N. Dales

发表

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Thomas M. Smith, D. Curtis, B. Tseng, 2015, Nature chemical biology.

Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.

James M. Gavin, T. Ocain, A. Gould, 2002, Journal of the American Chemical Society.

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.

D. McLaren, N. Dales, N. Pokrovskaia, 2015, Bioorganic & medicinal chemistry.

Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.

D. McLaren, B. Hubbard, N. Dales, 2014, Bioorganic & medicinal chemistry letters.

Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Thomas M. Smith, John A. Tallarico, D. Curtis, 2015, Nature chemical biology.

Synthesis of (3R)-Amino-(2S)-Hydroxy Amino Acids for Inhibition of Methionine Aminopeptidase-1

D. Rich, N. Dales, Stacy J. Keding, 1998 .

The effect of detergents on proteins analyzed by electrospray ionization.

P. Andrews, N. Dales, R. Loo, 1996, Methods in molecular biology.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

D. Curtis, M. Hild, Yiping Shen, 2018, Journal of medicinal chemistry.

Design and synthesis of unsymmetrical peptidyl urea inhibitors of aspartic peptidases.

R. Bohacek, K. Satyshur, D. Rich, 2001, Organic letters.

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Saurabh Menon, T. Parsons, M. Pantoliano, 2004, Journal of Biological Chemistry.

Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.

N. Dales, M. Winther, Zaihui Zhang, 2014, Journal of medicinal chemistry.

An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion

R. Dolmetsch, M. Hild, B. Borowsky, 2022, Nature Communications.

Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.

D. McLaren, B. Hubbard, N. Dales, 2014, Bioorganic & medicinal chemistry letters.

Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.

John A. Tallarico, Charles A. Wartchow, G. Dranoff, 2023, Cell chemical biology.

BET bromodomain inhibitors regulate keratinocyte plasticity

Mathias Frederiksen, H. Ruffner, T. Bouwmeester, 2021, Nature Chemical Biology.

Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of N-Methyl-5-aryl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators.

D. Chin, L. Hamann, K. Briner, 2021, Journal of medicinal chemistry.

Enzymatic Characterization of the Pancreatic Islet-specific Glucose-6-Phosphatase-related Protein (IGRP)*

L. Tartaglia, Qing Yang, T. Parsons, 2004, Journal of Biological Chemistry.

Surfactant effects on protein structure examined by electrospray ionization mass spectrometry

P. Andrews, R. Loo, N. Dales, 1994, Protein science : a publication of the Protein Society.

Synthesis of large multideterminant peptide immunogens using a poly-proline beta-turn helix motif.

P. Andrews, R. Montelaro, J. Fontenot, 1993, Peptide research.

Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.

A. Winiski, N. Dales, A. Billich, 2013, The Journal of investigative dermatology.

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.

Thomas M. Smith, John A. Tallarico, D. Curtis, 2015, Nature chemical biology.

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.

D. McLaren, N. Dales, N. Pokrovskaia, 2015, Bioorganic & medicinal chemistry.