Alison R. Gregro

发表

Scheme 1, Synthesis of ML342

Larry A. Sklar, Alan S. Waggoner, Craig W. Lindsley, 2013 .

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2004, Journal of medicinal chemistry.

Evaluating scoring functions for docking and designing β-secretase inhibitors

Alison R. Gregro, M. Katharine Holloway, Georgia B. McGaughey, 2007 .

Discovery of Isonicotinamide Derived β-Secretase Inhibitors: In Vivo Reduction of β-Amyloid

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007 .

Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2007, Journal of medicinal chemistry.

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.

Alison R. Gregro, Julie L. Engers, Anna L. Blobaum, 2018, Bioorganic & medicinal chemistry letters.

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.

Alison R. Gregro, Julie L. Engers, Bruce J. Melancon, 2016, Bioorganic & medicinal chemistry letters.

The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.

Alison R. Gregro, Andrew S. Felts, Anna L. Blobaum, 2019, Bioorganic & medicinal chemistry letters.

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

Inhibitors of FAP-fluorogen interaction as a multiplex assay tool compound for receptor internalization assays

Philip H. Tapia, Alison R. Gregro, A. Waggoner, 2013 .

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.

Alison R. Gregro, Andrew S. Felts, N. Schnetz-Boutaud, 2019, Bioorganic & medicinal chemistry letters.

Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.

Alison R. Gregro, Julie L. Engers, C. Lindsley, 2019, Bioorganic & medicinal chemistry letters.

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.

Alison R. Gregro, Georgia B McGaughey, M Katharine Holloway, 2007, Bioorganic & medicinal chemistry letters.

Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Alison R. Gregro, A. Simon, G. McGaughey, 2009, ChemMedChem.

Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.

Alison R. Gregro, Julie L. Engers, C. Lindsley, 2017, Bioorganic & medicinal chemistry letters.

VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate.

Alison R. Gregro, Andrew S. Felts, N. Brandon, 2019, Bioorganic & medicinal chemistry letters.