A. Agrotis

发表

A new age in functional genomics using CRISPR/Cas9 in arrayed library screening

R. Ketteler, A. Agrotis, 2015, Front. Genet..

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

P. Tipping, A. Agrotis, B. Toh, 2011, Circulation research.

Alternative splicing within the TGF‐β type I receptor gene (ALK‐5) generates two major functional isoforms in vascular smooth muscle cells

M. Condron, A. Agrotis, A. Bobik, 2000, FEBS letters.

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

S. Akira, M. Sweet, K. Peter, 2014, Arteriosclerosis, thrombosis, and vascular biology.

The Genetic Basis for Altered Blood Vessel Function in Disease: Large Artery Stiffening

A. Agrotis, 2005, Vascular health and risk management.

Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

R. Ketteler, J. Kriston-Vizi, C. Luft, 2018, Front. Cell Dev. Biol..

DIFFERENTIAL REGULATION BY TRANSFORMING GROWTH FACTOR‐β1 OF PLATELET‐DERIVED GROWTH FACTOR‐ STIMULATED PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS

A. Agrotis, A. Bobik, J. Saltis, 1992, Clinical and experimental pharmacology & physiology.

EFFECT OF TRANSFORMING GROWTH FACTOR‐β1 ON PLATELET‐DERIVED GROWTH FACTOR RECEPTOR BINDING AND GENE EXPRESSION IN VASCULAR SMOOTH MUSCLE CELLS FROM SHR AND WKY RATS

A. Agrotis, A. Bobik, J. Saltis, 1994, Clinical and experimental pharmacology & physiology.

Higher throughput drug screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

P. Beales, R. Ketteler, S. Hart, 2021, European Respiratory Journal.

High-content screening for rare respiratory diseases: readthrough therapy in primary ciliary dyskinesia

P. Beales, R. Ketteler, S. Hart, 2020, bioRxiv.

Vascular types I and II transforming growth factor‐beta receptor expression: differential dependency on tyrosine kinases during induction by TGF‐β

M. Ward, G. Jennings, A. Agrotis, 1998, FEBS letters.

Inhibition of protein tyrosine kinases attenuates increases in expression of transforming growth factor-beta isoforms and their receptors following arterial injury.

M. Ward, G. Jennings, R. Dilley, 1997, Arteriosclerosis, thrombosis, and vascular biology.

VASCULAR REMODELLING AND MOLECULAR BIOLOGY: NEW CONCEPTS AND THERAPEUTIC POSSIBILITIES

A. Agrotis, A. Bobik, Alex Agrotis, 1996, Clinical and experimental pharmacology & physiology.

REGULATION AND INTERACTIONS OF TRANSFORMING GROWTH FACTOR‐β WITH CARDIOVASCULAR CELLS: IMPLICATIONS FOR DEVELOPMENT AND DISEASE

A. Agrotis, A. Bobik, J. Saltis, 1996, Clinical and experimental pharmacology & physiology.

Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines.

N. Kalinina, A. Agrotis, P. Kanellakis, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Sex hormones and cardiomyopathic phenotype induced by cardiac beta 2-adrenergic receptor overexpression.

A. Dart, G. Jennings, E. Woodcock, 2003, Endocrinology.

Lesions : Role of Activated Macrophages and Cytokines Increased Expression of the DNA-Binding Cytokine HMGB 1 in Human Atherosclerotic

N. Kalinina, A. Agrotis, P. Kanellakis, 2004 .

Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions: Role of Activated Macrophages and Cytokines

N. Kalinina, A. Agrotis, P. Kanellakis, 2004 .

Transforming growth factor-beta 1 gene activation and growth of smooth muscle from hypertensive rats.

A. Agrotis, A. Bobik, J. Saltis, 1994, Hypertension.

AGE‐DEPENDENT ALTERATIONS IN VASCULAR SMOOTH MUSCLE CELL RESPONSIVENESS TO PLATELET‐DERIVED GROWTH FACTOR IN GENETIC HYPERTENSION

A. Agrotis, A. Bobik, J. Saltis, 1993, Clinical and experimental pharmacology & physiology.

Actin remodelling controls proteasome homeostasis upon stress

A. Agrotis, Houjiang Zhou, Thomas D. Williams, 2022, Nature Cell Biology.

Blood flow regulates the development of vascular hypertrophy, smooth muscle cell proliferation, and endothelial cell nitric oxide synthase in hypertension.

A. Agrotis, P. Kanellakis, A. Bobik, 2000, Hypertension.

STIM1: a new therapeutic target in occlusive vascular disease?

A. Agrotis, C. Koulis, 2008, Cardiovascular research.

STIM 1 : a new therapeutic target in occlusive vascular disease ?

A. Agrotis, C. Koulis, 2022 .

, Cell Migration , and Activity of Genes Regulating Migration Low Blood Flow After Angioplasty Augments Mechanisms of Restenosis : Inward Vessel

Alex, P. Tsao, M. Ward, 2001 .

Low Blood Flow After Angioplasty Augments Mechanisms of Restenosis: Inward Vessel Remodeling, Cell Migration, and Activity of Genes Regulating Migration

P. Tsao, M. Ward, G. Jennings, 2001, Arteriosclerosis, thrombosis, and vascular biology.

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

M. Sweet, K. Peter, I. Ahrens, 2015, Thrombosis and Haemostasis.

Expression of growth factor receptors in arterial smooth muscle cells. Dependency on cell phenotype and serum factors.

J. Campbell, A. Agrotis, A. Bobik, 1995, Atherosclerosis.

VASCULAR SMOOTH MUSCLE CELL PROLIFERATION IN SHR AND WKY RATS: EVIDENCE FOR SPECIFIC DIFFERENCES IN GROWTH INHIBITORY REGULATORY MECHANISMS

A. Agrotis, A. Bobik, P. Bray, 1993, Clinical and experimental pharmacology & physiology.

TGF-beta 1 potentiates growth factor-stimulated proliferation of vascular smooth muscle cells in genetic hypertension.

A. Agrotis, A. Bobik, J. Saltis, 1992, The American journal of physiology.

Angiotensin-converting enzyme inhibition abolishes medial smooth muscle PDGF-AB biosynthesis and attenuates cell proliferation in injured carotid arteries: relationships to neointima formation.

G. Jennings, R. Dilley, A. Agrotis, 1997, Circulation.

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

F. Mackay, S. Gerondakis, M. Maxwell, 2017, Nature Communications.

Transforming growth factor-beta 1 and the development of vascular hypertrophy in hypertension.

R. Dilley, A. Agrotis, A. Bobik, 1995, Blood pressure. Supplement.

Darbepoetin‐mediated cardioprotection after myocardial infarction involves multiple mechanisms independent of erythropoietin receptor–common β‐chain heteroreceptor

Xiao-Ming Gao, Xiaojun Du, A. Agrotis, 2010, British journal of pharmacology.

Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries.

M. Ward, G. Jennings, R. Dilley, 1998, Atherosclerosis.

Multiple types of ryanodine receptor/Ca2+ release channels are expressed in vascular smooth muscle.

A. Agrotis, A. Bobik, C. Neylon, 1995, Biochemical and biophysical research communications.

On ATG4B as Drug Target for Treatment of Solid Tumours—The Knowns and the Unknowns

R. Ketteler, A. Agrotis, 2019, Cells.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Simvastatin, an inhibitor of epithelial-to-mesenchymal transition in experimental atherosclerotic renovascular disease?

A. Agrotis, 2008, Journal of hypertension.

Aggravates Atherosclerosis Ameliorates whereas Its Adoptive Transfer Conventional B2 B Cell Depletion

P. Tipping, A. Agrotis, B. Toh, 2010 .

An association between ADH protein levels and polymorphic nucleotide variation in the Adh gene of Drosophila melanogaster.

A. Agrotis, A. C. Taylor, S. McKechnie, 1992, Molecular biology and evolution.

Molecular relationships between alcohol dehydrogenase null-activity alleles from natural populations of Drosophila melanogaster.

J. Gibson, A. Agrotis, A. V. Wilks, 1992, Molecular biology and evolution.

Cytokine Therapy With Interleukin-2/Anti–Interleukin-2 Monoclonal Antibody Complexes Expands CD4+CD25+Foxp3+ Regulatory T Cells and Attenuates Development and Progression of Atherosclerosis

P. Tipping, A. Agrotis, B. Toh, 2012, Circulation.

NKT Cell Subsets Mediate Differential Proatherogenic Effects in ApoE−/− Mice

G. Besra, A. Agrotis, B. Toh, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with the postural tachycardia syndrome

T. Dawood, A. Agrotis, M. Esler, 2008, Autonomic Neuroscience.

Cytokine Therapy with IL-2/anti-IL-2mAb Complexes Expands CD4+CD25+Foxp3+ Regulatory T Cells and Attenuates Development and of Developed Atherosclerosis

P. Tipping, A. Agrotis, B. Toh, 2012 .

Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells

R. Ketteler, A. Agrotis, N. Pengo, 2019, Autophagy.

Vascular Smooth Muscle Cells Express Multiple Type I Receptors for TGF-β,Activin, and Bone Morphogenetic Proteins ☆

A. Agrotis, A. Bobik, M. Samuel, 1996 .

Transforming Growth Factor-β, Cell Signaling and Cardiovascular Disorders

N. Kalinina, A. Agrotis, A. Bobik, 2005 .

Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with the postural tachycardia syndrome

Markus Schlaich, Elisabeth Lambert, Murray Esler, 2008, Autonomic Neuroscience.

Smad Expression in Human Atherosclerotic Lesions Evidence for Impaired TGF-β/Smad Signaling in Smooth Muscle Cells of Fibrofatty Lesions

N. Kalinina, A. Agrotis, A. Bobik, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Inhibition of the Nuclear Receptor ROR&ggr; and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia

A. Agrotis, D. Deliyanti, Dean M. Talia, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

F. Mackay, S. Gerondakis, M. Maxwell, 2017, Nature Communications.

NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy.

R. Touyz, H. Schmidt, M. Cooper, 2014, Antioxidants & redox signaling.

Urokinase plasminogen activator augments cell proliferation and neointima formation in injured arteries via proteolytic mechanisms.

V. Tkachuk, Y. Parfyonova, A. Agrotis, 2001, Atherosclerosis.

Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy.

A. Agrotis, I. Rana, Roksana Armani, 2013, Clinical science.

Successful In Vitro Expansion and Differentiation of Cord Blood Derived CD34+ Cells into Early Endothelial Progenitor Cells Reveals Highly Differential Gene Expression

I. Haviv, C. Bode, K. Peter, 2011, PloS one.

Epigenetic Modification of the Norepinephrine Transporter Gene in Postural Tachycardia Syndrome

M. Esler, A. El-Osta, A. Agrotis, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Understanding the role of transforming growth factor-beta1 in intimal thickening after vascular injury.

A. Agrotis, A. Bobik, R. Khan, 2007, Cardiovascular research.

High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice

K. Peter, M. Nishibori, I. Ahrens, 2011, Arteriosclerosis, thrombosis, and vascular biology.

CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart

A. Agrotis, P. Kanellakis, A. Bobik, 2011, Journal of hypertension.

Tranilast Prevents Activation of Transforming Growth Factor-&bgr; System, Leukocyte Accumulation, and Neointimal Growth in Porcine Coronary Arteries After Stenting

M. Ward, G. Jennings, A. Agrotis, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

P. Tipping, A. Agrotis, B. Toh, 2010, The Journal of Immunology.

Distinct patterns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions. Colocalization implicates TGF-beta in fibrofatty lesion development.

M. Condron, R. Dilley, A. Agrotis, 1999, Circulation.

Vascular derived growth factors: potential role in the development of the tumour vasculature

P. Little, A. Agrotis, A. Bobik, 1997 .

The retinal renin–angiotensin system: Roles of angiotensin II and aldosterone

A. Agrotis, D. Deliyanti, J. L. Wilkinson-Berka, 2012, Peptides.

Cytochrome b558—Dependent NAD(P)H Oxidase—Phox Units in Smooth Muscle and Macrophages of Atherosclerotic Lesions

N. Kalinina, A. Agrotis, P. Kanellakis, 2002, Arteriosclerosis, thrombosis, and vascular biology.

A Novel Mouse Model of Atherosclerotic Plaque Instability for Drug Testing and Mechanistic/Therapeutic Discoveries Using Gene and MicroRNA Expression Profiling

I. Haviv, K. Peter, R. Hannan, 2013, Circulation research.

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

J. Jones, R. Ketteler, A. Agrotis, 2017, Nature Communications.

A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B

J. Jones, R. Ketteler, A. Agrotis, 2017, Nature Communications.

Transforming Growth Factor-/Jl Gene Activation and Growth of Smooth Muscle From Hypertensive Rats

A. Agrotis, A. Bobik, J. Saltis, 2005 .

Transforming growth factor-beta and receptor tyrosine kinase-activating growth factors negatively regulate collagen genes in smooth muscle of hypertensive rats.

A. Agrotis, A. Bobik, P. Bray, 1998, Hypertension.

Negatively Regulate Collagen Genes in Smooth Muscle of Hypertensive Rats Activating Growth Factors − and Receptor Tyrosine Kinase β Transforming Growth Factor

A. Agrotis, A. Bobik, P. Bray, 1998 .

DEVELOPMENTALLY REGULATED TRANSFORMING GROWTH FACTOR‐β1 ACTION ON VASCULAR SMOOTH MUSCLE GROWTH IN THE SHR

A. Agrotis, P. Kanellakis, A. Bobik, 1994, Clinical and experimental pharmacology & physiology.

Proximity interactome of LC3B in normal growth conditions

V. Rajeeve, P. Cutillas, R. Ketteler, 2021, bioRxiv.

Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins

Lucas von Chamier, R. Ketteler, A. Agrotis, 2019, The Journal of Biological Chemistry.

Inhibition of Fibroblast Growth Factor Receptor Signaling Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice

G. Jennings, A. Agrotis, P. Kanellakis, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Human Atherosclerotic Lesions : Colocalization Implicates TGF-Isoform and Receptor Expression in β Distinct Patterns of Transforming Growth Factor

M. Condron, R. Dilley, A. Agrotis, 1999 .

Prorenin stimulates a pro‐angiogenic and pro‐inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia

A. Agrotis, D. Campbell, D. Deliyanti, 2015, Clinical and experimental pharmacology & physiology.

Retinal Vasculopathy Is Reduced by Dietary Salt Restriction: Involvement of Glia, ENaC&agr;, and the Renin–Angiotensin–Aldosterone System

A. Agrotis, W. Figgett, D. Deliyanti, 2014, Arteriosclerosis, thrombosis, and vascular biology.

A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-kappaB signaling.

A. Husband, P. Nestel, A. Agrotis, 2009, Atherosclerosis.

Transforming growth factor-beta, cell signaling and cardiovascular disorders.

N. Kalinina, A. Agrotis, A. Bobik, 2005, Current vascular pharmacology.

Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells.

P. Little, A. Agrotis, A. Bobik, 1993, European journal of pharmacology.

Proliferation of Neointimal Smooth Muscle Cells after Arterial Injury

G. Jennings, R. Hannan, A. Agrotis, 2004, Journal of Biological Chemistry.

Differences in growth characteristics of vascular smooth muscle from spontaneously hypertensive and Wistar—Kyoto rats are growth factor dependent

A. Agrotis, A. Bobik, J. Saltis, 1993, Journal of hypertension.