A. Gray

发表

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Sheng-Cai Lin, D. Hardie, S. Hawley, 2017, Nature.

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

I. Gout, C. Downes, N. Leslie, 2004, The Journal of cell biology.

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

J. Padbury, D. Hardie, C. Phornphutkul, 2017, American journal of physiology. Heart and circulatory physiology.

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts.

Henric Olsson, I. Batty, A. Gray, 2003, Analytical biochemistry.

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups.

I. Batty, C. Downes, A. Gray, 2005, Biochemical Society transactions.

Probing phosphoinositide functions in signaling and membrane trafficking.

C. Downes, A. Gray, J. Lucocq, 2005, Trends in cell biology.

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

A. Prescott, I. Batty, C. Downes, 2004, The Biochemical journal.

Activity of any class IA PI3K isoform can sustain cell proliferation and survival

B. Vanhaesebroeck, A. Khwaja, A. Gray, 2010, Proceedings of the National Academy of Sciences.

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation

C. Sutherland, A. Gray, K. Ning, 2004, BMC Neuroscience.

University of Dundee A novel , de novo mutation in PRKAG 2 gene

D. Hardie, C. Phornphutkul, Y. Tseng, 2017 .

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

Hiroki Nakanishi, Nicolas Le Novère, Phillip T. Hawkins, 2017, Molecular cell.

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells.

É. Hajduch, H. S. Hundal, A. Gray, 2004, The Biochemical journal.

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo.

C. Downes, A. Gray, J. V. D. Kaay, 1999 .

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

B. Vanhaesebroeck, W. Pearce, A. Gray, 2011, The Biochemical journal.

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

F. Ross, D. Hardie, G. Gowans, 2016, Molecular Cancer Research.

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

Cornelis J. Weijer, Helene Maccario, Lindsay Davidson, 2009, Oncogene.

Enhanced Insulin Sensitivity Associated with Provision of Mono and Polyunsaturated Fatty Acids in Skeletal Muscle Cells Involves Counter Modulation of PP2A

É. Hajduch, H. S. Hundal, C. Lipina, 2014, PloS one.

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

D. Hardie, D. Hardie, D. Hodson, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR

A. Gurney, S. Heldens, W. Wood, 1999, Current Biology.

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression

C. Downes, N. Leslie, A. Gray, 2006, Journal of Cell Science.

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

A. Whetton, C. Downes, A. Pierce, 2005, Leukemia.

Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase.

I. Pass, C. Downes, N. Leslie, 2000, The Biochemical journal.

Alexander G. Gray, J. van der Kaay, C. Downes, 1999, The Biochemical journal.

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake*

D. Alessi, N. Leslie, K. Sakamoto, 2008, Journal of Biological Chemistry.

A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening.

M. J. Paterson, A. Gray, R. Hurteaux, 2010, Analytical biochemistry.

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.

A. Prescott, N. Leslie, K. Peyrollier, 2000, The Biochemical journal.

Toll-Like Receptor Signaling Pathways in Macrophages Downstream of α Cross Talk between the Akt and p38

M. Gaestel, N. Leslie, J. Dean, 2013 .

Cross Talk between the Akt and p 38 Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

M. Gaestel, S. O'keefe, I. Batty, 2013 .

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach Published, JLR Papers in Press, November 27, 2006.

H. Guillou, P. Hawkins, L. Stephens, 2007, Journal of Lipid Research.

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

D. Hardie, S. Hawley, A. Gray, 2018, Methods in molecular biology.

Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress*

C. Downes, N. Leslie, A. Gray, 2010, The Journal of Biological Chemistry.

Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

P. Finan, K. Okkenhaug, A. Bilancio, 2004, Nature.

Advances in procedures for the detection and localization of inositol phospholipid signals in cells, tissues, and enzyme assays.

C. Downes, A. Gray, J. Lucocq, 2003, Methods in enzymology.

Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling

Mark Boothby, M. Gaestel, J. Arthur, 2013, Molecular and Cellular Biology.

Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

F. Ross, S. Hawley, D. Hardie, 2022, Cell reports.

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

P. Cohen, A. Casamayor, D. Alessi, 1999, The Biochemical journal.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

David K. Finlay, Linda V. Sinclair, Thijs J. Hagenbeek, 2008, Nature Immunology.

Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

K. Okkenhaug, D. Cantrell, H. Spits, 2008, Nature Immunology.

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

P. Seeburg, T. Libermann, A. Ullrich, 1985, Science.

Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.

A. Mason, A. Gray, A. Gray, 1990, Science.

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.

K. Siddle, C. Downes, A. Gray, 2006, Molecular endocrinology.

Comparison of phosphatidylinositol‐3‐kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild‐type PIK3CA

C. Dive, A. Gray, C. Morrow, 2005, FEBS letters.

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

C. Chresta, D. Alessi, R. Clarke, 2009, The Biochemical journal.

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components.

C. Downes, A. Gray, I. Fleming, 2000, The Biochemical journal.

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival

D. Hardie, A. Gray, M. Dandapani, 2017, Molecular Cancer Research.

PDK1 controls upstream PI3K expression and PIP3 generation

M. Bonin, S. Wesselborg, B. Stork, 2014, Oncogene.

reveals differences in expression of proteins regulating motility Comparative proteomics of primitive hematopoietic cell populations

S. Gaskell, C. Downes, A. Pierce, 2013 .

Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

S. Gaskell, A. Whetton, C. Downes, 2004, Blood.

PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

G. Barton, N. Schurch, N. Leslie, 2012, Science Signaling.

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

I. Batty, N. Leslie, A. Gray, 2012, Advances in biological regulation.

Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

Ager, Thijs J. Hagenbeek, K. Okkenhaug, 2011 .

Redox regulation of PI 3‐kinase signalling via inactivation of PTEN

C. Downes, N. Leslie, A. Gray, 2003, The EMBO journal.

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

E. Vigorito, D. Rawlings, C. Downes, 2002, The Journal of experimental medicine.

Activity Expression and Invasion , a Tumor-Suppressing Phenotype , But Not with PTEN Protein Phosphatase Activity Correlates with Control of Gene `

G. Barton, N. Schurch, N. Leslie, 2012 .

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

I. Pass, C. Downes, N. Leslie, 2001, Biochemical Society transactions.

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.

D. Alessi, D. Wasserman, K. Sakamoto, 2011, The Biochemical journal.

Role of TAPP 1 and TAPP 2 adaptor binding to PtdIns ( 3 , 4 ) P 2 in regulating insulin sensitivity defined by knockin analysis

D. Alessi, D. Wasserman, K. Sakamoto, 2011 .

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

B. G. Hale, R. Randall, P. Kerry, 2010, Proceedings of the National Academy of Sciences.

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

D. Hardie, J. Tavaré, D. Carling, 2018, The Biochemical journal.

University of Dundee Isoform-specific AMPK association with TBC 1 D 1 is reduced by a mutation associated with severe obesity

D. Hardie, J. Tavaré, D. Carling, 2018 .

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

W. Wood, A. Gray, H. Avraham, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

D. Alessi, C. Downes, L. Trinkle-Mulcahy, 2002 .

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.

D. Alessi, C. Downes, L. Trinkle-Mulcahy, 2002, The Biochemical journal.

A Screen for Novel Phosphoinositide 3-kinase Effector Proteins*

F. Boisvert, I. Batty, C. Downes, 2011, Molecular & Cellular Proteomics.

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.

I. Batty, J. van der Kaay, C. Downes, 2007, The Biochemical journal.

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

P. Finan, K. Okkenhaug, A. Bilancio, 2004, Nature.

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells*

B. Viollet, A. Marette, D. Hardie, 2012, The Journal of Biological Chemistry.

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

K. Hoang-Xuan, I. Pass, C. Downes, 2001, The Biochemical journal.

Pleckstrin homology polypeptides and dna encoding such

S. Dowler, D. Alessi, D. Campbell, 2001 .

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold*

D. V. van Aalten, I. Batty, C. Downes, 2012, The Journal of Biological Chemistry.

Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses*

J. van der Kaay, C. Downes, A. Gray, 1999, The Journal of Biological Chemistry.

UBIQUITINATION OF PTEN INHIBITS PHOSPHATASE ACTIVITY AND IS ENHANCED BY MEMBRANE TARGETING AND HYPEROSMOTIC STRESS

C. Downes, N. Leslie, A. Gray, 2010 .

PDK 1 controls upstream PI 3 K expression and PIP 3 generation

M. Bonin, S. Wesselborg, B. Stork, 2015 .

reveals differences in expression of proteins regulating motility Comparative proteomics of primitive hematopoietic cell populations

S. Gaskell, A. Whetton, C. Downes, 2013 .

Phospholipase C‐η2 is required for retinoic acid‐stimulated neurite growth

A. Gray, Petra Popovics, Deana Finelli, 2013, Journal of neurochemistry.

The rhythm of retinoids in the brain

K. Siddle, C. Downes, P. Morgan, 2013, Journal of neurochemistry.

The rhythm of retinoids in the brain

K. Siddle, C. Downes, A. Gray, 2013, Journal of neurochemistry.

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.

P. Cohen, A. Casamayor, D. Alessi, 1999, The Biochemical journal.