Yoshitane Nozaki

发表

Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin

K. Maeda, H. Kusuhara, Y. Sugiyama, 2005, Molecular Pharmacology.

Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates

H. Kusuhara, Yoshitane Nozaki, Yoko Nagaya, 2020, Drug Metabolism and Disposition.

Utility of cerebrospinal fluid drug concentration as a surrogate for unbound brain concentration in nonhuman primates.

H. Kusuhara, Yoshitane Nozaki, T. Yoshimura, 2014, Drug metabolism and pharmacokinetics.

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2017, Journal of pharmaceutical sciences.

Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.

H. Kusuhara, Y. Sugiyama, Yoshitane Nozaki, 2017, Drug metabolism and pharmacokinetics.

Alteration in the Plasma Concentrations of Endogenous Organic Anion–Transporting Polypeptide 1B Biomarkers in Patients with Non–Small Cell Lung Cancer Treated with Paclitaxel

K. Maeda, H. Kusuhara, S. Kusumoto, 2020, Drug Metabolism and Disposition.

Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier

Yuichi Sugiyama, Hiroyuki Kusuhara, H. Kusuhara, 2004, Journal of Pharmacology and Experimental Therapeutics.

Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier

H. Kusuhara, T. Mizuno, K. Kawabata, 2020, Drug Metabolism and Disposition.

Functional investigation of solute carrier family 35, member F2 (SLC35F2) in three cellular models of the primate blood–brain barrier

Kei, H. Kusuhara, T. Mizuno, 2020 .

Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2018, Molecular pharmaceutics.

Expression and Functional Involvement of Organic Anion Transporting Polypeptide Subtype 3 (Slc21a7) in Rat Choroid Plexus

T. Abe, H. Kusuhara, Y. Sugiyama, 2003, Pharmaceutical Research.

Functional Characterization of Rat Brain-specific Organic Anion Transporter (Oatp14) at the Blood-Brain Barrier

S. Ishikawa, H. Aburatani, H. Kusuhara, 2003, Journal of Biological Chemistry.

Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats.

H. Kusuhara, Yoshitane Nozaki, T. Yoshimura, 2016, Drug metabolism and pharmacokinetics.

Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters.

Yoshitane Nozaki, Saki Izumi, 2019, Drug metabolism and pharmacokinetics.

Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices

H. Kusuhara, Y. Sugiyama, T. Okano, 2007, Journal of Pharmacology and Experimental Therapeutics.

Characterization of the Uptake of Organic Anion Transporter (OAT) 1 and OAT3 Substrates by Human Kidney Slices

Yuichi Sugiyama, Teruo Okano, Hiroyuki Kusuhara, 2007, Journal of Pharmacology and Experimental Therapeutics.

Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2015, Drug Metabolism and Disposition.

Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2014 .

Substrate-Dependent Inhibition of Organic Anion Transporting Polypeptide 1B1: Comparative Analysis with Prototypical Probe Substrates Estradiol-17β-Glucuronide, Estrone-3-Sulfate, and Sulfobromophthalein

K. Maeda, H. Kusuhara, Y. Sugiyama, 2013, Drug Metabolism and Disposition.

Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

K. Maeda, H. Kusuhara, Y. Sugiyama, 2016, Molecular pharmaceutics.

Alteration in the Plasma Concentrations of Endogenous Organic Anion–Transporting Polypeptide 1B Biomarkers in Patients with Non–Small Cell Lung Cancer Treated with Paclitaxel

K. Maeda, H. Kusuhara, S. Kusumoto, 2020, Drug Metabolism and Disposition.

Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A

Y. Sugiyama, Yoshitane Nozaki, Wooin Lee, 2022, Drug Metabolism and Disposition.

FUNCTIONAL INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 2 (SLC22A7) IN THE HEPATIC UPTAKE OF THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG KETOPROFEN

H. Kusuhara, Y. Sugiyama, H. Endou, 2005, Drug Metabolism and Disposition.

Preincubation Time-Dependent, Long-Lasting Inhibition of Drug Transporters and Impact on the Prediction of Drug−Drug Interactions

Yoshitane Nozaki, Saki Izumi, 2023, Drug Metabolism and Disposition.

Alteration in the plasma concentrations of endogenous OATP1B-biomarkers in non-small cell lung cancer patients treated with paclitaxel

K. Maeda, H. Kusuhara, S. Kusumoto, 2020 .

Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development — Minireview Preincubation Time-Dependent, Long-Lasting Inhibition of Drug Transporters and Impact on the Prediction of Drug 2 Drug Interactions S

Yoshitane Nozaki, Saki Izumi, 2022 .

Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions

K. Maeda, H. Kusuhara, Y. Sugiyama, 2015, Drug Metabolism and Disposition.