Tanglong Yuan

发表

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

L. Steinmetz, Yixue Li, Yidi Sun, 2019, Science.

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects

Hui Yang, Changyang Zhou, Yixue Li, 2020, Nature Methods.

High-fidelity base editor with no detectable genome-wide off-target effects

Yixue Li, Yidi Sun, Erwei Zuo, 2020, bioRxiv.

Base editing generates substantial off-target single nucleotide variants

Lars M. Steinmetz, Hui Yang, L. Steinmetz, 2018, bioRxiv.

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

A. Kolomeisky, Isaac B. Hilton, Xue Gao, 2020, Science Advances.

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos

L. Steinmetz, Yixue Li, Yidi Sun, 2020, Nature Protocols.

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Jinsheng Lai, Dongming Zhou, G. Geng, 2021, Nature Methods.

Novel miniature CRISPR–Cas13 systems from uncultivated microbes effective in degrading SARS-CoV-2 sequences and influenza viruses

Dongming Zhou, G. Geng, Zikang Wang, 2020 .

Programmable RNA editing with compact CRISPR–Cas13 systems from uncultivated microbes

Jinsheng Lai, G. Geng, Zikang Wang, 2021, Nature Methods.

Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods

Yidi Sun, Erwei Zuo, Tanglong Yuan, 2021, Nature Communications.

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice

Yidi Sun, Erwei Zuo, Tanglong Yuan, 2023, Nature Communications.