A. Takahashi

发表

HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes.

Y. Iwamoto, H. Sone, H. Shimano, 2002, Life sciences.

Protein Kinase A Suppresses Sterol Regulatory Element-binding Protein-1C Expression via Phosphorylation of Liver X Receptor in the Liver*

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2007, Journal of Biological Chemistry.

Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.

H. Sone, H. Shimano, N. Yamada, 2004, Biochemical and biophysical research communications.

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

H. Shimano, N. Yahagi, N. Yamada, 2010, Journal of Lipid Research.

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

H. Sone, H. Shimano, N. Yahagi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Elovl6 promotes nonalcoholic steatohepatitis

R. Matsumori, H. Sone, H. Shimano, 2012, Hepatology.

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.

Kazuto Kobayashi, H. Sone, H. Shimano, 2012, American journal of physiology. Endocrinology and metabolism.

Disease model: hyperinsulinemia and insulin resistance. Part A-targeted disruption of insulin signaling or glucose transport.

H. Sone, A. Takahashi, N. Yamada, 2001, Trends in molecular medicine.

Distinct effects of pravastatin, atorvastatin, and simvastatin on insulin secretion from a beta-cell line, MIN6 cells.

H. Shimano, N. Yamada, S. Oikawa, 2006, Journal of atherosclerosis and thrombosis.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

A. Fukamizu, H. Sone, H. Shimano, 2004, Nature Cell Biology.

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice*

Satoru Takahashi, H. Sone, H. Shimano, 2011, The Journal of Biological Chemistry.

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.

H. Sone, H. Shimano, N. Yamada, 2005, Biochimica et biophysica acta.

Circulating Malondialdehyde-Modified LDL-Related Variables and Coronary Artery Stenosis in Asymptomatic Patients with Type 2 Diabetes

A. Sato, K. Fujihara, H. Sone, 2015, Journal of diabetes research.

Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus.

A. Sato, K. Fujihara, H. Sone, 2013, Journal of atherosclerosis and thrombosis.

Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice.

H. Shimano, A. Takahashi, M. Sakauchi, 2001, Biochemical and biophysical research communications.

Lipid Synthetic Transcription Factor SREBP-1a Activates p21 WAF1/CIP1 , a Universal Cyclin-Dependent

H. Sone, H. Shimano, N. Yahagi, 2005 .

Lipid Synthetic Transcription Factor SREBP-1a Activates p21WAF1/CIP1, a Universal Cyclin-Dependent Kinase Inhibitor

H. Sone, H. Shimano, N. Yahagi, 2005, Molecular and Cellular Biology.

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

H. Shimano, N. Yahagi, N. Yamada, 2008, Journal of lipid research.

Disease model: hyperinsulinemia and insulin resistance. Part B--polygenic and other animal models.

H. Sone, A. Takahashi, K. Iida, 2001, Trends in molecular medicine.

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.

A. Iwama, H. Sone, H. Shimano, 2002, American journal of physiology. Endocrinology and metabolism.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.

H. Gomi, Satoru Takahashi, H. Sone, 2006, Cell metabolism.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy.

H. Sone, H. Shimano, N. Yahagi, 2015, Biochemical and biophysical research communications.

Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*

S. Perrey, H. Sone, H. Shimano, 2001, The Journal of Biological Chemistry.

Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis.

H. Sone, H. Shimano, N. Yamada, 2001, Biochemical and Biophysical Research Communications - BBRC.

glycogen supercompensation in rats Effect of endurance exercise training on muscle

N. Yahagi, T. Matsuzaka, L. Nolte, 2015 .

Elevated levels of vascular endothelial growth factor in the sera of patients with rheumatoid arthritis correlation with disease activity.

H. Shimano, H. Toyoshima, A. Takahashi, 2001, Life sciences.

Mouse Elovl-6 promoter is an SREBP target.

H. Shimano, N. Yahagi, N. Yamada, 2008, Biochemical and biophysical research communications.

Transgenic Mice Overexpressing Nuclear SREBP-1 c in Pancreatic-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

H. Sone, H. Shimano, N. Yahagi, 2005 .

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.

H. Sone, H. Shimano, N. Yahagi, 2014, Biochemical and biophysical research communications.

SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes*

H. Sone, H. Shimano, N. Yahagi, 2004, Journal of Biological Chemistry.

Dual regulation of mouse D 5-and D 6-desaturase gene expression by SREBP-1 and PPAR a

H. Sone, H. Shimano, N. Yahagi, 2002 .

Involvement of glomerular SREBP-1c in diabetic nephropathy.

H. Sone, H. Shimano, N. Yamada, 2007, Biochemical and biophysical research communications.

expression in human skeletal muscle Effects of exercise on GLUT-4 and glycogenin gene

M. Huss, M. Lindholm, S. Kjellqvist, 2015 .

Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction.

H. Shimano, N. Yamada, T. Kato, 2007, Diabetes, obesity & metabolism.

Thunderclap headache without hypertension in a patient with pheochromocytoma

H. Shimano, Masahiko Watanabe, A. Tamaoka, 2010, The Journal of Headache and Pain.

Cyclin-dependent Kinase Inhibitor, p21 WAF1/CIP1 , Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Cyclin-dependent Kinase Inhibitor , p 21 WAF 1 / CIP 1 , Is Involved in Adipocyte Differentiation and Hypertrophy , Linking to Obesity , and Insulin Resistance *

H. Shimano, N. Yahagi, N. Yamada, 2008 .

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells.

H. Sone, H. Shimano, N. Yahagi, 2005, Diabetes.

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

H. Sone, H. Shimano, N. Yahagi, 2003, Molecular endocrinology.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

Hitoshi Shimano, Takashi Matsuzaka, Hirohito Sone, 2003, Molecular endocrinology.

Cross-Talk between Peroxisome Proliferator-Activated Receptor ( PPAR ) and Liver X Receptor ( LXR ) in Nutritional Regulation of Fatty Acid Metabolism

H. Sone, H. Shimano, N. Yahagi, 2003 .

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

H. Sone, H. Shimano, N. Yahagi, 2006, Nature Medicine.

Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

H. Sone, H. Shimano, N. Yahagi, 2002 .

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

H. Sone, H. Shimano, N. Yahagi, 2008, Diabetes.

Sterol regulatory element–binding protein‐1c and pancreatic β‐cell dysfunction

H. Shimano, T. Kato, A. Takahashi, 2007 .

Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements*

H. Sone, H. Shimano, N. Yahagi, 2002, The Journal of Biological Chemistry.

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2007, Nature Medicine.

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

H. Sone, H. Shimano, N. Yahagi, 2014, Endocrinology.

National Cholesterol Awareness Month Article Macrophage Elovl 6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

R. Matsumori, H. Sone, H. Shimano, 2011 .

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

H. Sone, H. Shimano, N. Yahagi, 2002, Journal of lipid research.

Cyclin-dependent Kinase Inhibitor, p21WAF1/CIP1, Is Involved in Adipocyte Differentiation and Hypertrophy, Linking to Obesity, and Insulin Resistance*

Hitoshi Shimano, Mayumi Ishikawa, Takashi Matsuzaka, 2008, Journal of Biological Chemistry.

Effects of atorvastatin on glucose metabolism and insulin resistance in KK/Ay mice.

H. Shimano, N. Yamada, Rumi Kihara, 2005, Journal of atherosclerosis and thrombosis.

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.

N. Aoki, H. Shimano, N. Yahagi, 2009, Biochemical and biophysical research communications.

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes

A. Sato, K. Fujihara, H. Sone, 2014, Journal of atherosclerosis and thrombosis.

Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.

S. Kuno, K. Kondo, H. Sone, 2007, Internal medicine.

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.

H. Sone, H. Shimano, N. Yahagi, 2002, Journal of lipid research.

Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects.

Hitoshi Shimano, Yuichi Noguchi, Hirohito Sone, 2003, Metabolism: clinical and experimental.

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.

H. Shimano, N. Yamada, T. Matsuzaka, 2010, Biochemical and biophysical research communications.

Continuity of diabetes care among elderly Japanese patients: a medical record review study in a specialized diabetes clinic

K. Yamazaki, A. Takahashi, K. Kawai, 2022, Diabetology International.

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.

H. Shimano, N. Yahagi, N. Yamada, 2009, Biochemical and biophysical research communications.