C. Schmitz‐Peiffer

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Lysophosphatidic Acid Induces Early Growth Response-1 (Egr-1) Protein Expression via Protein Kinase Cδ-regulated Extracellular Signal-regulated Kinase (ERK) and c-Jun N-terminal Kinase (JNK) Activation in Vascular Smooth Muscle Cells*

T. Iyoda, Fuqiang Zhang, Longsheng Sun, 2012, The Journal of Biological Chemistry.

Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.

C. Schmitz‐Peiffer, 2000, Cellular signalling.

Onset of Stimulated Degranulation of II and Coincides with the β Protein Kinase C Is Mediated by 1917 Chain IIA on Ser Phosphorylation of Nonmuscle Myosin Heavy Hughes

J. Stehn, W. E. Hughes, T. Kranenburg, 2006 .

Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser1917 Is Mediated by Protein Kinase CβII and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells1

J. Stehn, W. E. Hughes, T. Kranenburg, 2006, The Journal of Immunology.

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

A. Coster, N. Turner, G. Cooney, 2016, Biochimica et biophysica acta.

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

T. Fath, N. Turner, G. Cooney, 2018, Nature Communications.

Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

J. Nadler, T. Mitchell, C. Schmitz‐Peiffer, 2010, Endocrinology.

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate*

C. Schmitz‐Peiffer, T. Biden, D. L. Craig, 1999, The Journal of Biological Chemistry.

PKCδ Blues for the β-Cell

C. Schmitz‐Peiffer, T. Biden, 2010, Diabetes.

Protein Kinase Cε Modulates Insulin Receptor Localization and Trafficking in Mouse Embryonic Fibroblasts

C. Schmitz‐Peiffer, J. Stöckli, D. J. Pedersen, 2013, PloS one.

The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity.

D. James, G. Ramm, J. Molero, 2006, The international journal of biochemistry & cell biology.

Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

E. Kraegen, D. R. Laybutt, N. Ruderman, 1999, American journal of physiology. Endocrinology and metabolism.

Targeting protein kinase C epsilon or theta as a therapeutic strategy for insulin resistance

C. Schmitz‐Peiffer, 2005 .

Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase.

C. Schmitz‐Peiffer, A. Taylor, Taylor Aj, 2006, The Journal of endocrinology.

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.

D. James, P. Meikle, M. Febbraio, 2019, Cell metabolism.

Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells.

R. Denton, C. Schmitz‐Peiffer, M. L. Reeves, 1992, Cellular signalling.

Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.

E. Kraegen, D. R. Laybutt, N. Ruderman, 1998, Advances in experimental medicine and biology.

Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

E. Kraegen, C. L. Browne, C. Schmitz‐Peiffer, 1997, American journal of physiology. Endocrinology and metabolism.

Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment

Nolan J. Hoffman, T. Mitchell, C. Schmitz‐Peiffer, 2013, Diabetologia.

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle

N. Turner, J. Burchfield, T. Mitchell, 2007, Diabetologia.

Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-theta localization.

G. Cooney, E. Kraegen, C. Schmitz‐Peiffer, 2000, American journal of physiology. Endocrinology and metabolism.

Protein Kinase C and Lipid‐Induced Insulin Resistance in Skeletal Muscle

C. Schmitz‐Peiffer, 2002, Annals of the New York Academy of Sciences.

Inhibition of glycogen synthesis by fatty acid in C2C12 muscle cells is independent of PKC-α, -ε, and -θ

C. Schmitz‐Peiffer, T. Biden, D. L. Craig, 2002 .

Targeting Ceramide Synthesis to Reverse Insulin Resistance

C. Schmitz‐Peiffer, 2010, Diabetes.

Protein Kinase C Function in Muscle, Liver, and β-Cells and Its Therapeutic Implications for Type 2 Diabetes

C. Schmitz‐Peiffer, T. Biden, 2008, Diabetes.

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells

J. Burchfield, M. Leitges, C. Schmitz‐Peiffer, 2009, Diabetes.

Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes.

W. E. Hughes, C. Schmitz‐Peiffer, Sophie A McManus, 2016, Molecular endocrinology.

Proteomic analysis of livers from fat‐fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism

M. Raftery, B. Parker, C. Schmitz‐Peiffer, 2014, Proteomics.

Diverse roles for protein kinase C δ and protein kinase C ε in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C δ

G. Cooney, J. Burchfield, M. Leitges, 2009, Diabetologia.

Deletion of protein kinase Cε in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis

M. Leitges, C. Schmitz‐Peiffer, K. Raddatz, 2012, Diabetologia.

The diverse roles of protein kinase C in pancreatic beta-cell function.

J. Burchfield, L. Carpenter, C. Schmitz‐Peiffer, 2008, Biochemical Society transactions.

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

G. Cooney, D. R. Laybutt, J. Burchfield, 2007, Cell metabolism.

Anarchy in the UPR: a Ca2+-insensitive PKC inhibits SERCA activity to promote ER stress

C. Schmitz‐Peiffer, 2018, Bioscience reports.

IRS‐1 Regulation in Health and Disease

J. Whitehead, C. Schmitz‐Peiffer, 2003, IUBMB life.

Characterisation of peptide interactions that regulate PKCε activation

R. Norton, C. Schmitz‐Peiffer, I. Chandrashekaran, 2018, FEBS letters.

Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

J. Nadler, T. Mitchell, C. Schmitz‐Peiffer, 2010, Endocrinology.

Evidence that insulin activates casein kinase 2 in rat epididymal fat-cells and that this may result in the increased phosphorylation of an acid-soluble 22 kDa protein.

G. Welsh, R. Denton, T. Diggle, 1991, The Biochemical journal.

Glucose Homeostasis in Mice Is Transglutaminase 2 Independent

R. Graham, G. Cooney, J. Burchfield, 2013, PloS one.

Docking proteins

R. Daly, T. Brummer, C. Schmitz‐Peiffer, 2010, The FEBS journal.

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

M. Raftery, N. Turner, M. Raftery, 2011, Diabetologia.

Regulation of Dendritic Cell Function and T Cell Priming by the Fatty Acid-Binding Protein aP21

C. Mackay, M. Rolph, C. Schmitz‐Peiffer, 2006, The Journal of Immunology.

Identification of BMP and Activin Membrane-Bound Inhibitor (BAMBI) as a Potent Negative Regulator of Adipogenesis and Modulator of Autocrine/Paracrine Adipogenic Factors

F. Newell, N. Turner, J. Whitehead, 2011, Diabetes.

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate.

L. Carpenter, C. Schmitz‐Peiffer, T. Biden, 2001, Diabetes.

Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

E. Kraegen, D. Chisholm, C. L. Browne, 1997, Diabetes.

Cell Priming by the Fatty Acid-Binding Regulation of Dendritic Cell Function and T

C. Mackay, M. Rolph, C. Schmitz‐Peiffer, 2006 .

Inhibition of PKCɛ Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance

G. Cooney, D. R. Laybutt, J. Burchfield, 2007 .

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

C. Schmitz‐Peiffer, T. Biden, L A Selbie, 1993, The Journal of biological chemistry.

Activated protein kinase C alpha associates with annexin VI from skeletal muscle.

C. L. Browne, C. Schmitz‐Peiffer, T. Biden, 1998, The Biochemical journal.

Deconstructing the Role of PKC Epsilon in Glucose Homeostasis

C. Schmitz‐Peiffer, 2020, Trends in Endocrinology & Metabolism.

Synergistic Interaction of Y1-Neuropeptide Y and -Adrenergic Receptors in the Regulation of Phospholipase C, Protein Kinase C, and Arachidonic Acid Production (*)

J. Shine, H. Herzog, C. L. Browne, 1995, The Journal of Biological Chemistry.

Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity ratio in a variety of tissues.

C. Schmitz‐Peiffer, K. Murray, J. Lynham, 1990, The Biochemical journal.

Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

P. Meikle, J. Molero, C. Schmitz‐Peiffer, 2016, Experimental and Clinical Endocrinology & Diabetes.

Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

E. Kraegen, D. Chisholm, C. L. Browne, 1997, Diabetes.

PKCdelta blues for the beta-cell.

C. Schmitz‐Peiffer, T. Biden, 2010, Diabetes.

The tail wagging the dog – regulation of lipid metabolism by protein kinase C

C. Schmitz‐Peiffer, 2013, The FEBS journal.

Akt Mediates Insulin-stimulated Phosphorylation of Ndrg2

G. Corthals, W. E. Hughes, J. Burchfield, 2004, Journal of Biological Chemistry.

Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

E. Kraegen, C. L. Browne, C. Schmitz‐Peiffer, 1997, The American journal of physiology.

Docking proteins

R. Daly, T. Brummer, C. Schmitz‐Peiffer, 2010, The FEBS journal.

Phosphorylation of Nonmuscle Myosin Heavy Chain IIA on Ser Is Mediated by Protein Kinase C II and Coincides with the Onset of Stimulated Degranulation of RBL-2H3 Mast Cells

C. Schmitz‐Peiffer, T. Biden, Z. Elgundi, 2006 .

Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

C. Schmitz‐Peiffer, J. Garrard, K. Raddatz, 2010, Endocrinology.

Activated protein kinase C a associates with annexin VI from skeletal muscle

C. Schmitz‐Peiffer, T. Biden, Carol L. Browne, 1998 .