U. Ochsner

发表

Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis.

S. Gottesman, M. Vasil, P. FitzGerald, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa.

J. Reiser, U. Ochsner, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and functional characterization of the Pseudomonas aeruginosa rhlC gene that encodes rhamnosyltransferase 2, an enzyme responsible for di‐rhamnolipid biosynthesis

C. Olvera, J. Lam, U. Ochsner, 2001, Molecular microbiology.

Aptamer-based multiplexed proteomic technology for biomarker discovery

Tracy R. Keeney, Jonathan D. Vaught, Sheri K. Wilcox, 2010, Nature Precedings.

Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers.

N. Janjić, E. Katilius, E. Olivas, 2019, Biochemistry.

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

Larry Gold, Nebojsa Janjic, D. Schneider, 2014, Molecular therapy. Nucleic acids.

Elucidating Novel Serum Biomarkers Associated with Pulmonary Tuberculosis Treatment

John L. Johnson, David G. Sterling, N. Janjić, 2013, PloS one.

Virulent Salmonella typhimurium has two periplasmic Cu, Zn-superoxide dismutases.

J. Foster, T. Laessig, F. Fang, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications

David G. Sterling, N. Janjić, U. Ochsner, 2017, Journal of Clinical Microbiology.

Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa

A Fiechter, J. Reiser, A. Fiechter, 1994, Journal of bacteriology.

Cloning and heterologous expression of a gene encoding an alkane-induced extracellular protein involved in alkane assimilation from Pseudomonas aeruginosa

K., J. Reiser, A. Fiechter, 1994, Applied and environmental microbiology.

Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors

U. Ochsner, J. Bullard, J. Guiles, 2012, Organic and medicinal chemistry letters.

An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels

M L Howell, D. Hassett, G. E. Dean, 1997, Journal of bacteriology.

Vanadium interferes with siderophore-mediated iron uptake in Pseudomonas aeruginosa.

M. Schäfer, J. M. Meyer, P. Cornelis, 2000, Microbiology.

Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters

M. Vasil, A. Vasil, U. Ochsner, 1995, Journal of bacteriology.

Genetics and biochemistry of Pseudomonas aeruginosa rhamnolipid biosurfactant synthesis

U. Ochsner, 1993 .

Mode of Action and Biochemical Characterization of REP8839, a Novel Inhibitor of Methionyl-tRNA Synthetase

F. Dean, N. Janjić, U. Ochsner, 2005, Antimicrobial Agents and Chemotherapy.

Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

T. Jarvis, M. Gonzalez-Juarrero, M. Jackson, 2018, Front. Microbiol..

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.

T. Jarvis, N. Janjić, U. Ochsner, 2009, The Journal of antimicrobial chemotherapy.

Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model.

N. Janjić, U. Ochsner, I. Critchley, 2009, The Journal of antimicrobial chemotherapy.

The Pseudomonas aeruginosa pirA gene encodes a second receptor for ferrienterobactin and synthetic catecholate analogues.

M. Vasil, P. Cornelis, U. Ochsner, 2005, FEMS microbiology letters.

Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.

F. Fang, M. Dinauer, C. Nathan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Genetics of Quorum Sensing Circuitry in Pseudomonas aeruginosa

D. Hassett, J. Whitsett, T. McDermott, 2002 .

Association of toxin-producing Clostridium botulinum with the macroalga Cladophora in the Great Lakes.

Eric A. Johnson, J. Peller, R. Whitman, 2013, Environmental science & technology.

Transfer and expression of heterologous genes in yeasts other than Saccharomyces cerevisiae.

J. Reiser, V. Glumoff, U. Ochsner, 1990, Advances in biochemical engineering/biotechnology.

Pseudomonas aeruginosa fur Overlaps with a Gene Encoding a Novel Outer Membrane Lipoprotein, OmlA

M. Vasil, A. Vasil, U. Ochsner, 1999, Journal of bacteriology.

Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection

Michael L Wilson, David G. Sterling, N. Janjić, 2016, Journal of Clinical Microbiology.

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

David G. Sterling, D. Zak, S. Kaufmann, 2019, PLoS medicine.

Hydrogen Peroxide Sensitivity of Catechol-2,3-Dioxygenase: a Cautionary Note on Use ofxylE Reporter Fusions under Aerobic Conditions

D. Hassett, J. Lipscomb, U. Ochsner, 2000, Applied and Environmental Microbiology.

Discovery of benzothiazole amides as potent antimycobacterial agents.

T. Jarvis, U. Ochsner, Joshua A Day, 2018, Bioorganic & medicinal chemistry letters.

Molecular analysis of the Trichosporon cutaneum DSM 70698 argA gene and its use for DNA-mediated transformations

J. Reiser, A. Fiechter, V. Glumoff, 1994, Journal of bacteriology.

Genetic transformation of auxotrophic mutants of the filamentous yeast Trichosporon cutaneum using homologous and heterologous marker genes

J. Reiser, A. Fiechter, V. Glumoff, 1991, Yeast.

Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa

M. Vasil, P. Beare, A. Vasil, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Aptamer-based multiplexed proteomic technology for biomarker discovery

Tracy R. Keeney, Jonathan D. Vaught, Sheri K. Wilcox, 2010, PloS one.

Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity

F. Dean, T. Jarvis, N. Janjić, 2008, Antimicrobial Agents and Chemotherapy.

Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.

G. Lamichhane, T. Jarvis, H. Zgurskaya, 2022, Tuberculosis.

Production of Pseudomonas aeruginosa Rhamnolipid Biosurfactants in Heterologous Hosts

A Fiechter, J. Reiser, B. Witholt, 1995, Applied and environmental microbiology.

Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors

T. Jarvis, N. Janjić, U. Ochsner, 2010, Antimicrobial Agents and Chemotherapy.

Common and distinct gene expression patterns induced by the herbicides 2,4-dichlorophenoxyacetic acid, cinidon-ethyl and tribenuron-methyl in wheat.

B. Keller, U. Ochsner, F. Pasquer, 2006, Pest management science.

Identification of new, conserved, non‐ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine

J. Ravel, M. Schäfer, N. Koedam, 2002, Molecular microbiology.

The pvc Gene Cluster ofPseudomonas aeruginosa: Role in Synthesis of the Pyoverdine Chromophore and Regulation by PtxR and PvdS

M. Vasil, K. Poole, U. Ochsner, 1999, Journal of bacteriology.

Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.

F. Dean, N. Janjić, U. Ochsner, 2009, Bioorganic & medicinal chemistry letters.

Bacterioferritin A Modulates Catalase A (KatA) Activity and Resistance to Hydrogen Peroxide in Pseudomonas aeruginosa

D. Hassett, M. Klotz, M. Vasil, 1999, Journal of bacteriology.

Biology, physiology, biochemistry and molecular genetics of Trichosporon yeasts

J. Reiser, A. Fiechter, V. Glumoff, 1993 .

Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis.

George M. Hilliard, P. R. Gardner, Richard C Boucher, 2002, Developmental cell.

Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities

D. Hassett, M. Vasil, U. Ochsner, 1996, Journal of bacteriology.

AnkB, a Periplasmic Ankyrin-Like Protein inPseudomonas aeruginosa, Is Required for Optimal Catalase B (KatB) Activity and Resistance to Hydrogen Peroxide

D. Hassett, M. Klotz, K. Blumenthal, 2000, Journal of bacteriology.

The response of Pseudomonas aeruginosa to iron: genetics, biochemistry and virulence

M. Vasil, U. Ochsner, 1999, Molecular microbiology.

Role of the Pseudomonas aeruginosa oxyR-recG Operon in Oxidative Stress Defense and DNA Repair: OxyR-Dependent Regulation of katB-ankB, ahpB, andahpC-ahpF

D. Hassett, M. Vasil, U. Ochsner, 2000, Journal of bacteriology.

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

Smitha Shankar, Gerhard Walzl, Stefan H E Kaufmann, 2019, PLoS medicine.

Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis

M. Vasil, A. Vasil, U. Ochsner, 2002, Proceedings of the National Academy of Sciences of the United States of America.

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa.

S. Beatson, M. Vasil, P. Cornelis, 2004, Microbiology.

Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa.

M. Vasil, U. Ochsner, Z. Johnson, 2000, Microbiology.

Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

J. Ravel, T. Jarvis, N. Janjić, 2019, Antimicrobial Agents and Chemotherapy.

Systematic selection of modified aptamer pairs for diagnostic sandwich assays.

L. Gold, N. Janjić, U. Ochsner, 2014, BioTechniques.

Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers.

N. Janjić, E. Katilius, U. Ochsner, 2013, Diagnostic microbiology and infectious disease.

GeneChip® expression analysis of the iron starvation response in Pseudomonas aeruginosa: identification of novel pyoverdine biosynthesis genes

M. Vasil, A. Vasil, P. Wilderman, 2002, Molecular microbiology.

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

John L. Johnson, David G. Sterling, Daniel E. Zak, 2017, PLoS Pathogens.

Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes.

M. Vasil, U. Ochsner, Urs A. Ochsner, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

Rachel Ostroff, Glenn Sanders, Dan Schneider, 2010, PLoS ONE.

A Protease-Resistant Catalase, KatA, Released upon Cell Lysis during Stationary Phase Is Essential for Aerobic Survival of a Pseudomonas aeruginosa oxyR Mutant at Low Cell Densities

D. Hassett, U. Ochsner, R. Wilmott, 2000, Journal of bacteriology.

Genetic and Physiological Characterization ofohr, Encoding a Protein Involved in Organic Hydroperoxide Resistance in Pseudomonas aeruginosa

D. Hassett, M. Vasil, U. Ochsner, 2001, Journal of bacteriology.

The Fur-Regulated Gene Encoding the Alternative Sigma Factor PvdS Is Required for Iron-Dependent Expression of the LysR-Type Regulator PtxR in Pseudomonas aeruginosa

M. Vasil, J. Colmer, A. Hamood, 1998, Journal of bacteriology.

Aminoacyl‐tRNA Synthetase Inhibitors

T. Jarvis, U. Ochsner, 2013 .

Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839.

U. Ochsner, I. Critchley, 2008, Current opinion in chemical biology.

Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents

Ian Critchley, Nebojsa Janjic, T. Jarvis, 2007, Expert opinion on investigational drugs.

Antibacterial Activity of REP8839, a New Antibiotic for Topical Use

N. Janjić, U. Ochsner, I. Critchley, 2005, Antimicrobial Agents and Chemotherapy.

Inhibitor of Methionyl-tRNA Synthetase Characterization of REP 8839 , a Novel Mode of Action and Biochemical

F. Dean, N. Janjić, U. Ochsner, 2005 .

Quorum sensing in Pseudomonas aeruginosa controls expression of catalase and superoxide dismutase genes and mediates biofilm susceptibility to hydrogen peroxide

P. Stewart, D. Hassett, T. McDermott, 1999, Molecular microbiology.

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis.

John L. Johnson, David G. Sterling, N. Janjić, 2014, Tuberculosis.

Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.

George M. Hilliard, D. Hassett, B. Trapnell, 2002, Advanced drug delivery reviews.

Discovery and Characterization of the Cryptic Ψ Subunit of the Pseudomonad DNA Replicase*

A. Beaudry, T. Jarvis, U. Ochsner, 2005, Journal of Biological Chemistry.

Discovery and Analysis of 4 H -Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors (cid:1)

T. Jarvis, N. Janjić, U. Ochsner, 2010 .

Potency of the novel PolC DNA polymerase inhibitor CRS0540 in a disseminated Listeria monocytogenes intracellular hollow-fibre model

T. Jarvis, U. Ochsner, Joshua A Day, 2022, The Journal of antimicrobial chemotherapy.

Transient Loss of High-Level Mupirocin Resistance in Staphylococcus aureus Due to MupA Polymorphism

U. Ochsner, C. Young, D. Driscoll, 2007, Antimicrobial Agents and Chemotherapy.

Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis.

J. Reiser, A. Fiechter, U. Ochsner, 1994, The Journal of biological chemistry.

Exotoxin A production in Pseudomonas aeruginosa requires the iron‐regulated pvdS gene encoding an alternative sigma factor

H. Cunliffe, M. Vasil, U. Ochsner, 1996, Molecular microbiology.

Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis

David G. Sterling, N. Janjić, U. Ochsner, 2017, Journal of Clinical Microbiology.

Global Analysis of Cellular Factors and Responses Involved in Pseudomonas aeruginosa Resistance to Arsenite

D. Hassett, T. McDermott, C. Jackson, 2005, Journal of bacteriology.

Production of rhamnolipid biosurfactants.

A. Fiechter, U. Ochsner, T. Hembach, 1995, Advances in biochemical engineering/biotechnology.

Effect of Catalase on Hydrogen Peroxide Penetration into Pseudomonas aeruginosa Biofilms

Z Lewandowski, P. Stewart, D. Hassett, 2000, Applied and Environmental Microbiology.

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

T. Jarvis, N. Janjić, J. Zenilman, 2017, Antimicrobial Agents and Chemotherapy.

The oxygen- and iron-dependent sigma factor pvdS of Pseudomonas aeruginosa is an important virulence factor in experimental infective endocarditis.

M. Vasil, A. Bayer, U. Ochsner, 2000, The Journal of infectious diseases.

Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production

M. Vasil, J. Colmer, U. Ochsner, 1996, Molecular microbiology.

Characterization of the 2‐ketogluconate utilization operon in Pseudomonas aeruginosa PAO1

M. Vasil, U. Ochsner, P. Phibbs, 2000, Molecular microbiology.