Shuo-Bin Chen

发表

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Yong Rao, Zhi-qi Kuang, Chan Li, 2021, Gut microbes.

Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton.

Ding Li, Jin-Qiang Hou, Shuo-Bin Chen, 2012, Analytical chemistry.

Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2014 .

Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2018, Journal of the American Chemical Society.

Dual-color Imaging of DNA and RNA Simultaneously with an Aggregation/Monomer-Based Deep-red Fluorescent Probe

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, Sensors and Actuators B: Chemical.

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2016, Journal of medicinal chemistry.

A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2016 .

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2016, Biosensors & bioelectronics.

A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology

Meicun Yao, Shuo-Bin Chen, Zhishu Huang, 2015, Scientific Reports.

Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders.

Ji-Ming Ye, Yong Rao, Chan Li, 2020, European journal of medicinal chemistry.

Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-Quadruplex Interaction.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2017, Journal of medicinal chemistry.

Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer.

Yong Rao, Shuo-Bin Chen, Zhishu Huang, 2022, Journal of medicinal chemistry.

Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2021, Journal of the American Chemical Society.

Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2022, Journal of medicinal chemistry.

Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach.

L. Luyt, Jin-Qiang Hou, Shuo-Bin Chen, 2015, Chemical communications.

Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2017 .

Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2016, Nucleic acids research.

Role of Hairpin-Quadruplex DNA Secondary Structural Conversion in the Promoter of hnRNP K in Gene Transcriptional Regulation.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2015, Organic letters.

Development of a highly sensitive fluorescent light-up probe for G-quadruplexes.

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2015, The Analyst.

Development of a Highly Selective and Sensitive Fluorescent Probe for Imaging RNA Dynamics in Live Cells

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, Molecules.

Tracking Stress Granule Dynamics in Live Cells and In Vivo with a Small Molecule.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2021, Analytical chemistry.

Studies on the binding of 5-N-methylated quindoline derivative to human telomeric G-quadruplex.

Wei Xu, Ding Li, Jin-Qiang Hou, 2011, Biochemical and biophysical research communications.

Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, Nucleic acids research.

Cladogenetic Orthogonal Light-Up Aptamers for Simultaneous Detection of Multiple Small Molecules in Cells.

N. Sugimoto, Shuo-Bin Chen, Jia-Heng Tan, 2022, Analytical chemistry.

Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2015, European journal of medicinal chemistry.

Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.

Ding Li, Jin-Qiang Hou, Shuo-Bin Chen, 2012, Bioorganic & medicinal chemistry.

Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2018 .

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe.

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2016, Journal of the American Chemical Society.

Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2014, Chemical communications.

Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives.

Ding Li, Hai-bin Luo, Jin-Qiang Hou, 2011, Organic & biomolecular chemistry.

Design, Synthesis and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom's Syndrome Protein (BLM) Helicase, Trigger DNA damage at the Telomere Region and Synergize with PARP Inhibitors.

Ding Li, Yong Rao, Yao-Hao Xu, 2020, Journal of medicinal chemistry.

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2013, Organic & biomolecular chemistry.

Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand.

Ding Li, Shuo-Bin Chen, Jia-Heng Tan, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2015, European journal of medicinal chemistry.

Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA.

Shuo-Bin Chen, Jia-Heng Tan, Lian-Quan Gu, 2010, Bioorganic & medicinal chemistry.

Synthesis and Evaluation of Quinazolone Derivatives as a New Class of c-KIT G-Quadruplex Binding Ligands.

Jin-Qiang Hou, Shuo-Bin Chen, Zhishu Huang, 2013, ACS medicinal chemistry letters.

Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2018, Sensors and Actuators B: Chemical.

Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells.

Shuo-Bin Chen, Zhishu Huang, Jia Yuan, 2018, Angewandte Chemie.

Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, European journal of medicinal chemistry.

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule

Ding Li, Jin-Qiang Hou, Shuo-Bin Chen, 2015, Nucleic acids research.

Efficient and rational development of a new fluorescent probe specific for RNA G-quadruplex imaging in cells

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2020 .

Recent advances in fluorescent probes for G-quadruplex nucleic acids.

Shuo-Bin Chen, Zhishu Huang, Jia Yuan, 2020, Biochemical and biophysical research communications.

Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2018, Molecules.

Benzoselenazolium-Based Hemicyanine Dye for G-Quadruplex Detection.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, Bioorganic & medicinal chemistry letters.

Development of a Smart Fluorescent Sensor That Specifically Recognizes the c-MYC G-Quadruplex.

Ruibo Wu, Shuo-Bin Chen, Zhishu Huang, 2019, Analytical chemistry.

Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex.

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2018, Journal of medicinal chemistry.

Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2011, European journal of medicinal chemistry.

Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2013, European journal of medicinal chemistry.

New insights from molecular dynamic simulation studies of the multiple binding modes of a ligand with G-quadruplex DNA

Ding Li, Jin-Qiang Hou, Shuo-Bin Chen, 2012, Journal of Computer-Aided Molecular Design.

Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.

Zepeng Zhang, Yong Zhao, Shuo-Bin Chen, 2018, Journal of medicinal chemistry.

Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2019, Journal of medicinal chemistry.

A novel HSF1 activator ameliorates non‐alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation

Shiying Guo, Yong Rao, Chan Li, 2021, British journal of pharmacology.

In vivo near-infrared fluorescence imaging of amyloid-β plaques with a dicyanoisophorone-based probe.

Lei Zhang, Shuo-Bin Chen, Shuo-Bin Chen, 2017, Analytica chimica acta.

Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c-MYC Transcription Inhibitors.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2023, Journal of medicinal chemistry.

Construction of a TICT-AIE-Integrated Unimolecular Platform for Imaging Lipid Droplet-Mitochondrion Interactions in Live Cells and In Vivo.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2022, ACS sensors.

Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques.

Shuo-Bin Chen, M. Cui, Lei Zhang, 2017, Chemical communications.

Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes.

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2014, Chemical communications.

Structural analysis and cellular visualization of APP RNA G-quadruplex† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02768h

C. Kwok, Shuo-Bin Chen, Jia-Heng Tan, 2019, Chemical science.

A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

Shuo-Bin Chen, Chun-Qiong Zhou, Tian-Zhu Ma, 2018, RSC advances.

Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism

Yao-Hao Xu, Yu-Tao Hu, Bing-Bing Song, 2023, European Journal of Medicinal Chemistry.

Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma.

Shuo-Bin Chen, Zhishu Huang, Tian-Miao Ou, 2023, Journal of medicinal chemistry.

Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA

Yao-Hao Xu, Shuo-Bin Chen, Zhishu Huang, 2023, Molecules.

Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2016, Biosensors & bioelectronics.

The role of positive charges on G-quadruplex binding small molecules: learning from bisaryldiketene derivatives.

Ding Li, Shuo-Bin Chen, Zhishu Huang, 2013, Biochimica et biophysica acta.

Neutral merocyanine dyes: for in vivo NIR fluorescence imaging of amyloid-β plaques.

Shuo-Bin Chen, M. Cui, Lei Zhang, 2017, Chemical communications.

Revealing Mitochondrion-Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2023, Analytical chemistry.

Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives.

Ding Li, Hai-bin Luo, Jin-Qiang Hou, 2011, Organic & biomolecular chemistry.

New insights into the structures of ligand-quadruplex complexes from molecular dynamics simulations.

Ding Li, Hai-bin Luo, Jun Xu, 2010, The journal of physical chemistry. B.

Mitochondrial RelA empowers mtDNA G-quadruplex formation for hypoxia adaptation in cancer cells.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2024, Cell chemical biology.

Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening.

Shuo-Bin Chen, Zhishu Huang, Jia-Heng Tan, 2024, Bioorganic & medicinal chemistry letters.