S. Matikainen

A. Vaheri, S. Matikainen, M. Hurme, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Expression of human pim family genes is selectively up‐regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation

R. Lahesmaa, P. Koskinen, R. Lund, 2005, Immunology.

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation*

T. Nyman, S. Matikainen, M. Lorey, 2017, Molecular & Cellular Proteomics.

Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages*

Susumu Y. Imanishi, T. Aittokallio, P. Hintsanen, 2016, Molecular & Cellular Proteomics.

Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

T. Nyman, S. Matikainen, Wojciech Cypryk, 2020, The Journal of Immunology.

From Inflammasome to Exosome—Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

T. Nyman, S. Matikainen, Wojciech Cypryk, 2018, Front. Immunol..

Tyrosine kinase activity is involved in the protein kinase C induced expression ofinterleukin‐1β gene in monocytic cells

S. Matikainen, M. Hurme, T. Palkama, 1993, FEBS letters.

Severe Acute Respiratory Syndrome Coronavirus Fails To Activate Cytokine-Mediated Innate Immune Responses in Cultured Human Monocyte-Derived Dendritic Cells

P. Österlund, K. Melén, I. Julkunen, 2005, Journal of Virology.

Streptococcus pyogenes and Lactobacillus rhamnosus differentially induce maturation and production of Th1‐type cytokines and chemokines in human monocyte‐derived dendritic cells

I. Julkunen, S. Matikainen, J. Sirén, 2004, Journal of leukocyte biology.

Measles virus enhances the expression of cellular immediate-early genes and DNA-binding of transcription factor AP-1 in lung epithelial A549 cells

T. Hyypiä, J. Heino, I. Julkunen, 2002, Archives of Virology.

Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.

R. Pine, I. Julkunen, S. Matikainen, 1996, Blood.

Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes.

D. Grandér, O. Sangfelt, I. Julkunen, 2002, European journal of biochemistry.

Okadaic Acid, a Phosphatase Inhibitor, Enhances the Phorbol Ester‐Induced Interleukin‐1B Expression via an AP‐1‐Mediated Mechanism

S. Matikainen, M. Hurme, 1993, Scandinavian journal of immunology.

Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways

S. Paludan, J. Melchjorsen, S. Matikainen, 2010, Journal of Virology.

Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.

P. Fisher, R. Krug, J. Hiscott, 2006, Microbes and infection.

Recognition of Cytoplasmic RNA Results in Cathepsin-Dependent Inflammasome Activation and Apoptosis in Human Macrophages

T. Nyman, N. Lietzén, S. Matikainen, 2011, The Journal of Immunology.

Pathway Activates Caspases 1 and 3 Cytosolic Antiviral RNA Recognition

P. Kovanen, H. Alenius, S. Matikainen, 2022 .

Regulation of kynurenine biosynthesis during influenza virus infection

Matthew S. Miller, T. Nyman, R. Le Goffic, 2017, The FEBS journal.

Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity.

E. Kieff, P. Koskinen, H. Ahlfors, 2005, Virology.

IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors.

T. Reunala, H. Wolff, M. Lehto, 2012, The Journal of investigative dermatology.

IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

D. Foster, I. Julkunen, M. Strengell, 2003, Journal of immunology.

NLRP3 inflammasome activation modulates exosomal RNA content and inhibits inflammatory responses in recipient cells

S. Matikainen, Wojciech Cypryk, 2021, ExRNA.

This information is current as Macrophages Inflammatory Response in Human Trichothecene Mycotoxins Activate

H. Wolff, H. Alenius, S. Matikainen, 2009 .

Activation and Evasion of Innate Antiviral Immunity by Herpes Simplex Virus

S. Paludan, J. Melchjorsen, S. Matikainen, 2009, Viruses.

Protein Secretion in Human Macrophages Autophagy-dependent Unconventional Dectin-1 Pathway Activates Robust

S. Hautaniemi, S. Matikainen, Nyman, 2022 .

Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model.

A. Puustinen, T. Nyman, H. Wolff, 2010, The Journal of investigative dermatology.

Proprotein convertase Furin1 expression in the Drosophila fat body is essential for a normal antimicrobial peptide response and bacterial host defense

M. Rämet, T. Nyman, M. Pesu, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Retinoic acid enhances IL-1 beta expression in myeloid leukemia cells and in human monocytes.

S. Matikainen, M. Hurme, E. Serkkola, 1991, Journal of immunology.

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

M. Baumann, P. Kovanen, H. Wolff, 2011, The Journal of Immunology.

Proteome analysis of human macrophages reveals the upregulation of manganese‐containing superoxide dismutase after toll‐like receptor activation

T. Nyman, S. Matikainen, Riitta Rakkola, 2007, Proteomics.

IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells.

I. Julkunen, M. Strengell, S. Matikainen, 2004, Journal of leukocyte biology.

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine.

T. Nyman, D. Bamford, X. Saelens, 2016, Antiviral research.

TNF-alpha and IFN-alpha enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells.

K. Melén, I. Julkunen, Riku Fagerlund, 2006, Virology.

Measles virus activates NF-kappa B and STAT transcription factors and production of IFN-alpha/beta and IL-6 in the human lung epithelial cell line A549.

T. Hyypiä, I. Julkunen, S. Matikainen, 2001, Virology.

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

P. Kovanen, K. Öörni, S. Matikainen, 2010, PloS one.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

T. Nyman, B. Schepens, X. Saelens, 2015, The Journal of general virology.

Kinetics ofcytokine andNFATgeneexpression inhumaninterleukin-2-de pendent Tlymphoblasts stimulated viaT-cell receptor

K. Melén, I. Julkunen, S. Matikainen, 1998 .

TNF-alpha and IFN-alpha pretreatment enhances influenza A virus-induced chemokine gene expression in lung epithelial cells

P. Österlund, K. Melén, I. Julkunen, 2006 .

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

M. Kurimoto, I. Julkunen, S. Matikainen, 1998, The Journal of Immunology.

Distinct patterns and kinetics of chemokine production regulate dendritic cell function

Antonio Lanzavecchia, Ilkka Julkunen, Sampsa Matikainen, 1999, European journal of immunology.

Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells

M. Kurimoto, I. Julkunen, S. Matikainen, 1998, Infection and Immunity.

Contrasting Immunological Effects of Two Disparate Dusts – Preliminary Observations

T. Haahtela, M. Mäkelä, J. Pakarinen, 2008, International Archives of Allergy and Immunology.

Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages.

I. Julkunen, M. Strengell, S. Matikainen, 2004, The Journal of general virology.

Trichothecene Mycotoxins Activate Inflammatory Response in Human Macrophages1

H. Wolff, H. Alenius, S. Matikainen, 2009, The Journal of Immunology.

Gene Expression and Antiviral Activity of Alpha/Beta Interferons and Interleukin-29 in Virus-Infected Human Myeloid Dendritic Cells

J. Hiscott, P. Österlund, I. Julkunen, 2005, Journal of Virology.

IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages.

I. Julkunen, S. Matikainen, J. Pirhonen, 2007, Journal of leukocyte biology.

Recognition of Cytoplasmic RNA Results in Cathepsin-Dependent Inflammasome Activation and Apoptosis in Human Macrophages

T. Nyman, N. Lietzén, S. Matikainen, 2011, The Journal of Immunology.

Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes.

T. Nyman, N. Kalkkinen, I. Julkunen, 2000, European journal of biochemistry.

Dectin-1 Pathway Activates Robust Autophagy-Dependent Unconventional Protein Secretion in Human Macrophages

S. Hautaniemi, T. Nyman, Anna-Maria Lahesmaa-Korpinen, 2014, The Journal of Immunology.

Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation.

T. Nyman, E. Eskelinen, S. Matikainen, 2014, Journal of proteome research.

IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12.

M. Kurimoto, I. Julkunen, S. Matikainen, 2001, European journal of immunology.

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation

Vittorio Fortino, Ville Pulkkinen, Minnamari Vippola, 2014, Particle and Fibre Toxicology.

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

L. Enquist, Zhijian J. Chen, T. Nyman, 2016, The EMBO journal.

Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis

E. Coccia, E. Giacomini, I. Julkunen, 2003, Journal of leukocyte biology.

Global Secretome Characterization of Herpes Simplex Virus 1-Infected Human Primary Macrophages

T. Nyman, S. Matikainen, Juho J Miettinen, 2012, Journal of Virology.

Expression and Regulation of the Human and Mouse Aspartylglucosaminidase Gene*

L. Peltonen, A. Jalanko, J. Tenhunen, 1997, The Journal of Biological Chemistry.

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.

I. Julkunen, S. Matikainen, A. Lehtonen, 1997, Journal of immunology.

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.

D. Levy, K. Melén, I. Julkunen, 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Differential regulation of the OASL and OAS1 genes in response to viral infections.

S. Paludan, J. Melchjorsen, S. Matikainen, 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Proteomic and transcriptomic characterization of interferon‐α‐induced human primary T helper cells

R. Lahesmaa, T. Nyman, S. Matikainen, 2005, Proteomics.

(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages

H. Wolff, H. Alenius, S. Matikainen, 2010, The Journal of Immunology.

Induction of transforming growth factor beta 1 and its receptor expression during myeloid leukemia cell differentiation.

J. Taipale, J. Keski‐Oja, S. Matikainen, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway.

T. Nyman, H. Wolff, H. Alenius, 2014, Human immunology.

Caspase-1-Dependent Pathway Production in Human Macrophages by a and IL-18 β Virus Infection Activates IL-1

M. Kurimoto, S. Matikainen, J. Pirhonen, 2013 .

Virus infection induces proteolytic processing of IL‐18 in human macrophages via caspase‐1 and caspase‐3 activation

I. Julkunen, S. Matikainen, J. Pirhonen, 2001, European journal of immunology.

Jaana Blood Mononuclear Cells Interferon Production in Human Peripheral Interleukin-12 ( IL-12 ) , IL-18 , and Gamma Lactobacilli and Streptococci Induce

M. Kurimoto, I. Julkunen, S. Matikainen, 1998 .

Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 31

P. Kovanen, H. Alenius, S. Matikainen, 2008, The Journal of Immunology.

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy

A. Hemminki, M. Hirvinen, S. Tähtinen, 2015, Molecular therapy oncolytics.

Native and oxidised lipoproteins negatively regulate the serum amyloid A‐induced NLRP3 inflammasome activation in human macrophages

P. Kovanen, D. Nordström, K. Öörni, 2021, Clinical & translational immunology.

Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

F. Weber, A. Bowie, S. Paludan, 2005, Journal of Virology.

IFNs activate toll-like receptor gene expression in viral infections

I. Julkunen, S. Matikainen, M. Miettinen, 2001, Genes and Immunity.

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA

R. Gorelick, S. Paludan, R. K. Berg, 2012, PloS one.

IFN-α Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression1

S. Meri, I. Julkunen, S. Matikainen, 2005, The Journal of Immunology.

Expression and Epithelial Cells by Up-Regulating TLR 3 Cytokine Expression in Human Endothelial Enhances TLR 3-Mediated Antiviral α IFN-Sampsa

S. Meri, I. Julkunen, S. Matikainen, 2005 .

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages

T. Nyman, Pauli M Turunen, S. Matikainen, 2016, The Journal of Immunology.

Expression in Human Macrophages Regulation of Virus-Induced IL-12 and IL-23

Ilkka Julkunen, Sampsa Matikainen, Jaana Pirhonen, 2013 .

Regulation of Virus-Induced IL-12 and IL-23 Expression in Human Macrophages1

I. Julkunen, S. Matikainen, J. Pirhonen, 2002, The Journal of Immunology.

Differential Expression of IFN Regulatory Factor 4 Gene in Human Monocyte-Derived Dendritic Cells and Macrophages1

R. Lahesmaa, L. Kinnunen, I. Julkunen, 2005, The Journal of Immunology.

MK2 signaling: lessons on tissue specificity in modulation of inflammation.

S. Matikainen, A. Lauerma, N. Fyhrquist, 2010, The Journal of investigative dermatology.

and T Cells Production in Human NK γ Enhances IFN- IL-21 in Synergy with IL-15 or IL-18

Jukka Sirén, Ilkka Julkunen, Timo Sareneva, 2013 .

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM‐CSF: Results in vitro, in rodents and in humans

D. Nettelbeck, A. Hemminki, Simona Bramante, 2015, International journal of cancer.

Inhibition of Human NK Cell Function by Valinomycin, a Toxin from Streptomyces griseus in Indoor Air

M. Salkinoja-Salonen, M. Andersson, R. Mikkola, 2000, Infection and Immunity.

IL‐21 enhances SOCS gene expression and inhibits LPS‐induced cytokine production in human monocyte‐derived dendritic cells

I. Julkunen, M. Strengell, S. Matikainen, 2006, Journal of leukocyte biology.

Dendritic Cells and Macrophages Factor 4 Gene in Human Monocyte-Derived Differential Expression of IFN Regulatory

R. Lahesmaa, L. Kinnunen, I. Julkunen, 2005 .

Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages.

I. Julkunen, S. Matikainen, J. Pirhonen, 2000, Virology.

TNF-α and IFN-α enhance influenza-A-virus-induced chemokine gene expression in human A549 lung epithelial cells

P. Österlund, K. Melén, I. Julkunen, 2006 .

Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation

Petri T. Kovanen, Sampsa Matikainen, Kari K. Eklund, 2016, Journal of Innate Immunity.

Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection In Vitro

O. Kallioniemi, V. Verkhusha, Dmitrii Bychkov, 2014, Antimicrobial Agents and Chemotherapy.

Lactobacilli and Streptococci activate NF-kappa B and STAT signaling pathways in human macrophages.

I. Julkunen, S. Matikainen, A. Lehtonen, 2000, Journal of immunology.

JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

S. Anders, T. Nyman, V. Velagapudi, 2016, Antiviral research.

Cathepsin B-Sensitive Pathway Receptor and a 7 Inflammasome via P 2 X Serum Amyloid A Activates the NLRP 3

M. Baumann, P. Kovanen, H. Wolff, 2011 .

Proteomics to study macrophage response to viral infection.

T. Nyman, S. Matikainen, 2017, Journal of proteomics.

Measles Virus Activates NF-κB and STAT Transcription Factors and Production of IFN-α/β and IL-6 in the Human Lung Epithelial Cell Line A549

T. Hyypiä, I. Julkunen, S. Matikainen, 2001 .

The proximal interferon-stimulated response elements are essential for interferon responsiveness: a promoter analysis of the antiviral MxA gene.

J. Palvimo, I. Julkunen, S. Matikainen, 1998, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The Peptide Toxin Amylosin of Bacillus amyloliquefaciens from Moisture-Damaged Buildings Is Immunotoxic, Induces Potassium Efflux from Mammalian Cells, and Has Antimicrobial Activity

M. Salkinoja-Salonen, C. Gahmberg, L. Andersson, 2015, Applied and Environmental Microbiology.

Intracellular RNA recognition pathway activates strong anti‐viral response in human mast cells

P. Kovanen, S. Matikainen, J. Lappalainen, 2013, Clinical and experimental immunology.

Phosphoproteome characterization reveals that Sendai virus infection activates mTOR signaling in human epithelial cells

T. Nyman, N. Lietzén, Sandra Söderholm, 2015, Proteomics.

Phosphoproteomics Combined with Quantitative 14-3-3-affinity Capture Identifies SIRT1 and RAI as Novel Regulators of Cytosolic Double-stranded RNA Recognition Pathway*

T. Aittokallio, P. Hintsanen, T. Nyman, 2014, Molecular & Cellular Proteomics.

IFN-alpha and IL-12 activate IFN regulatory factor 1 (IRF-1), IRF-4, and IRF-8 gene expression in human NK and T cells.

Riitta Lahesmaa, Ilkka Julkunen, Timo Sareneva, 2003, Cytokine.

Lipoprotein(a) induces caspase-1 activation and IL-1 signaling in human macrophages

M. Boffa, M. Koschinsky, M. Hermansson, 2023, Frontiers in Cardiovascular Medicine.

Cytosolic RNA recognition pathway activates 14-3-3 protein mediated signaling and caspase-dependent disruption of cytokeratin network in human keratinocytes.

T. Nyman, N. Lietzén, J. Melchjorsen, 2010, Journal of proteome research.

Primary Macrophages upon Influenza A Virus Infection of Human Components Translocate to Mitochondria Actin and RIGI / MAVS Signaling

T. Nyman, N. Kalkkinen, S. Matikainen, 2009 .

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

T. Aittokallio, R. Bruzzone, T. Nyman, 2017, Viruses.

Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts.

S. Matikainen, M. Hurme, S Matikainen, 1994, Immunology letters.

Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

T. Paunio, V. Salomaa, S. Ripatti, 2013, PloS one.

This Reprint May Differ from the Original in Pagination and Typographic Detail. Partial Sleep Restriction Activates Immune Response-related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans Partial Sleep Restriction Activates Immune Response- Related Gene Expression Pathwa

T. Paunio, V. Salomaa, S. Ripatti, 2022 .

Cholesterol crystals activate the NLRP3 inflammasome in human monocytes and macrophages

P. Kovanen, K. Öörni, S. Matikainen, 2010 .