Katie Chan

发表

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

D. Durocher, C. Myers, J. Moffat, 2017, G3: Genes, Genomes, Genetics.

Bioactivation of fluorotelomer alcohols in isolated rat hepatocytes.

S. Mabury, Katie Chan, P. O'Brien, 2009, Chemico-biological interactions.

Application of structure–activity relationships to investigate the molecular mechanisms of hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated aldehydes

Katie Chan, P. O'Brien, R. Poon, 2008, Journal of applied toxicology : JAT.

Structure–activity relationships for hepatocyte toxicity and electrophilic reactivity of α,β‐unsaturated esters, acrylates and methacrylates

Katie Chan, P. O'Brien, 2008, Journal of applied toxicology : JAT.

Structure – activity relationships for hepatocyte toxicity and electrophilic reactivity of a , b-unsaturated esters , acrylates and methacrylates STRUCTURE – ACTIVITY RELATIONSHIPS FOR HEPATOCYTE TOXICITY

Katie Chan, P. O'Brien, 2008 .

Selection of Clinically Relevant Protease Inhibitor-Resistant Viruses Using the Genotype 2a Hepatitis C Virus Infection System

W. Zhong, Maria V. Pokrovskii, Huiling Yang, 2011, Antimicrobial Agents and Chemotherapy.

Development of a robust luciferase reporter 1b/2a hepatitis C virus (HCV) for characterization of early stage HCV life cycle inhibitors.

Huiling Yang, Katie Chan, Margaret F. Robinson, 2013, Antiviral research.

Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes.

H. Sadeghi-aliabadi, H. Lehmler, L. Robertson, 2007, Chemico-biological interactions.

Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatocytes.

Katie Chan, P. O'Brien, N. Jensen, 2007, Chemico-biological interactions.

Tetramethylphenylenediamine-induced hepatocyte cytotoxicity caused by lysosomal labilisation and redox cycling with oxygen activation.

Katie Chan, P. O'Brien, J. Pourahmad, 2008, Chemico-biological interactions.

Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity.

Katie Chan, P. O'Brien, N. Shangari, 2007, Molecular nutrition & food research.

Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p‐benzoquinone compounds

Katie Chan, P. O'Brien, N. Jensen, 2008, Journal of applied toxicology : JAT.

Interleukin-17 stimulates the expression of interleukin-8, growth-related oncogene-alpha, and granulocyte-colony-stimulating factor by human airway epithelial cells.

Katie Chan, Carol E. Jones, 2002, American journal of respiratory cell and molecular biology.

Tumor expression of Integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor Snail: an immunohistochemical study in ductal pancreatic adenocarcinoma

C. Scudamore, D. Owen, A. Buczkowski, 2010, Virchows Archiv.

An adaptive mutation in NS2 is essential for efficient production of infectious 1b/2a chimeric hepatitis C virus in cell culture.

H. Mo, W. Zhong, Maria V. Pokrovskii, 2012, Virology.

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.

H. Mo, Simin Xu, W. Delaney, 2013, Antiviral research.

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.

T. Appleby, G. Cheng, Tetsuya Kobayashi, 2019, Bioorganic & medicinal chemistry letters.

Robust and Persistent Replication of the Genotype 6a Hepatitis C Virus Replicon in Cell Culture

Huiling Yang, W. Delaney, G. Cheng, 2014, Antimicrobial Agents and Chemotherapy.

Development of robust hepatitis C virus genotype 4 subgenomic replicons.

H. Mo, Huiling Yang, Simin Xu, 2013, Gastroenterology.

Evaluation and Design of Genome-Wide CRISPR / SpCas 9 Knockout Screens

D. Durocher, C. Myers, J. Moffat, 2017 .

Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent

Xiaohong Liu, G. Cheng, Katie Chan, 2015, PloS one.

P0899 : Preclinical profile of the pan-genotypic HCV NS3/4A protease inhibitor GS-9857

E. Nejati, T. Appleby, H. Dvory‐Sobol, 2015 .

Base excision repair fidelity in normal and cancer cells.

G. Dianov, Katie Chan, Qiu-Mei Zhang, 2006, Mutagenesis.

Drug-induced mitochondrial toxicity

Katie Chan, P. O'Brien, N. Shangari, 2005, Expert opinion on drug metabolism & toxicology.

Overexpression of DNA polymerase beta results in an increased rate of frameshift mutations during base excision repair.

G. Dianov, I. Hickson, Katie Chan, 2007, Mutagenesis.

Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes

H. Lehmler, L. Robertson, Katie Chan, 2009, Journal of applied toxicology : JAT.

Human and animal hepatocytes in vitro with extrapolation in vivo.

Katie Chan, P. O'Brien, P. Silber, 2004, Chemico-biological interactions.

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

Keith Lawson, Maximilian Billmann, Michael Aregger, 2017, bioRxiv.

Drug‐Associated Mitochondrial Toxicity

Katie Chan, P. O'Brien, R. Mehta, 2008 .

Structure-activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes

Katie Chan, P. O'Brien, Katie Chan, 2007 .

825 DEVELOPMENT AND MOLECULAR CHARACTERIZATION OF A ROBUST GENOTYPE 4 HEPATITIS C VIRUS SUBGENOMIC REPLICON

H. Mo, Simin Xu, W. Delaney, 2012 .

1191 GS-5816, A SECOND GENERATION HCV NS5A INHIBITOR WITH POTENT ANTIVIRAL ACTIVITY, BROAD GENOTYPIC COVERAGE AND A HIGH RESISTANCE BARRIER

Huiling Yang, W. Delaney, G. Cheng, 2013 .