M. Watt

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An integrative systems genetic analysis of mammalian lipid metabolism

D. James, P. Meikle, R. Lazarus, 2019, Nature.

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

Robert J A Goode, M. Febbraio, B. Kingwell, 2015, Cell metabolism.

Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity.

B. Kemp, J. Hawley, D. Rivas, 2009, Endocrinology.

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

A. Russell, J. Chang, D. Nomura, 2013, Nature chemical biology.

implications for health and disease Triacylglycerol lipases and metabolic control

L. Spriet, M. Watt, 2016 .

Triacylglycerol lipases and metabolic control: implications for health and disease.

L. Spriet, M. Watt, 2010, American journal of physiology. Endocrinology and metabolism.

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice.

R. Zechner, M. Watt, C. van der Poel, 2009, American journal of physiology. Endocrinology and metabolism.

Triglyceride lipases alter fuel metabolism and mitochondrial gene expression.

M. Watt, 2009, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Regulation and function of triacylglycerol lipases in cellular metabolism.

G. Steinberg, M. Watt, 2008, The Biochemical journal.

Adipocyte triglyceride lipase expression in human obesity.

B. Kemp, G. Steinberg, M. Watt, 2007, American journal of physiology. Endocrinology and metabolism.

Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity

Robert V Farese, A. Hevener, C. Newgard, 2011, Proceedings of the National Academy of Sciences.

Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle

G. Muscat, M. Watt, P. Lau, 2011, Diabetologia.

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.

M. Febbraio, B. Kemp, A. Garnham, 2006, American journal of physiology. Endocrinology and metabolism.

The Influence of Aerobic Exercise on Hippocampal Integrity and Function: Preliminary Findings of a Multi-Modal Imaging Analysis

M. Yücel, V. Lorenzetti, Y. Chye, 2018, Brain plasticity.

Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity.

J. Hawley, D. Rivas, L. Koch, 2013, American journal of physiology. Endocrinology and metabolism.

Triglyceride metabolism in exercising muscle.

M. Watt, Y. Cheng, Yunsheng Cheng, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Unraveling the roles of PLIN5: linking cell biology to physiology

M. Watt, R. Mason, 2015, Trends in Endocrinology & Metabolism.

Cellular Localization and Associations of the Major Lipolytic Proteins in Human Skeletal Muscle at Rest and during Exercise

A. Russell, M. Watt, R. Meex, 2014, PloS one.

TCPTP-deficiency in muscle does not alter insulin signalling and glucose homeostasis.

B. Neel, Zhon-Yin Zhang, M. Watt, 2012 .

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

B. Neel, M. Watt, T. Tiganis, 2012, Diabetologia.

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones.

C. Glass, M. Febbraio, S. Subramaniam, 2007, The Journal of clinical investigation.

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance

M. Febbraio, N. Turner, G. Cooney, 2009, Diabetes.

Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise.

T. Stellingwerff, L. Spriet, G. Heigenhauser, 2005, Journal of applied physiology.

effect on substrate phosphorylation at the onset of exercise in man Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no

T. Stellingwerff, L. Spriet, G. Heigenhauser, 2006 .

Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man

T. Stellingwerff, L. Spriet, G. Heigenhauser, 2002, The Journal of physiology.

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

P. Meikle, J. Horowitz, B. Kingwell, 2013, Diabetes.

Pigment Epithelium‐Derived Factor, Insulin Sensitivity, and Adiposity in Polycystic Ovary Syndrome: Impact of Exercise Training

H. Teede, A. Joham, C. Harrison, 2012, Obesity.

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide

J. Horowitz, M. Watt, S. Schenk, 2012, Diabetologia.

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation.

M. Febbraio, M. Watt, A. Hoy, 2011, Endocrinology.

Impact of endurance exercise training on adipocyte microRNA expression in overweight men

B. Canny, D. Powell, M. Watt, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose–Fed Mice Despite Increased Endoplasmic Reticulum Stress

Hao Wang, Xiao-Yi Zeng, Ji-Ming Ye, 2013, Diabetes.

Reduced glycogen availability is associated with increased AMPKalpha2 activity, nuclear AMPKalpha2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle.

M. Febbraio, B. Kemp, D. Stapleton, 2006, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression[S]

P. Meikle, S. Rensen, J. Greve, 2018, Journal of Lipid Research.

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality.

P. Sanders, C. Nalliah, Geoffrey Lee, 2020, Journal of the American College of Cardiology.

GIP receptor deletion in mice confers resistance to HFD-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.

J. Holst, M. Watt, G. Boer, 2021, American journal of physiology. Endocrinology and metabolism.

Nonesterified Fatty Acids: The Multi-Ethnic Study of Atherosclerosis n-3 Fatty Acids Attenuate the Risk of Diabetes Associated With Elevated Serum

M. Febbraio, L. Steffen, A. Klip, 2015 .

Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments.

R. Coleman, D. Muoio, M. Watt, 2012, American journal of physiology. Endocrinology and metabolism.

Storing up trouble: does intramyocellular triglyceride accumulation protect skeletal muscle from insulin resistance?

M. Watt, M. Att, 2008 .

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Robert V Farese, C. Newgard, M. Sajan, 2007, American journal of physiology. Endocrinology and metabolism.

Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro

M. Febbraio, R. Southgate, S. Pinnamaneni, 2006, Diabetologia.

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

M. Febbraio, S. Pinnamaneni, M. Watt, 2006, Journal of applied physiology.

accumulation of lipid metabolites induce insulin resistance: role of intramuscular Saturated, but not n-6 polyunsaturated, fatty acids

M. Febbraio, S. Pinnamaneni, M. Watt, 2006 .

Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.

B. Neel, M. Waters, M. Watt, 2014, Cell metabolism.

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

M. Watt, A. Hoy, J. Honeyman, 2010, Diabetologia.

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle.

M. Febbraio, N. Turner, J. Hawley, 2004, Endocrinology.

AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation

B. Kemp, S. L. Macaulay, S. Jørgensen, 2008, The Journal of physiology.

Fatty acids stimulate AMP‐activated protein kinase and enhance fatty acid oxidation in L6 myotubes

M. Febbraio, B. Kemp, G. Steinberg, 2006, The Journal of physiology.

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

M. Febbraio, S. Rose-John, B. Kemp, 2006, Nature Medicine.

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues.

P. O’Brien, M. Watt, P. Burton, 2019, Cell reports.

Early intervention exercise training does not delay prostate cancer progression in Pten−/− mice

M. Watt, Renea A. Taylor, A. Clark, 2020, The Prostate.

Fat talks: a new role for adipose tissue in promoting prostate cancer in obesity

M. Watt, Renea A. Taylor, 2016 .

Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting.

D. Cameron-Smith, L. Spriet, M. Watt, 2004, Journal of applied physiology.

Pigment Epithelium–Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase

P. Meikle, E. Duh, R. Zechner, 2011, Diabetes.

Radical gastric cancer surgery results in widespread upregulation of pro‐tumourigenic intraperitoneal cytokines

M. Watt, P. Burton, M. D. de Veer, 2018, ANZ journal of surgery.

Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice[S]

P. Meikle, M. Grounds, M. Watt, 2019, Journal of Lipid Research.

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity.

M. Watt, P. Burton, Renea A. Taylor, 2020, American journal of physiology. Endocrinology and metabolism.

Impact of Lipotoxicity on Tissue "Cross Talk" and Metabolic Regulation.

M. Watt, M. Montgomery, William De Nardo, 2019, Physiology.

Dietary glycotoxins exacerbate progression of experimental fatty liver disease.

P. Angus, J. Forbes, M. Watt, 2014, Journal of hepatology.

Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

M. Watt, J. Bayliss, Paula M. Miotto, 2022, Molecular metabolism.

Molecular regulators of lipid metabolism in the intestine - underestimated therapeutic targets for obesity?

J. Mariadason, M. Watt, Mercedes Dàvalos-Salas, 2020, Biochemical pharmacology.

Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability.

M. Febbraio, M. Watt, Stanley M. H. Chan, 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

D. James, M. Febbraio, B. Pedersen, 2006, Diabetes.

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice.

Hao Wang, Xiao-Yi Zeng, Ji-Ming Ye, 2015, Biochimica et biophysica acta.

Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion

M. Febbraio, B. K. Pedersen, F. Kraemer, 2004, Diabetologia.

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.

Micah L. Burch, S. Lamon, J. Kloehn, 2015, Biochimica et biophysica acta.

Altering dietary nutrient intake that reduces glycogen content leads to phosphorylation of nuclear p38 MAP kinase in human skeletal muscle: association with IL‐6 gene transcription during contraction

M. Febbraio, M. Watt, S. McGee, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats.

M. Febbraio, B. Kemp, R. Southgate, 2008, The Journal of endocrinology.

Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle interleukin-6 mRNA expression and protein release.

M. Febbraio, M. Watt, A. Holmes, 2004, Metabolism: clinical and experimental.

Examination of ‘lipotoxicity’ in skeletal muscle of high‐fat fed and ob/ob mice

A. Hevener, B. Kemp, R. Southgate, 2009, The Journal of physiology.

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice.

M. Febbraio, B. Kemp, J. Proietto, 2006, Endocrinology.

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

J. Sadoshima, E. Salimova, M. Watt, 2021, Science advances.

Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle.

M. Febbraio, B. Kemp, J. Hawley, 2006, American journal of physiology. Endocrinology and metabolism.

Exercise serum increases GLUT4 in human adipocytes

M. Watt, M. Hargreaves, M. Flores-Opazo, 2019, Experimental physiology.

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function.

Pengyi Yang, E. Richter, B. Kiens, 2022, Cell metabolism.

Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle.

M. Febbraio, B. Kemp, G. Steinberg, 2004, American journal of physiology. Endocrinology and metabolism.

Insulin-mediated suppression of lipolysis in adipose tissue and skeletal muscle of obese type 2 diabetic men and men with normal glucose tolerance

L. V. van Loon, M. Watt, E. Blaak, 2013, Diabetologia.

Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

M. Watt, M. Montgomery, Stacey N. Keenan, 2020, Current Diabetes Reports.

Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation.

N. Turner, G. Cooney, E. Kraegen, 2009, American journal of physiology. Endocrinology and metabolism.

Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase.

P. O’Brien, J. Pagnon, M. Watt, 2012, Endocrinology.

Ciliary Neurotrophic Factor Stimulates Muscle Glucose Uptake by a PI3-Kinase–Dependent Pathway That Is Impaired With Obesity

M. Birnbaum, B. Kemp, S. Jørgensen, 2009, Diabetes.

Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle

H. Parkington, M. Watt, C. Bruce, 2018, Diabetes.

Pigment epithelium-derived factor contributes to insulin resistance in obesity.

D. James, A. Hevener, E. Duh, 2009, Cell metabolism.

Adipose tissue–skeletal muscle crosstalk: are endocannabinoids an unwanted caller?

M. Watt, 2009, Diabetologia.

skeletal muscle during exercise: is there a controversy? Intramuscular triacylglycerol utilization in human

G. Heigenhauser, G. Navis, A. Kwakernaak, 2015 .

Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver.

C. Rantzau, J. Proietto, M. Watt, 2008, American journal of physiology. Endocrinology and metabolism.

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.

M. Watt, P. Gregorevic, C. Harrison, 2016, Cancer research.

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues.

M. Febbraio, A. Hevener, G. Lancaster, 2006, Endocrinology.

Suppressing lipolysis increases interleukin-6 at rest and during prolonged moderate-intensity exercise in humans.

M. Febbraio, M. Watt, A. Holmes, 2004, Journal of applied physiology.

Hematopoietic Cell–Restricted Deletion of CD36 Reduces High-Fat Diet–Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue

M. Febbraio, A. Bonen, M. Watt, 2011, Diabetes.

Fat Partitioning and Insulin Sensitivity

E. Kraegen, M. Watt, 2009, Diabetes.

Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness.

B. Kemp, E. Kraegen, M. Watt, 2008, Molecular endocrinology.

Fat Partitioning and Insulin Sensitivity Robbing Peter to Pay Paul?

E. Kraegen, M. Watt, 2008 .

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

M. O’Bryan, A. O'Connor, Z. Andrews, 2016, Endocrinology.

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.

A. Russell, P. Meikle, M. Febbraio, 2015, Cell metabolism.

muscle during aerobic exercise hormone-sensitive lipase activity in human skeletal Effects of reduced free fatty acid availability on

G. Heigenhauser, M. Giera, L. Havekes, 2015 .

exercisein human skeletal muscle during prolonged Hormone-sensitive lipase activity and fatty acyl-CoA

G. Heigenhauser, M. Watt, R. Meex, 2015 .

with caffeine exhaustive exercise when carbohydrate is coingested High rates of muscle glycogen resynthesis after

H. Lieberman, B. Drust, T. McLellan, 2015 .

High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine.

J. Hawley, V. Coffey, S. Lessard, 2008, Journal of applied physiology.

High Rates Of Muscle Glycogen Resynthesis After Exhaustive Exercise When Carbohydrate Is Co-ingested With Caffeine: 669

J. Hawley, V. Coffey, S. Lessard, 2008 .

Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration.

T. Stellingwerff, J. Hawley, L. Burke, 2006, American journal of physiology. Endocrinology and metabolism.

metabolism during transient and steady-state exercise Effects of hyperoxia on skeletal muscle carbohydrate

T. Stellingwerff, L. Spriet, M. Watt, 2006 .

Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise.

L. Spriet, G. Heigenhauser, M. Watt, 2004, Journal of applied physiology.

Effects of dynamic exercise intensity on the activation of hormone‐sensitive lipase in human skeletal muscle

L. Spriet, G. Heigenhauser, M. Watt, 2003, The Journal of physiology.

Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise

L. Spriet, G. Heigenhauser, M. Watt, 2003 .

Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase.

T. Stellingwerff, L. Spriet, G. Heigenhauser, 2003, American journal of physiology. Endocrinology and metabolism.

Regulation of glucose kinetics during intense exercise in humans: effects of α- and β-adrenergic blockade

M. Febbraio, M. Watt, M. Hargreaves, 2003 .

Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling.

M. Febbraio, B. Kemp, A. Garnham, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise.

L. Spriet, G. Heigenhauser, M. Watt, 2003, Journal of applied physiology.

Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training.

M. Watt, R. Murphy, M. Montgomery, 2016, American journal of physiology. Endocrinology and metabolism.

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle.

M. Watt, R. Meex, A. Hoy, 2015, American journal of physiology. Endocrinology and metabolism.

Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise.

G. Heigenhauser, B. Kemp, M. Duong, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

M. Watt, N. J. Michael, N. Michael, 2020, Neuroscience.

The role of Ap2a2 in PPARα‐mediated regulation of lipolysis in adipose tissue

S. Ting, M. Watt, J. Bayliss, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points.

M. Molloy, D. D. De Souza, C. Krisp, 2021, American journal of physiology. Endocrinology and metabolism.

Proteome analysis of human visceral and subcutaneous adipocytes identifies depot-specific heterogeneity at metabolic control points

M. Molloy, C. Krisp, M. Watt, 2020, bioRxiv.

CNTF Stimulates Muscle Glucose Uptake by a PI3-Kinase Dependent Pathway that is Impaired with Obesity

M. Birnbaum, S. Jørgensen, G. Steinberg, 2009 .

Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements.

R. Evans, M. Watt, Amany Abdelkader, 2014, American journal of physiology. Endocrinology and metabolism.

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis.

P. Meikle, A. Earnest, B. Parker, 2021, Journal of hepatology.

Effects of Plasma Adrenaline on Hormone‐Sensitive Lipase at Rest and during Moderate Exercise in Human Skeletal Muscle

T. Stellingwerff, L. Spriet, G. Heigenhauser, 2003, The Journal of physiology.

activity in contracting human skeletal muscle Glucose ingestion blunts hormone-sensitive lipase

A. Russell, B. Saltin, N. Secher, 2005 .

Glucose ingestion blunts hormone-sensitive lipase activity in contracting human skeletal muscle.

B. Saltin, N. Secher, P. Krustrup, 2004, American journal of physiology. Endocrinology and metabolism.

Regulation and role of hormone-sensitive lipase activity in human skeletal muscle

L. Spriet, M. Watt, 2004, The Proceedings of the Nutrition Society.

Decreased Skeletal Muscle Pyruvate Dehydrogenase Activation During Cycling Following Short-term High-fat Adaptation With Carbohydrate Restoration: 56 10:15 AM - 10:30 AM

T. Stellingwerff, J. Hawley, L. Burke, 2005 .

Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise.

L. Spriet, G. Heigenhauser, J. G. Inglis, 2004, Journal of applied physiology.

No effect of mild heat stress on the regulation of carbohydrate metabolism at the onset of exercise.

M. Febbraio, P. Saunders, A. Garnham, 2001, Journal of applied physiology.

Acute plasma volume expansion: effect on metabolism during submaximal exercise.

M. Febbraio, A. Garnham, M. Watt, 1999, Journal of applied physiology.

Sobs Annual Report | | 2008 80 Primary

J. Whisstock, P. Taylor, L. Poston, 2022 .

Human visceral and subcutaneous adipose stem and progenitor cells retain depot-specific adipogenic properties during obesity

B. Pedersen, C. Schéele, M. Watt, 2022, Frontiers in Cell and Developmental Biology.

ACSM1 and ACSM3 regulate prostate cancer fatty acid metabolism to promote tumour growth and constrain ferroptosis

L. Quek, R. Iggo, L. Selth, 2022, bioRxiv.

Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats

M. Watt, M. Cotter, N. Cameron, 1995, Diabetologia.

Ectodysplasin A Is Increased in NonAlcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes

M. Watt, P. Burton, J. Bayliss, 2021 .

Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue.

D. Mutch, C. G. Perry, M. Watt, 2016, American journal of physiology. Cell physiology.

Lipid metabolism in contracting muscle – HSL takes a back seat

M. Watt, 2013, The Journal of physiology.

Central Administration of the Ciliary Neurotrophic Factor Analogue, Axokine, Does Not Play a Role in Long-Term Energy Homeostasis in Adult Mice

Z. Andrews, B. Oldfield, M. Watt, 2015, Neuroendocrinology.

Lipid droplets and ferroptosis as new players in brain cancer glioblastoma progression and therapeutic resistance

M. Watt, J. Dimou, Ayenachew Bezawork‐Geleta, 2022, Frontiers in Oncology.

Exerkines in health, resilience and disease

Ian R. Lanza, A. Pandey, R. Gerszten, 2022, Nature Reviews Endocrinology.

Reactive oxygen species enhance insulin sensitivity.

Atsushi Fukushima, Sofianos Andrikopoulos, M. Febbraio, 2009, Cell metabolism.

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

M. Tremblay, M. Watt, S. Andrikopoulos, 2010, Diabetes.

Hexosaminidase A (HEXA) regulates hepatic sphingolipid and lipoprotein metabolism in mice

M. Watt, S. Nie, N. Williamson, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

P. Meikle, N. Mokbel, M. Watt, 2014, Molecular metabolism.

Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man

L. Spriet, G. Heigenhauser, M. Watt, 2002, The Journal of physiology.

HSP72 protects against obesity-induced insulin resistance

Jason Chung, Bronwyn A. Kingwell, Matthew J. Watt, 2008, Proceedings of the National Academy of Sciences.

Western Diet Induced Remodelling of the Tongue Proteome

B. Parker, M. Watt, Hamzeh Karimkhanloo, 2021, Proteomes.

Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity

J. Windsor, C. Nowell, C. Porter, 2021, Nature Metabolism.

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

D. Nomura, M. Frydenberg, L. Selth, 2019, Science Translational Medicine.

α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors

S. Luquet, M. Tschöp, T. Reinehr, 2016, Molecular metabolism.

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury

Jennifer P. Ngo, R. Evans, M. Watt, 2018, American journal of physiology. Renal physiology.

Regulator of Calcineurin 1 helps coordinate whole‐body metabolism and thermogenesis

D. McMillan, A. Lusis, M. Oh, 2018, EMBO reports.

Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity.

B. Kemp, M. Watt, S. M. Turpin, 2008, Endocrinology.

Metabolic remodelling in adipocytes promotes CNTF-mediated fat loss in obesity

B. Kemp, M. Watt, S. M. Turpin, 2008 .

PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle

M. Febbraio, M. Birnbaum, R. Southgate, 2005, The FASEB Journal.

Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes.

M. Febbraio, R. Southgate, M. Watt, 2004, Journal of molecular endocrinology.

Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity.

B. Kemp, J. Hawley, L. Koch, 2007, American journal of physiology. Endocrinology and metabolism.

Cytokine Regulation of AMPK signalling.

M. Febbraio, G. Steinberg, M. Watt, 2009, Frontiers in bioscience.

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

R. Nadon, O. Larsson, I. Topisirovic, 2014, Oncotarget.

Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts

M. Frydenberg, G. Risbridger, M. Watt, 2016, Oncotarget.

Linking obesogenic dysregulation to prostate cancer progression

M. Watt, J. Lo, Renea A. Taylor, 2015, Endocrine connections.

Metabolic communication during exercise

M. Febbraio, M. Watt, R. Murphy, 2020, Nature metabolism.

No evidence of white adipocyte browning after endurance exercise training in obese men

B. Canny, M. Watt, R. Meex, 2018, International Journal of Obesity.

Exercise and the Regulation of Adipose Tissue Metabolism.

M. Watt, T. Tsiloulis, 2015, Progress in molecular biology and translational science.

Personalized Medicine for Prostate Cancer: Is Targeting Metabolism a Reality?

M. Watt, Gio Fidelito, Renea A. Taylor, 2022, Frontiers in Oncology.

The liver as an endocrine organ - linking NAFLD and insulin resistance.

M. Watt, Paula M. Miotto, M. Montgomery, 2019, Endocrine reviews.

Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance.

M. Febbraio, G. Lancaster, M. Watt, 2006, American journal of physiology. Endocrinology and metabolism.

Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function.

M. Watt, A. Hoy, 2012, American journal of physiology. Endocrinology and metabolism.

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

P. Meikle, M. Febbraio, J. Jansson, 2010, Diabetologia.

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

M. Febbraio, B. Pedersen, O. Mortensen, 2013, Diabetes.

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

O. Ohara, Aliki A. Rasmiena, A. Treloar, 2018, Cell.

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

M. Febbraio, M. Karin, M. Watt, 2019, Cell metabolism.

Fluxing the mitochondria to insulin resistance.

A. Hevener, M. Watt, 2008, Cell metabolism.

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

M. Watt, R. Meex, Ruth C. R. Meex, 2017, Nature Reviews Endocrinology.

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K. Harvey, A. El-Osta, B. Parker, 2021, Nature Communications.

Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control

J. Granneman, M. Watt, R. Schittenhelm, 2020, Journal of lipid research.

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

K. Tory, M. Febbraio, A. Hevener, 2014, Diabetes.

Metabolic effects of lipectomy and of adipose tissue transplantation

M. Watt, S. Hocking, J. Gunton, 2022, Obesity.

Regulatory mechanisms in the interaction between carbohydrate and lipid oxidation during exercise.

L. Spriet, M. Watt, 2003, Acta physiologica Scandinavica.

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Shivakumar Keerthikumar, S. Mathivanan, A. Scott, 2019, Nature Communications.

Effect of epinephrine on glucose disposal during exercise in humans: role of muscle glycogen.

Mark Hargreaves, M. Watt, M. Hargreaves, 2002, American journal of physiology. Endocrinology and metabolism.

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Robert V Farese, A. Hevener, C. Newgard, 2007, Cell metabolism.

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

G. Steinberg, D. Stroud, M. Watt, 2020, Molecular metabolism.

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity*

B. Kemp, S. Jørgensen, J. Schertzer, 2010, The Journal of Biological Chemistry.

Adipose tissue development and the molecular regulation of lipid metabolism.

M. Watt, T. Tsiloulis, Arthe Raajendiran, 2016, Essays in biochemistry.

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

L. Selth, D. Samocha-Bonet, G. Steinberg, 2020, Science Translational Medicine.

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

Laurent Vergnes, Peter Tontonoz, Matthew J. Watt, 2009, Diabetes.

Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice.

A. Hevener, M. Watt, M. Nguyen, 2010, American journal of physiology. Endocrinology and metabolism.

Endurance training modulates intramyocellular lipid compartmentalization and morphology in skeletal muscle of lean and obese women.

M. Tarnopolsky, G. Steinberg, M. Watt, 2013, The Journal of clinical endocrinology and metabolism.

Intergenerational effects of a paternal Western diet during adolescence on offspring gut microbiota, stress reactivity, and social behavior

A. Hannan, A. Reichelt, Geraldine Kong, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Intergenerational effects of a paternal Western diet during adolescence on offspring gut microbiota, stress reactivity and social behavior

A. Hannan, A. Reichelt, Geraldine Kong, 2021, bioRxiv.

Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans

Mark Hargreaves, M. Febbraio, L. Spriet, 2001, The Journal of physiology.

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

M. Febbraio, B. Pedersen, O. Mortensen, 2009, Diabetologia.

Hypothalamic Neurogenesis Is Not Required for the Improved Insulin Sensitivity Following Exercise Training

Z. Andrews, B. Oldfield, M. Watt, 2014, Diabetes.

Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?

L. Spriet, G. Heigenhauser, M. Watt, 2002, Journal of applied physiology.

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.

M. Watt, M. Stathopoulos, S. Andrikopoulos, 2014, Antioxidants & redox signaling.

A Neural basis for Octanoic acid regulation of energy balance

F. Zhao, M. Watt, Russell D. Brown, 2020, Molecular metabolism.

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

M. Watt, R. Meex, J. Lo, 2019, Diabetes.

Thiazolidinediones enhance skeletal muscle triacylglycerol synthesis while protecting against fatty acid-induced inflammation and insulin resistance.

A. Hevener, J. Le, M. Watt, 2007, American journal of physiology. Endocrinology and metabolism.

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

David Carling, Sofianos Andrikopoulos, M. Febbraio, 2006, Cell metabolism.

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

A. Earnest, M. Watt, P. Burton, 2018, Obesity Surgery.

STORING UP TROUBLE: DOES ACCUMULATION OF INTRAMYOCELLULAR TRIGLYCERIDE PROTECT SKELETAL MUSCLE FROM INSULIN RESISTANCE?

M. Watt, 2009, Clinical and experimental pharmacology & physiology.

Reply to ‘Lactate as a major myokine and exerkine’

Ian R. Lanza, A. Pandey, R. Gerszten, 2022, Nature Reviews Endocrinology.

Exercise Training does not Enhance Hypothalamic Responsiveness to Leptin or Ghrelin in Male Mice

Z. Andrews, M. Watt, M. L. Borg, 2014, Journal of neuroendocrinology.

Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid.

L. Spriet, G. Heigenhauser, G. Steinberg, 2003, American journal of physiology. Endocrinology and metabolism.

Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

M. Febbraio, O. Mortensen, B. K. Pedersen, 2015, Diabetologia.

Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies

M. Watt, S. Nie, N. Williamson, 2023, Scientific Reports.

Phosphorylation of adipose triglyceride lipase Ser(404) is not related to 5'-AMPK activation during moderate-intensity exercise in humans.

M. Watt, R. Meex, B. Canny, 2012, American journal of physiology. Endocrinology and metabolism.

Fat talks: a new role for adipose

M. Watt, Renea A. Taylor, 2018 .

Metabolic communication during exercise

M. Febbraio, M. Watt, R. Murphy, 2020, Nature Metabolism.

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning.

S. Luquet, Z. Andrews, S. Lockie, 2018, Cell reports.

Pathways involved in lipid-induced insulin resistance in obesity

G. Steinberg, M. Watt, 2007 .

M. Febbraio, R. Southgate, M. Watt, 2004, Journal of molecular endocrinology.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

A. Hevener, K. Korach, E. Stefani, 2016, Science Translational Medicine.

Identification of Metabolic ally Distinct Adipocyte Progenitor Cells in Human Adipose Tissues Graphical Abstract Highlights

P. O’Brien, M. Watt, P. Burton, 2019 .

Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

M. Watt, P. Burton, S. Nie, 2022, Nature Communications.

Consumption of a high‐fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice

P. Meikle, M. Watt, J. Weir, 2012, The Journal of physiology.

TCPTP attenuates STAT 3 and insulin signaling in the liver to regulate gluconeogenesis

M. Tremblay, M. Watt, S. Andrikopoulos, 2010 .

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

M. Febbraio, P. Angus, K. Sourris, 2017, Scientific Reports.

Effect of acute plasma volume expansion on thermoregulation and exercise performance in the heat.

M. Febbraio, A. Garnham, M. Watt, 2000, Medicine and science in sports and exercise.

Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide

M. Cowley, A. Stefanidis, B. Oldfield, 2017, Neuropharmacology.

Liver‐specific suppressor of cytokine signaling‐3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity 1

Sofianos Andrikopoulos, A. Hevener, T. Kay, 2010, Hepatology.

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance*

A. Hevener, B. Kemp, S. Jørgensen, 2009, The Journal of Biological Chemistry.

Effect of early environmental experience on the motor development of the preterm infant

J. Darrah, M. Watt, P. Byrne, 1990 .

Insights into the neurochemical signature of the Innervation of Beige Fat

A. Stefanidis, B. Oldfield, M. Watt, 2018, Molecular metabolism.

Ectodysplasin A Is Increased in Non-Alcoholic Fatty Liver Disease, But Is Not Associated With Type 2 Diabetes

M. Watt, P. Burton, J. Bayliss, 2021, Frontiers in Endocrinology.

Comparative analysis of microRNA expression in mouse and human brown adipose tissue

A. Russell, S. Kajimura, T. Crowley, 2015, BMC Genomics.

restoration following fat adaptation with carbohydrate Decreased PDH activation and glycogenolysis during

John A. Hawley, Louise M. Burke, Matthew J. Watt, 2006 .

Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signalling and Glucose Transport in Skeletal Muscle.

C. Goodman, M. Watt, P. Burton, 2022, Diabetes.

Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue

M. Mori, M. Watt, H. Petrick, 2022, Function.

humansduring prolonged moderate-intensity exercise in Suppressing lipolysis increases interleukin-6 at rest

M. Febbraio, F. Karpe, S. Kersten, 2015 .