Yoshihiro Toya

发表

Learning from quantitative data to understand central carbon metabolism.

H. Shimizu, F. Matsuda, Yoshihiro Toya, 2017, Biotechnology advances.

Application of adaptive laboratory evolution to overcome a flux limitation in an Escherichia coli production strain

H. Shimizu, C. Furusawa, F. Matsuda, 2018, Biotechnology and bioengineering.

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

H. Mori, Nobuyoshi Ishii, M. Tomita, 2009, Molecular systems biology.

Integrating Kinetic Model of E. coli with Genome Scale Metabolic Fluxes Overcomes Its Open System Problem and Reveals Bistability in Central Metabolism

Ahmad A. Mannan, A. Kierzek, J. McFadden, 2015, PloS one.

Metabolic flux analysis and visualization.

M. Tomita, N. Kono, K. Arakawa, 2011, Journal of proteome research.

SSDesign: Computational metabolic pathway design based on flux variability using elementary flux modes

H. Shimizu, Yoshihiro Toya, T. Shiraki, 2015, Biotechnology and bioengineering.

13C‐metabolic flux analysis for batch culture of Escherichia coli and its pyk and pgi gene knockout mutants based on mass isotopomer distribution of intracellular metabolites

Nobuyoshi Ishii, M. Tomita, K. Nakahigashi, 2010, Biotechnology progress.

Flux analysis and metabolomics for systematic metabolic engineering of microorganisms.

H. Shimizu, Yoshihiro Toya, 2013, Biotechnology advances.

Magnesium starvation improves production of malonyl-CoA-derived metabolites in Escherichia coli.

H. Shimizu, F. Matsuda, Brady F. Cress, 2019, Metabolic engineering.

Direct measurement of isotopomer of intracellular metabolites using capillary electrophoresis time-of-flight mass spectrometry for efficient metabolic flux analysis.

Masaru Tomita, Tomoyoshi Soga, Takashi Hirasawa, 2007, Journal of chromatography. A.

Estimation of linear and cyclic electron flows in photosynthesis based on 13C-metabolic flux analysis.

H. Shimizu, Yoshihiro Toya, Sayaka Kitamura, 2020, Journal of bioscience and bioengineering.

13C-Metabolic Flux Analysis Reveals Effect of Phenol on Central Carbon Metabolism in Escherichia coli

H. Shimizu, Yoshihiro Toya, Sayaka Kitamura, 2019, Front. Microbiol..

Investigation of useful carbon tracers for 13C-metabolic flux analysis of Escherichia coli by considering five experimentally determined flux distributions

H. Shimizu, F. Matsuda, Kousuke Maeda, 2016, Metabolic engineering communications.

Flux balance analysis of cyanobacteria reveals selective use of photosynthetic electron transport components under different spectral light conditions

H. Shimizu, Yoshihiro Toya, M. Toyoshima, 2019, Photosynthesis Research.

Time-resolved metabolomics of a novel trebouxiophycean alga using (13)CO2 feeding.

M. Tomita, N. Kurano, M. Sugimoto, 2013, Journal of bioscience and bioengineering.

Omics‐Integrated Approach for Metabolic State Analysis of Microbial Processes

H. Shimizu, C. Furusawa, F. Matsuda, 2017 .

Construction of a Genome-Scale Metabolic Model of Arthrospira platensis NIES-39 and Metabolic Design for Cyanobacterial Bioproduction

H. Shimizu, C. Furusawa, A. Kondo, 2015, PloS one.

Enhanced dipicolinic acid production during the stationary phase in Bacillus subtilis by blocking acetoin synthesis

H. Shimizu, S. Ishikawa, N. Ogasawara, 2015, Bioscience, biotechnology, and biochemistry.

Optimal 13C-labeling of glycerol carbon source for precise flux estimation in Escherichia coli.

H. Shimizu, Yoshihiro Toya, S. Ohashi, 2017, Journal of bioscience and bioengineering.

13 C-metabolic flux analysis in heterologous cellulase production by Bacillus subtilis genome-reduced strain.

H. Shimizu, N. Ogasawara, K. Ozaki, 2014, Journal of biotechnology.

Flux controlling technology for central carbon metabolism for efficient microbial bio-production.

H. Shimizu, Yoshihiro Toya, 2020, Current opinion in biotechnology.

Optogenetic switch for controlling the central metabolic flux of Escherichia coli.

H. Shimizu, Yoshihiro Toya, S. T. Tandar, 2019, Metabolic engineering.

Combinatorial deletions of glgC and phaCE enhance ethanol production in Synechocystis sp. PCC 6803.

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2016, Journal of biotechnology.

Metabolic impact of nutrient starvation in mevalonate-producing Escherichia coli.

H. Shimizu, Yoshihiro Toya, Ami Masuda, 2017, Bioresource technology.

Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties

H. Shimizu, Teppei Niide, Yoshihiro Toya, 2022, ACS synthetic biology.

Metabolic pathway design for growth-associated phenylalanine production using synthetically designed mutualism

H. Shimizu, Yoshihiro Toya, Ryutaro Kawai, 2022, Bioprocess and Biosystems Engineering.

Metabolic pathway engineering for the non-growth-associated succinate production in Escherichia coli based on flux solution space.

H. Shimizu, Yoshihiro Toya, 2022, Journal of bioscience and bioengineering.

Conversion of Mevalonate to Isoprenol Using Light Energy in Escherichia coli without Consuming Sugars for ATP Supply.

H. Shimizu, K. Hara, Jun Ishii, 2022, ACS synthetic biology.

Metabolic engineering of mevalonate-producing Escherichia coli strains based on thermodynamic analysis.

H. Shimizu, Yoshihiro Toya, Ami Masuda, 2018, Metabolic engineering.

Transcriptome analysis of the cyanobacterium Synechocystis sp. PCC 6803 and mechanisms of photoinhibition tolerance under extreme high light conditions.

H. Shimizu, K. Ogawa, Yoshihiro Toya, 2018, Journal of bioscience and bioengineering.

Prediction of rate-limiting reactions for growth-associated production using a constraint-based approach.

H. Shimizu, Yoshihiro Toya, Kento Tokuyama, 2019, Biotechnology journal.

Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced Bacillus subtilis strain and improves its metabolite production

H. Shimizu, S. Ishikawa, N. Ogasawara, 2022, DNA research : an international journal for rapid publication of reports on genes and genomes.

Functional evaluation of non-oxidative glycolysis in Escherichia coli in the stationary phase under microaerobic conditions.

H. Shimizu, Teppei Niide, Yoshihiro Toya, 2023, Journal of bioscience and bioengineering.

Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations

Pei Yee Ho, H. Mori, Nobuyoshi Ishii, 2007, Science.

Effect of precise control of flux ratio between the glycolytic pathways on mevalonate production in Escherichia coli

H. Shimizu, Yoshihiro Toya, K. Kamata, 2019, Biotechnology and bioengineering.

Mutations in hik26 and slr1916 lead to high-light stress tolerance in Synechocystis sp. PCC6803

H. Shimizu, K. Ogawa, Yoshihiro Toya, 2021, Communications Biology.

Mutations in hik26 and slr1916 lead to high-light stress tolerance in Synechocystis sp. PCC6803

H. Shimizu, K. Ogawa, Yoshihiro Toya, 2021, Communications biology.

Proteome analysis of response to different spectral light irradiation in Synechocystis sp. PCC 6803.

H. Shimizu, Yoshihiro Toya, M. Toyoshima, 2021, Journal of proteomics.

Role of type I NADH dehydrogenase in Synechocystis sp. PCC 6803 under phycobilisome excited red light.

H. Shimizu, Yoshihiro Toya, C. Yamamoto, 2020, Plant science : an international journal of experimental plant biology.

Flux balance analysis of cyanobacteria reveals selective use of photosynthetic electron transport components under different spectral light conditions

H. Shimizu, Yoshihiro Toya, M. Toyoshima, 2019, Photosynthesis Research.

High-yielding rice Takanari has superior photosynthetic response to a commercial rice Koshihikari under fluctuating light

H. Shimizu, S. Adachi, M. Kawai‐Yamada, 2019, Journal of experimental botany.

Identification of alcohol stress tolerance genes of Synechocystis sp. PCC 6803 using adaptive laboratory evolution

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2017, Biotechnology for Biofuels.

Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling

H. Shimizu, N. Tobori, H. Kurokawa, 2018, Applied Microbiology and Biotechnology.

Metabolic engineering of Synechocystis sp. PCC 6803 for enhanced ethanol production based on flux balance analysis

Katsunori Yoshikawa, Yoshihiro Toya, Hiroshi Shimizu, 2017, Bioprocess and Biosystems Engineering.

Optogenetic reprogramming of carbon metabolism using light-powering microbial proton pump systems.

H. Shimizu, S. Tsunoda, K. Hara, 2022, Metabolic engineering.

Evolutionary approach for improved proton pumping activity of heterologous rhodopsin expressed in Escherichia coli.

K. Hara, Jun Ishii, Yoshihiro Toya, 2022, Journal of bioscience and bioengineering.

Glycogen is the primary source of glucose during the lag phase of E. coli proliferation.

Hiroshi Matsuno, Tomoyoshi Soga, Adrien Fauré, 2012, Biochimica et biophysica acta.

In vitro production of cysteine from glucose

K. Okano, R. Iwakiri, Yoshihiro Toya, 2019, Applied Microbiology and Biotechnology.

Identification of a rate-limiting step in a metabolic pathway using the kinetic model and in vitro experiment.

H. Shimizu, Yoshihiro Toya, Sayaka Kitamura, 2020, Journal of bioscience and bioengineering.

Transcription Factor ArcA is a Flux Sensor for the Oxygen Consumption Rate in Escherichia Coli.

H. Shimizu, Yoshihiro Toya, Naoya Nochino, 2020, Biotechnology journal.

Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data.

Masaru Tomita, Kazuyuki Shimizu, Kenji Nakahigashi, 2012, Molecular bioSystems.

Metabolic flux of the oxidative pentose phosphate pathway under low light conditions in Synechocystis sp. PCC 6803.

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2018, Journal of bioscience and bioengineering.

13C-metabolic flux analysis for mevalonate-producing strain of Escherichia coli.

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2017, Journal of bioscience and bioengineering.

Recent advances in metabolic engineering-integration of in silico design and experimental analysis of metabolic pathways.

H. Shimizu, Yoshihiro Toya, 2021, Journal of bioscience and bioengineering.

Data science-based modeling of the lysine fermentation process.

Hiroaki Nakai, Fumio Matsuda, Kento Tokuyama, 2020, Journal of bioscience and bioengineering.

Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 ΔnrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions.

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2017, Plant & cell physiology.

High-yielding rice Takanari has superior photosynthetic response under fluctuating light to a commercial rice Koshihikari.

H. Shimizu, S. Adachi, M. Kawai‐Yamada, 2019, Journal of experimental botany.

Light‐inducible flux control of triosephosphate isomerase on glycolysis in Escherichia coli

H. Shimizu, Yoshihiro Toya, Sayaka Kitamura, 2019, Biotechnology and bioengineering.

Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 &Dgr;nrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions

H. Shimizu, Yoshihiro Toya, K. Yoshikawa, 2017, Plant & cell physiology.

Theophylline-inducible riboswitch accurately regulates protein expression at low level in Escherichia coli

H. Shimizu, Yoshihiro Toya, Fumio Matsuda, 2019, Biotechnology Letters.

Soft-sensor development for monitoring the lysine fermentation process.

H. Shimizu, Yoshihiro Toya, Kento Tokuyama, 2021, Journal of bioscience and bioengineering.

Characterization of oil-producing yeast Lipomyces starkeyi on glycerol carbon source based on metabolomics and 13C-labeling

H. Shimizu, N. Tobori, H. Kurokawa, 2018, Applied Microbiology and Biotechnology.

Metabolome analysis of metabolic burden in Escherichia coli caused by overexpression of green fluorescent protein and delta-rhodopsin.

K. Hara, Teppei Niide, Yoshihiro Toya, 2024, Journal of bioscience and bioengineering.

Glycogen is the primary source of glucose during the lag phase of E. coli proliferation.

H. Mori, K. Nakahigashi, T. Soga, 2012, Biochimica et biophysica acta.