L. Trottet

发表

Ketoprofen: release from, permeation across and rheology of simple gel formulations that simulate increasing dryness.

S. Gallagher, L. Trottet, C. Heard, 2003, International journal of pharmaceutics.

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Christophe Simon, P. Bamborough, R. Prinjha, 2014, Journal of medicinal chemistry.

Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride.

J. Hadgraft, L. Trottet, A. Davis, 2004, International journal of pharmaceutics.

Effects of Membrane Type and Liquid/Liquid Phase Boundary on In Vitro Release of Ketoprofen from Gel Formulations

S. Gallagher, L. Trottet, C. Heard, 2003, Journal of drug targeting.

Discovery of Pyridones As Oral AMPK Direct Activators.

E. Nicodème, L. Trottet, O. Mirguet, 2013, ACS medicinal chemistry letters.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

Key Factors Affecting the Efficacy of a Topical Drug Candidate: Learnings from Past Topical Drug Development

H. Maibach, L. Trottet, 2017 .

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

M. Hann, D. Mole, J. Liddle, 2017, Bioorganic & medicinal chemistry letters.

Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.

A. Hovnanian, J. Liddle, P. Thomas, 2019, Bioorganic & medicinal chemistry letters.

Choosing Topical Drug Candidate: Historical Overview

H. Maibach, L. Trottet, 2017 .

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

E. Nicodème, J. Kirilovsky, L. Trottet, 2012, Bioorganic & medicinal chemistry letters.

A potent and selective Kallikrein-5 inhibitor delivers high pharmacological activity in Netherton Syndrome patient skin.

M. Lennon, A. Hovnanian, D. Grillot, 2021, The Journal of investigative dermatology.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

J. Iredale, S. Howie, J. Hughes, 2015, Nature Medicine.

Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials.

J Hadgraft, S C Wilkinson, G B Kasting, 2005, Journal of pharmaceutical sciences.

The Pharmaceutical Drug Development Process: Selecting a Suitable Drug Candidate

L. Trottet, 2021, Fundamentals of Drug Delivery.

Topical pharmacokinetics for a rational and effective topical drug development process.

L. Trottet, 2004 .

Assessing Drug Concentration in Skin: Direct and Indirect Methods

H. Maibach, L. Trottet, 2017 .

Topical Versus Oral/Systemic Drug Discovery

H. Maibach, L. Trottet, 2017 .

Are all aciclovir cream formulations bioequivalent?

J. Heylings, L. Trottet, A. Davis, 2005, International journal of pharmaceutics.

Assessing Topical Efficacy

H. Maibach, L. Trottet, 2017 .

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Xiaozhong Zheng, D. Mole, D. Clapham, 2017, Journal of medicinal chemistry.

Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury

B. Matrot, A. Edwards, P. Gressens, 2018, Brain, Behavior, and Immunity.

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).

C. Murray, Zehong Wan, V. Berdini, 2016, Journal of medicinal chemistry.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

C. Murray, F. Holding, V. Berdini, 2016, Journal of medicinal chemistry.

Topical Drug Candidate Selection Criteria and Cascade

H. Maibach, L. Trottet, 2017 .

Topical Vehicle Selection: Myths and Reality

Lionel Trottet, Howard I. Maibach, H. Maibach, 2017 .

Naphthyridines as Novel BET Family Bromodomain Inhibitors

Lionel Trottet, Antonia Lewis, Paul Bamborough, 2014, ChemMedChem.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury

B. Matrot, A. Edwards, B. Fleiss, 2018, Brain, Behavior, and Immunity.