B. Bachmann

发表

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

Cody R. Goodwin, J. McLean, Dagmara K. Derewacz, 2013, Proceedings of the National Academy of Sciences.

Bioactive oligosaccharide natural products.

B. Bachmann, E. K. McCranie, 2014, Natural product reports.

Bioretrosynthetic construction of a didanosine biosynthetic pathway

T. Iverson, C. A. Starbird, B. Bachmann, 2014, Nature chemical biology.

Biosynthesis: is it time to go retro?

B. Bachmann, 2010, Nature chemical biology.

Lipophilic Mediated Assays for β-Hematin Inhibitors

D. Wright, B. Bachmann, M. D. Carter, 2010 .

A unifying nitrososynthase involved in nitrosugar biosynthesis.

D. Kahne, B. Bachmann, Yunfeng Hu, 2008, Journal of the American Chemical Society.

Structural mass spectrometry: rapid methods for separation and analysis of peptide natural products.

Cody R. Goodwin, Larissa S Fenn, J. McLean, 2012, Journal of natural products.

Structural Separations for Natural Product Characterization by Ion Mobility–Mass Spectrometry

Cody R. Goodwin, J. McLean, Kelly M. Hines, 2014 .

β-Lactam synthetase: A new biosynthetic enzyme

C. Townsend, Rongfeng Li, B. Bachmann, 1998 .

Applied evolutionary theories for engineering of secondary metabolic pathways.

B. Bachmann, 2016, Current opinion in chemical biology.

Substrate Binding to the α-Ketoglutarate-Dependent Non-Heme Iron Enzyme Clavaminate Synthase 2: Coupling Mechanism of Oxidative Decarboxylation and Hydroxylation

C. Townsend, E. Solomon, B. Bachmann, 1998 .

Structure and Stereochemical Determination of Hypogeamicins from a Cave-Derived Actinomycete

L. Marnett, G. Scalmani, Dagmara K. Derewacz, 2014, Journal of natural products.

Adenylation enzyme characterization using γ-18O4-ATP pyrophosphate exchange

B. Bachmann, V. Phelan, Vanessa V. Phelan, 2009 .

Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility- Imaging Mass Spectrometry and Unsupervised Segmentation.

J. McLean, B. Bachmann, LeRoy B. Martin, 2019, Analytical chemistry.

Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.

Cody R. Goodwin, J. Wikswo, J. McLean, 2015, Chemistry & biology.

Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis.

Ioanna Ntai, B. Bachmann, V. Phelan, 2006, Chemical communications.

A bifunctional nitrone conjugated secondary metabolite targeting the ribosome.

Jeffrey M. Spraggins, Daniel N. Wilson, R. Green, 2020, Journal of the American Chemical Society.

Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway.

B. Bachmann, J. Vey, Ahmad H Al-Mestarihi, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus.

T. Iverson, B. Bachmann, T. Panosian, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS

J. Thorson, A. Staffa, C. Farnet, 2002, Science.

Benzodiazepine Biosynthesis in Streptomyces refuineus (DOI:10.1016/j.chembiol.2007.05.009)

Ioanna Ntai, C. Farnet, B. Bachmann, 2007 .

An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products

J. Irish, Madeline J. Hayes, B. Bachmann, 2022, The Journal of biological chemistry.

Fluorescent probes of the apoptolidins and their utility in cellular localization studies.

L. Marnett, A. Ustione, D. Piston, 2015, Angewandte Chemie.

Five‐Component Cascade Synthesis of Nucleotide Analogues in an Engineered Self‐Immobilized Enzyme Aggregate

B. Bachmann, R. Scism, 2009, Chembiochem : a European journal of chemical biology.

Response of Secondary Metabolism of Hypogean Actinobacterial Genera to Chemical and Biological Stimuli

Jeffrey M. Spraggins, B. Bachmann, Audrey E Yñigez-Gutierrez, 2018, Applied and Environmental Microbiology.

Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine.

B. Bachmann, Audrey E Yñigez-Gutierrez, Audrey E. Ynigez-Gutierrez, 2019, Journal of medicinal chemistry.

Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26.

Ioanna Ntai, B. Bachmann, 2008, Bioorganic & medicinal chemistry letters.

Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis.

David P Nannemann, Brian O Bachmann, B. Bachmann, 2011, Future medicinal chemistry.

Biosynthetic origins of C-P bond containing tripeptide K-26.

Ioanna Ntai, B. Bachmann, D. Hachey, 2005, Organic letters.

The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins

B. Bachmann, J. Buynak, L. Hua, 1995 .

Synthesis and biological activity of 7-alkylidenecephems.

B. Bachmann, J. Buynak, L. Hua, 1995, Journal of medicinal chemistry.

Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.

John A McLean, Brian O Bachmann, J. McLean, 2017, Natural product reports.

7-alkylidenecephalosporin esters as inhibitors of human leukocyte elastase.

B. Bachmann, J. Buynak, B. Geng, 1997, Journal of medicinal chemistry.

Benzodiazepine biosynthesis in Streptomyces refuineus.

Ioanna Ntai, C. Farnet, B. Bachmann, 2007, Chemistry & biology.

Development and application of a high throughput assay system for the detection of Rieske dioxygenase activity.

Aaron S. Jackson, B. Bachmann, Jordan T Froese, 2021, Organic & biomolecular chemistry.

Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.

E. Sturrock, K. Acharya, B. Bachmann, 2014, ACS medicinal chemistry letters.

Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster.

E. Sturrock, K. Acharya, Ioanna Ntai, 2010, Biochemical and biophysical research communications.

The catalytic cycle of β-lactam synthetase observed by x-ray crystallographic snapshots

C. Townsend, A. Rosenzweig, B. Bachmann, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

Emmanuel Zazopoulos, James B McAlpine, Brian O Bachmann, 2005, Journal of natural products.

Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily

T. Iverson, B. Bachmann, E. K. McCranie, 2015, Proceedings of the National Academy of Sciences.

Bacillus cereus Phosphopentomutase Is an Alkaline Phosphatase Family Member That Exhibits an Altered Entry Point into the Catalytic Cycle*

W. McDonald, T. Iverson, B. Wadzinski, 2010, The Journal of Biological Chemistry.

Methyltransferase Contingencies in the Pathway of Everninomicin D Antibiotics and Analogues

Jeffrey M. Spraggins, Dagmara K. Derewacz, B. Bachmann, 2020, Chembiochem : a European journal of chemical biology.

Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase.

B. Bachmann, D. Stec, R. Scism, 2007, Organic letters.

Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase.

T. Iverson, B. Bachmann, W. Birmingham, 2012, Biochemistry.

Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.

Hung‐wen Liu, B. Bachmann, Ahmad H Al-Mestarihi, 2013, Journal of the American Chemical Society.

The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.

T. Iverson, B. Bachmann, Sandra Berndt, 2018, Biochemistry.

Crystal structure of a peptidyl‐dipeptidase K‐26‐DCP from Actinomycete in complex with its natural inhibitor

K. Acharya, G. Cozier, B. Bachmann, 2016, The FEBS journal.

Design and directed evolution of a dideoxy purine nucleoside phosphorylase.

Jens Meiler, David P Nannemann, Brian O Bachmann, 2010, Protein engineering, design & selection : PEDS.

Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase

J. Rubinstein, B. Bachmann, G. Sulikowski, 2021, Nature Chemical Biology.

Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds.

J. Porco, B. Bachmann, Jonathan H Boyce, 2020, Angewandte Chemie.

A genomics-guided approach for discovering and expressing cryptic metabolic pathways

Brian O. Bachmann, Alfredo Staffa, Wen Liu, 2003, Nature Biotechnology.

Tracing MYC Expression for Small Molecule Discovery.

R. Cencic, J. Pelletier, David E. Williams, 2019, Cell chemical biology.

Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

J. Irish, B. Bachmann, P. Ferrell, 2018, Nature Communications.

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

Brian O. Bachmann, Richard H. Baltz, R. H. Baltz, 2014, Journal of Industrial Microbiology & Biotechnology.

Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities.

C. Townsend, E. Solomon, B. Bachmann, 2001, Journal of the American Chemical Society.

Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data.

Jacques Ravel, Brian O Bachmann, J. Ravel, 2009, Methods in enzymology.

A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia

J. Rubinstein, B. Bachmann, G. Sulikowski, 2021, bioRxiv.

The IsdG‐family of haem oxygenases degrades haem to a novel chromophore

Eric P. Skaar, M. Murphy, D. Wright, 2010, Molecular microbiology.

Structure of β-lactam synthetase reveals how to synthesize antibiotics instead of asparagine

C. Townsend, A. Rosenzweig, B. Bachmann, 2001, Nature Structural Biology.

Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange.

J. McLean, B. Bachmann, V. Phelan, 2009, Chemistry & biology.

Mapping Microbial Response Metabolomes for Induced Natural Product Discovery.

J. McLean, B. Bachmann, Brett C. Covington, 2015, ACS chemical biology.

Decoding chemical structures from genomes

Brian O Bachmann, B. Bachmann, 2005, Nature chemical biology.

Metabolic model for diversity-generating biosynthesis

Elizabeth Pierce, B. Bachmann, B. Olivera, 2016, Proceedings of the National Academy of Sciences.

The use of fluorescently-tagged apoptolidins in cellular uptake and response studies

Rebecca A. Ihrie, J. Irish, R. Ihrie, 2016, The Journal of Antibiotics.

Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.

J. Ravel, Dagmara K. Derewacz, B. Bachmann, 2011, Tetrahedron.

Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus.

C. Townsend, B. Bachmann, 2000, Biochemistry.

Reassembly of Anthramycin Biosynthetic Gene Cluster by Using Recombinogenic Cassettes

Emmanuel Zazopoulos, Brian O Bachmann, B. Bachmann, 2008, Chembiochem : a European journal of chemical biology.

Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data

John P. Wikswo, Brian O. Bachmann, Stacy D. Sherrod, 2014, Analytical chemistry.

Biocatalysis in pharmaceutical preparation and alteration.

B. Wilkinson, B. Bachmann, 2006, Current opinion in chemical biology.

Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis .

T. Iverson, B. Bachmann, Yunfeng Hu, 2010, Biochemistry.

Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics

J. Irish, B. Bachmann, P. Ferrell, 2018, Nature Communications.

Distance Geometry Protocol to Generate Conformations of Natural Products to Structurally Interpret Ion Mobility-Mass Spectrometry Collision Cross Sections

Cody R. Goodwin, T. Lybrand, J. McLean, 2014, The journal of physical chemistry. B.

Foundations for directed alkaloid biosynthesis.

B. Bachmann, 2007, Chemistry & biology.

EvdS6 is a bifunctional decarboxylase from the everninomicin gene cluster

M. Voehler, B. Bachmann, T. M. Iverson, 2023, The Journal of biological chemistry.

Design and directed evolution of a dideoxy purine nucleoside phosphorylase.

J. Meiler, B. Bachmann, D. Nannemann, 2010, Protein engineering, design & selection : PEDS.

Response of Secondary Metabolism of Hypogean Actinobacterial Genera to Chemical and Biological Stimuli

B. Bachmann, Audrey E Yñigez-Gutierrez, Brett C. Covington, 2018, Applied and Environmental Microbiology.

Bioactive oligosaccharide natural products.

B. Bachmann, E. K. McCranie, 2014, Natural product reports.

Reassembly of Anthramycin Biosynthetic Gene Cluster by Using Recombinogenic Cassettes

C. Farnet, B. Bachmann, Yunfeng Hu, 2008, Chembiochem : a European journal of chemical biology.

Lactococcus lactis fabH, Encoding β-Ketoacyl-Acyl Carrier Protein Synthase, Can Be Functionally Replaced by the Plasmodium falciparum Congener

S. Prigge, B. Bachmann, Jacob D. Johnson, 2010, Applied and Environmental Microbiology.

Lactococcus lactis fabH , Encoding (cid:1) -Ketoacyl-Acyl Carrier Protein Synthase, Can Be Functionally Replaced by the Plasmodium falciparum Congener (cid:1)

S. Prigge, B. Bachmann, Jacob D. Johnson, 2010 .