D. Burnett

发表

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

B. Hawes, K. O'neill, J. Lisnock, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

J. Clader, D. Burnett, E. Parker, 2011, Biochemistry.

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

W. Greenlee, R. Bertorelli, A. Reggiani, 2009, Bioorganic & medicinal chemistry letters.

Remote functionalization of SCH 39166: discovery of potent and selective benzazepine dopamine D1 receptor antagonists.

W. Greenlee, J. Lachowicz, D. Burnett, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, T. Kowalski, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, K. O'neill, 2006, Bioorganic & medicinal chemistry letters.

Tetrahydroisoquinolines as MCH-R1 antagonists.

W. Greenlee, B. Hawes, K. O'neill, 2006, Bioorganic & medicinal chemistry letters.

Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.

W. Greenlee, R. Bertorelli, A. Reggiani, 2007, Journal of medicinal chemistry.

2-Azetidinones as inhibitors of cholesterol absorption.

R. Burrier, J. Clader, H. Davis, 1994, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer's Disease.

D. Burnett, Raksha A. Acharya, H. Patzke, 2017, Journal of medicinal chemistry.

Tricyclic sulfones as orally active gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Lynn A. Hyde, W. Greenlee, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Lynn A. Hyde, W. Greenlee, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

An enzymatic synthesis of glucuronides of azetidinone-based cholesterol absorption inhibitors.

D. Burnett, P. Reiss, A. Zaks, 1999, Bioorganic & medicinal chemistry.

Atherosclerosis: Cholesterol Management

D. Burnett, S. Edmondson, Harry R. Davis, 2021, Burger's Medicinal Chemistry and Drug Discovery.

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.

J. Clader, G. Scapin, J. Voigt, 2016, Bioorganic & medicinal chemistry.

A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties.

W. Greenlee, R. Bertorelli, A. Reggiani, 2010, Bioorganic & medicinal chemistry letters.

Discovery of Oxazoline Enhancers of Cellular Progranulin Release.

R. Hurst, D. Burnett, Xiaowen Peng, 2022, Bioorganic & medicinal chemistry letters.

Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Jinsong Hao, A. Stamford, G. Scapin, 2016, ACS medicinal chemistry letters.

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2013, Bioorganic & medicinal chemistry letters.

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain.

W. Greenlee, D. Tulshian, R. Bertorelli, 2012, Bioorganic & medicinal chemistry letters.

2-Azetidinone cholesterol absorption inhibitors: structure-activity relationships on the heterocyclic nucleus.

R. Burrier, J. Clader, H. Zhao, 1996, Journal of medicinal chemistry.

β-lactam cholesterol absorption inhibitors

D. Burnett, 2004 .

Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.

J. Clader, S. Altmann, H. Davis, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists.

W. Greenlee, J. Clader, B. Hawes, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolizidinone and indolizidinone synthesis: generation and intramolecular addition of .alpha.-acylamino radicals to olefins and allenes

D. Hart, D. Burnett, Joong-Kwon Choi, 1984 .

Synthesis of 3-(1-hydroxyethyl)-2-azetidinones via ester-imine condensations

J. Gallucci, D. Hart, D. Burnett, 1985 .

Asymmetric synthesis and absolute stereochemistry of cholesterol absorption inhibitor, SCH 48461

D. Burnett, 1994 .

Iminoheterocycles as gamma-secretase modulators.

Lynn A. Hyde, J. Voigt, Zhaoning Zhu, 2010, Bioorganic & medicinal chemistry letters.

Pyrrolizidinone and indolizidinone synthesis: generation and intramolecular addition of .alpha.-acylamino radicals to olefins and allenes

D. Hart, D. Burnett, Joong-Kwon Choi, 1984 .

Atherosclerosis I: LDL Cholesterol Lowering

H. Davis, D. Burnett, 2010 .

The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.

C. Strader, X. Yao, S. Altmann, 2002, Biochimica et biophysica acta.

.beta.-Lactams from esters and sulfenimines: a new route to monobactams

D. Hart, D. Burnett, Jun Liu, 1986 .

Trans diastereoselective synthesis of 3-alkyl substituted β-lactams via the acid chloride-imine reaction of nonactivated acid chlorides

J. Clader, D. Burnett, S. Dugar, 1995 .

Synthesis of Fluorescent Biochemical Tools Related to the 2‐Azetidinone Class of Cholesterol Absorption Inhibitors.

J. Clader, H. Davis, D. Burnett, 2002 .

Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461.

R. Burrier, J. Clader, H. Davis, 1995, Atherosclerosis.

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.

Lynn A. Hyde, W. Greenlee, Wei Zhou, 2012, ACS medicinal chemistry letters.

β-Stannyl enones as radical traps: a very direct route to PGF2α

D. Burnett, G. E. Keck, 1987 .

Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.

William J Greenlee, W. Greenlee, J. Lachowicz, 2005, Journal of medicinal chemistry.

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

W. Greenlee, R. Xu, J. Clader, 2012, ACS medicinal chemistry letters.

Strategic and Tactical Approaches to the Synthesis of 5,6-Dihydro-[1,2,4]oxadiazines

W. Zonneveld, E. Heijne, D. Burnett, 2016 .

4‐(Chloromethyl)‐3,5‐dimethylisoxazole

D. Burnett, M. E. Browne, 2001 .

SAR of tricyclic sulfones as γ-secretase inhibitors

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2011 .

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

W. Greenlee, Mark D. McBriar, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator.

D. Burnett, Raksha A. Acharya, H. Patzke, 2021, Journal of medicinal chemistry.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

W. Greenlee, D. Tulshian, D. Burnett, 2010, Bioorganic & medicinal chemistry letters.

Chapter 6. Recent advances in the science and treatment of atherosclerosis

H. Davis, D. Burnett, 2001 .

Hydrazides of clozapine: a new class of D1 dopamine receptor subtype selective antagonists.

J. Lachowicz, D. Burnett, T. Sasikumar, 2006, Bioorganic & medicinal chemistry letters.

Modification of the clozapine structure by parallel synthesis.

J. Lachowicz, D. Burnett, B. Mckittrick, 2006, Bioorganic & medicinal chemistry letters.

SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: taming hERG.

W. Greenlee, J. Clader, B. Hawes, 2007, Bioorganic & medicinal chemistry.

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

W. Greenlee, B. Hawes, T. Kowalski, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

W. Greenlee, B. Hawes, T. Kowalski, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.

W. Greenlee, D. Tulshian, R. Bertorelli, 2012, Bioorganic & medicinal chemistry letters.

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

D. Burnett, H. Patzke, Cuyue Tang, 2016, Alzheimer's Research & Therapy.

Discovery of a Novel, Potent Spirocyclic Series of γ-Secretase Inhibitors.

Lynn A. Hyde, R. Xu, J. Clader, 2015, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.

D. Burnett, A. Fawzi, Hongtao Zhang, 2002, Bioorganic & medicinal chemistry letters.

Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4 -hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption.

J. Clader, T. Huynh, H. Davis, 1998, Journal of medicinal chemistry.

SCH 48461, a novel inhibitor of cholesterol absorption

R. Burrier, J. Clader, H. Davis, 1994 .

Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists.

W. Greenlee, J. Lachowicz, Zhaoning Zhu, 2010, Bioorganic & medicinal chemistry letters.