N. Damle

发表

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

P. Linsley, J. Bradshaw, J. Ledbetter, 1992, The Journal of experimental medicine.

Biopharmaceutical drug discovery using novel protein scaffolds.

N. Damle, D. Gill, 2006, Current opinion in biotechnology.

The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin.

K. Myers, K. Marquette, N. Damle, 2008, International journal of oncology.

Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 μl) blood samples

I. Chaudhary, N. Damle, E. Boghaert, 2008, Cancer Chemotherapy and Pharmacology.

CD20-specific antibody-targeted chemotherapy of non-Hodgkin’s B-cell lymphoma using calicheamicin-conjugated rituximab

N. Damle, E. Boghaert, J. Dijoseph, 2007, Cancer Immunology, Immunotherapy.

Anticorps anti-5t4 humanises et conjugues anticorps anti-5t4/calicheamicine

K. Marquette, N. Damle, D. Gill, 2005 .

Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma

N. Damle, E. Boghaert, J. Dijoseph, 2004, Clinical Cancer Research.

Autologous Mixed Lymphocyte Reaction in Man

N. Damle, S. Gupta, 1982, Scandinavian journal of immunology.

CD45 ligation in T cells regulates signal transduction through both the interleukin-2 receptor and the CD3/Ti T-cell receptor complex.

G. Schieven, J. Ledbetter, N. Damle, 1990, Tissue antigens.

Tumoricidal effect of calicheamicin immuno-conjugates using a passive targeting strategy.

C. Discafani, S. Jones, N. Damle, 2006, International journal of oncology.

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

P. Linsley, A. Aruffo, N. Damle, 1992, Journal of immunology.

Preclinical anti-tumor activity of antibody-targeted chemotherapy with CMC-544 (inotuzumab ozogamicin), a CD22-specific immunoconjugate of calicheamicin, compared with non-targeted combination chemotherapy with CVP or CHOP

Bin-Bing S. Zhou, N. Damle, J. Dijoseph, 2011, Cancer Chemotherapy and Pharmacology.

Antibody-drug conjugates ace the tolerability test

N. Damle, 2008, Nature Biotechnology.

DOMAIN OF LYMPHOCYTE FUNCTION ASSOCATED ANTIGEN 3 TO INITIATE T CELLACTIVATION

P. Linsley, N. Damle, K. Klussman, 2017 .

ASN004, A 5T4-targeting scFv-Fc Antibody–Drug Conjugate with High Drug-to-Antibody Ratio, Induces Complete and Durable Tumor Regressions in Preclinical Models

N. Damle, H. Usansky, Sanjeeva P. Reddy, 2021, Molecular Cancer Therapeutics.

Direct interaction with primed CD4+ CD45R0+ memory T lymphocytes induces expression of endothelial leukocyte adhesion molecule‐1 and vascular cell adhesion molecule‐1 on the surface of vascular endothelial cells

N. Damle, M. van der Vieren, Chris Eberhardt, 1991, European journal of immunology.

Stimulation of cloned human T lymphocytes via the CD3 or CD28 molecules induces enhancement in vascular endothelial permeability to macromolecules with participation of type‐1 and type‐2 intercellular adhesion pathways

N. Damle, L. Doyle, 1990, European journal of immunology.

Interleukin 2-activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelial cells and cause their lysis.

J. Bender, N. Damle, L. Doyle, 1987, Journal of immunology.

Direct helper T cell‐induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, European journal of immunology.

Interleukin 2-activated human killer cells are derived from phenotypically heterogeneous precursors.

N. Damle, L. Doyle, E. Bradley, 1986, Journal of immunology.

Proliferation of human T lymphocytes induced with superantigens is not dependent on costimulation by the CD28 counter-receptor B7.

P. Linsley, N. Damle, G. Leytze, 1993, Journal of immunology.

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytes.

A. Aruffo, N. Damle, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Antigen-specific suppressor T lymphocytes in man.

E. Engleman, N. Damle, 1989, Clinical immunology and immunopathology.

Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors.

E. Engleman, J. Hansen, N. Damle, 1983, Journal of immunology.

Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.

S. Kanner, J. Ledbetter, N. Damle, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.

P. Linsley, A. Aruffo, J. Ledbetter, 1992, Journal of immunology.

MHC-Restricted Antigen-Receptor Specific Regulatory T Cell Circuits in Man

E. Engleman, N. Damle, D. Fishwild, 1985 .

Immunoregulatory t cell circuits in man - An overview of recent advances

E. Engleman, N. Damle, 1984, Survey of immunologic research.

Activation with superantigens induces programmed death in antigen‐primed CD4+ class II+ major histocompatibility complex T lymphocytes via a CD11a/CD18‐dependent mechanism

J. Ledbetter, N. Damle, G. Leytze, 1993, European journal of immunology.

Regulation of HIV production by blood mononuclear cells from HIV-infected donors: II. HIV-1 production depends on T cell-monocyte interaction.

J. Ledbetter, N. Damle, M. Diegel, 1993, AIDS research and human retroviruses.

IL-2-activated human killer lymphocytes but not their secreted products mediate increase in albumin flux across cultured endothelial monolayers. Implications for vascular leak syndrome.

N. Damle, L. Doyle, 1989, Journal of immunology.

Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.

P. Linsley, A. Aruffo, J. Ledbetter, 1993, Journal of immunology.

Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7.

P. Linsley, A. Aruffo, J. Ledbetter, 1994, Journal of immunology.

Generation of antigen receptor-specific suppressor T cell clones in man

E. Engleman, N. Damle, N. Mohagheghpour, 1986, The Journal of experimental medicine.

United States Patent Linsley

N. Damle, 2017 .

Autologous Mixed Lymphocyte Reaction in Man

N. Damle, S. Gupta, 1982, Scandinavian journal of immunology.

Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.

A. Aruffo, N. Damle, K. Klussman, 1992, Journal of immunology.

CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

S. Kanner, A. Aruffo, J. Ledbetter, 1992, Journal of immunology.

Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus

E. Engleman, N. Damle, 1983, The Journal of experimental medicine.

Autologous mixed lymphocyte reaction in man. IV. Decreased autologous mixed lymphocyte culture response in patients with common variable immunodeficiency

Sudhir Gupta, N. Damle, 2004, Journal of Clinical Immunology.

Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes.

J. Ledbetter, N. Damle, L. Grosmaire, 1988, Journal of immunology.

Vascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD 4 ' T lymphocytes ( costimulation )

N. Damle, Alejandro Aruffo Oncogen, 2022 .

Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction.

J. Hansen, R. Good, N. Damle, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Ability of human T lymphocytes to adhere to vascular endothelial cells and to augment endothelial permeability to macromolecules is linked to their state of post-thymic maturation.

N. Damle, L. Doyle, 1990, Journal of immunology.

Immunoregulatory T lymphocytes in man. Soluble antigen-specific suppressor-inducer T lymphocytes are derived from the CD4+CD45R-p80+ subpopulation.

N. Damle, A. Childs, L. Doyle, 1987, Journal of immunology.

Immunoregulatory T cell circuits in man. Identification of a distinct T cell subpopulation of the helper/inducer lineage that amplifies the development of alloantigen-specific suppressor T cells.

E. Engleman, N. Damle, D. Fishwild, 1985, Journal of immunology.

Autologous mixed lymphocyte reaction in man. II. Histamine-induced suppression of the autologous mixed lymphocyte reaction by T-cell subsets defined with monoclonal antibodies

Sudhir Gupta, N. Damle, 1981, Journal of Clinical Immunology.

CTLA-4 is a second receptor for the B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, The Journal of experimental medicine.

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

P. Linsley, A. Aruffo, J. Ledbetter, 1991, The Journal of experimental medicine.

Regulation of the immune response in man by a cascade of interactive T lymphocytes.

E. Engleman, N. Damle, N. Mohagheghpour, 1985, Current topics in cellular regulation.

A human alloreactive inducer T cell clone that selectively activates antigen-specific suppressor T cells.

E. Engleman, N. Damle, N. Mohagheghpour, 1984, Journal of immunology.

Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigen-pulsed accessory cells: phenotypic definition of suppressor-inducer and suppressor-effector cells.

E. Engleman, N. Damle, N. Mohagheghpour, 1984, Journal of immunology.

Antitumor Efficacy of a Combination of CMC-544 (Inotuzumab Ozogamicin), a CD22-Targeted Cytotoxic Immunoconjugate of Calicheamicin, and Rituximab against Non-Hodgkin's B-Cell Lymphoma

N. Damle, E. Boghaert, J. Dijoseph, 2006, Clinical Cancer Research.

Antibody-targeted chemotherapy with immunoconjugates of calicheamicin.

P. Frost, N. Damle, 2003, Current opinion in pharmacology.

Tumour-targeted chemotherapy with immunoconjugates of calicheamicin

N. Damle, 2004, Expert opinion on biological therapy.

Costimulation of T-cell activation and virus production by B7 antigen on activated CD4+ T cells from human immunodeficiency virus type 1-infected donors.

P. Linsley, J. Bradshaw, O. Haffar, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu-4/T3-associated structures on the surface of inducer T lymphocytes.

E. Engleman, N. Damle, N. Mohagheghpour, 1984, Journal of immunology.

Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies.

Boris Gorovits, P. Frost, S. Stephens, 2004, Blood.

Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22

A. Lawson, S. Stephens, N. Damle, 2004, Cancer Immunology, Immunotherapy.

Cellular sensitization in chronic myeloid leukaemia patients to leukaemic blast antigens.

N. Damle, S. Advani, S. Gangal, 1979, British Journal of Cancer.

Interleukin‐2 activated human killer lymphocytes: Lack of involvement of interferon in the development of IL‐2‐activated killer lymphocytes

N. Damle, L. Doyle, 1987, International journal of cancer.

Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia

N. Damle, J. Dijoseph, D. Armellino, 2007, Leukemia.

Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells.

P. Frost, N. Damle, E. Boghaert, 2002, Cancer letters.

Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193-N-Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewisy and Eliminates Lewisy-Positive Human Carcinoma Cells and Xenografts

P. Frost, N. Damle, E. Boghaert, 2004, Clinical Cancer Research.

Bispecific receptor globulins, novel tools for the study of cellular interactions. Preparation and characterization of an E-selectin/P-selectin bispecific receptor globulin.

P. Linsley, A. Aruffo, J. Ledbetter, 1993, Journal of immunological methods.

GMP‐140 (P‐selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines

A. Aruffo, N. Damle, N. Mohagheghpour, 1992, European journal of immunology.

virus (RSV) vaccination model but does not adversely affect humoral responses in a respiratory syncytial B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model

Xiaochuan Zhou, M. Hegen, N. Damle, 2013 .

B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model.

Xiaochuan Zhou, M. Hegen, M. Collins, 2005, Blood.

Short title: Effect of B cell depletion in CIA and RSV models

Xiaochuan Zhou, M. Hegen, M. Collins, 2005 .

Antibody-Targeted Chemotherapy with Immunoconjugates of Calicheamicin: Differential Anti-Tumor Activity of Conjugated Calicheamicin Targeted to B-Cell Lymphoma Via B-Cell Lineage Specific Molecules CD19, CD20 and CD22.

N. Damle, E. Boghaert, J. Dijoseph, 2004 .

Plasma and cerebrospinal fluid pharmacokinetics of vodobatinib, a neuroprotective c-Abl tyrosine kinase inhibitor for the treatment of Parkinson's disease.

R. R. Walsh, S. Piccoli, N. Damle, 2023, Parkinsonism & related disorders.

Costimulation via vascular cell adhesion molecule-1 induces in T cells increased responsiveness to the CD28 counter-receptor B7.

P. Linsley, H. Ochs, A. Aruffo, 1993, Cellular immunology.

CTLA-4 is a second receptor for the B cell activation antigen B7

P. Linsley, J. Ledbetter, N. Damle, 1991, The Journal of experimental medicine.

Immunoregulatory T cell circuits in man. Alloantigen-primed inducer T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus

E. Engleman, N. Damle, 1983, Journal of Experimental Medicine.

Heterogeneity of concanavalin A-induced suppressor T cells in man defined with monoclonal antibodies.

N. Damle, S. Gupta, 1982, Clinical and experimental immunology.

Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4+CD29+CD45R- memory T lymphocytes.

N. Damle, L. Doyle, 1989, Journal of immunology.

Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

M. Greene, A. Bhandoola, R. Hintzen, 1993, Journal of immunology.

Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies.

P. Frost, S. Stephens, N. Damle, 2004, Blood.