M. Braun

发表

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

B. Hawes, K. O'neill, J. Lisnock, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cu(I)Br‐mediated preparation of 14C‐labeled 3‐pyridineacetate derivatives and synthesis of a novel 14C‐labeled PDE‐IV inhibitor

M. Braun, J. Ho, 2007 .

Use of Dibutyl[14C]formamide as a Formylating Reagent in the Vilsmeier–Haack Reaction and Synthesis of a 14C‐Labeled Novel Phosphodiesterase‐4 (PDE‐4) Inhibitor

D. Dean, D. Melillo, M. Braun, 2005 .

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

T. Baillie, Yong Zhang, Wei Tang, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac.

M. Braun, T. Tephly, C. King, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide

T. Baillie, K. Samuel, Sanjeev Kumar, 2002, Journal of Pharmacology and Experimental Therapeutics.

Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant

W. Kraft, H. Greenberg, D. Dean, 2011, Cancer Chemotherapy and Pharmacology.

Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

D. Dean, Sanjeev Kumar, A. Bergman, 2010, Drug Metabolism and Disposition.

Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys

D. Dean, Sanjeev Kumar, M. Braun, 2010, Drug Metabolism and Disposition.

A potent and orally active HIV-1 integrase inhibitor.

Wei Xu, D. Hazuda, Michael D. Miller, 2007, Bioorganic & medicinal chemistry letters.

DMD051524 2206..2214

Sanjeev Kumar, M. Braun, C. Adreani, 2013 .

Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats

Sanjeev Kumar, M. Braun, C. Adreani, 2013, Drug Metabolism And Disposition.

Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans

J. Chodakewitz, D. Dean, Sanjeev Kumar, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Transport of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate by the Multidrug Resistance Proteins MRP1, MRP2, and MRP3

X. Chu, R. Evers, B. Sarkadi, 2004, Journal of Pharmacology and Experimental Therapeutics.

Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques.

T. Baillie, D. Dean, D. Melillo, 2001, Drug metabolism and disposition: the biological fate of chemicals.

IN VITRO AND IN VIVO METABOLISM OF A POTENT AND SELECTIVE INTEGRIN (cid:1) v (cid:2) 3 ANTAGONIST IN RATS, DOGS, AND MONKEYS

J. Yergey, R. Subramanian, M. Braun, 2004 .

Synthesis of a tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor

R. Young, M. Braun, A. Chaudhary, 2011 .

A two-step, three-component synthesis of PGE1: utilization of .alpha.-iodo enones in Pd(0)-catalyzed cross-couplings of organoboranes

Carl R. Johnson, M. Braun, 1993 .

In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.

R. Young, R. Zamboni, Y. Aubin, 2007, Bioorganic & medicinal chemistry letters.

Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake

F. Ujjainwalla, M. Braun, Y. S. Tang, 2008, Molecular Pharmacology.

Synthesis of a 14C‐labeled FPTase inhibitor via a Pd‐catalyzed cyanation with Zn(14CN)2 and via bromo[14C]acetic acid

M. Braun, C. Elmore, J. Ho, 2008 .

An efficient synthesis of carbon‐14‐labeled 6‐[2‐(dimethylamino)ethyl]‐14‐(1‐ethylpropyl)‐5,6,7,8‐tetrahydroindolo [2,1‐α] [2,5]benzodiazocine‐11‐carboxylic acid using Curtius rearrangement reaction as a key step

M. Braun, J. Ho, A. S. Zhang, 2011 .

Synthesis of [phenyl-U-14C]aryl and [8-14C]carboxy labeled tracers of vorinostat

M. Braun, Eric D Soli, 2006 .

Modified stille coupling utilizing α-iodoenones

Joseph P. Adams, Carl R. Johnson, M. Braun, 1992 .

Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein

Shiyao Xu, Arthur J Bergman, X. Chu, 2007, Journal of Pharmacology and Experimental Therapeutics.

Efficient Synthesis of 14C-Labeled 1H-Pyrazolo[3,4-d]pyrimidine and Related [4.3.0]-Bicyclic Pyrimidino Systems

M. Braun, J. Ho, Kyle R. Van Arsdale, 2008 .

Direct α-iodination of cycloalkenones

Joseph P. Adams, Carl R. Johnson, P. Wovkulich, 1992 .

Palladium‐catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon‐14 labeled Maxi‐K channel blocker

M. Braun, S. Natarajan, Luping Liu, 2010 .

Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand.

J. Lisnock, R. DeVita, M. Garcia-Calvo, 2009, Bioorganic & medicinal chemistry letters.

2-(4-Methoxyphenyl)-2-Cyclohexen-1-One: Preparation of 2-Iodo-2-Cyclohexen-1-One and Suzuki Coupling With 4-Methoxyphenylboronic Acid

Carl R. Johnson, M. Braun, Frederic S. Ruel, 2003 .

Chemoenzymatic Synthesis of Azasugars: D-Talo- and D-Manno-1-Deoxynojirimycin

Carl R. Johnson, M. Braun, A. Gołębiowski, 1995 .

Chemoenzymatic synthesis of 1,3-dideoxynojirimycin

Carl R. Johnson, M. Braun, A. Gołębiowski, 1994 .

Chemoenzymatic Synthesis of Azasugars: D‐talo and D‐manno‐1‐ Deoxynojirimycin.

Carl R. Johnson, M. Braun, A. Gołębiowski, 1995 .

IN VITRO AND IN VIVO METABOLISM OF A POTENT AND SELECTIVE INTEGRIN v 3 ANTAGONIST IN RATS , DOGS , AND MONKEYS

J. Yergey, R. Subramanian, M. Braun, 2004 .

EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS

David C Evans, T. Baillie, M. Braun, 2006, Drug Metabolism and Disposition.

Bioactivation of diclofenac via benzoquinone imine intermediates-identification of urinary mercapturic acid derivatives in rats and humans.

T. Baillie, P. Griffin, M. Braun, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Preparation of α-Halo-α,β-Unsaturated Bicyclic Lactams and Their Use in Palladium-Catalyzed Cross Coupling Reactions

Carl R. Johnson, M. Braun, B. Newhouse, 1993 .

Modified Stille Coupling Utilizing α-Iodoenones.

Joseph P. Adams, Carl R. Johnson, M. Braun, 1992 .

In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations

T. Baillie, J. G. Slatter, D. Dean, 2008, Drug Metabolism And Disposition.

LC/MS/MS plasma assay for the peptidomimetic VLA4 antagonist I and its major active metabolite II: for treatment of asthma by inhalation.

C. Raab, M. Braun, D. Musson, 2002, Journal of pharmaceutical and biomedical analysis.

Metabolism and Renal Elimination of Gaboxadol in Humans: Role of UDP-Glucuronosyltransferases and Transporters

X. Chu, R. Evers, M. Braun, 2009, Pharmaceutical Research.

Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.

Desmond O'Connor, Robert Maxey, J. Atack, 2006, Bioorganic & medicinal chemistry letters.

Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR.

Charles C. Lin, C. Gibson, R. Subramanian, 2003, Drug metabolism and disposition: the biological fate of chemicals.

In vitro and in vivo metabolism of a potent and selective integrin alpha v beta 3 antagonist in rats, dogs, and monkeys.

J. Yergey, R. Subramanian, M. Braun, 2004, Drug metabolism and disposition: the biological fate of chemicals.

High-throughput simultaneous determination of the HIV protease inhibitors indinavir and L-756423 in human plasma using semi-automated 96-well solid phase extraction and LC-MS/MS.

G. Gatto, M. Braun, E. Woolf, 2000, Journal of pharmaceutical and biomedical analysis.

Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

D. Dean, Sanjeev Kumar, A. Bergman, 2010, Drug Metabolism and Disposition.