Megumi Watanabe

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Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, International journal of molecular sciences.

The EP2 agonist, omidenepag, alters the physical stiffness of 3D spheroids prepared from human corneal stroma fibroblasts differently depending on the osmotic pressure

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hypoxia Differently Affects TGF-β2-Induced Epithelial Mesenchymal Transitions in the 2D and 3D Culture of the Human Retinal Pigment Epithelium Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, International journal of molecular sciences.

Fatty Acid-Binding Proteins 4 and 5 Are Involved in the Pathogenesis of Retinal Vascular Diseases in Different Manners

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Life.

An α2-Adrenergic Agonist, Brimonidine, Beneficially Affects the TGF-β2-Treated Cellular Properties in an In Vitro Culture Model

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Bioengineering.

Prostaglandin F2α and EP2 agonists, and a ROCK inhibitor modulate the formation of 3D organoids of Grave's orbitopathy related human orbital fibroblasts.

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Experimental eye research.

Human Trabecular Meshwork (HTM) Cells Treated with TGF-β2 or Dexamethasone Respond to Compression Stress in Different Manners

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Biomedicines.

All Trans-Retinoic Acids Facilitate the Remodeling of 2D and 3D Cultured Human Conjunctival Fibroblasts

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Bioengineering.

Addition of ROCK Inhibitors Alleviates Prostaglandin-Induced Inhibition of Adipogenesis in 3T3L-1 Spheroids

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Bioengineering.

The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Bioengineering.

Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Bioengineering.

G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells

M. Furuhashi, Y. Hirohashi, T. Torigoe, 2023, International journal of molecular sciences.

Unexpected Crosslinking Effects of a Human Thyroid Stimulating Monoclonal Autoantibody, M22, with IGF1 on Adipogenesis in 3T3L-1 Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2023, International journal of molecular sciences.

Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Scientific Reports.

Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, PloS one.

TGF-β-3 Induces Different Effects from TGF-β-1 and -2 on Cellular Metabolism and the Spatial Properties of the Human Trabecular Meshwork Cells

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, International journal of molecular sciences.

3D Spheroid Configurations Are Possible Indictors for Evaluating the Pathophysiology of Melanoma Cell Lines

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, Cells.

Autotaxin May Have Lysophosphatidic Acid-Unrelated Effects on Three-Dimension (3D) Cultured Human Trabecular Meshwork (HTM) Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, International journal of molecular sciences.

Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Biomedicines.

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Biomedicines.

Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Cells.

Screening of the Drug-Induced Effects of Prostaglandin EP2 and FP Agonists on 3D Cultures of Dexamethasone-Treated Human Trabecular Meshwork Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Biomedicines.

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Translational vision science & technology.

A simple method for evaluation of aqueous humor dynamics “A weight on-off test” in patients with glaucom

Megumi Watanabe, H. Ohguro, Ikuyo Ohguro, 2015 .

FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Scientific Reports.

All-trans Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, International journal of molecular sciences.

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Scientific Reports.

STAT3 Is the Master Regulator for the Forming of 3D Spheroids of 3T3-L1 Preadipocytes

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Cells.

Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Current issues in molecular biology.

ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, FASEB bioAdvances.

Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids.

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Prostaglandins, leukotrienes, and essential fatty acids.

Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, International journal of molecular sciences.

Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Scientific Reports.

Diverse effects of pan-ROCK and ROCK2 inhibitors on 2 D and 3D cultured human trabecular meshwork (HTM) cells treated with TGFβ2

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Scientific Reports.

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2021, Molecules.

Addition of ROCK inhibitors to prostaglandin derivative (PG) synergistically affects adipogenesis of the 3D spheroids of human orbital fibroblasts (HOFs)

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Human Cell.

Addition of ROCK inhibitors to prostaglandin derivative (PG) synergistically affects adipogenesis of the 3D spheroids of human orbital fibroblasts (HOFs)

Yosuke Ida, Megumi Watanabe, H. Ohguro, 2021, Human Cell.

Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2022, Journal of clinical medicine.

Prostanoid FP and EP2 Receptor Agonists Induce Epithelial and Subepithelial Fibrogenetic Changes in Human Conjunctival Fibroblasts in Different Manners.

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Simultaneous Effects of a Selective EP2 Agonist, Omidenepag, and a Rho-Associated Coiled-Coil Containing Protein Kinase Inhibitor, Ripasudil, on Human Orbital Fibroblasts.

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

TGF-β Isoforms Affect the Planar and Subepithelial Fibrogenesis of Human Conjunctival Fibroblasts in Different Manners

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, Biomedicines.

Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts

Hiromu Suzuki, M. Furuhashi, Megumi Watanabe, 2023, Cells.

Three-Dimensional Spheroid Configurations and Cellular Metabolic Properties of Oral Squamous Carcinomas Are Possible Pharmacological and Pathological Indicators

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, Cancers.

TGF-β2 Induces Epithelial–Mesenchymal Transitions in 2D Planer and 3D Spheroids of the Human Corneal Stroma Fibroblasts in Different Manners

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2023, Biomedicines.

mTOR Inhibitors Modulate the Physical Properties of 3D Spheroids Derived from H9c2 Cells

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, International journal of molecular sciences.

Lipid Metabolism Regulators Are the Possible Determinant for Characteristics of Myopic Human Scleral Stroma Fibroblasts (HSSFs)

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2023, International journal of molecular sciences.

Modulation of Epithelial–Mesenchymal Transition Is a Possible Underlying Mechanism for Inducing Chemoresistance in MIA PaCa-2 Cells against Gemcitabine and Paclitaxel

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2024, Biomedicines.

Benzalkonium chloride greatly deteriorates the biological activities of human corneal stroma fibroblasts in a concentration-dependent manner.

M. Furuhashi, Yosuke Ida, Megumi Watanabe, 2023, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.

Intraocular fatty acids induce reinforcement of barrier functions on the outer blood-retinal barrier.

Megumi Watanabe, H. Ohguro, Tatsuya Sato, 2024, Prostaglandins, Leukotrienes and Essential Fatty Acids.

Fatty Acid-Binding Protein 4-Mediated Regulation Is Pivotally Involved in Retinal Pathophysiology: A Review

Megumi Watanabe, H. Ohguro, Fumihito Hikage, 2024, International journal of molecular sciences.

The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2024, Biomedicines.

Differential Effects of Benzalkonium Chloride on Human Trabecular Meshwork Cells Not Treated or Treated with Transforming Growth Factor-β2 or Dexamethasone.

Megumi Watanabe, H. Ohguro, Tatsuya Sato, 2024, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Significant and Various Effects of ML329-Induced MITF Suppression in the Melanoma Cell Line

M. Furuhashi, Megumi Watanabe, H. Ohguro, 2024, Cancers.

Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts.

Megumi Watanabe, H. Ohguro, Tatsuya Sato, 2024, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.

TGF-β Isoforms and Local Environments Greatly Modulate Biological Nature of Human Retinal Pigment Epithelium Cells

Megumi Watanabe, H. Ohguro, Nami Nishikiori, 2024, Bioengineering.

TGF-β effects on adipogenesis of 3T3-L1 cells differ in 2D and 3D cell culture conditions.

Megumi Watanabe, H. Ohguro, Tatsuya Sato, 2024, FEBS open bio.

Lysophosphatidic Acid Modulates TGF-β2-Induced Biological Phenotype in Human Conjunctival Fibroblasts

Megumi Watanabe, H. Ohguro, Nami Nishikiori, 2024, Life.