T. Ratovitski

发表

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

D. Borchelt, D. Price, N. Jenkins, 1997, Neuron.

Co-expression of multiple transgenes in mouse CNS: a comparison of strategies.

D. Borchelt, N. Copeland, N. Jenkins, 2001, Biomolecular engineering.

Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites

Amanda J. Kedaigle, E. Fraenkel, M. MacDonald, 2019, Human Molecular Genetics.

Huntingtin Phosphorylation Sites Mapped by Mass Spectrometry

Michael P. Cusack, C. Ross, Cameron Torcassi, 2006, Journal of Biological Chemistry.

Nemo-like Kinase Reduces Mutant Huntingtin Levels and Mitigates Huntington's Disease.

Janghoo Lim, C. Ross, J. Troncoso, 2020, Human molecular genetics.

Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.

Amanda J. Kedaigle, E. Fraenkel, R. Cole, 2021, Human molecular genetics.

Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

D. Borchelt, D. Price, A. Levey, 1997, Nature Medicine.

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

D. Borchelt, N. Jenkins, S. Sisodia, 2002, Neurobiology of Aging.

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line

C. Ross, Tsonwin Hai, M. Poirier, 2009, Brain Research.

Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin

M. Hayden, S. Mori, C. Ross, 2012, The Journal of Neuroscience.

Corrigendum: Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin (Human Molecular Genetics (1999) 8 (397-407))

D. Borchelt, D. Price, C. Ross, 1999 .

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Eric N. Anderson, C. Ross, J. Lucas, 2020, Cell reports.

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors*

C. L. Harris, D. Borchelt, D. Price, 1997, The Journal of Biological Chemistry.

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

C. Ross, T. Ratovitski, N. Arbez, 2015, Cell cycle.

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.

T. Gillis, J. Mysore, M. MacDonald, 2012, Cell stem cell.

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin*

D. Borchelt, D. Price, S. Sisodia, 1997, The Journal of Biological Chemistry.

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

D. Borchelt, V. Culotta, L. Corson, 1999, Human molecular genetics.

pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model

M. Hayden, C. Ross, Xiaohong Xu, 2020, Cell Death & Disease.

Expression of myostatin pro domain results in muscular transgenic mice

R. Wall, T. Ratovitski, M. Solomon, 2001, Molecular reproduction and development.

Characterization and identification of the inhibitory domain of GDF-8 propeptide.

L. Liang, T. Ratovitski, M. Jiang, 2004, Biochemical and biophysical research communications.

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

R. Cole, C. Ross, T. Boronina, 2012, Cell cycle.

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.

D. Borchelt, D. Price, C. Ross, 1999, Human molecular genetics.

Cysteine Proteases Bleomycin Hydrolase and Cathepsin Z Mediate N-terminal Proteolysis and Toxicity of Mutant Huntingtin*

T. Ratovitski, E. Waldron, R. Hirschhorn, 2011, The Journal of Biological Chemistry.

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.

R. Cole, C. Ross, R. Chaerkady, 2017, Journal of proteome research.

DOPAMINE-INDUCED APOPTOSIS IN HUMAN NEURONAL CELLS: INHIBITION BY NUCLEIC ACIDS ANTISENSE TO THE DOPAMINE TRANSPORTER

T. Ratovitski, R. Simantov, M. Gabbay, 1996, Neuroscience.

Quantitative Proteomic Analysis Reveals Similarities between Huntington's Disease (HD) and Huntington's Disease-Like 2 (HDL2) Human Brains.

R. Cole, C. Ross, R. Chaerkady, 2016, Journal of proteome research.

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells*

R. Cole, M. Hayden, C. Ross, 2009, Journal of Biological Chemistry.

Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein*

S. Finkbeiner, C. Ross, P. Muchowski, 2012, The Journal of Biological Chemistry.

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

R. Cole, C. Ross, T. Ratovitski, 2014, PloS one.

N-Terminal Proteolysis of Full-Length Mutant Huntingtin in an Inducible PC12 Cell Model of Huntington’s Disease

Christopher A Ross, D. Borchelt, M. Hayden, 2007, Cell cycle.

A role for serotonin in the circadian system revealed by the distribution of serotonin transporter and light-induced Fos immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet

S. Amir, J. Stewart, T. Ratovitski, 1998, Neuroscience.

Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.

R. Cole, C. Ross, Anikó Faragó, 2021, Human molecular genetics.

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

C. Ross, D. Lavery, T. Ratovitski, 2017, The Journal of Biological Chemistry.

Carrier-mediated Serotonin Release Induced by d-Fenfluramine: Studies with Human Neuroblastoma Cells Transfected with a Rat Serotonin Transporter

M. Gobbi, T. Ratovitski, R. Simantov, 1997, Neuropharmacology.

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line

C. Ross, Tsonwin Hai, Wanli W. Smith, 2009, Brain Research.

Arginine methylation of RNA-binding proteins is impaired in Huntington’s disease

R. Cole, C. Ross, T. Ratovitski, 2023, Human molecular genetics.