J. Harkema

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Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress

Brian J. Bennett, A. Nel, M. Kleinman, 2008, Circulation research.

Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice.

Sarah E. Reese, T. Zacharewski, L. Burgoon, 2011, Toxicology and applied pharmacology.

Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract

M. Pino, J. Harkema, R. Herbert, 2009, Toxicologic pathology.

Nanotoxicology—A Pathologist’s Perspective

V. Castranova, S. Benkovic, A. Hubbs, 2011, Toxicologic pathology.

Comparative Aspects of Nasal Airway Anatomy: Relevance to Inhalation Toxicology*1

J. Harkema, J R Harkema, 1991, Toxicologic pathology.

The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium

J. Harkema, S. Carey, J. Wagner, 2006, Toxicologic pathology.

Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease

F. Cassee, R. Vandebriel, G. Folkerts, 2020, The World Allergy Organization journal.

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

A. D. Jones, P. Ganey, R. Roth, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues

S. Rajagopalan, M. Lippmann, Lung-Chi Chen, 2011, Particle and Fibre Toxicology.

HIF1α Is Essential for Normal Intrauterine Differentiation of Alveolar Epithelium and Surfactant Production in the Newborn Lung of Mice*

J. Harkema, J. LaPres, Y. Saini, 2008, Journal of Biological Chemistry.

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice

Russell S. Thomas, T. Zacharewski, L. Burgoon, 2015, PloS one.

Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

J. Harkema, J. LaPres, Y. Saini, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

J. Harkema, J. Wagner, J. LaPres, 2012, American journal of physiology. Lung cellular and molecular physiology.

Chronic, Elevated Maternal Corticosterone During Pregnancy in the Mouse Increases Allergic Airway Inflammation in Offspring

J. Harkema, Emmanuel Paul, K. Racicot, 2020, Frontiers in Immunology.

The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells

A. Pearson, M. Hoenerhoff, J. Harkema, 2018, Toxicologic pathology.

DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS.

Y. Tesfaigzi, J. Harkema, J. F. Harris, 2004, American journal of physiology. Lung cellular and molecular physiology.

Concurrent increases in the storage and release of mucin-like molecules by rat airway epithelial cells in response to bacterial endotoxin.

C. Basbaum, J. Harkema, J. Hotchkiss, 1995, American journal of respiratory cell and molecular biology.

In vivo deposition of inhaled ultrafine particles in the respiratory tract of rhesus monkeys

H. Yeh, J. Harkema, B. Muggenburg, 1997 .

2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

T. Zacharewski, N. Kaminski, K. A. Fader, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Human health no-effect levels of TiO 2 1 nanoparticles as a function of their primary size 2 3

Alexis Laurent, O. Jolliet, Mikołaj Owsianiak, 2018 .

Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid

A. Nel, Ning Li, C. Sioutas, 2010, Proteomics.

The clear and persistent impact of air pollution on chronic respiratory diseases: a call for interventions

I. Annesi-Maesano, G. Thurston, F. Forastiere, 2021, European Respiratory Journal.

Fluticasone propionate attenuates ozone-induced rhinitis and mucous cell metaplasia in rat nasal airway epithelium.

J. Harkema, H. Cho, J. Hotchkiss, 1998, American journal of respiratory cell and molecular biology.

Synthetic Reconstruction of Zoonotic and Early Human Severe Acute Respiratory Syndrome Coronavirus Isolates That Produce Fatal Disease in Aged Mice

R. Baric, M. Heise, M. Cameron, 2007, Journal of Virology.

PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.

T. Zacharewski, L. Burgoon, J. Harkema, 2010, Toxicology and applied pharmacology.

Hyperspectral microscopy of subcutaneously released silver nanoparticles reveals sex differences in drug distribution

R. Hamilton, A. Holian, Lou A. Herritt, 2021, Micron.

Epidemiological and Experimental Links between Air Pollution and Type 2 Diabetes

S. Rajagopalan, Qinghua Sun, J. Harkema, 2013, Toxicologic pathology.

Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice

R. Worden, N. Kaminski, G. Baker, 2013, Particle and Fibre Toxicology.

Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz.

R. Henderson, J. Harkema, J. Hotchkiss, 1991, Toxicology and applied pharmacology.

Differential effects of inhalation exposure to PM2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats.

P. Balasubramanian, P. MohanKumar, J. Harkema, 2013, Neurotoxicology.

Comparative pathology of the nasal mucosa in laboratory animals exposed to inhaled irritants.

J. Harkema, 1990, Environmental health perspectives.

Omega-3 Polyunsaturated Fatty Acid Intervention Against Established Autoimmunity in a Murine Model of Toxicant-Triggered Lupus

Quanzhen Li, P. Akbari, J. Pestka, 2021, Frontiers in Immunology.

Time-Dependent Airway Epithelial and Inflammatory Cell Responses Induced by Influenza Virus A/PR/8/34 in C57BL/6 Mice

N. Kaminski, J. Buchweitz, J. Harkema, 2007, Toxicologic pathology.

Correction: Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

A. Holian, J. Pestka, J. Harkema, 2017, PloS one.

Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

A. Holian, J. Pestka, J. Harkema, 2016, PloS one.

Design-Based Sampling and Quantitation of the Respiratory Airways

D. Hyde, C. Plopper, J. Harkema, 2006, Toxicologic pathology.

Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge.

A. Bartolucci, R. Mcdonald, J. Harkema, 2011, American journal of physiology. Lung cellular and molecular physiology.

Responses of rat nasal epithelium to short‐ and long‐term exposures of ozone: Image analysis of epithelial injury, adaptation and repair

E. Barr, J. Harkema, J. Hotchkiss, 1997, Microscopy research and technique.

Effects of concentrated ambient particles on normal and hypersecretory airways in rats.

E. Timm, N. Kaminski, E. Barr, 2004, Research report.

Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.

J. Harkema, J. Wagner, J. Hotchkiss, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium.

J. Harkema, J. Wagner, J. Hotchkiss, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations.

J. Harkema, J. Wagner, J. Hotchkiss, 2001, Environmental health perspectives.

A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats.

R. Henderson, K. R. Maples, E. Barr, 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Response of the macaque nasal epithelium to ambient levels of ozone. A morphologic and morphometric study of the transitional and respiratory epithelium.

D. Hyde, J. S. St. George, C. Plopper, 1987, The American journal of pathology.

Response of rat alveolar macrophages to ozone: quantitative assessment of population size, morphology, and proliferation following acute exposure.

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Experimental lung research.

Proliferative responses of rat nasal epithelia to ozone.

R. Henderson, N. Johnson, J. Harkema, 1990, Toxicology and applied pharmacology.

Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol).

J. Pestka, J. Harkema, H. Zhou, 1999, Journal of toxicology and environmental health. Part A.

Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.

J. Pestka, R. Roth, J. Harkema, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Repeated ozone exposure exacerbates insulin resistance and activates innate immune response in genetically susceptible mice

S. Rajagopalan, Qinghua Sun, Jixin Zhong, 2016, Inhalation toxicology.

Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus

S. Rajagopalan, S. Maurya, Xiaohua Xu, 2014, Particle and Fibre Toxicology.

Chapter 51 – Respiratory System

W. Haschek, K. Nikula, J. Harkema, 2013 .

Safety and efficacy of a technique for thoracoscopically guided pulmonary wedge resection in horses.

J. Harkema, J. Peroni, N. E. Robinson, 2002, American journal of veterinary research.

Omega-3 fatty acid intake suppresses induction of diverse autoantibody repertoire by crystalline silica in lupus-prone mice

Quanzhen Li, J. Pestka, A. Benninghoff, 2020, Autoimmunity.

Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring

J. Pestka, A. Benninghoff, J. Harkema, 2020, Frontiers in Immunology.

Effects of an ambient level of ozone on primate nasal epithelial mucosubstances. Quantitative histochemistry.

D. Hyde, J. S. St. George, C. Plopper, 1987, The American journal of pathology.

Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome

R. Brook, S. Rajagopalan, J. Dvonch, 2013, Environmental health perspectives.

Pulmonary Function Alterations in F344 Rats Following Chronic Ozone Inhalation

J. Mauderly, W. Griffith, J. Harkema, 1996 .

Contributes to Airway Epithelial Injury and Repair Activation of Calcitonin Gene-Related Peptide Receptor during Ozone Inhalation

S. Rennard, D. Hyde, J. Harkema, 2015 .

Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats.

D. Hyde, J. Harkema, E. Schelegle, 1999, Journal of applied physiology.

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans

F. J. Miller, D. Hyde, D. Einstein, 2012, Inhalation toxicology.

Role of hypoxia-inducible factor 1 in modulating cobalt-induced lung inflammation

J. Harkema, J. LaPres, Y. Saini, 2010 .

Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.

N. Parameswaran, J. Harkema, J. LaPres, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.

J. Harkema, J. LaPres, Y. Saini, 2010, American journal of physiology. Lung cellular and molecular physiology.

The Role of Hypoxia Inducible Factor 1α (HIF1α) in Modulating Cobalt-Induced Lung Inflammation Authors:

J. Harkema, J. LaPres, Lori A. Bramble, 2009 .

Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse

A. Holian, P. Akbari, J. Pestka, 2018, Front. Immunol..

Sex Differences in Renal Inflammation and Injury in High-Fat Diet–Fed Dahl Salt-Sensitive Rats

J. Galligan, G. Fink, J. Harkema, 2018, Hypertension.

Persistent mucin glycoprotein alterations in equine recurrent airway obstruction.

C. Basbaum, J. Harkema, N. E. Robinson, 2001, American journal of physiology. Lung cellular and molecular physiology.

Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF.

S. Kleeberger, J. Harkema, M. Longphre, 1999, Journal of applied physiology.

An Atypical Neuroendocrine Tumor in the Lung of a Beagle Dog

J. Harkema, D. Wilson, S. E. Jones, 1992, Veterinary pathology.

Respiratory System and Mesothelium

R. A. Miller, K. Morgan, J. Harkema, 2001 .

Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs.

J. A. Bond, V. Russell, J. Harkema, 1988, Drug metabolism and disposition: the biological fate of chemicals.

Influence of total western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice

J. Pestka, A. Benninghoff, Kristen N Gilley, 2020, PloS one.

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

R. Brook, S. Rajagopalan, S. Maurya, 2014, Particle and Fibre Toxicology.

CD 36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure

S. Rajagopalan, Lung-Chi Chen, Qinghua Sun, 2014 .

Silica Triggers Inflammation and Ectopic Lymphoid Neogenesis in the Lungs in Parallel with Accelerated Onset of Systemic Autoimmunity and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse

A. Holian, J. Pestka, J. Harkema, 2015, PloS one.

A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia.

P. Wright, J. Th’ng, J. Harkema, 1996, American journal of respiratory cell and molecular biology.

Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice.

T. Zacharewski, Andrea W Lee, L. Burgoon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice.

T. Zacharewski, L. Burgoon, J. Harkema, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

NITRIC OXIDE DIMINISHES APOPTOSIS AND p53 GENE EXPRESSION AFTER RENAL ISCHEMIA AND REPERFUSION INJURY1

L. Toledo-Pereyra, P. Ward, G. Vercruysse, 2000, Transplantation.

Effects of adsorption of benzo[a]pyrene onto carbon black particles on levels of DNA adducts in lungs of rats exposed by inhalation.

J. A. Bond, R. McClellan, R. Henderson, 1989, Toxicology and applied pharmacology.

Distribution of DNA adducts in the respiratory tract of rats exposed to diesel exhaust.

J. A. Bond, R. McClellan, R. Henderson, 1988, Toxicology and applied pharmacology.

Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene.

J. Swenberg, E. Donner, J. Harkema, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice.

T. Zacharewski, J. Harkema, B. Chittim, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Long-lasting effects of chronic ozone exposure on rat nasal epithelium.

M. Gallup, C. Basbaum, E. Barr, 1999, American journal of respiratory cell and molecular biology.

Mucous cell metaplasia in rat nasal epithelium after a 20-month exposure to ozone: a morphometric study of epithelial differentiation.

W. Griffith, J. Harkema, J. Hotchkiss, 1997, American journal of respiratory cell and molecular biology.

Proliferative and Metaplastic Lesions in Nonolfactory Nasal Epithelia Induced by Inhaled Chemicals

K. Morgan, J. Harkema, 1996 .

Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats.

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Toxicology and applied pharmacology.

Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure.

J. Pestka, J. Harkema, C. Amuzie, 2008, Toxicology.

Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet

R. Brook, S. Rajagopalan, Xiaowei Yan, 2013, Particle and Fibre Toxicology.

Exposure to cigarette smoke and Chlamydia pneumoniae infection in mice: Effect on infectious burden, systemic dissemination and cytokine responses: A pilot study

J. Zelikoff, P. Apfalter, J. Harkema, 2016, Journal of immunotoxicology.

The role of parity status on cigarette smoke-induced modulation of anti-tumor immune mechanisms

J. Zelikoff, J. Harkema, S. Ng, 2009, Journal of immunotoxicology.

In vivo effects of endotoxin on DNA synthesis in rat nasal epithelium

J. Harkema, J. Hotchkiss, 1993, Microscopy research and technique.

Combined Adjuvant Effects of Ambient Vapor-phase Organic Components and Particulate Matter Potently Promote Allergic Sensitization and Th2-skewing Cytokine and Chemokine Milieux in Mice: The Importance of Mechanistic Multi-pollutant Research

Ning Li, J. Froines, P. Akbari, 2021, Toxicology Letters.

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

J. Harkema, J. Wagner, 2012 .

Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.

P. Renzi, J. Harkema, L. Paquet, 2010, Cytokine.

Response of macaque bronchiolar epithelium to ambient concentrations of ozone.

D. Hyde, J. S. St. George, C. Plopper, 1993, The American journal of pathology.

Neurotoxic, Inflammatory, and Mucosecretory Responses in the Nasal Airways of Mice Repeatedly Exposed to the Macrocyclic Trichothecene Mycotoxin Roridin A

Z. Islam, J. Pestka, K. Corps, 2010, Toxicologic pathology.

Platelet activating factor stimulates rapid mucin secretion in rat nasal airways in vivo.

J. Harkema, J. Hotchkiss, M. Stam, 1993, Experimental lung research.

Altered Heart Rate Variability in Spontaneously Hypertensive Rats Is Associated with Specific Particulate Matter Components in Detroit, Michigan

Ali S. Kamal, B. Mukherjee, J. Harkema, 2010, Environmental health perspectives.

Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model

S. Rajagopalan, Qinghua Sun, Jixin Zhong, 2016, Inhalation toxicology.

Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection.

C. Cuff, J. Pestka, J. Harkema, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Neutrophil-dependent and neutrophil-independent alterations in the nasal epithelium of ozone-exposed rats.

J. Harkema, J. Hotchkiss, C. B. Bennett, 2000, American journal of respiratory and critical care medicine.

Epithelial cells of the conducting airways : a species comparison

D. Hyde, C. Plopper, J. Harkema, 1991 .

MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease

D. Romberger, Ying Tang, T. Kielian, 2020, Respiratory Research.

Strain Differences in a Murine Model of Air Pollutant–induced Nonatopic Asthma and Rhinitis

J. Harkema, J. Wagner, R. Lewandowski, 2017, Toxicologic pathology.

Rodent models of allergic rhinitis: Relevance to human pathophysiology

J. Harkema, J. Wagner, 2007, Current allergy and asthma reports.

A comparison of starvation and elastase models of emphysema in the rat.

J. Mauderly, J. Harkema, J. Pickrell, 1984, The American review of respiratory disease.

Immune Responses in the Lung and Local Lymph Node of A/J Mice to Intranasal Sensitization and Challenge with Adjuvant-Free Ovalbumin

N. Kaminski, J. Harkema, A. Farraj, 2003, Toxicologic pathology.

Specific biological effects of an anti-rat PMN antiserum intraperitoneally infected into f344/n rats.

J. Harkema, J. Hotchkiss, A. Rebar, 1995, Veterinary clinical pathology.

Prevention of Drug-Induced Lung Fibrosis via Inhibition of the MRTF/SRF Transcription Pathway

R. Neubig, K. Pawelec, J. Harkema, 2021 .

Airway inflammation is associated with mucous cell metaplasia and increased intraepithelial stored mucosubstances in horses.

J. Harkema, N. E. Robinson, H. deFeijter-Rupp, 2006, Veterinary journal.

Effect of inhaled endotoxin on intraepithelial mucosubstances in F344 rat nasal and tracheobronchial airways.

J. Harkema, T. Gordon, 1994, American journal of respiratory cell and molecular biology.

In vivo effects of endotoxin on intraepithelial mucosubstances in rat pulmonary airways. Quantitative histochemistry.

J. Harkema, J. Hotchkiss, Jack R. Harkema, 1992, The American journal of pathology.

Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium.

J. Harkema, M. Fanucchi, J. Hotchkiss, 1998, Toxicology and applied pharmacology.

Modulation of Airway Responses to Influenza A/PR/8/34 by Δ9-Tetrahydrocannabinol in C57BL/6 Mice

N. Kaminski, J. Buchweitz, J. Harkema, 2007, Journal of Pharmacology and Experimental Therapeutics.

Topical application versus intranasal instillation: a qualitative comparison of the effect of the route of sensitization on trimellitic anhydride-induced allergic rhinitis in A/J mice.

N. Kaminski, J. Harkema, A. Farraj, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: enhancement of toxicant-induced airway injury.

J. Harkema, J. Wagner, 2005, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice.

N. Kaminski, J. Harkema, A. Farraj, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5 ppm ozone.

N. Johnson, J. Harkema, J. Hotchkiss, 1997, Toxicology and applied pharmacology.

T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis.

Z. Islam, J. Pestka, J. Harkema, 2006, Toxicology and applied pharmacology.

Bcl-2 sustains increased mucous and epithelial cell numbers in metaplastic airway epithelium.

S. Randell, J. Hotchkiss, Y. Tesfaigzi, 2005, American journal of respiratory and critical care medicine.

Pulmonary Leukostasis and the Inhibition of Airway Neutrophil Recruitment are Early Events in the Endotoxemic Rat

R. Roth, J. Harkema, J. Wagner, 2002, Shock.

The Need for a Tighter Particulate-Matter Air-Quality Standard.

D. Dockery, H. Frey, J. Chow, 2020, The New England journal of medicine.

Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of Δ9‐tetrahydrocannabinol

N. Kaminski, J. Buchweitz, J. Harkema, 2008, Journal of leukocyte biology.

Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways.

J. Harkema, J. Wagner, 2002, Novartis Foundation symposium.

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

T. Zacharewski, J. Luyendyk, J. Harkema, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.

Ning Li, J. Harkema, J. Wagner, 2016, American journal of respiratory cell and molecular biology.

Mass cells contribute to O3-induced epithelial damage and proliferation in nasal and bronchial airways of mice.

S. Kleeberger, J. Harkema, L. Zhang, 1996, Journal of applied physiology.

In vivo effects of transient neutrophil influx on nasal respiratory epithelial mucosubstances. Quantitative histochemistry.

R. Henderson, J. Harkema, J. Hotchkiss, 1988, The American journal of pathology.

Molecular Dosimetry of Inhaled Diesel Exhaust

J. A. Bond, R. McClellan, R. Henderson, 1989 .

Expression of the Bcl-2 protein in nasal epithelia of F344/N rats during mucous cell metaplasia and remodeling.

J. Harkema, J. Hotchkiss, J. Tesfaigzi, 1998, American journal of respiratory cell and molecular biology.

Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats.

W. Parks, J. Last, J. Harkema, 1993, Toxicology.

CHAPTER 30 – The Respiratory System and its Use in Research

C. Plopper, J. Harkema, J. Harkema, 2005 .

Changes in lipids of lung lavage in monkeys after chronic exposure to ambient levels of ozone.

J. Harkema, E. Larkin, G. A. Rao, 1985, Toxicology letters.

The role of DNA adducts in diesel exhaust-induced pulmonary carcinogenesis.

J. A. Bond, R. McClellan, R. Henderson, 1990, Progress in clinical and biological research.

Histopathology of Nasal Olfactory Mucosa from Selected Inhalation Toxicity Studies Conducted with Volatile Chemicals

R. Garman, K. Morgan, J. Harkema, 1999, Toxicologic pathology.

A comparative analysis of primate nasal airways using magnetic resonance imaging and nasal casts.

H. Yeh, J. Harkema, B. Muggenburg, 1997, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease

J. Tiedje, M. Vital, J. Harkema, 2015, Journal of immunology research.

Role of Neutrophils in Preventing and Resolving Acute Fungal Sinusitis

G. Huffnagle, J. Harkema, N. Falkowski, 2007, Infection and Immunity.

Human health no-effect levels of TiO2 nanoparticles as a function of their primary size

Olivier Jolliet, Mikolaj Owsianiak, Alexis Laurent, 2017, Journal of nanoparticle research.

Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus

A. Richardson, Quanzhen Li, J. Buchweitz, 2022, Frontiers in Immunology.

Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage

J. Pestka, J. Harkema, B. Westendorp, 2022, Frontiers in Immunology.

CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors.

J. Hotchkiss, J. Harkema, S. Sarang, 2012, Regulatory toxicology and pharmacology : RTP.

The Adjuvant Effect of Ambient Particulate Matter Is Closely Reflected by the Particulate Oxidant Potential

Meiying Wang, Constantinos Sioutas, Andre E. Nel, 2009, Environmental health perspectives.

Development of a Computational High-Throughput Tool for the Quantitative Examination of Dose-Dependent Histological Features

T. Zacharewski, D. Colbry, J. Harkema, 2015, Toxicologic pathology.

Changes in the levels of polyunsaturated fatty acids in the lung and lecithin cholesterol acyl transferase activity in plasma of monkeys exposed to ambient levels of ozone.

J. Harkema, E. Larkin, G. A. Rao, 1985, Toxicology letters.

Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways.

S. Randell, R. Boucher, T. Rogers, 2013, American journal of physiology. Lung cellular and molecular physiology.

Cannabidiol (CBD) enhances lipopolysaccharide (LPS)-induced pulmonary inflammation in C57BL/6 mice

N. Kaminski, Barbara L F Kaplan, J. Harkema, 2013, Journal of immunotoxicology.

Altered thymocyte and T cell development in neonatal mice with hyperoxia-induced lung injury

T. Mansour, B. Schutte, J. Harkema, 2017, Journal of perinatal medicine.

Cotton dust produces an increase in intraepithelial mucosubstances in rat airways.

J. Harkema, T. Gordon, 1995, American journal of respiratory and critical care medicine.

Draft OECD Guidance Document on Histopathology for inhalation toxicity studies, Supporting TG 412 (Subacute Inhalation Toxicity: 28-Day) and TG 413 (Subchronic Inhalation Toxicity: 90-Day)

J. Everitt, J. Harkema, R. Renne, 2009 .

The Effects of Targeted Deletion of Cannabinoid Receptors CB1 and CB2 on Intranasal Sensitization and Challenge with Adjuvant-free Ovalbumin

N. Kaminski, Barbara L F Kaplan, J. Harkema, 2010, Toxicologic pathology.

Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway

R. Neubig, J. Harkema, B. Auerbach, 2022, Pharmacology research & perspectives.

Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.

P. Ganey, R. Roth, J. Harkema, 2000, Toxicology and applied pharmacology.

Erratum: Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants (PLoS Medicine 3,12 DOI: 10.1371/journal.pmed.0030525)

R. Johnston, R. Baric, M. Heise, 2007 .

Reexamination of Respiratory Tract Responses in Rats, Mice, and Rhesus Monkeys Chronically Exposed to Inhaled Chlorine

A. Jarabek, K. Morgan, J. Harkema, 1996 .

Enhancement of nasal inflammatory and epithelial responses after ozone and allergen coexposure in Brown Norway rats.

J. Harkema, J. Wagner, J. Hotchkiss, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole.

J. Harkema, F. Murray, G. Cruzan, 2015, Regulatory toxicology and pharmacology : RTP.

Interspecies comparison of cellular localization of the cyanide metabolizing enzyme rhodanese within olfactory mucosa

J. Lewis, J. Harkema, A. Dahl, 1992, The Anatomical record.

Lupus, Silica, and Dietary Omega-3 Fatty Acid Interventions

J. Pestka, J. Harkema, K. Wierenga, 2019, Toxicologic pathology.

Toxicology and carcinogenesis studies of Ginkgo biloba extract (CAS No. 90045-36-6) in F344/N rats and B6C3F1/N mice (Gavage studies).

S. Elmore, R. Miller, R. Maronpot, 2013, National Toxicology Program technical report series.

Purification and Comparative Neurotoxicity of the Trichothecenes Satratoxin G and Roridin L2 from Stachybotrys Chartarum

Z. Islam, J. Pestka, J. Harkema, 2009, Journal of toxicology and environmental health. Part A.

Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma.

Jack R Harkema, J. Pestka, D. Dearborn, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation

J. Pestka, A. Benninghoff, J. Harkema, 2022, Frontiers in Immunology.

A rat monoclonal antibody specific for murine type 1 pneumocytes.

S. Kennel, J. Harkema, J. Hotchkiss, 1992, Experimental and molecular pathology.

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis.

T. Zacharewski, J. Matthews, J. Harkema, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Nonolfactory surface epithelium of the nasal cavity of the bonnet monkey: a morphologic and morphometric study of the transitional and respiratory epithelium.

D. Hyde, J. S. St. George, C. Plopper, 1987, The American journal of anatomy.

Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.

P. Ganey, R. Roth, J. Harkema, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

A. Nel, V. Castranova, T. Kavanagh, 2013, Environmental health perspectives.

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

R. Johnston, R. Baric, M. Heise, 2006, PLoS medicine.

Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.

Ping Yang, Chengfeng Yang, Zhishan Wang, 2020, Environment international.

Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice

T. Zacharewski, J. Harkema, R. Nault, 2017, PloS one.

A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling.

Jack R Harkema, Joshua C Kwekel, Lyle D Burgoon, 2005, Physiological genomics.

The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.

P. Ganey, R. Roth, J. Harkema, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice

S. Kleeberger, A. Jedlicka, K. Holroyd, 1997, Nature Genetics.

Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection

N. Kaminski, J. Harkema, Peer W F Karmaus, 2011, Journal of leukocyte biology.

Outdoor Air Pollution and New-Onset Airway Disease. An Official American Thoracic Society Workshop Report

E. Burchard, C. White, I. Annesi-Maesano, 2020, Annals of the American Thoracic Society.

Preneoplastic transformation of rat tracheal epithelial cells by ozone.

W. Griffith, J. Harkema, D. Thomassen, 1991, Toxicology and applied pharmacology.

Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation

J. Harkema, C. Shuey, M. Campen, 2020, Particle and Fibre Toxicology.

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.

Brock Chittim, Darrell R Boverhof, Jack R Harkema, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity.

Brock Chittim, Darrell R Boverhof, Jack R Harkema, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

AMERICAN THORACIC SOCIETY DOCUMENTS

E. Burchard, I. Annesi-Maesano, G. Thurston, 2003 .

Inflammatory and epithelial responses during the development of ozone-induced mucous cell metaplasia in the nasal epithelium of rats.

J. Harkema, H Y Cho, J A Hotchkiss, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Pulmonary Immunotoxicology

J. Zelikoff, Lung-Chi Chen, R. Schlesinger, 2000, Springer US.

Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice.

A. Livraghi, R. Boucher, J. Harkema, 2008, American journal of respiratory and critical care medicine.

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

Richard C Boucher, Jack R Harkema, R. Boucher, 2004, Nature Medicine.

Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways.

J. Harkema, J. Hotchkiss, 1993, Toxicology letters.

Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure.

Z. Islam, J. Pestka, J. Harkema, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Normal Morphology of the Nasal Passages in Laboratory Rodents

K. Morgan, J. Harkema, 1996 .

Nonneoplastic Lesions of the Olfactory Mucosa

K. Morgan, J. Harkema, 1996 .

15.03 – Nasal Airways☆

J. Harkema, S. Carey, J. Wagner, 2018 .

8.02 – Nasal Airways

J. Harkema, S. Carey, J. Wagner, 2010 .

Satratoxin G from the Black Mold Stachybotrys chartarum Evokes Olfactory Sensory Neuron Loss and Inflammation in the Murine Nose and Brain

Z. Islam, J. Pestka, J. Harkema, 2006, Environmental health perspectives.

Identification of mucosal injury in the murine nasal airways by magnetic resonance imaging: site-specific lesions induced by 3-methylindole.

A. Koretsky, A. Wiethoff, J. Harkema, 2001, Toxicology and applied pharmacology.

Assessment of particulate matter toxicity and physicochemistry at the Claim 28 uranium mine site in Blue Gap, AZ

J. Harkema, C. Shuey, M. Campen, 2020, Journal of toxicology and environmental health. Part A.

Three-Dimensional Mapping of Ozone-Induced Injury in the Nasal Airways of Monkeys Using Magnetic Resonance Imaging and Morphometric Techniques

Kevin R. Minard, Richard A. Corley, Lynn L. Trease, 2007, Toxicologic pathology.

Effects of subchronic inhalation exposure to carbon black nanoparticles in the nasal airways of laboratory rats

Robert Gelein, Günter Oberdörster, Alison Elder, 2008 .

Nose, Sinus, Pharynx, and Larynx

J. Harkema, S. Dintzis, S. Carey, 2012 .

Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium.

B. T. Chen, J. Harkema, G. Finch, 1995, Toxicology and applied pharmacology.

Chapter 14 – Respiratory System

W. Haschek, K. Nikula, J. Harkema, 2018 .

Pathology of the Respiratory System

J. Harkema, J. Wagner, 2019, Toxicologic Pathology for Non-Pathologists.

Comparative Structure of the Respiratory Tract: Airway Architecture in Humans and Animals

K. Pinkerton, C. Plopper, J. Harkema, 2000 .

Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

B. Coull, R. Raimundo, J. Godleski, 2017, Particle and Fibre Toxicology.

Regional differences in quantities of histochemically detectable mucosubstances in nasal, paranasal, and nasopharyngeal epithelium of the bonnet monkey.

D. Hyde, J. S. St. George, C. Plopper, 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Rapid Induction of Pulmonary Inflammation, Autoimmune Gene Expression, and Ectopic Lymphoid Neogenesis Following Acute Silica Exposure in Lupus-Prone Mice

J. Pestka, A. Benninghoff, Kristen N Gilley, 2021, Frontiers in Immunology.

Imipramine blocks acute silicosis in a mouse model

A. Holian, J. Harkema, Kevin L Trout, 2017, Particle and Fibre Toxicology.

Biochemical and morphologic responses of rat nasal epithelia to hyperoxia.

K. Nikula, J. Harkema, P. Sabourin, 1991, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

J. Pestka, J. Harkema, Olivia K. Favor, 2023, Frontiers in Immunology.

Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.

D. Peden, Q. Jiang, J. Harkema, 2014, Free radical biology & medicine.

Morphometric cell biology of air space epithelium

D. Hyde, C. Plopper, J. Harkema, 1990 .

Satratoxin-G from the Black Mold Stachybotrys chartarum Induces Rhinitis and Apoptosis of Olfactory Sensory Neurons in the Nasal Airways of Rhesus Monkeys

Z. Islam, J. Pestka, D. Hyde, 2012, Toxicologic pathology.

Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys.

A. Bartolucci, C. Plopper, R. Mcdonald, 2011, American journal of physiology. Lung cellular and molecular physiology.

The effects of emphysema on oxygen toxicity in rats.

J. Mauderly, F. Hahn, J. Harkema, 2015, The American review of respiratory disease.

Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis.

R. Henderson, F. Hahn, J. Harkema, 1988, Experimental and molecular pathology.

Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?

P. Ganey, R. Roth, J. Harkema, 1997, Toxicology and applied pharmacology.

Respiratory and systemic impacts following MWCNT inhalation in B6C3F1/N mice

R. Bhargava, R. Hamilton, A. Holian, 2021, Particle and fibre toxicology.

Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse

A. Holian, J. Pestka, A. Benninghoff, 2019, Front. Immunol..

Docosahexaenoic Acid Consumption Impedes Early Interferon- and Chemokine-Related Gene Expression While Suppressing Silica-Triggered Flaring of Murine Lupus

A. Holian, J. Pestka, A. Benninghoff, 2019, Front. Immunol..

Production of interferon-gamma by influenza hemagglutinin-specific CD8 effector T cells influences the development of pulmonary immunopathology.

A. Cerwenka, R. Dutton, J. Harkema, 2001, The American journal of pathology.

The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study

R. Brook, R. Bard, S. Rajagopalan, 2013, Inhalation toxicology.

Ozone-Induced Structural Changes in Monkey Respiratory System

D. Hyde, C. Plopper, J. Harkema, 1989 .

Cardiovascular, acid-base, electrolyte, and plasma volume changes in ponies developing alimentary laminitis.

J. Harkema, J. Scott, N. E. Robinson, 1978, American journal of veterinary research.

Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains

J. Harkema, C. Barkauskas, J. Wagner, 2020, Environmental health perspectives.

Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists

J. Galligan, B. Uhal, R. Roth, 2006, BMC clinical pathology.

Pulmonary Inflammation and DNA Adducts in Rats Inhaling Diesel Exhaust or Carbon Black

J. A. Bond, R. Henderson, J. Mauderly, 1990 .

Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location.

James Brian Byrd, R. Brook, R. Bard, 2016, Journal of the American Society of Hypertension : JASH.

Enhanced allergic airway disease in old mice is associated with a Th17 response

J. Harkema, C. Brandenberger, J. Wagner, 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

GADOLINIUM CHLORIDE PRETREATMENT PROTECTS AGAINST HEPATIC INJURY BUT PREDISPOSES THE LUNGS TO ALVEOLITIS AFTER LIPOPOLYSACCHARIDE ADMINISTRATION

Alan P. Brown, P. Ganey, R. Roth, 1997, Shock.

Comparative Anatomy and Epithelial Cell Biology of the Nose

J. Harkema, 2015 .

Activation of the Stress Axis and Neurochemical Alterations in Specific Brain Areas by Concentrated Ambient Particle Exposure with Concomitant Allergic Airway Disease

P. MohanKumar, J. Harkema, J. Wagner, 2006, Environmental health perspectives.

Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains.

Jack R Harkema, Y. Tan, S. Haslam, 2009, Reproductive toxicology.

CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure

S. Rajagopalan, Lung-Chi Chen, Qinghua Sun, 2014, Circulation research.

Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

R. Johnston, R. Baric, M. Heise, 2007, PLoS Medicine.

Targeted deletion of cannabinoid receptors CB1 and CB2 produced enhanced inflammatory responses to influenza A/PR/8/34 in the absence and presence of Delta9-tetrahydrocannabinol.

N. Kaminski, J. Buchweitz, J. Harkema, 2008, Journal of leukocyte biology.

Attenuation of the ovalbumin-induced allergic airway response by cannabinoid treatment in A/J mice.

N. Kaminski, J. Harkema, A. Farraj, 2003, Toxicology and applied pharmacology.

An Adjuvant-Free Mouse Model of Tree Nut Allergy Using Hazelnut as a Model Tree Nut

J. Harkema, N. Birmingham, V. Gangur, 2007, International Archives of Allergy and Immunology.

Imipramine blocks acute silicosis in a mouse model

A. Holian, J. Harkema, Kevin L Trout, 2017, Particle and Fibre Toxicology.

Innate Lymphoid Cell–Dependent Airway Epithelial and Inflammatory Responses to Inhaled Ozone: A New Paradigm in Pathogenesis

J. Harkema, J. Wagner, 2019, Toxicologic pathology.

Ozone enhancement of lower airway allergic inflammation is prevented by γ-tocopherol

B. Ames, D. Patel, D. Peden, 2007 .

Ozone enhancement of lower airway allergic inflammation is prevented by gamma-tocopherol.

B. Ames, D. Patel, D. Peden, 2007, Free radical biology & medicine.

Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats.

J. McDonald, N. Kaminski, J. Harkema, 2009, Research report.

National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health.

J. Balmes, K. Pinkerton, J. Harkema, 2016, American journal of respiratory and critical care medicine.

Dose-Dependent Histological Features Development of a Computational High-Throughput Tool for the Quantitative Examination of

T. Zacharewski, D. Colbry, J. Harkema, 2014 .

Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location

R. Brook, R. Bard, S. Rajagopalan, 2014, Environmental health perspectives.

Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models

M L Gargas, K R Minard, R A Corley, 2009, Inhalation toxicology.

Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans

Ali S. Kamal, R. Brook, R. Bard, 2009, Hypertension.

Inhalation exposure to ethylene induces eosinophilic rhinitis and nasal epithelial remodeling in Fischer 344 rats.

J. Harkema, C. Brandenberger, L. Pottenger, 2015, Chemico-biological interactions.

Cholecystotomy as treatment for obstructive jaundice in a dog.

D. Kusewitt, J. Harkema, J. Pickrell, 1982, Journal of the American Veterinary Medical Association.

Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part VII: Effects on the nasal mucociliary apparatus.

P. Catalano, W. Griffith, K. Morgan, 1994, Research report.

Effect of cumulative ozone exposure on ozone-induced nasal epithelial hyperplasia and secretory metaplasia in rats.

R. Henderson, J. Harkema, J. Hotchkiss, 1991, Experimental lung research.

The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures

R. Brook, R. Bard, S. Rajagopalan, 2014, Journal of Exposure Science and Environmental Epidemiology.

No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function

Marcus A. Badgeley, R. Brook, R. Bard, 2014, Inhalation toxicology.

Pathogenesis and Persistence of Increased Epithelial Mucosubstances in the Nasal Airways of Rats and Mice Episodically Exposed to Ethylene

J. Harkema, J. Wagner, J. Hotchkiss, 2020, Toxicologic pathology.

Respiratory tract toxicity in rats exposed to Mexico City air.

L. Calderón-Garcidueñas, K. Morgan, J. Harkema, 2001, Research report.

Comparison of 3 methods of exposing rats to cigarette smoke.

J. A. Bond, R. Henderson, J. Mauderly, 1989, Experimental pathology.

Effects of repeated inhalation exposures to 1-nitropyrene, benzo[a]pyrene, Ga2O3 particles, and SO2 alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathology.

A. F. Eidson, R. McClellan, R. Henderson, 1989, Journal of toxicology and environmental health.

Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog. II. The conducting airways.

Mark D. Hoover, R. Henderson, J. Harkema, 1993, Toxicology and applied pharmacology.

World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice.

A. Ledbetter, D. Costa, Lung-Chi Chen, 2002, Environmental health perspectives.

Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone

Ning Li, J. Harkema, J. Wagner, 2017, Toxicologic pathology.

Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice.

T. Zacharewski, J. Harkema, C. Brandenberger, 2016, American journal of respiratory cell and molecular biology.

Toxicology and carcinogenesis studies of Ginkgo biloba extract (CAS No. 90045-36-6) in F344/N rats and B6C3F1/N mice (Gavage studies).

S. Elmore, R. Miller, R. Maronpot, 2013, National Toxicology Program technical report series.

Air Pollution–Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice

S. Rajagopalan, Xiaohua Xu, Aixia Wang, 2013, Environmental health perspectives.

Endotoxin or cytokines attenuate ozone-induced DNA synthesis in rat nasal transitional epithelium.

J. Harkema, J. Hotchkiss, 1992, Toxicology and applied pharmacology.

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.

A. D. Jones, T. Zacharewski, M. Angrish, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares.

Zhi Ning, Meiying Wang, Constantinos Sioutas, 2010, American journal of physiology. Lung cellular and molecular physiology.

Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

W. Goldsmith, V. Castranova, J. Harkema, 2021, Particle and Fibre Toxicology.

Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function.

R. Brook, R. Bard, S. Rajagopalan, 2018, The American journal of cardiology.

Short-Term Blood Pressure Responses to Ambient Fine Particulate Matter Exposures at the Extremes of Global Air Pollution Concentrations

R. Brook, R. Bard, S. Rajagopalan, 2018, American journal of hypertension.

Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates.

David M. Reif, Stephen W. Edwards, Brooke L Heidenfelder, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

T. Zacharewski, J. Harkema, R. Nault, 2017, Scientific Reports.

PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio

Ali S. Kamal, B. Mukherjee, J. Harkema, 2011, Inhalation toxicology.

Cardiopulmonary Toxicity Induced by Ambient Particulate Matter (BI City Concentrated Ambient Particle Study)

J. Harkema, G. Keeler, A. Rohr, 2010 .

Cardiopulmonary responses in spontaneously hypertensive and Wistar-Kyoto rats exposed to concentrated ambient particles from Detroit, Michigan

Ali S. Kamal, J. Harkema, G. Keeler, 2010, Inhalation toxicology.

Science-based Policy Recommendations for Fine Particulate Matter in the United States

J. Harkema, Alison G. Lee, K. Cromar, 2022, American journal of respiratory and critical care medicine.

Neutrophil involvement in the retention and clearance of dust intratracheally instilled into the lungs of F344/N rats.

J. Harkema, J. Hotchkiss, D. Bice, 1997, Experimental lung research.

Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan

Niko Kaciroti, Masako Morishita, Robert L Bard, 2014, Journal of Exposure Science and Environmental Epidemiology.

Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution.

R. Brook, R. Bard, S. Rajagopalan, 2013, The Science of the total environment.

PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions

Ali S. Kamal, J. Dvonch, J. Harkema, 2014, Particle and Fibre Toxicology.

Source identification of ambient PM2.5 for inhalation exposure studies in Steubenville, Ohio using highly time-resolved measurements

Ali S. Kamal, J. Harkema, G. Keeler, 2011 .

γ-Tocopherol Attenuates Ozone-induced Exacerbation of Allergic Rhinosinusitis in Rats

B. Ames, D. Peden, Q. Jiang, 2009, Toxicologic pathology.

Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma.

B. Ames, D. Peden, Q. Jiang, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Influx, Persistence, and Recall of Eosinophils and GATA-3+ Innate Lymphoid Cells in the Nasal Mucosa of Mice Exposed and Reexposed to the Gaseous Air Pollutant Ozone

J. Harkema, J. Wagner, Ryan P. Lewandowski, 2019, Toxicologic pathology.

Transcriptional profiling of the murine airway response to acute ozone exposure

J. Harkema, Gregory J. Smith, S. Kelada, 2019, bioRxiv.

Source identification of ambient PM2.5 during summer inhalation exposure studies in Detroit, MI

J. Harkema, G. Keeler, J. Wagner, 2006 .

Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice

F. Cassee, R. Vandebriel, S. Dekkers, 2019, Particle and Fibre Toxicology.

Neighborhood air pollution and household environmental health as it relates to respiratory health and healthcare utilization among elderly persons with asthma

B. Arnetz, J. Arnetz, H. Jamil, 2020, The Journal of asthma : official journal of the Association for the Care of Asthma.

Long-Term Exposure to Concentrated Ambient PM2.5 Increases Mouse Blood Pressure through Abnormal Activation of the Sympathetic Nervous System: A Role for Hypothalamic Inflammation

R. Brook, S. Rajagopalan, Xiaohua Xu, 2013, Environmental health perspectives.

Airborne particulate matter from goat farm increases acute allergic airway responses in mice

F. Cassee, R. Vandebriel, G. Folkerts, 2020, Inhalation toxicology.

Pulmonary Retention of Particulate Matter is Associated with Airway Inflammation in Allergic Rats Exposed to Air Pollution in Urban Detroit

E. Timm, J. Dvonch, J. Harkema, 2004, Inhalation toxicology.

Deposition and Clearance of Radiolabeled Particles from Small Ciliated Airways in Beagle Dogs

J. Mauderly, R. Wolff, J. Harkema, 1989 .

Personal-level exposure to environmental temperature is a superior predictor of endothelial-dependent vasodilatation than outdoor-ambient level.

R. Brook, R. Bard, S. Rajagopalan, 2017, Journal of the American Society of Hypertension : JASH.

Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes

R. Brook, S. Rajagopalan, S. Maurya, 2014, Particle and Fibre Toxicology.

In vitro culture of microdissected rat nasal airway tissues.

C. Plopper, J. Harkema, M. Fanucchi, 1999, American journal of respiratory cell and molecular biology.

Effects of Concentrated Fine Ambient Particles on Rat Plasma Levels of Asymmetric Dimethylarginine

R. Brook, S. Rajagopalan, J. Brook, 2004, Inhalation toxicology.

Breathing pattern response and epithelial labeling in ozone-induced airway injury in neutrophil-depleted rats.

D. Hyde, J. Harkema, E. Schelegle, 1999, American journal of respiratory cell and molecular biology.

A Murine Model of Ozone-induced Nonatopic Asthma from the Collaborative Cross.

T. Moran, J. Harkema, Gregory J. Smith, 2021, American journal of respiratory cell and molecular biology.

Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

W. Goldsmith, V. Castranova, J. Harkema, 2021, Particle and fibre toxicology.

In vivo effects of endotoxin on nasal epithelial mucosubstances: quantitative histochemistry.

J. Harkema, J. Hotchkiss, 1991, Experimental lung research.

Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses.

J. Harkema, N. E. Robinson, V. Gerber, 2009, Equine veterinary journal.

Effects of pre-existing rhinitis on ozone-induced mucous cell metaplasia in rat nasal epithelium.

J. Harkema, J. Hotchkiss, C. B. Bennett, 1999, Toxicology and applied pharmacology.

Effects of 0.12 and 0.80 ppm Ozone on Rat Nasal and Nasopharyngeal Epithelial Mucosubstances: Quantitative Histochemistry

R. Henderson, J. Harkema, J. Hotchkiss, 1989, Toxicologic pathology.

Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part XII: Atrophy of bone in nasal turbinates.

P. Catalano, J. Harkema, J. Hotchkiss, 1997, Research report.

Morphometric approaches for evaluating pulmonary toxicity in mammals: implications for risk assessment.

D. Hyde, C. Plopper, J. Harkema, 1994, Risk analysis : an official publication of the Society for Risk Analysis.

Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, blocks steatosis and alters the inflammatory response in a mouse model of inflammation-dioxin interaction.

P. Ganey, R. Roth, J. Harkema, 2021, Chemico-biological interactions.

PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions

Ali S. Kamal, J. Dvonch, J. Harkema, 2014, Particle and Fibre Toxicology.

Source-to-receptor pathways of anthropogenic PM2.5 in Detroit, Michigan: Comparison of two inhalation exposure studies

J. McDonald, R. Ewing, J. Harkema, 2009 .

Relationship between collateral flow resistance and alveolar pores in the aging beagle dog.

J. Mauderly, W. Griffith, J. Harkema, 1989, Experimental lung research.

Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption

A. Holian, J. Pestka, J. Harkema, 2016, PloS one.

Regional Differences in Ozone-Induced Nasal Epithelial Cell Proliferation in F344 Rats: Comparison with Computational Mass Flux Predictions of Ozone Dosimetry

J. Harkema, J. Kimbell, G. Hatch, 1994, Inhalation Toxicology.

Identification of ambient PM2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements

Ali S. Kamal, J. Harkema, G. Keeler, 2011 .

Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice

F. Cassee, R. Vandebriel, S. Dekkers, 2019, Particle and Fibre Toxicology.

CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure

S. Rajagopalan, Lung-Chi Chen, Qinghua Sun, 2014, Circulation research.

AMERICAN THORACIC SOCIETY DOCUMENTS

E. Burchard, I. Annesi-Maesano, G. Thurston, 2020 .

Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys.

A. Bartolucci, C. Plopper, R. Mcdonald, 2011, American journal of physiology. Lung cellular and molecular physiology.

Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.

P. Renzi, J. Harkema, L. Paquet, 2010, Cytokine.

Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies

J. Harkema, G. Keeler, J. Wagner, 2012, Environmental Health.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

T. Zacharewski, J. Harkema, R. Nault, 2017, Scientific Reports.