A. Reaume

发表

Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions.

J. A. Gruner, D. Flood, A. Reaume, 1999, The American journal of pathology.

Cardiac malformation in neonatal mice lacking connexin43.

B L Langille, J. Rossant, A. Reaume, 1995, Science.

Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD‐1 mice

R. Burkard, R. Salvi, D. Ding, 1999, The Journal of comparative neurology.

theraTRACE®: a mechanism unbiased in vivo platform for phenotypic screening and drug repositioning

A. Reaume, M. Saporito, 2011 .

Presenilin P264L knock-in mutation: Differential effects on abproduction, amyloid deposition, and neuronal vulnerability

D. Flood, A. Reaume, R. Scott, 2000, Neurobiology of Aging.

Presenilin-1 P264L Knock-In Mutation: Differential Effects on Aβ Production, Amyloid Deposition, and Neuronal Vulnerability

D. Flood, A. Reaume, R. Scott, 2000, The Journal of Neuroscience.

Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

B. Greenberg, A. Reaume, R. Scott, 1998, The Journal of Neuroscience.

Effects of over- and under-expression of Cu,Zn-superoxide dismutase on the toxicity of glutamate analogs in transgenic mouse striatum

J. Coyle, A. Reaume, R. Scott, 1998, Brain Research.

Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis

C. Epstein, R. Hotchkiss, P. Swanson, 2000, Critical care medicine.

Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia.

A. Reaume, T. Bray, Y. Tsai, 2001, American journal of physiology. Lung cellular and molecular physiology.

Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.

L. Bruijn, S. D. Anderson, D. Cleveland, 1998, Science.

Phenotypes of Mice Lacking Extracellular Superoxide Dismutase and Copper- and Zinc-containing Superoxide Dismutase*

S. Marklund, S. Basu, A. Reaume, 2006, Journal of Biological Chemistry.

Xanthine dehydrogenase is transported to the Drosophila eye.

A. Reaume, A. Chovnick, S. Clark, 1989, Genetics.

Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts.

C. Epstein, P. Chan, E. Carlson, 1997, Archives of biochemistry and biophysics.

Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice.

C. Epstein, P. Chan, E. Carlson, 1997, Acta neurochirurgica. Supplement.

Identification of Two Regulatory Elements within the Promoter Region of the Mouse Connexin 43 Gene (*)

J. Rossant, S. Lye, X. Bai, 1995, The Journal of Biological Chemistry.

High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept.

C. Lipinski, A. Reaume, 2020, Bioorganic & medicinal chemistry.

Normal development of preimplantation mouse embryos deficient in gap junctional coupling.

J. Rossant, A. Reaume, P. D. De Sousa, 1997, Journal of cell science.

Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs

C. Lipinski, A. Reaume, 2022, Frontiers in Pharmacology.

Reduction of CuZn-Superoxide Dismutase Activity Exacerbates Neuronal Cell Injury and Edema Formation after Transient Focal Cerebral Ischemia

C. Epstein, Ting-Ting Huang, P. Chan, 1997, The Journal of Neuroscience.

In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase.

S. Marklund, A. Reaume, K. Karlsson, 2001, Free radical biology & medicine.

Notch1 is required for the coordinate segmentation of somites.

J. Rossant, A. Reaume, R. A. Conlon, 1995, Development.

Expression analysis of a Notch homologue in the mouse embryo.

J. Rossant, R. Zirngibl, A. Reaume, 1992, Developmental biology.

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

B. Strooper, W. Annaert, D. Flood, 2002, Neurobiology of Aging.

Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence*

B. Greenberg, A. Reaume, R. Scott, 1996, The Journal of Biological Chemistry.

The rosy Locus in Drosophila melanoguster: Xanthine Dehydrogenase and Eye Pigments

D. Knecht, A. Reaume, A. Chovnick, 2002 .

Meiotic gene conversion tract length distribution within the rosy locus of Drosophila melanogaster.

G Harauz, G. Harauz, A. Hilliker, 1994, Genetics.

Phenotypic In Vivo Screening to Identify New, Unpredicted Indications for Existing Drugs and Drug Candidates

Christopher A. Lipinski, C. Lipinski, A. Reaume, 2012 .

Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol*

B. Greenberg, D. Flood, A. Reaume, 1998, The Journal of Biological Chemistry.

The rosy locus and xanthine dehydrogenase in Drosophila melanogaster.

A. Reaume, A. Chovnick, S. Clark, 1990, Progress in clinical and biological research.

In vivo phenotypic screening: clinical proof of concept for a drug repositioning approach.

A. Reaume, J. Ciallella, 2017, Drug discovery today. Technologies.

in Brain by Cholesterol -Peptide β Precursor Protein and Amyloid -Amyloid β Modulation of Secreted CELL BIOLOGY AND METABOLISM:

B. Greenberg, J. Savage, D. Flood, 2013 .

Drug Repositioning and Phenotypic Screening through Metabolomics

A. Reaume, M. Saporito, 2013 .

Drug repurposing Drug repurposing through nonhypothesis driven phenotypic screening

A. Reaume, 2012 .

Drug repurposing through nonhypothesis driven phenotypic screening

A. Reaume, Andrew G. Reaume, 2011 .

FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.

B. de Strooper, W. Annaert, D. Flood, 2002, Neurobiology of aging.

MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect

F. Greenway, A. Reaume, C. Rebello, 2021, Pharmaceuticals.

Targeted Deletion of the Cytosolic Cu/Zn-Superoxide Dismutase Gene (Sod1) Increases Susceptibility to Noise-Induced Hearing Loss

James S. Wright, Richard J. Salvi, R. Salvi, 1999, Audiology and Neurotology.

Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy

J. Shefner, D. Flood, A. Reaume, 1999, Neurology.

The Lyn Kinase Activator MLR-1023 Is a Novel Insulin Receptor Potentiator that Elicits a Rapid-Onset and Durable Improvement in Glucose Homeostasis in Animal Models of Type 2 Diabetes

C. Lipinski, A. Reaume, J. Handler, 2012, Journal of Pharmacology and Experimental Therapeutics.

MLR-1023 Is a Potent and Selective Allosteric Activator of Lyn Kinase In Vitro That Improves Glucose Tolerance In Vivo

Christopher A Lipinski, C. Lipinski, A. Reaume, 2012, Journal of Pharmacology and Experimental Therapeutics.

R. Salvi, D. Ding, D. Flood, 1999, Neurobiology of Aging.

Altered calcium homeostasis in spinal motoneurons but not in oculomotor neurons of SOD-1 knockout mice

R. Adalbert, S. Appel, A. Reaume, 2000, Acta Neuropathologica.

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

M. Beal, R. Ferrante, N. Kowall, 1996, Nature Genetics.