P. Sinko

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Physiologically-based pharmacokinetic simulation modelling.

G. Grass, P. Sinko, 2002, Advanced drug delivery reviews.

Martin's Physical Pharmacy and Pharmaceutical Sciences

P. Sinko, 2005 .

Drug delivery across the blood–brain barrier: why is it difficult? how to measure and improve it?

Yaming Su, P. Sinko, 2006, Expert opinion on drug delivery.

Quantitative assessment of the cell penetrating properties of RI-Tat-9: evidence for a cell type-specific barrier at the plasma membrane of epithelial cells.

Yaming Su, P. Sinko, M. Leibowitz, 2004, Molecular pharmaceutics.

Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries.

P. Sinko, J. Laskin, A. Menjoge, 2011, Biomaterials.

Estimating Human Drug Oral Absorption Kinetics from Caco-2 Permeability Using an Absorption-Disposition Model: Model Development and Evaluation and Derivation of Analytical Solutions for ka and Fa

P. Sinko, Patrick J Sinko, H. Usansky, 2005, Journal of Pharmacology and Experimental Therapeutics.

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.

W. Welsh, V. Kholodovych, P. Sinko, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Safety, Formulation and In Vitro Antiviral Activity of the Antimicrobial Peptide Subtilosin Against Herpes Simplex Virus Type 1

Qingrong Huang, M. Chikindas, P. Sinko, 2013, Probiotics and Antimicrobial Proteins.

Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment.

Andrew Owen, Zoltan Szekely, C. Flexner, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Doxycycline hydrogels as a potential therapy for ocular vesicant injury.

M. Gallo, J. Schlager, K. Svoboda, 2010, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide.

D. Laskin, D. Heck, P. Sinko, 2010, Toxicology and applied pharmacology.

The Architecture and Biological Function of Dual Antibody-Coated Dendrimers: Enhanced Control of Circulating Tumor cells and Their Hetero-Adhesion to Endothelial Cells for Metastasis Prevention

T. Yu, Jingwei Shao, L. Jia, 2014, Theranostics.

Regional oral absorption, hepatic first-pass effect, and non-linear disposition of salmon calcitonin in beagle dogs.

P. Sinko, Lisa M. Falzone, Y. Hee Lee, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In silico tools for drug absorption prediction

G. Grass, P. Sinko, Pankaj V. Paranjpe, 2003 .

Characterization of the oral absorption of beta-lactam antibiotics. II. Competitive absorption and peptide carrier specificity.

G. Amidon, P. Sinko, 1989, Journal of pharmaceutical sciences.

Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in Humans

P. Sinko, P. Hu, 2004, Pharmaceutical Research.

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. II. In vivo investigation.

P. Sinko, N. Puri, 2000, Journal of controlled release : official journal of the Controlled Release Society.

The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention.

T. Yu, L. Jia, Yingying Zhang, 2016, Small.

Differential Roles of P-Glycoprotein, Multidrug Resistance-Associated Protein 2, and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats

P. Sinko, H. Usansky, P. Hu, 2008, Drug Metabolism and Disposition.

Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard.

D. Laskin, D. Heck, P. Sinko, 2014, Experimental and molecular pathology.

Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage.

D. Laskin, D. Heck, P. Sinko, 2011, Experimental and molecular pathology.

Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)

G. Knipp, P. Sinko, A. Liu, 2002, Antimicrobial Agents and Chemotherapy.

Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials.

Jingwei Shao, L. Jia, Yu Gao, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Nef-Mediated Receptor Endocytosis and Simian Immunodeficiency Virus and a Tyrosine Motif, Are Involved in HIV-1 Two Sorting Motifs, a Ubiquitination Motif

P. Sinko, S. Burakoff, Xiaoping Zhang, 2011 .

Two Sorting Motifs, a Ubiquitination Motif and a Tyrosine Motif, Are Involved in HIV-1 and Simian Immunodeficiency Virus Nef-Mediated Receptor Endocytosis

P. Sinko, S. Burakoff, Xiaoping Zhang, 2011, The Journal of Immunology.

Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial

L. Jia, Hongning Chen, P. Sinko, 2015, Journal of Nanobiotechnology.

Multivalent Conjugation of Antibody to Dendrimers for the Enhanced Capture and Regulation on Colon Cancer Cells

L. Jia, Hongning Chen, P. Sinko, 2015, Scientific Reports.

Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex

T. Yu, Jingwei Shao, L. Jia, 2015, Scientific Reports.

Enhanced Specificity in Capturing and Restraining Circulating Tumor Cells with Dual Antibody–Dendrimer Conjugates

Jingwei Shao, L. Jia, Hongning Chen, 2015 .

Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide.

S. Dharap, T. Minko, P. Sinko, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tumor-targeted and activated bioconjugates for improved camptothecin delivery

P. Sinko, S. Stein, Pankaj V. Paranjpe, 2005, Anti-cancer drugs.

Carrier‐mediated intestinal absorption of valacyclovir, the L‐valyl ester prodrug of acyclovir. 1. Interactions with peptides, organic anions and organic cations in rats

P. Sinko, P. Balimane, 1998, Biopharmaceutics & drug disposition.

Biostable Aptamer Rings Conjugated for Targeting Two Biomarkers on Circulating Tumor Cells in Vivo with Great Precision

Jingwei Shao, L. Jia, Zai‐Sheng Wu, 2017 .

The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4

Fanfan Zhou, Jianjie Ma, P. Sinko, 2005, Molecular Pharmacology.

Oxidants and antioxidants in sulfur mustard–induced injury

D. Laskin, D. Heck, Y. Jan, 2010, Annals of the New York Academy of Sciences.

Skin remodeling and wound healing in the Gottingen minipig following exposure to sulfur mustard.

D. Laskin, D. Heck, P. Sinko, 2020, Experimental and molecular pathology.

Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity.

D. Laskin, B. Weinberger, D. Heck, 2011, Pulmonary Pharmacology & Therapeutics.

Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites.

Chung S. Yang, J. Lambert, P. Sinko, 2003, Biochemical and biophysical research communications.

Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells.

P. Sinko, M. Leibowitz, M. Chan, 2002, Bioconjugate chemistry.

Core functional sequence of C-terminal GAG-binding domain directs cellular uptake of IGFBP-3-derived peptides.

P. Sinko, Xiaoping Zhang, Jieming Gao, 2013, Protein and peptide letters.

Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers.

Matthew J. Bruzek, R. Prud’homme, D. Adamson, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Active efflux kinetics of etoposide from rabbit small intestine and colon

P. Sinko, J. Kunta, V. Makhey, 2000, Biopharmaceutics & drug disposition.

Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides.

S. Dharap, T. Minko, P. Sinko, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Differential Roles of Pgp, Mrp2 and CYP3A on Saquinavir Oral Absorption in Sprague-Dawley Rats

P. Sinko, H. Usansky, P. Hu, 2008 .

Polymeric Drug Delivery Systems: An Overview

P. Sinko, J. Kohn, 1993 .

Determining the absolute surface hydrophobicity of microparticulates using thin layer wicking.

D. Norris, P. Sinko, M. Labib, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1.

A. Guo, P. Sinko, F. Luo, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan.

Yaming Su, P. Sinko, P. Hu, 2007, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins.

P. Sinko, P. Chao, S. Stein, 2006, Journal of controlled release : official journal of the Controlled Release Society.

P-Glycoprotein and Mutlidrug Resistance-Associated Proteins Limit the Brain Uptake of Saquinavir in Mice

P. Sinko, Seonghee Park, 2005, Journal of Pharmacology and Experimental Therapeutics.

DIFFERENTIATION OF GUT AND HEPATIC FIRST-PASS LOSS OF VERAPAMIL IN INTESTINAL AND VASCULAR ACCESS-PORTED (IVAP) RABBITS

P. Sinko, J. Kunta, B. Perry, 2004, Drug Metabolism and Disposition.

antimicrobial subtilosin, for prophylaxis of bacterial vaginosis 3

S. S. Rajan, M. Chikindas, Veronica L. Cavera, 2014 .

Susceptibility of Gardnerella vaginalis Biofilms to Natural Antimicrobials Subtilosin, ε-Poly-L-Lysine, and Lauramide Arginine Ethyl Ester

M. Chikindas, P. Sinko, Ammar Algburi, 2012, Infectious diseases in obstetrics and gynecology.

Microfluidic generation of droplets with a high loading of nanoparticles.

Matthew J. Bruzek, H. Stone, Robert K. Prudhomme, 2012, Langmuir : the ACS journal of surfaces and colloids.

Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor.

A. Gow, D. Laskin, P. Sinko, 2012, Toxicology and applied pharmacology.

Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance.

Yaming Su, P. Sinko, Sung-Hack Lee, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard.

D. Laskin, D. Heck, P. Sinko, 2013, Toxicology and applied pharmacology.

A Novel Bivalent Mannosylated Targeting Ligand Displayed on Nanoparticles Selectively Targets Anti-Inflammatory M2 Macrophages

R. Prud’homme, D. Laskin, P. Sinko, 2020, Pharmaceutics.

Responsive foams for nanoparticle delivery.

R. Prud’homme, Christina Tang, P. Sinko, 2015, Colloids and surfaces. B, Biointerfaces.

Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer.

Yaming Su, P. Sinko, Xiaoping Zhang, 2007, Cancer letters.

DELINEATION OF HPEPT1 MEDIATED UPTAKE AND TRANSPORT OF SUBSTRATES WITH VARYING TRANSPORTER AFFINITIES UTILIZING STABLY TRANSFECTED HPEPT1/MDCK CLONES AND CACO-2 CELLS

P. Sinko, O. Gudmundsson, D. Herrera-Ruiz, 2005 .

A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.

P. Sinko, P. Chao, M. Deshmukh, 2010, Journal of medicinal chemistry.

ASeriesofr-AminoAcidEsterProdrugsofCamptothecin:InVitroHydrolysisandA549HumanLung Carcinoma Cell Cytotoxicity

P. Sinko, P. Chao, M. Deshmukh, 2010 .

ASeries of r-AminoAcid Ester Prodrugs of Camptothecin : In VitroHydrolysis and A 549 Human Lung Carcinoma Cell Cytotoxicity

P. Sinko, P. Chao, M. Deshmukh, 2010 .

Differentiation of Gut and Hepatic First-Pass Effect of Drugs: 1. Studies of Verapamil in Ported Dogs

P. Sinko, J. Kunta, B. Perry, 2001, Pharmaceutical Research.

China and the United States--Global partners, competitors and collaborators in nanotechnology development.

L. Jia, Yu Gao, Huijuan Zhang, 2016, Nanomedicine : nanotechnology, biology, and medicine.

Synthesis, Characterization, and In Vitro Assay of Folic Acid Conjugates of 3′-Azido-3′-Deoxythymidine (AZT): Toward Targeted AZT Based Anticancer Therapeutics

R. Doyle, P. Sinko, Anthony R. Vortherms, 2008, Nucleosides, nucleotides & nucleic acids.

Modulation of Nonspecific Binding in Ultrafiltration Protein Binding Studies

K. Holme, P. Sinko, T. Hollenbeck, 2003, Pharmaceutical Research.

Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis

M. Chikindas, P. Sinko, K. Sutyak Noll, 2011, Probiotics and antimicrobial proteins.

Multiple-Peptide Conjugates for Binding β-Amyloid Plaques of Alzheimer's Disease

P. Sinko, M. Leibowitz, Guobao Zhang, 2003 .

Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing

G. Sharma, F. Berthiaume, I. Kaur, 2021, Antioxidants.

Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethyleneglycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells

T. Minko, P. Sinko, S. Stein, 2002, Cancer Chemotherapy and Pharmacology.

Impact of Regional Intestinal pH Modulation on Absorption of Peptide Drugs: Oral Absorption Studies of Salmon Calcitonin in Beagle Dogs

P. Sinko, Lisa M. Falzone, B. Perry, 1999, Pharmaceutical Research.

Regional Differences in Intestinal Spreading and pH Recovery and the Impact on Salmon Calcitonin Absorption in Dogs

P. Sinko, B. Perry, J. Sutyak, 2004, Pharmaceutical Research.

Improved longevity and functionality of a canine model providing portal vein and multi-site intestinal access.

P. Sinko, V. Makhey, B. Perry, 2000, Comparative medicine.

Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix.

D. Laskin, D. Heck, P. Sinko, 2022, Experimental and molecular pathology.

A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells

L. Jia, Zai‐Sheng Wu, P. Sinko, 2016, Molecular therapy. Nucleic acids.

Recent trends in targeted anticancer prodrug and conjugate design.

P. Sinko, Y. Singh, Patrick J Sinko, 2008, Current medicinal chemistry.

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.

S. Bates, J. Schellens, D. Ross, 2003, Cancer research.

Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds.

P. Sinko, A. Menjoge, Sivanaga S Anumolu, 2010, Biomaterials.

Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model

D. Laskin, S. S. Rajan, P. Sinko, 2010, Anti-cancer drugs.

Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach.

D. A. Johnson, G. Amidon, P. Sinko, 1988, Journal of theoretical biology.

THE BLOOD-BRAIN BARRIER SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER: A MOLECULAR FUNCTIONAL IN VITRO-IN SITU CORRELATION

P. Sinko, Seonghee Park, 2005, Drug Metabolism and Disposition.

Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide

V. Ganapathy, P. Prasad, P. Sinko, 2001, Pharmaceutical Research.

Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide.

P. Sinko, M. Leibowitz, S. Ramanathan, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Synthesis of poly(ethylene glycol)-based saquinavir prodrug conjugates and assessment of release and anti-HIV-1 bioactivity using a novel protease inhibition assay.

A. Rabson, P. Sinko, M. Leibowitz, 2004, Bioconjugate chemistry.

Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response.

P. Sinko, Y. Singh, S. Stein, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Nonenzymatic, Self‐Elimination Degradation Mechanism of Glutathione

P. Sinko, S. Stein, M. Deshmukh, 2009, Chemistry & biodiversity.

Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.

A. Guo, T. Nakanishi, I. Tamai, 1998, Biochemical and biophysical research communications.

Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences

Patrick J. Sinko, P. Sinko, Y. Singh, 2006 .

Adjuvancy enhancement of muramyl dipeptide by modulating its release from a physicochemically modified matrix of ovalbumin microspheres. I. In vitro characterization.

P. Sinko, J. H. Kou, N. Puri, 2000, Journal of controlled release : official journal of the Controlled Release Society.

The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly-l-Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

M. Chikindas, P. Sinko, M. Prichard, 2012, Antimicrobial Agents and Chemotherapy.

Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.

D. Laskin, D. Heck, P. Sinko, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

The role of crystallinity on differential attachment/proliferation of osteoblasts and fibroblasts on poly (caprolactone-co-glycolide) polymeric surfaces

Helen Cui, Patrick J. Sinko, P. Sinko, 2012, Frontiers of Materials Science.

A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery.

P. Sinko, M. Leibowitz, Patrick J Sinko, 2003, Biomaterials.

Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer.

Kevin Holme, K. Holme, G. Grass, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism.

P. Sinko, Y. Singh, S. Stein, 2010, Biomaterials.

Characterization of the Regional Intestinal Kinetics of Drug Efflux in Rat and Human Intestine and in Caco-2 Cells

Patrick J. Sinko, Ailan Guo, A. Guo, 1998, Pharmaceutical Research.

Carrier mediated transport of amino acids, small peptides, and their drug analogs

G. Amidon, P. Sinko, Ming Hu, 1987 .

CARRIER MEDIATED TRANSPORT OF AMINO ACIDS, THEIR DRUG ANALOGS*

G. Amidon, P. Sinko, Ming Hu, 1987 .

Oral absorption of anti-AIDS nucleoside analogues. 1. Intestinal transport of didanosine in rat and rabbit preparations.

P. Sinko, P. Hu, A. P. Waclawski, 1995, Journal of pharmaceutical sciences.

Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations.

P. Sinko, A. P. Waclawski, 1996, Journal of pharmaceutical sciences.

Analysis of Intestinal Perfusion Data for Highly Permeable Drugs Using a Numerical Aqueous Resistance—Nonlinear Regression Method

P. Sinko, G. Leesman, H. Yu, 1996, Pharmaceutical Research.

Site-specific oral absorption of didanosine: in situ characterization and correlation with extent of absorption in vivo

P. Sinko, P. Hu, N. Patel, 1994 .

Biopharmaceutical Approaches for Developing and Assessing Oral Peptide Delivery Strategies and Systems: In Vitro Permeability and In Vivo Oral Absorption of Salmon Calcitonin

Patrick J. Sinko, Hongshi Yu, P. Sinko, 2004, Pharmaceutical Research.

Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.

P. Sinko, Y. Singh, M. Palombo, 2009, Journal of drug delivery science and technology.

Development of predictive pharmacokinetic simulation models for drug discovery.

P J Sinko, G. Grass, D. Norris, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.

P J Sinko, A. Guo, P. Sinko, 1999, The Journal of pharmacology and experimental therapeutics.

Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds

Patrick J. Sinko, Gordon L. Amidon, G. Amidon, 2004, Pharmaceutical Research.

Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach

Patrick J. Sinko, Gordon L. Amidon, G. Amidon, 1991, Pharmaceutical Research.

Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ

G. Amidon, P. Sinko, 1988, Pharmaceutical Research.

Evidence for Diminished Functional Expression of Intestinal Transporters in Caco-2 Cell Monolayers at High Passages

Hongshi Yu, T. J. Cook, P. Sinko, 1997, Pharmaceutical Research.

Characterization of the Oral Absorption of Some β-Lactams Effect of the α-Amino Side Chain Group

G. Amidon, P. Sinko, D. Oh, 1993 .

Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

G. Amidon, P. Sinko, Oh D-M, 1992, International journal of pharmaceutics.

Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds

G. Amidon, P. Sinko, D. Oh, 1991 .

Influence of the microporous substratum and hydrodynamics on resistances to drug transport in cell culture systems: calculation of intrinsic transport parameters.

P. Sinko, H. Yu, 1997, Journal of pharmaceutical sciences.

Fed-state effects on zidovudine absorption.

D. Fleisher, P. Sinko, H. Lu, 1991, AIDS.

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats.

D. Laskin, P. Sinko, P. Chao, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Single‐Step Assembly of Multimodal Imaging Nanocarriers: MRI and Long‐Wavelength Fluorescence Imaging

Nan Yao, Carlos Rinaldi, Carlos Pacheco, 2015, Advanced healthcare materials.

siRNA--getting the message out.

P. Sinko, S. H. Lee, Sung-Hack Lee, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The intestinal absorption of camptothecin, a highly lipophilic drug, across Caco-2 cells is mediated by active transporter(s).

P. Sinko, E. Rubin, E. Gupta, 2000, Anticancer research.

An investigation of the intradermal route as an effective means of immunization for microparticulate vaccine delivery systems.

P. Sinko, E. Weyand, N. Puri, 2000, Vaccine.

Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects

A. Rabson, P. Sinko, M. Leibowitz, 2006, AIDS research and therapy.

Oral delivery of salmon calcitonin.

P J Sinko, P. Sinko, Y H Lee, 2000, Advanced drug delivery reviews.

Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications

G. Amidon, P. Sinko, G. Leesman, 1993, Pharmaceutical Research.

Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs.

P. Sinko, K. Gunaseelan, Xiaoping Zhang, 2010, Advanced drug delivery reviews.

Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT).

A. Guo, P. Sinko, P. Hu, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Utility of pharmacodynamic measures for assessing the oral bioavailability of peptides. 1. Administration of recombinant salmon calcitonin in rats.

P. Sinko, E. Wagner, W. Stern, 1995, Journal of pharmaceutical sciences.

Optimal structural design of mannosylated nanocarriers for macrophage targeting.

L. Jia, R. Prud’homme, P. Sinko, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.

Yaming Su, P. Sinko, Xiaoping Zhang, 2004, Molecular pharmaceutics.

Practical Aspects of Transporter Model Systems: A Case Study Involving SQV

Yaming Su, P. Sinko, Sung-Hack Lee, 2004, Drug metabolism reviews.

The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1.

G. Knipp, P. Sinko, Gregory C. Williams, 2003, Journal of pharmaceutical sciences.

Development of a novel intestinal and vascular access port (IVAP) rabbit model to study regiospecific oral absorption pharmacokinetics.

P. Sinko, J. Kunta, B. Perry, 2001, Comparative medicine.

Differentiation of Gut and Hepatic First Pass Metabolism and Secretion of Saquinavir in Ported Rabbits

P. Sinko, J. Kunta, H. Usansky, 2004, Journal of Pharmacology and Experimental Therapeutics.

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

D. Laskin, D. Heck, P. Sinko, 2011, Toxicology and applied pharmacology.

Selective Cytotoxicity and Combined Effects of Camptothecin or Paclitaxel with Sodium-R-Alpha Lipoate on A549 Human Non-Small Cell Lung Cancer Cells

P. Sinko, S. Ibrahim, Dayuan Gao, 2014, Nutrition and cancer.

Fetal and Perinatal Exposure to Drugs and Chemicals : Novel Biomarkers of Risk

P. Sinko, Jieming Gao, M. Deshmukh, 2014 .

Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

Ailan Guo, A. Guo, P. Sinko, 2004, BMC medicine.

BMC Medicine BioMed Central

A. Guo, P. Sinko, E. Rubin, 2003 .

Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates.

Debra L Laskin, Jeffrey D Laskin, D. Laskin, 2012, Journal of controlled release : official journal of the Controlled Release Society.

Design and evaluation of a CXCR4 targeting peptide 4DV3 as an HIV entry inhibitor and a ligand for targeted drug delivery

P. Sinko, Xiaoping Zhang, Z. Székely, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Enhanced passive pulmonary targeting and retention of PEGylated rigid microparticles in rats.

D. Laskin, P. Sinko, P. Chao, 2010, International journal of pharmaceutics.

Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery.

P. Sinko, Jieming Gao, M. Deshmukh, 2014, Annual review of pharmacology and toxicology.

Computation of Log BB Values for Compounds Transported Through Carrier-Mediated Mechanisms Using in Vitro Permeability Data from Brain Microvessel Endothelial Cell (BMEC) Monolayers

Patrick J. Sinko, P. Sinko, H. Usansky, 2003, Pharmaceutical Research.

Breast intraductal nanoformulations for treating ductal carcinoma in situ I: Exploring metal-ion complexation to slow ciclopirox release, enhance mammary persistence and efficacy.

S. Love, P. Sinko, Dipti Kakkar, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Polyethylene Glycol-Based Hydrogels for Controlled Release of the Antimicrobial Subtilosin for Prophylaxis of Bacterial Vaginosis

M. Chikindas, Veronica L. Cavera, P. Sinko, 2014, Antimicrobial Agents and Chemotherapy.

Noninvasive detection of passively targeted poly(ethylene glycol) nanocarriers in tumors.

P. Sinko, Y. Singh, S. Stein, 2012, Molecular pharmaceutics.

Multimeric peptide-based PEG nanocarriers with programmable elimination properties.

P. Sinko, S. Stein, Xiaoping Zhang, 2009, Biomaterials.

Endocytosis and membrane potential are required for HeLa cell uptake of R.I.-CKTat9, a retro-inverso Tat cell penetrating peptide.

P. Sinko, Patrick J Sinko, Xiaoping Zhang, 2009, Molecular pharmaceutics.

Colorectal delivery and retention of PEG-Amprenavir-Bac7 nanoconjugates—proof of concept for HIV mucosal pre-exposure prophylaxis

P. Sinko, Y. Singh, Xiaoping Zhang, 2016, Drug Delivery and Translational Research.

Influence of Molecular Size on the Retention of Polymeric Nanocarrier Diagnostic Agents in Breast Ducts

S. Love, P. Sinko, Y. Singh, 2012, Pharmaceutical Research.

Intestinal drug transporters: in vivo function and clinical importance.

P. Sinko, J. Kunta, Patrick J Sinko, 2004, Current drug metabolism.

Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery.

H. Stone, R. Prud’homme, J. Anthony, 2014, Biomacromolecules.

Antiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin

M. Chikindas, P. Sinko, V. Castilla, 2014, Journal of applied microbiology.

Novel monodisperse PEGtide dendrons: design, fabrication, and evaluation of mannose receptor-mediated macrophage targeting.

P. Sinko, Y. Singh, S. Stein, 2013, Bioconjugate chemistry.

Breast intraductal nanoformulations for treating ductal carcinoma in situ II: Dose de-escalation using a slow releasing/slow bioconverting prodrug strategy

S. Love, P. Sinko, Dipti Kakkar, 2021, Drug Delivery and Translational Research.

Breast intraductal nanoformulations for treating ductal carcinoma in situ II: Dose de-escalation using a slow releasing/slow bioconverting prodrug strategy

S. Love, P. Sinko, Dipti Kakkar, 2021, Drug delivery and translational research.

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

Debra L Laskin, Jeffrey D Laskin, Diane E Heck, 2010, Toxicology and applied pharmacology.

Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard.

Sherri C. Young, D. Laskin, D. Heck, 2014, Toxicology and applied pharmacology.

Intestinal Absorption of Peptides and Peptide Analogues: Implications of Fasting Pancreatic Serine Protease Levels and pH on the Extent of Oral Absorption in Dogs and Humans

P. Sinko, 1992, Pharmaceutical Research.

Evaluation of intraductal delivery of poly(ethylene glycol)‐doxorubicin conjugate nanocarriers for the treatment of ductal carcinoma in situ (DCIS)‐like lesions in rats

S. Love, P. Sinko, Z. Székely, 2018, Journal of interdisciplinary nanomedicine.

Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications for microemboli-based drug delivery systems.

D. Laskin, S. Li, P. Sinko, 2013, Toxicology and applied pharmacology.

Influence of Molecular Size on the Retention of Polymeric Nanocarrier Diagnostic Agents in Breast Ducts

S. Love, P. Sinko, Y. Singh, 2012, Pharmaceutical Research.

Effect of diverse datasets on the predictive capability of ADME models in drug discovery

G. Grass, P. Sinko, 2001 .

Depilatory double‐disc mouse model for evaluation of vesicant dermal injury pharmacotherapy countermeasures

P. Sinko, J. Laskin, Dayuan Gao, 2023, Animal models and experimental medicine.

Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry

Suhong Yu, Lee Jia, Jingwei Shao, 2015, Cancer.

Solubility and distribution phenomena

Patrick J. Sinko, P. Sinko, 2013 .

Effect of size, surface charge, and hydrophobicity on the translocation of polystyrene microspheres through gastrointestinal mucin

Patrick J. Sinko, D. Norris, P. Sinko, 1997 .

Targeted Antitubercular Peptide Nanocarriers Prepared by Flash NanoPrecipitation with Hydrophobic Ion Pairing

Simon A McManus, R. Prud’homme, S. Franzblau, 2022, Advanced Materials & Technologies.

Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment.

M. Chikindas, P. Sinko, Sujata Sundara Rajan, 2014, Journal of Controlled Release.

Peritoneal Macrophage Uptake, Pharmacokinetics and Biodistribution of Macrophage-Targeted PEG-fMLF (N-Formyl-Methionyl-Leucyl-Phenylalanine) Nanocarriers for Improving HIV Drug Delivery

P. Sinko, M. Leibowitz, S. Stein, 2007, Pharmaceutical Research.

Delineation of Human Peptide Transporter 1 (hPepT1)-Mediated Uptake and Transport of Substrates with Varying Transporter Affinities Utilizing Stably Transfected hPepT1/Madin-Darby Canine Kidney Clones and Caco-2 Cells

G. Knipp, P. Sinko, Patrick J Sinko, 2005, Journal of Pharmacology and Experimental Therapeutics.

Antitubercular Nanocarrier Combination Therapy: Formulation Strategies and in Vitro Efficacy for Rifampicin and SQ641

Y. Liu, R. Prud’homme, P. Sinko, 2015, Molecular pharmaceutics.

Optimizing size and copy number for PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarrier uptake by macrophages.

P. Sinko, M. Leibowitz, S. Stein, 2008, Bioconjugate chemistry.

Comprar Martin's Physical Pharmacy And Pharmaceutical Sciences 7th Ed. | Patrick J. Sinko | 9781496353443 | Lippincott Williams & Wilkins

P. Sinko, 2016 .

The nanotechnology race between China and the United States

Haiyan Dong, Yu Gao, Patrick J. Sinko, 2016 .

Oral absorption of the HIV protease inhibitors: a current update.

P. Sinko, Sinko, Williams, 1999, Advanced drug delivery reviews.

Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cells

P. Sinko, P. Balimane, 2000, Biopharmaceutics & drug disposition.

Drug Transporters in the Intestine

P. Sinko, 2014 .

The effect of size and polymer architecture of doxorubicin–poly(ethylene) glycol conjugate nanocarriers on breast duct retention, potency and toxicity

S. Love, P. Sinko, Y. Singh, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4

Fanfan Zhou, Jianjie Ma, P. Sinko, 2005, Molecular Pharmacology.

Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment.

M. Chikindas, P. Sinko, Sujata Sundara Rajan, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response.

P. Sinko, Y. Singh, S. Stein, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard.

D. Laskin, D. Heck, P. Sinko, 2014, Experimental and molecular pathology.

Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats.

D. Laskin, P. Sinko, P. Chao, 2010, Journal of Controlled Release.

Optimizing Nanosuspension Drug Release and Wound Healing Using a Design of Experiments Approach: Improving the Drug Delivery Potential of NDH-4338 for Treating Chemical Burns

P. Sinko, J. Laskin, Dayuan Gao, 2024, Pharmaceutics.