S. Kennedy

发表

Detecting ultralow-frequency mutations by Duplex Sequencing

Brendan F. Kohrn, Scott R. Kennedy, L. Loeb, 2014, Nature Protocols.

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

Scott R. Kennedy, L. Loeb, Michael W. Schmitt, 2013, PLoS genetics.

Detection of ultra-rare mutations by next-generation sequencing

Jesse J. Salk, Scott R. Kennedy, Joseph B Hiatt, 2012, Proceedings of the National Academy of Sciences.

Targeted genome fragmentation with CRISPR/Cas9 improves hybridization capture, reduces PCR bias, and enables efficient high-accuracy sequencing of small targets

Elizabeth K. Schmidt, Kathryn T. Baker, Brendan F. Kohrn, 2018 .

Rate volatility and asymmetric segregation diversify mutation burden in mutator cells

Scott R. Kennedy, A. Herr, S. Kennedy, 2020, bioRxiv.

The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum.

Scott R. Kennedy, L. Loeb, Michael W. Schmitt, 2011, Journal of molecular biology.

Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.

Scott R. Kennedy, T. Kunkel, L. Perera, 2022, Nucleic acids research.

Myometrial oxidative stress drives MED12 mutations in leiomyoma

Brendan F. Kohrn, Scott R. Kennedy, Xiuhua Xu, 2022, Cell & bioscience.

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

Brendan F. Kohrn, Scott R. Kennedy, P. Rabinovitch, 2022, bioRxiv.

Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans

Brendan F. Kohrn, Scott R. Kennedy, S. Gregory, 2022, Nucleic acids research.

Somatic mutations in aging, cancer and neurodegeneration

Scott R. Kennedy, L. Loeb, A. Herr, 2012, Mechanisms of Ageing and Development.

Templated nucleoside triphosphate binding to a noncatalytic site on RNA polymerase regulates transcription

Scott R. Kennedy, Scott R Kennedy, D. Erie, 2011, Proceedings of the National Academy of Sciences.

Forks, pincers, and triggers: the tools for nucleotide incorporation and translocation in multi-subunit RNA polymerases.

Scott R Kennedy, D. Erie, S. Kennedy, 2009, Current opinion in structural biology.

Modulation of transcription elongation via the main channel of Escherichia coli RNA polymerase

Scott R. Kennedy, S. Kennedy, 2007 .

Next‐Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk

Scott R. Kennedy, Jesse J Salk, Scott R Kennedy, 2019, Environmental and molecular mutagenesis.

Next-GenerationGenotoxicology : UsingModernSequencing Technologies toAssess SomaticMutagenesis andCancerRisk

J. Salk, S. Kennedy, 2019 .

Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant

Scott R. Kennedy, A. Herr, S. Kennedy, 2017, Scientific Reports.

PolyG-DS: An ultrasensitive polyguanine tract–profiling method to detect clonal expansions and trace cell lineage

Brendan F. Kohrn, Scott R. Kennedy, H. Clevers, 2021, Proceedings of the National Academy of Sciences.

Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.

Scott R. Kennedy, R. Risques, S. Kennedy, 2019, Trends in cancer.

Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues

Scott R. Kennedy, M. Emond, L. Loeb, 2016, Proceedings of the National Academy of Sciences.

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

Scott R. Kennedy, C. Sander, N. Schultz, 2019, eLife.

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes

Scott R. Kennedy, D. Promislow, M. Kaeberlein, 2019, Proceedings of the National Academy of Sciences.

Volatility of Mutator Phenotypes at Single Cell Resolution

Brendan F. Kohrn, Scott R. Kennedy, Thomas M. Chappell, 2015, PLoS genetics.

DNA Replication Error-Induced Extinction of Diploid Yeast

Scott R. Kennedy, B. Preston, A. Herr, 2014, Genetics.

replication and repair , polymerase fidelity , cancer , lethal mutagenesis , mutational robustness

Scott R. Kennedy, B. Preston, A. Herr, 2014 .

Aging and the rise of somatic cancer-associated mutations in normal tissues

Scott R. Kennedy, Rosa Ana Risques, Scott R Kennedy, 2018, PLoS genetics.

Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer

Kathryn T. Baker, Scott R. Kennedy, M. Emond, 2018, Molecular Cancer Research.

The Complicated Nature of Somatic mtDNA Mutations in Aging

Scott R. Kennedy, S. Kennedy, M. Sanchez-Contreras, 2022, Frontiers in Aging.

Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage

Scott R. Kennedy, Scott R Kennedy, T. Montine, 2016, Annals of neurology.

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

Scott R. Kennedy, L. Pallanck, F. Cardozo-Pelaez, 2014, PLoS genetics.

Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

Scott R. Kennedy, Mark J. P. Chaisson, L. Pallanck, 2018, PLoS genetics.

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster

Scott R. Kennedy, Maulik R. Patel, Janet M. Young, 2016, eLife.

A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA

Elizabeth K. Schmidt, Brendan F. Kohrn, Scott R. Kennedy, 2021, Nucleic acids research.

Rate volatility and asymmetric segregation diversify mutation burden in cells with mutator alleles

Scott R. Kennedy, A. Herr, S. Kennedy, 2021, Communications Biology.

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Elizabeth K. Schmidt, Kathryn T. Baker, Brendan F. Kohrn, 2018, Genome research.

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Scott R. Kennedy, J. Harper, A. Ordureau, 2015, Neuron.

A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome composition

Elizabeth K. Schmidt, Brendan F. Kohrn, Scott R. Kennedy, 2021, bioRxiv.

Werner syndrome through the lens of tissue and tumour genomics

Scott R. Kennedy, P. Welcsh, R. Monnat, 2016, Scientific Reports.

Loss of vacuolar acidity results in iron-sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae

Scott R. Kennedy, Kenneth L. Chen, Matthew M. Crane, 2020, GeroScience.

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

Elizabeth K. Schmidt, Scott R. Kennedy, M. Minczuk, 2019, Nature Communications.

Resistance of mitochondrial DNA to chemical-induced germline mutations is independent of mitophagy in C. elegans

Brendan F. Kohrn, Scott R. Kennedy, Joel N. Meyer, 2022, bioRxiv.

TITLE: Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells ABSTRACT: Aging is characterized by the accumulation of amyloid and prion-like proteins. However, the molecular mechanisms

Scott R. Kennedy, B. Benayoun, J. Rosenthal, 2023 .

Corrigendum: Detecting ultralow-frequency mutations by Duplex Sequencing

Brendan F. Kohrn, Scott R. Kennedy, L. Loeb, 2014, Nature Protocols.