J. Piganelli

J. Crapo, A. Shapiro, T. Kin, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A novel redox-active metalloporphyrin reduces reactive oxygen species and inflammatory markers but does not improve marginal mass engraftment in a murine donation after circulatory death islet transplantation model

J. Crapo, A. Shapiro, R. Pawlick, 2016, Islets.

Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice*

C. Jiang, J. Yamauchi, H. Harashima, 2015, The Journal of Biological Chemistry.

FoxO 6 in glucose metabolism FoxO 6 Depletion Attenuates Hepatic Gluconeogenesis and Protects Against Fat-Induced Glucose Disorder in Mice

C. Jiang, J. Yamauchi, H. Harashima, 2015 .

A Noncanonical Role for Plasminogen Activator Inhibitor Type 1 in Obesity-Induced Diabetes.

G. Michalopoulos, W. Mars, B. Bhushan, 2019, The American journal of pathology.

Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes

Erin C O'Connor, Dana M Previte, J. Piganelli, 2017, Antioxidants.

Using Metalloporphyrins to Preserve β Cell Mass and Inhibit Immune Responses in Diabetes

Dana M Previte, J. Piganelli, G. Coudriet, 2016 .

Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes

C. Mathews, R. Mason, D. Ganini, 2015, Diabetes.

Autoimmune Diabetes in Mice Galectin-1 Delay Onset of Dendritic Cells Expressing Transgenic

M. Trucco, S. Bertera, J. Piganelli, 2010 .

Diabetes in Mice Galectin-1 Delay Onset of Autoimmune Dendritic Cells Expressing Transgenic

L. Baum, M. Trucco, S. Bertera, 2006 .

DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice

C. Mathews, M. Trucco, G. Prud’homme, 2005, Gene Therapy.

Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-κB pathway

H. Tse, M. Trucco, J. Piganelli, 2008, Diabetologia.

Preeclampsia Activates Circulating Immune Cells with Engagement of the NF‐κB Pathway

J. Deloia, J. Piganelli, K. Lain, 2006, American journal of reproductive immunology.

Auto-antigen and Immunomodulatory Agent–Based Approaches for Antigen-Specific Tolerance in NOD Mice

S. Little, J. Piganelli, Ethan J Bassin, 2021, Current Diabetes Reports.

FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages

Yi Lu, Jian Zhang, J. Piganelli, 2009, Diabetes.

Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis

A. Soto-Gutiérrez, J. Yamauchi, Sucha Singh, 2022, The Journal of clinical investigation.

Redox Modulation Protects Islets From Transplant-Related

J. Crapo, R. Gill, R. Bottino, 2010 .

Caspase-1 is not required for type 1 diabetes in the NOD mouse.

A. Chervonsky, C. Choisy-Rossi, E. Leiter, 2004, Diabetes.

Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse.

C. Mathews, J. Piganelli, M. Poulin, 2004, Methods in molecular medicine.

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

K. Prasadan, P. Witkowski, J. Piganelli, 2018, Cell Stem Cell.

A multivalent vaccine for type 1 diabetes skews T cell subsets to Th2 phenotype in NOD mice

M. Trucco, M. Pietropaolo, S. Bertera, 2011, Immunologic research.

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

L. Moldawer, M. Delano, Terri C. Thayer, 2011, Diabetes.

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

L. Wen, C. Mathews, M. Trucco, 2006, Diabetes.

Analysis of leukocytes recruited to the pancreas by diabetogenic T cell clones.

J. Peterson, K. Haskins, J. Piganelli, 1998, Cellular immunology.

Autoreactive T‐cell responses: new technology in pursuit of an old nemesis

C. Mathews, J. Piganelli, 2007, Pediatric diabetes.

Response of human islets to isolation stress and the effect of antioxidant treatment.

R. Bottino, M. Trucco, J. Piganelli, 2004, Diabetes.

Redox Modulation Protects Islets From Transplant-Related Injury

J. Crapo, R. Gill, R. Bottino, 2010, Diabetes.

Administration of a Negative Vaccination Induces Hyporesponsiveness to Islet Allografts

M. Trucco, S. Bertera, J. Piganelli, 2013, Cell transplantation.

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs

K. Haruma, R. Bottino, M. Wijkstrom, 2016, Islets.

The metalloporphyrin BMX-010 in human islet isolation and clinical transplantation

J. Crapo, A. M. Shapiro, T. Kin, 2016 .

Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome

R. Steiner, K. Gibson, G. Hoffmann, 2007, Journal of Inherited Metabolic Disease.

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

K. Haskins, J. Piganelli, T. Martin, 1998, Diabetes.

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind

M. Trucco, D. Vignali, A. Styche, 2012, Diabetes.

Disruption of Innate-Mediated Proinflammatory Cytokine and Reactive Oxygen Species Third Signal Leads to Antigen-Specific Hyporesponsiveness1

M. Trucco, J. Piganelli, H. Tse, 2007, The Journal of Immunology.

Antigen-Specific Hyporesponsiveness Oxygen Species Third Signal Leads to Proinflammatory Cytokine and Reactive Disruption of Innate-Mediated

M. Trucco, J. Piganelli, H. Tse, 2006 .

Immunopathology and Infectious Diseases Extracellular Superoxide Dismutase in Macrophages Augments Bacterial Killing by Promoting Phagocytosis

Simon C Watkins, J. Crapo, M. Manni, 2011 .

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

J. Crapo, W. Paschen, I. Batinic-Haberle, 2009, Free radical biology & medicine.

5 - The Specific Immune System: Humoral Defense

J. Piganelli, S. Kaattari, 1996 .

Cytotoxic T lymphocyte antigen 4 (CD152) regulates self-reactive T cells in BALB/c but not in the autoimmune NOD mouse.

J. Allison, K. Haskins, J. Piganelli, 2000, Journal of autoimmunity.

Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury.

M. Manni, T. Oury, T. Blackwell, 2012, American journal of physiology. Lung cellular and molecular physiology.

mt-Nd2a Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic β-Cell

C. Mathews, J. Chen, E. Leiter, 2010, Diabetes.

Chromogranin A is an autoantigen in type 1 diabetes

Nichole Reisdorph, Philippa Marrack, Thomas Delong, 2010, Nature Immunology.

Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion

R. Clark, T. Billiar, J. Piganelli, 2014, Molecular medicine.

Hepatocyte Growth Factor Modulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications for Inflammatory Mediated Diseases

W. Mars, M. Trucco, J. Piganelli, 2010, PloS one.

Evaluation of a whole cell, p57- vaccine against Renibacterium salmoninarum.

G. Wiens, J. Zhang, J. Piganelli, 1999, Diseases of aquatic organisms.

Elevated temperature treatment as a novel method for decreasing p57 on the cell surface of Renibacterium salmoninarum.

G. Wiens, J. Piganelli, S. Kaattari, 1999, Diseases of aquatic organisms.

Immunization with bacterial antigens: bacterial kidney disease.

J. Piganelli, S. Kaattari, 1997, Developments in biological standardization.

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

M. Bugliani, P. Marchetti, C. Mathieu, 2018, Diabetes.

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes

D. Harlan, A. Powers, R. Bottino, 2018, Diabetes.

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

J. Piganelli, Jon D. Piganelli, Meghan M. Delmastro, 2011, Clinical & developmental immunology.

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice1

J. Alcorn, A. Ray, J. Kolls, 2008, The Journal of Immunology.

Dendritic Cells Expressing Transgenic Galectin-1 Delay Onset of Autoimmune Diabetes in Mice1

L. Baum, M. Trucco, S. Bertera, 2006, The Journal of Immunology.

Reactive Oxygen Species and Their Implications on CD4+ T Cells in Type 1 Diabetes.

Dana M Previte, J. Piganelli, 2017, Antioxidants & redox signaling.

Changing the energy of an immune response.

J. Piganelli, Meghan M Delmastro-Greenwood, 2013, American journal of clinical and experimental immunology.

β cell ER stress and the implications for immunogenicity in type 1 diabetes

E. James, J. Piganelli, Meghan L. Marré, 2015, Front. Cell Dev. Biol..

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Erin C O'Connor, Dana M Previte, J. Piganelli, 2017, PloS one.

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells.

Greg M. Delgoffe, Erin C O'Connor, Dana M Previte, 2019, Cell reports.

Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetes.

Xuehui Geng, M. Trucco, S. Bertera, 2016, Journal of autoimmunity.

Antioxidant levels represent a major determinant in the regenerative capacity of muscle stem cells.

J. Vella, K. Tobita, J. Huard, 2009, Molecular biology of the cell.

Enteric coated microspheres as an oral method for antigen delivery to salmonids

J. Piganelli, J. M. Christensen, S. Kaattari, 1994 .

Targeting T cell Metabolism to Combat Autoimmunity: Implications for the Future of Type 1 Diabetes Therapeutics

J. Piganelli, Christina Martins, 2020, Immunometabolism.

TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model

S. Little, J. Piganelli, Ethan J Bassin, 2020, PloS one.

NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

Terri C. Thayer, C. Mathews, L. Morel, 2010, The Journal of Immunology.

Protecting functional β cells with a therapeutic peptide.

E. James, J. Piganelli, Meghan L. Marré, 2018, Annals of translational medicine.

The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

M. Mamula, E. James, J. Piganelli, 2021, Frontiers in Endocrinology.

Redox modulation inhibits CD8 T cell effector function.

J. Piganelli, H. Tse, M. Sklavos, 2008, Free radical biology & medicine.

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

I. Batinic-Haberle, M. Trucco, Artak Tovmasyan, 2013, Antioxidants & redox signaling.

Erratum to: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

M. Dewhirst, D. S. St. Clair, I. Batinic-Haberle, 2010, Amino Acids.

Calcium/calmodulin–dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation

M. Rosengart, S. Ranganathan, J. Piganelli, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells.

M. Trucco, J. Piganelli, Jing He, 2008, Atherosclerosis.

Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach

Hiroshi Yagi, Yuko Kitagawa, Minoru Tanabe, 2013, Cell transplantation.

TH 17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice 1

J. Alcorn, A. Ray, J. Kolls, 2008 .

Environmental Factors Contribute to β Cell Endoplasmic Reticulum Stress and Neo-Antigen Formation in Type 1 Diabetes

J. Piganelli, Meghan L. Marré, 2017, Front. Endocrinol..

Lack of the Receptor for Advanced Glycation End-Products Attenuates E. coli Pneumonia in Mice

J. Enghild, Y. Vodovotz, M. Manni, 2011, PloS one.

Lymphocyte activation gene 3 (LAG-3) regulates activation-induced CD4+ T cell metabolic transition (IRM6P.725)

Dana M Previte, J. Piganelli, Meghan M Delmastro-Greenwood, 2014 .