D. Hatters

发表

Hidden information on protein function in censuses of proteome foldedness.

G. Reid, C. Ang, D. Cox, 2022, Nature communications.

Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

G. Reid, C. Ang, D. Hatters, 2020, bioRxiv.

Immiscible inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

G. Reid, C. Ang, D. Hatters, 2020, PloS one.

Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

Douglas E. V. Pires, M. Vendruscolo, G. Reid, 2019, bioRxiv.

Macromolecular Crowding Accelerates Amyloid Formation by Human Apolipoprotein C-II*

A. Minton, G. Howlett, D. Hatters, 2002, The Journal of Biological Chemistry.

Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation.

B. Kobe, E. Valkov, P. Dodds, 2011, Cell host & microbe.

Identifying polyglutamine protein species in situ that best predict neurodegeneration

B. Shaby, M. Segal, S. Finkbeiner, 2011, Nature chemical biology.

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

Douglas E. V. Pires, M. Vendruscolo, G. Reid, 2020, Proceedings of the National Academy of Sciences.

Protein folding: Illuminating chaperone activity.

D. Hatters, 2017, Nature chemical biology.

The Molecular Chaperone, α-Crystallin, Inhibits Amyloid Formation by Apolipoprotein C-II*

J. Carver, G. Howlett, D. Hatters, 2001, The Journal of Biological Chemistry.

Cellular aging impedes stress-activation of a crucial JDP-Hsp70 protein disaggregase

H. Kampinga, S. Arumugam, D. Cox, 2022 .

Sequence grammar underlying the unfolding and phase separation of globular proteins.

R. Pappu, S. Radford, D. Ascher, 2022, Molecular cell.

Modest Declines in Proteo me Quality Impair Hematopoietic Stem Cell Self-Renewal

Yuning Hong, D. Hatters, M. Sunshine, 2022 .

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

D. Saunders, I. Blair, S. Warraich, 2015, Scientific Reports.

Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin.

Mark R. Wilson, G. Howlett, D. Hatters, 2002, European journal of biochemistry.

Hidden information on protein function in censuses of proteome foldedness

Nadinath B. Nillegoda, C. Ang, D. Cox, 2021, Nature Communications.

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length.

R. Pappu, A. Purcell, A. Fox, 2018, Journal of molecular biology.

Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

R. Pappu, A. Purcell, A. Fox, 2017, bioRxiv.

Sub‐micellar phospholipid accelerates amyloid formation by apolipoprotein C‐II

G. Howlett, L. Lawrence, D. Hatters, 2001, FEBS letters.

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

Elise M. Stewart, C. Dobson, G. Guillemin, 2015, Molecular Neurodegeneration.

Diagnostics for amyloid fibril formation: where to begin?

D. Hatters, M. Griffin, 2011, Methods in molecular biology.

Arginine valency in C9ORF72 dipolypeptides mediates promiscuous proteome binding that stalls ribosomes, disable actin cytoskeleton assembly and impairs arginine methylation of endogenous proteins

C. Ang, D. Cox, D. Hatters, 2019, bioRxiv.

A biosensor of protein foldedness identifies increased “holdase” activity of chaperones in the nucleus following increased cytosolic protein aggregation

A. Dickson, S. Ebbinghaus, Christian Makhoul, 2022, The Journal of biological chemistry.

A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells

A. Dickson, S. Ebbinghaus, G. McColl, 2021, bioRxiv.

Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli

D. Cox, D. Hatters, Angelique R. Ormsby, 2022, bioRxiv.

KineticMSI, an R-based framework for relative quantification of spatial isotopic incorporation in mass spectrometry imaging experiments

A. Hannan, D. Hatters, B. Boughton, 2022, bioRxiv.

Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure.

S. Finkbeiner, K. Weisgraber, M. Arrasate, 2012, Journal of molecular biology.

Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.

P. Gleeson, D. Hatters, Pei Zhi Cheryl Chia, 2015, Methods in molecular biology.

Sedimentation analysis of novel DNA structures formed by homo-oligonucleotides.

T. Mulhern, G. Howlett, D. Hatters, 2001, Biophysical journal.

Simultaneous Binding of the Anti-Cancer IgM Monoclonal Antibody PAT-SM6 to Low Density Lipoproteins and GRP78

T. Mulhern, G. Howlett, D. Hatters, 2013, PloS one.

AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding.

Jong-Tae Park, D. Neumann, D. Stapleton, 2012, Biophysical journal.

Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.

C. MacPhee, G. Howlett, L. Lawrence, 2000, Biochemistry.

High‐Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry

P. Gleeson, D. Hatters, Pei Zhi Cheryl Chia, 2014, Traffic.

The Anti-Cancer IgM Monoclonal Antibody PAT-SM6 Binds with High Avidity to the Unfolded Protein Response Regulator GRP78

T. Mulhern, G. Howlett, L. Ilag, 2012, PloS one.

Apolipoprotein E4 Forms a Molten Globule

B. Rupp, K. Weisgraber, K. Oberg, 2002, The Journal of Biological Chemistry.

Protein aggregation in cell biology: An aggregomics perspective of health and disease.

D. Cox, D. Hatters, Xiaojing Sui, 2020, Seminars in cell & developmental biology.

The circularization of amyloid fibrils formed by apolipoprotein C-II.

Jonathan A. Jones, Jason J. Davis, C. Dobson, 2003, Biophysical journal.

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

Yuning Hong, D. Hatters, M. Sunshine, 2020, Cell reports.

Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice

A. Hannan, M. McConville, Shanshan Li, 2022, Neurobiology of Disease.

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Ching-Seng Ang, Steven Finkbeiner, Anthony W Purcell, 2017, Cell reports.

When proteostasis goes bad: Protein aggregation in the cell

D. Hatters, M. Radwan, Rebecca J. Wood, 2017, IUBMB life.

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles

C. Bond, Diwei Ho, K. Iyer, 2015, The Journal of cell biology.

Tyrosine 416 Is Phosphorylated in the Closed, Repressed Conformation of c-Src

T. Mulhern, D. Hatters, Rebecca J. Wood, 2013, PloS one.

A biosensor-based framework to measure latent proteostasis capacity

M. Oliveberg, A. Dickson, S. Ebbinghaus, 2018, Nature Communications.

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways

A. Hannan, A. Oshlack, R. Hannan, 2017, Molecular and Cellular Neuroscience.

Walking the tightrope: proteostasis and neurodegenerative disease

A. Dillin, D. Saunders, P. Beart, 2016, Journal of neurochemistry.

Tracking protein aggregation and mislocalization in cells with flow cytometry

N. Croft, A. Purcell, M. Bogoyevitch, 2012, Nature Methods.

Sedimentation velocity analysis of flexible macromolecules: self-association and tangling of amyloid fibrils.

G. Howlett, L. Lawrence, D. Hatters, 2003, Biophysical journal.

Apolipoprotein E structure: insights into function.

K. Weisgraber, D. Hatters, C. Peters-Libeu, 2006, Trends in biochemical sciences.

A biosensor of SRC family kinase conformation by exposable tetracysteine useful for cell-based screening.

D. Huang, T. Mulhern, D. Hatters, 2014, ACS chemical biology.

Flipping the switch: How cysteine oxidation directs tau amyloid conformations

D. Hatters, 2021, The Journal of biological chemistry.

Polyglutamine aggregation in Huntington and related diseases.

A. Hill, D. Hatters, Saskia Polling, 2012, Advances in experimental medicine and biology.

A Census of Hsp70-Mediated Proteome Solubility Changes upon Recovery from Heat Stress.

D. Cox, D. Hatters, S. Nie, 2022, Journal of proteome research.

Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate

M. Ritchie, L. Furic, J. Mintern, 2022, bioRxiv.

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity*

C. Ang, D. Cox, D. Hatters, 2020, Molecular & Cellular Proteomics.

Sedimentation velocity analysis of amyloid oligomers and fibrils using fluorescence detection.

T. Ryan, G. Howlett, D. Hatters, 2011, Methods.

Manuscript in preparation : I . Aging in Rats Promotes Alzheimer ’ s Disease β-amyloid Aggregation and Toxicity by Metallostasis of Extraneuronal Zinc

Blaine R. Roberts, C. Masters, G. Juhász, 2012 .

A Platform to View Huntingtin Exon 1 Aggregation Flux in the Cell Reveals Divergent Influences from Chaperones hsp40 and hsp70*

D. Hatters, Angelique R. Ormsby, Yee-Foong Mok, 2013, The Journal of Biological Chemistry.

Putting huntingtin "aggregation" in view with windows into the cellular milieu.

D. Hatters, 2013, Current topics in medicinal chemistry.

Tracking Mutant Huntingtin Aggregation Kinetics in Cells Reveals Three Major Populations That Include an Invariant Oligomer Pool*

Andrew F Hill, A. Hill, M. Bailey, 2010, The Journal of Biological Chemistry.

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

S. Finkbeiner, A. Hill, D. Hatters, 2010, Chemistry & biology.

Protein misfolding inside cells: The case of huntingtin and Huntington's disease

D. Hatters, 2008, IUBMB life.

Tandem Repeats in Genes, Proteins, and Disease

A. Hannan, D. Hatters, 2013, Methods in Molecular Biology.

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

A. Suhrbier, W. Schroder, D. Saunders, 2015, PloS one.

Fibrillar Amyloid Protein Present in Atheroma Activates CD36 Signal Transduction*

K. Moore, Lea A. Medeiros, G. Howlett, 2004, Journal of Biological Chemistry.

Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils.

K. Weisgraber, D. Hatters, E. Rutenber, 2006, Journal of molecular biology.

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell*

A. Hill, B. J. Turner, D. Hatters, 2014, The Journal of Biological Chemistry.

Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge.

D. Hatters, Yee-Foong Mok, Saskia Polling, 2013, Methods in molecular biology.

A biosensor-based framework to measure latent proteostasis capacity

M. Oliveberg, A. Dickson, S. Ebbinghaus, 2018, Nature Communications.

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

T. Kálai, K. Hideg, K. Weisgraber, 2010, Journal of Lipid Research.

Phospholipid complexation and association with apolipoprotein C-II: insights from mass spectrometry.

C. Robinson, L. Ilag, Jonathan Malo, 2003, Biophysical Journal.

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.

S. Ebbinghaus, D. Hatters, E. Newcombe, 2017, Physical chemistry chemical physics : PCCP.

The Allosteric Mechanism Induced by Protein Kinase A (PKA) Phosphorylation of Dematin (Band 4.9)*

Jeffrey W. Brown, C. McKnight, D. Hatters, 2013, The Journal of Biological Chemistry.

Model of Biologically Active Apolipoprotein E Bound to Dipalmitoylphosphatidylcholine*

K. Weisgraber, D. Hatters, Y. Newhouse, 2006, Journal of Biological Chemistry.

Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II.

G. Howlett, L. Lawrence, D. Hatters, 2002, Biochemistry.

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

P. Muchowski, D. Hatters, Angelique R. Ormsby, 2017, Journal of Huntington's disease.

A thiol probe for measuring unfolded protein load and proteostasis in cells

L. Tilley, B. Tang, Yuning Hong, 2017, Nature Communications.

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

D. Priest, D. Cox, D. Hatters, 2020, PloS one.

Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence.

A. Hill, R. Cappai, D. Hatters, 2009, Biochemical and biophysical research communications.

Apolipoprotein E4 Forms a Molten Globule A POTENTIAL BASIS FOR ITS ASSOCIATION WITH DISEASE*

K. Weisgraber, K. Oberg, D. Hatters, 2002 .

ReAsH/FlAsH labeling and image analysis of tetracysteine sensor proteins in cells.

T. Mulhern, D. Hatters, Sevgi Irtegun, 2011, Journal of visualized experiments : JoVE.

Distinct Pathways in the Cell Superoxide Dismutase 1 Aggregate via Misfolded Polyglutamine , Polyalanine , and Molecular Bases of Disease :

A. Hill, B. J. Turner, D. Hatters, 2014 .

Engineering Conformational Destabilization into Mouse Apolipoprotein E

K. Weisgraber, D. Hatters, C. Peters-Libeu, 2005, Journal of Biological Chemistry.

Modulation of Apolipoprotein E Structure by Domain Interaction

K. Weisgraber, J. Voss, M. Budamagunta, 2005, Journal of Biological Chemistry.

Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy.

K. Weisgraber, J. Voss, M. Budamagunta, 2009, Journal of molecular biology.

The Asian Biophysics Association—supporting biophysics in the greater Asia region

H. Noji, D. Hatters, 2019, Biophysical Reviews.

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.

C. Ang, D. Cox, D. Hatters, 2020, Molecular & cellular proteomics : MCP.

Replicative aging impedes stress-induced assembly of a key human protein disaggregase

Nadinath B. Nillegoda, H. Kampinga, D. Cox, 2023, bioRxiv.

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

James N. Hughes, A. Hill, C. Shoubridge, 2015, Nature Structural &Molecular Biology.

Grand challenges in biomolecular condensates: structure, function, and formation

D. Hatters, 2023, Frontiers in Biophysics.

SUPPLEMENTARY INFORMATION Identifying polyglutamine protein species in situ that best predict neurodegeneration

B. Shaby, M. Segal, S. Finkbeiner, 2011 .

The structural basis for amyloid formation by plasma apolipoproteins: a review

G. Howlett, D. Hatters, 2002, European Biophysics Journal.

Probing Protein Solubility Patterns with Proteomics for Insight into Network Dynamics.

D. Cox, D. Hatters, M. Radwan, 2022, Methods in molecular biology.

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding.

C. MacPhee, D. Hatters, G J Howlett, 2000, Biochemistry.

Conformation sensors that distinguish monomeric proteins from oligomers in live cells.

S. Finkbeiner, A. Hill, D. Hatters, 2010, Chemistry & biology.

NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate.

G. Howlett, P. Gooley, D. Hatters, 2001, Biochemistry.

Polyalanine expansions drive a shift into -helical clusters without amyloid fibril formation.

C. Shoubridge, D. Hatters, T. Böcking, 2016 .

Putting huntingtin "aggregation" in view with windows into the cellular milieu.

D. Hatters, 2013, Current topics in medicinal chemistry.

Systemic administration of a novel Beclin 1-derived peptide significantly upregulates autophagy in the spinal motor neurons of autophagy reporter mice.

D. Hatters, F. Shabanpoor, Nirma D Perera, 2024, International journal of pharmaceutics.

Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

R. Pappu, A. Purcell, A. Fox, 2017, bioRxiv.