E. Trybulski

发表

Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter

R. Blakely, R. Winneker, D. Deecher, 2007, Journal of Pharmacology and Experimental Therapeutics.

JPET # 125716 1 DESVENLAFAXINE SUCCINATE ( DVS ) IDENTIFIES NOVEL ANTAGONIST BINDING DETERMINANTS IN THE HUMAN NOREPINEPHRINE TRANSPORTER

R. Blakely, R. Winneker, D. Deecher, 2007 .

TITLE PAGE DESVENLAFAXINE SUCCINATE ( DVS ) IDENTIFIES NOVEL ANTAGONIST BINDING DETERMINANTS IN THE HUMAN NOREPINEPHRINE TRANSPORTER

R. Blakely, R. Winneker, D. Deecher, 2007 .

1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.

L. Leventhal, E. Koury, D. Deecher, 2010, Journal of medicinal chemistry.

Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists.

David K. Williams, R. Steffan, E. Trybulski, 2006, Bioorganic & medicinal chemistry letters.

Control of chronic inflammation with pathway selective estrogen receptor ligands.

R. Winneker, R. Steffan, E. Trybulski, 2006, Current topics in medicinal chemistry.

Chapter 16. Vasopressin receptor modulators: From non-peptide antagonists to agonists

E. Trybulski, 2001 .

The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives

E. Trybulski, G. Francisco, R. Mangano, 1992 .

Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: hydroxybenzoyl-3,4-dihydroquinoxalin-2(1H)-ones.

R. Steffan, P. Mahaney, E. Trybulski, 2006, Bioorganic & medicinal chemistry.

Anti-arrhythmic agents

E. Trybulski, 1997 .

Update Cardiovascular & Renal Anti-arrhythmic agents

E. Trybulski, 1997 .

A synthetic approach to the skeleton of histrionicotoxin.

E. Trybulski, J. Tufariello, 1974, The Journal of organic chemistry.

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.

G. Welmaker, R. Bhat, P. Bodine, 2009, Journal of medicinal chemistry.

Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.

J. Keith, R. Steffan, E. Trybulski, 2004, Journal of medicinal chemistry.

2-Benzazepines. I. Synthesis of 2-benzazepin-4-ones and -5-ones via 2-acetylenic benzophenones

E. Trybulski, J. Blount, R. I. Fryer, 1982 .

Total Synthesis of Erythromycins. 4. Total Synthesis of Erythronolide B1

E. Corey, K. Nicolaou, J. Falck, 1978 .

Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

A. Robichaud, R. Winneker, E. Koury, 2009, Bioorganic & medicinal chemistry.

2-Benzazepines. 4. [1,2,3]Triazolo[4,5-d][2]benzazepines and dibenzo[c,f][1,2,3]triazolo[3,4-a]azepines: synthesis and evaluation as central nervous system agents.

E. Trybulski, R. I. Fryer, A. Walser, 1983, Journal of medicinal chemistry.

Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).

E. Trybulski, A. Rusinko, R. Mangano, 1990, Journal of medicinal chemistry.

2-Benzazepines. 9. Synthesis and chemistry of 3H-2-benzazepine and pyrimido[4,5-d][2]benzazepine derivatives

E. Trybulski, L. Todaro, R. I. Fryer, 1986 .

Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B

E. Corey, K. Nicolaou, J. Falck, 1978 .

Quinazolines and 1,4-benzodiazepines. 88. Synthesis and rearrangement of 3,4,5,6-tetrahydro-3H-imidazo[1,5-a][1,4]benzodiazepines

E. Trybulski, J. Blount, R. I. Fryer, 1978 .

Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

E. Trybulski, G. Mullen, S. Wong, 1979 .

Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.

K. Burroughs, D. Deecher, P. Mahaney, 2010, Bioorganic & medicinal chemistry letters.

Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan.

E. Trybulski, A. Molinari, W. Demaio, 2007, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.

D. Deecher, E. Trybulski, G. Whiteside, 2010, Bioorganic & medicinal chemistry letters.

Total synthesis of erythromycins. 3. Stereoselective routes to intermediates corresponding to C(1) to C(9) and C(10) to C(13) fragments of erythronolide B

E. Corey, K. Nicolaou, J. Falck, 1978 .

A SYNTHETIC APPROACH TO THE SKELETON OF HISTRIONICOTOXIN

E. Trybulski, J. Tufariello, 1975 .

TOTAL SYNTHESIS OF ERYTHROMYCINS. 4. TOTAL SYNTHESIS OF ERYTHRONOLIDE B

E. Corey, K. Nicolaou, J. Falck, 1978 .

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).

L. Leventhal, D. Deecher, E. Trybulski, 2010, Journal of medicinal chemistry.

A new protecting group for the carbonyl function

E. Corey, E. Trybulski, J. Suggs, 1977 .

Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

E. Trybulski, G. Mullen, S. Wong, 1979 .

2-benzazepines. 6. Synthesis and pharmacological properties of the metabolites of 9-chloro-7-(2-chlorophenyl)-5H-pyrimido[5,4-d] [2]benzazepine.

E. Trybulski, J. Blount, R. I. Fryer, 1983, Journal of medicinal chemistry.

The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.

E. Trybulski, J. Zhang, R. Mangano, 1993, Journal of medicinal chemistry.

Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.

K. Burroughs, D. Deecher, P. Mahaney, 2009, Bioorganic & medicinal chemistry letters.

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.

B. Komm, G. Welmaker, R. Bhat, 2009, Bone.

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

E. Koury, D. Deecher, P. Mahaney, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors.

E. Koury, D. Deecher, P. Mahaney, 2008, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.

L. Leventhal, E. Koury, K. Burroughs, 2008, Journal of medicinal chemistry.

Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines.

L. Leventhal, P. Mahaney, E. Trybulski, 2006, Bioorganic & medicinal chemistry.

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.

K. Burroughs, D. Deecher, P. Mahaney, 2010, ACS medicinal chemistry letters.

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.

R. Bhat, R. Winneker, J. Keith, 2005, Proceedings of the National Academy of Sciences of the United States of America.

5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist.

Raymond J. Unwalla, R. Winneker, E. Trybulski, 2007, Bioorganic & medicinal chemistry.

2-benzazepines. 5. Synthesis of pyrimido[5,4-d][2]benzazepines and their evaluation as anxiolytic agents.

E. Trybulski, N. W. Gilman, R. I. Fryer, 1983, Journal of medicinal chemistry.

Quinidine preferentially blocks the slow delayed rectifier potassium channel in the rested state.

G. Tseng, E. Trybulski, J. Yao, 1996, The Journal of pharmacology and experimental therapeutics.

1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.

R. Winneker, E. Trybulski, T. Berrodin, 2010, Bioorganic & medicinal chemistry letters.

5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators.

R. Winneker, E. Trybulski, T. Berrodin, 2009, Bioorganic & medicinal chemistry letters.

WAY‐318068: a novel, potent and selective noradrenaline re‐uptake inhibitor with activity in rodent models of pain and depression

P. Zhang, L. Leventhal, C. Beyer, 2010, British journal of pharmacology.

Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.

S. Gardell, R. Magolda, E. Trybulski, 2009, Journal of medicinal chemistry.

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.

R. Bhat, P. Bodine, G. Krishnamurthy, 2010, Bioorganic & medicinal chemistry.

1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Journal of medicinal chemistry.

Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists.

E. Trybulski, A. Failli, Yanan He, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2008, Bioorganic & Medicinal Chemistry Letters.

3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ols.

D. Deecher, P. Mahaney, E. Trybulski, 2009, Bioorganic & medicinal chemistry letters.