S. W. Barnes

发表

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

K. Kuhen, D. Plouffe, M. P. Tan, 2010, Nature Communications.

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

Richard J. Mural, Mathew T. Pletcher, Tim Wiltshire, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

Alejandro Llanos-Cuentas, S. Batalov, K. Kuhen, 2010, Proceedings of the National Academy of Sciences.

Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa

J. Walker, C. Dean, S. W. Barnes, 2011, Antimicrobial Agents and Chemotherapy.

Kriti tuberculosis Cell Wall Core of Mycobacterium Involved in Mycolic Acid Donation to the Transporter of Trehalose Monomycolate SQ 109 Targets MmpL 3 , a Membrane

D. Alland, E. Fischer, J. Walker, 2012 .

“3D, human renal proximal tubule (RPTEC-TERT1) organoids ‘tubuloids’ for translatable evaluation of nephrotoxins in high-throughput”

J. Sutherland, Guray Kuzu, S. W. Barnes, 2022, PloS one.

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Joel S. Freundlich, C. Vilchèze, L. Kremer, 2013, Nature chemical biology.

University of Birmingham Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Peter G. Schultz, Morad Hassani, Feng Wang, 2013 .

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Glen Spraggon, Badry Bursulaya, Todd Groessl, 2016, Nature.

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

B. Korber, K. Murakami, J. Theiler, 2014, Molecular microbiology.

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Z. Zwirko, J. Walker, C. Dean, 2018, Antimicrobial Agents and Chemotherapy.

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

Yingyao Zhou, G. Bonamy, K. Kuhen, 2011, Science.

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.

Yingyao Zhou, K. Kuhen, J. Walker, 2020, Virology.

Guide Swap enables genome-scale pooled CRISPR–Cas9 screening in human primary cells

John Lamb, Orzala Sharif, Jennifer L. Snead, 2018, Nature Methods.

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

T. Andrews, M. Field, J. Cyster, 2013, eLife.

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

K. Kuhen, E. Winzeler, R. Price, 2014, Antimicrobial Agents and Chemotherapy.

Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis

C. Vilchèze, W. Jacobs, J. Walker, 2011, Antimicrobial Agents and Chemotherapy.

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

Vinod Nair, David Alland, Elizabeth Fischer, 2012, Antimicrobial Agents and Chemotherapy.

Identification of Elongation Factor G as the Conserved Cellular Target of Argyrin B

Christopher J. Wilson, J. Tallarico, R. Riedl, 2012, PloS one.

Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse

Serge Batalov, Andrew I Su, Tim Wiltshire, 2004, PLoS biology.

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.

J. Leeds, S. W. Barnes, S. Mullin, 2014, The Journal of antimicrobial chemotherapy.

Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves.

W. Jacobs, H. Vordermeier, R. G. Hewinson, 2009, Vaccine.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Paul W Smith, K. Kuhen, P. Tonge, 2015, Science Translational Medicine.

Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9

E. Winzeler, C. Valim, J. Walker, 2013, Malaria Journal.

Title Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9 Permalink

E. Winzeler, C. Valim, J. Walker, 2013 .

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

F. Supek, M. Phillips, M. Arkin, 2015, PLoS pathogens.

Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9

E. Winzeler, C. Valim, S. W. Barnes, 2013, Malaria Journal.

A high-throughput 3D cantilever array to model airway smooth muscle hypercontractility in asthma

Minhua Qiu, S. W. Barnes, Chien-cheng Shih, 2022, bioRxiv.

Defects in Efflux (oprM), β-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61

J. Walker, C. Dean, S. W. Barnes, 2019, Antimicrobial Agents and Chemotherapy.

Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms

J. Walker, C. Dean, S. W. Barnes, 2019, Antimicrobial Agents and Chemotherapy.

A high-throughput cigarette smoke-treated bronchosphere model for disease-relevant phenotypic compound screening

Young Jae Woo, S. W. Barnes, Doug Quackenbush, 2023, PloS one.

A high-throughput COPD bronchosphere model for disease-relevant phenotypic compound screening

Young Jae Woo, S. W. Barnes, Doug Quackenbush, 2022, bioRxiv.

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β′ subunit of RNA polymerase

B. Korber, K. Murakami, J. Theiler, 2014, Molecular microbiology.