is essential for separating patterning domains during facial morphogenesis

J. D. Engel, T. Cox, K. Lim, 2021, bioRxiv.

Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells

J. D. Engel, Y. Guan, Fan Zhu, 2014, PLoS genetics.

An erythroid to myeloid cell fate conversion is elicited by LSD1 inactivation.

J. D. Engel, M. Rosenfeld, J. Bushweller, 2021, Blood.

Defining the Functional Boundaries of the Gata2 Locus by Rescue with a Linked Bacterial Artificial Chromosome Transgene*

J. D. Engel, Masayuki Yamamoto, K. Lim, 2008, Journal of Biological Chemistry.

Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions

J. D. Engel, K. Lim, A. Friedman, 2023, Blood advances.