T. Sugimoto

发表

Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2016, Endocrine journal.

FAM210A is a novel determinant of bone and muscle structure and strength

J. Richards, John A. Morris, S. Wing, 2018, Proceedings of the National Academy of Sciences.

Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, The Journal of clinical endocrinology and metabolism.

Stimulatory effect of bone morphogenetic protein‐2 on osteoclast‐like cell formation and bone‐resorbing activity

K. Chihara, M. Fukase, H. Kaji, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation.

K. Chihara, H. Kaji, T. Sugimoto, 1996, Endocrinology.

Cloning and characterization of the 5'-flanking region of the mouse diastrophic dysplasia sulfate transporter gene.

K. Chihara, K. Saijoh, T. Sugimoto, 1997, Biochemical and biophysical research communications.

Effect of low-dose of recombinant human growth hormone on bone metabolism in elderly women with osteoporosis.

S. Mohan, K. Chihara, S. Yano, 2002, European journal of endocrinology.

Bone metabolism and body composition in Japanese patients with active acromegaly

K. Chihara, H. Kaji, Y. Okimura, 2001, Clinical endocrinology.

Age-dependent changes in body composition in postmenopausal Japanese women: relationship to growth hormone secretion as well as serum levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

K. Chihara, T. Sugimoto, D. Nakaoka, 1998, European journal of endocrinology.

Significance of GH-IGF-I Axis in Changes in Body Composition, Bone and Lipid Metabolism in Perimenopausal Women

K. Chihara, T. Sugimoto, 1997 .

Short-term effects of glucocorticoid therapy on biochemical markers of bone metabolism in Japanese patients: a prospective study

S. Kawano, T. Sugimoto, H. Kaji, 2008, Journal of Bone and Mineral Metabolism.

Elevated Serum Pentosidine and Decreased Serum IGF-I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus.

I. Kanazawa, T. Sugimoto, K. Tanaka, 2015, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Effect of high phosphate concentration on osteoclast differentiation as well as bone‐resorbing activity

K. Chihara, T. Sugimoto, M. Kanatani, 2003, Journal of cellular physiology.

High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells.

K. Chihara, S. Yano, T. Sugimoto, 1999, Biochemical and biophysical research communications.

High extracellular calcium stimulates osteoclast‐like cell formation and bone‐resorbing activity in the presence of osteoblastic cells

K. Chihara, H. Kaji, T. Sugimoto, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast‐like cells

K. Chihara, M. Fukase, H. Kaji, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effect of elevated extracellular calcium on the proliferation of osteoblastic MC3T3-E1 cells:its direct and indirect effects via monocytes.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Biochemical and biophysical research communications.

Diabetes and Osteoporosis

I. Kanazawa, T. Sugimoto, 2018 .

Bazedoxifene Ameliorates Homocysteine-Induced Apoptosis and Accumulation of Advanced Glycation End Products by Reducing Oxidative Stress in MC3T3-E1 Cells

I. Kanazawa, T. Sugimoto, T. Tomita, 2017, Calcified Tissue International.

Activation of AMP-activated protein kinase protects against homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by regulating the expressions of NADPH oxidase 1 (Nox1) and Nox2.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2015, Bone.

Advanced glycation end product 3 (AGE3) suppresses the mineralization of mouse stromal ST2 cells and human mesenchymal stem cells by increasing TGF-β expression and secretion.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2014, Endocrinology.

Advanced Glycation End Product 3 (AGE3) Increases Apoptosis and the Expression of Sclerostin by Stimulating TGF-β Expression and Secretion in Osteocyte-Like MLO-Y4-A2 Cells

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2017, Calcified Tissue International.

Comparison of bone mineral content among Japanese, Koreans, and Taiwanese assessed by dual‐photon absorptiometry

M. Lee, K. Tsai, M. Fukase, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A case report of fulminant type 1 diabetes mellitus associated with drug-induced hypersensitivity syndrome in an elderly patient with coxsackie B4 virus infection and human leukocyte antigen-A24 haplotype.

Ayumu Takeno, I. Kanazawa, T. Sugimoto, 2017, Endocrine journal.

Low-dose parathyroid hormone and estrogen reverse alkaline phosphatase activity suppressed by dexamethasone in mouse osteoblastic cells

K. Chihara, H. Sowa, T. Sugimoto, 2005, Journal of Bone and Mineral Metabolism.

Risedronate therapy in patients with mild-to-moderate chronic kidney disease with osteoporosis: post-hoc analysis of data from the risedronate phase III clinical trials

T. Shigematsu, Y. Nishizawa, T. Sugimoto, 2017, BMC Nephrology.

Estrogen modulates osteoblast proliferation and function regulated by parathyroid hormone in osteoblastic SaOS-2 cells: role of insulin-like growth factor (IGF)-I and IGF-binding protein-5.

K. Chihara, H. Kaji, T. Sugimoto, 2000, The Journal of endocrinology.

Involvement of osteoprotegerin/osteoclastogenesis inhibitory factor in the stimulation of osteoclast formation by parathyroid hormone in mouse bone cells.

K. Chihara, T. Sugimoto, M. Kanatani, 2000, European journal of endocrinology.

Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2019, Calcified Tissue International.

Parathyroid Hormone-responsive Smad3-related Factor, Tmem119, Promotes Osteoblast Differentiation and Interacts with the Bone Morphogenetic Protein-Runx2 Pathway*

R. Kitazawa, S. Kitazawa, S. Seino, 2011, The Journal of Biological Chemistry.

Effects of uremic toxin p-cresol on proliferation, apoptosis, differentiation, and glucose uptake in 3T3-L1 cells.

S. Yano, A. Sheikh, A. Nagai, 2014, Artificial organs.

Decreased serum insulin-like growth factor-I level is associated with the increased mortality in type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, H. Miyake, 2016, Endocrine journal.

Effects of intensive glycemic control on serum levels of insulin-like growth factor-I and dehydroepiandrosterone sulfate in Type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, T. Yamaguchi, 2011, Journal of Endocrinological Investigation.

Safety Profiles, Pharmacokinetics, and Changes in Bone Turnover Markers After Twice‐Weekly Subcutaneous Administration of Teriparatide in Healthy Japanese Postmenopausal Women: A Single‐Blind Randomized Study

Y. Kumagai, T. Sugimoto, A. Ose, 2019, Clinical pharmacology in drug development.

Advanced Glycation End Products, Diabetes, and Bone Strength

T. Sugimoto, Masahiro Yamamoto, 2016, Current Osteoporosis Reports.

Fracture Risk in Diabetes

T. Sugimoto, Masahiro Yamamoto, 2016 .

Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid

T. Sugimoto, Toru Yamaguchi, M. Yamauchi, 2010, Osteoporosis International.

Glucocorticoid Excess Affects Cortical Bone Geometry in Premenopausal, but not Postmenopausal, Women

K. Chihara, T. Sugimoto, M. Yamauchi, 2008, Calcified Tissue International.

The threshold of bone mineral density for vertebral fracture in female patients with glucocorticoid-induced osteoporosis.

K. Chihara, T. Sugimoto, M. Yamauchi, 2006, Endocrine journal.

Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL–RANK interaction

K. Chihara, H. Sowa, T. Sugimoto, 2004, Journal of cellular physiology.

Radial bone mineral content of normal Japanese infants and prepubertal children: influence of age, sex and body size.

K. Chihara, M. Fukase, T. Sugimoto, 1994, Bone and mineral.

Stimulatory Effect of Insulin‐Like Growth Factor Binding Protein‐5 on Mouse Osteoclast Formation and Osteoclastic Bone‐Resorbing Activity

K. Chihara, T. Sugimoto, M. Kanatani, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation.

K. Anderson, E. Brown, K. Chihara, 2002, Biochemical and biophysical research communications.

Executive summary of clinical practice guide on fracture risk in lifestyle diseases

H. Hagino, M. Inaba, Y. Takeuchi, 2020, Journal of Bone and Mineral Metabolism.

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.

K. White, M. Econs, H. Jüppner, 2003, The New England journal of medicine.

Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes

S. Yano, T. Sugimoto, S. Kurioka, 2014, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus

I. Kanazawa, T. Sugimoto, Sayuri Tanaka, 2018, Calcified Tissue International.

Relationship between bone biochemical markers versus glucose/lipid metabolism and atherosclerosis; a longitudinal study in type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2011, Diabetes research and clinical practice.

Fasting plasma glucose levels are related to bone mineral density in postmenopausal women with primary hyperparathyroidism.

K. Chihara, T. Sugimoto, H. Kaji, 2008, International journal of clinical and experimental medicine.

Analysis of factors affecting increase in bone mineral density at lumbar spine by bisphosphonate treatment in postmenopausal osteoporosis

M. Kasuga, T. Sugimoto, H. Kaji, 2008, Journal of Bone and Mineral Metabolism.

Kobe University Repository : Kernel タイトル Tit le Smad 3 Different ly Affects Osteoblast Different iat ion Depending upon its Different iat ion Stage 著者

H. Sowa, T. Sugimoto, H. Kaji, 2018 .

Role of Smad3, acting independently of transforming growth factor‐β, in the early induction of Wnt‐β‐catenin signaling by parathyroid hormone in mouse osteoblastic cells

K. Chihara, G. Hendy, T. Sugimoto, 2009, Journal of cellular biochemistry.

Serum soluble factors induce the proliferation, alkaline phosphatase activity and transforming growth factor-beta signal in osteoblastic cells in the patient with hepatitis C-associated osteosclerosis.

K. Chihara, H. Sowa, T. Sugimoto, 2006, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Dexamethasone suppresses Smad3 pathway in osteoblastic cells.

K. Chihara, H. Sowa, T. Sugimoto, 2005, The Journal of endocrinology.

Parathyroid Hormone-Smad3 Axis Exerts Anti-apoptotic Action and Augments Anabolic Action of Transforming Growth Factor β in Osteoblasts*

K. Chihara, H. Sowa, T. Sugimoto, 2003, Journal of Biological Chemistry.

Smad3 Promotes Alkaline Phosphatase Activity and Mineralization of Osteoblastic MC3T3‐E1 Cells

K. Chihara, H. Sowa, T. Sugimoto, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Menin Is Required for Bone Morphogenetic Protein 2- and Transforming Growth Factor β-regulated Osteoblastic Differentiation through Interaction with Smads and Runx2*

K. Chihara, T. Komori, G. Hendy, 2004, Journal of Biological Chemistry.

Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03

M. Fukunaga, E. Itoi, Y. Ohashi, 2017, Journal of Bone and Mineral Metabolism.

Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese Osteoporosis Intervention Trial-03 (JOINT-03)

M. Fukunaga, E. Itoi, Y. Ohashi, 2014, Journal of Bone and Mineral Metabolism.

Determinants of vertebral fragility: the participation of cortical bone factors

K. Chihara, T. Sugimoto, M. Yamauchi, 2004, Journal of Bone and Mineral Metabolism.

Kobe University Repository : Kernel タイトル Tit le Effect of alendronate on bone metabolic indices and bone mineral density in pat ients t reated with high-dose glucocort icoid : a prospect ive study 著者

T. Sugimoto, H. Kaji, F. Kanda, 2018 .

Effect of alendronate on bone metabolic indices and bone mineral density in patients treated with high-dose glucocorticoid: a prospective study

T. Sugimoto, H. Kaji, F. Kanda, 2010, Osteoporosis International.

Serum Levels of Insulin-Like Growth Factor (IGF); IGF-Binding Proteins-3, -4, and -5; and Their Relationships to Bone Mineral Density and the Risk of Vertebral Fractures in Postmenopausal Women

S. Mohan, K. Chihara, H. Kaji, 2006, Calcified Tissue International.

Diabetes Mellitus-induced Bone Fragility

I. Kanazawa, T. Sugimoto, 2018, Internal medicine.

R. Burge, T. Sugimoto, A. Brnabic, 2016, Value in health regional issues.

Efficacy and Safety of Risedronate in Osteoporosis Subjects with Comorbid Diabetes, Hypertension, and/or Dyslipidemia: A Post Hoc Analysis of Phase III Trials Conducted in Japan

Y. Nishizawa, T. Sugimoto, R. Okazaki, 2015, Calcified Tissue International.

1. Progress in the Treatment of Osteoporosis

T. Sugimoto, 2012 .

Low Serum Level of the Endogenous Secretory Receptor for Advanced Glycation End Products (esRAGE) Is a Risk Factor for Prevalent Vertebral Fractures Independent of Bone Mineral Density in Patients with Type 2 Diabetes

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2010, Diabetes Care.

Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification

S. Yano, A. Sheikh, A. Nagai, 2016, International Journal of Molecular Sciences.

Mild renal dysfunction is a risk factor for a decrease in bone mineral density and vertebral fractures in Japanese postmenopausal women.

T. Shigematsu, T. Sugimoto, Toru Yamaguchi, 2010, The Journal of clinical endocrinology and metabolism.

Long-term Efficacy and Safety of Sitagliptin in Elderly Patients with Type 2 Diabetes Mellitus.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2016, Internal medicine.

Long-term efficacy and safety of vildagliptin add-on therapy in type 2 diabetes mellitus with insulin treatment.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2017, Diabetes research and clinical practice.

A Case of Alzheimer Disease with Hepatocellular Carcinoma whose Dementia was Manifested by Non-islet Cell Tumor Hypoglycemia.

T. Sugimoto, Masahiro Yamamoto, K. Hara, 2010 .

Adiponectin is associated with changes in bone markers during glycemic control in type 2 diabetes mellitus.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, The Journal of clinical endocrinology and metabolism.

Effect of natural menopause on serum levels of IGF-I and IGF-binding proteins: relationship with bone mineral density and lipid metabolism in perimenopausal women.

K. Chihara, T. Sugimoto, M. Nasu, 1997, European journal of endocrinology.

1 Long-term Efficacy and Safety of Vildagliptin Add-on Therapy in Type 2 Diabetes Mellitus Treatment with Insulin Running title : Vildagliptin with insulin therapy

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2016 .

Interrelationship between glucose metabolism and undercarboxylated osteocalcin: a cross-sectional study in a community-dwelling population.

S. Yamaguchi, Tsuyoshi Hamano, M. Yamasaki, 2015, Asia Pacific journal of clinical nutrition.

The Levels of Somatostatin Receptors in Causative Tumors of Oncogenic Osteomalacia Are Insufficient for Their Agonist to Normalize Serum Phosphate Levels

K. Wakasa, T. Ueda, J. Hashimoto, 2010, Calcified Tissue International.

Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK–eIF2α–ATF4 Pathway in the Commitment of Myoblastic into Osteoblastic Cells

G. Hendy, I. Kanazawa, Ken-ichiro Tanaka, 2013, Calcified Tissue International.

Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report

Ayumu Takeno, M. Notsu, T. Sugimoto, 2016, BMC Endocrine Disorders.

Randomized head-to-head comparison of minodronic acid and raloxifene for fracture incidence in postmenopausal Japanese women: the Japanese Osteoporosis Intervention Trial (JOINT)-04

T. Sone, M. Fukunaga, A. Taguchi, 2020, Current medical research and opinion.

Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid

A. Taguchi, Toshitaka Nakamura, Shiro Tanaka, 2019, Journal of Bone and Mineral Metabolism.

Study design of multi-center, open-label randomized controlled, head-to-head trial comparing minodronic acid and raloxifene: Japanese Osteoporosis Intervention Trial (JOINT)-04

T. Sone, M. Fukunaga, A. Taguchi, 2018, Journal of Bone and Mineral Metabolism.

Bridging analysis of the efficacy and safety of bazedoxifene in Japanese and global populations of postmenopausal women with osteoporosis

A. Chines, T. Sugimoto, G. Constantine, 2013, Journal of Bone and Mineral Metabolism.

Relationship between Endogenous Parathyroid Hormone and Bone Metabolism/Geometry in Female Patients Treated with Glucocorticoid

K. Chihara, T. Sugimoto, M. Yamauchi, 2007, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography: comparisons between female and male.

K. Chihara, T. Sugimoto, M. Yamauchi, 2005, Endocrine journal.

The threshold of bone mineral density for vertebral fractures in female patients with primary hyperparathyroidism.

K. Chihara, T. Sugimoto, M. Yamauchi, 2005, European journal of endocrinology.

Body composition and vertebral fracture risk in female patients treated with glucocorticoid

K. Chihara, H. Kaji, T. Sugimoto, 2005, Osteoporosis International.

Femoral and spinal bone mineral density in Japanese osteoporotics with hip fracture

K. Chihara, M. Fukase, T. Fujita, 1994, Osteoporosis International.

Determinants of Bone Mineral Density and Spinal Fracture Risk in Postmenopausal Japanese Women

K. Chihara, S. Yano, T. Sugimoto, 2001, Osteoporosis International.

The effects of once-weekly teriparatide on hip geometry assessed by hip structural analysis in postmenopausal osteoporotic women with high fracture risk.

T. Tomomitsu, T. Sone, M. Fukunaga, 2014, Bone.

Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D3 load in Japanese subjects

I. Endo, Toshio Matsumoto, T. Sugimoto, 2011, Journal of Bone and Mineral Metabolism.

Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women

K. Chihara, S. Yano, T. Sugimoto, 2001, Clinical endocrinology.

Renal Phosphate Reabsorption is Correlated with the Increase in Lumbar Bone Mineral Density in Patients Receiving Once-Weekly Teriparatide

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2015, Calcified Tissue International.

New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide

Sakae Tanaka, T. Adachi, J. Bilezikian, 2014, Bone Research.

Author’s Response to Letter to the Editor

Toshitaka Nakamura, Shiro Tanaka, T. Sugimoto, 2014, Current medical research and opinion.

Once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis: reply to T. Kawada

T. Sugimoto, M. Shiraki, T. Nakamura, 2014, Osteoporosis International.

The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT

M. Ito, T. Sone, M. Fukunaga, 2013, Osteoporosis International.

Profile of changes in bone turnover markers during once-weekly teriparatide administration for 24 weeks in postmenopausal women with osteoporosis

T. Sugimoto, M. Shiraki, T. Nakamura, 2013, Osteoporosis International.

Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women

T. Sugimoto, M. Shiraki, T. Nakamura, 2012, Osteoporosis International.

Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-month, randomized, placebo-controlled, double-blind and 12-month open-label phases.

Toshitaka Nakamura, Toshio Matsumoto, M. Warner, 2010, Bone.

Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects.

K. Chihara, H. Sowa, T. Sugimoto, 2003, The Journal of clinical endocrinology and metabolism.

Smad3 Differently Affects Osteoblast Differentiation Depending upon its Differentiation Stage

K. Chihara, H. Sowa, T. Sugimoto, 2006, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism.

R. Kitazawa, S. Maeda, S. Kitazawa, 2000, Kidney international.

IGF‐I mediates the stimulatory effect of high phosphate concentration on osteoblastic cell proliferation

K. Chihara, T. Sugimoto, M. Kanatani, 2002, Journal of cellular physiology.

Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial

N. Yorioka, Y. Ikari, K. Iseki, 2018, JAMA.

Pioglitazone Increases Serum DPP-4 Level in Type 2 Diabetes Mellitus

I. Kanazawa, M. Notsu, T. Sugimoto, 2014 .

Serum insulin-like growth factor-I is negatively associated with serum adiponectin in type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2011, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus

S. Yano, I. Kanazawa, T. Sugimoto, 2010, Osteoporosis International.

Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2010, Metabolism: clinical and experimental.

Association between Erythropoietin Requirements and Antihypertensive Agents

S. Yano, S. Imamura, T. Sugimoto, 2008, Nephron Clinical Practice.

An Open-label Longitudinal Study on the Efficacy of Switching from Insulin Glargine or Detemir to Degludec in Type 2 Diabetes Mellitus.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2015, Internal medicine.

Calcium-Corrected Intact PTH: A Clinically Useful Parameter for Quantifying Parathyroid Function in Patients Undergoing Hemodialysis

E. Brown, S. Yano, T. Sugimoto, 2010, Nephron Clinical Practice.

Bone metabolism after cinacalcet administration in patients with secondary hyperparathyroidism

K. Shigeno, S. Yano, T. Sugimoto, 2010, Journal of Bone and Mineral Metabolism.

Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells.

S. Yano, T. Sugimoto, Toru Yamaguchi, 2013, Journal of diabetes and its complications.

Phenylacetic Acid Stimulates Reactive Oxygen Species Generation and Tumor Necrosis Factor‐α Secretion in Vascular Endothelial Cells

S. Yano, T. Sugimoto, Toru Yamaguchi, 2011, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

Factors affecting bone mineral density in hemodialysis patients with diabetic nephropathy.

K. Chihara, T. Sugimoto, H. Kaji, 2003, Endocrine journal.

Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells.

K. Chihara, G. Hendy, H. Sowa, 2006, Endocrinology.

Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.

S. Yano, I. Kanazawa, T. Sugimoto, 2008, Biochemical and biophysical research communications.

Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement.

I. Endo, Hiroyuki Tanaka, Toshio Matsumoto, 2008, Bone.

Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2019, International journal of molecular sciences.

Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts

J. Richards, D. Goltzman, I. Kanazawa, 2020, Calcified Tissue International.

Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2015, Calcified Tissue International.

Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells

S. Yano, I. Kanazawa, T. Sugimoto, 2007, BMC Cell Biology.

Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes.

S. Yano, I. Kanazawa, T. Sugimoto, 2011, Bone.

Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus.

I. Kanazawa, M. Notsu, T. Sugimoto, 2016, Diabetes research and clinical practice.

Undercarboxylated osteocalcin is positively associated with free testosterone in male patients with type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, M. Yamauchi, 2013, Osteoporosis International.

DPP-4 Inhibitors Improve Liver Dysfunction in Type 2 Diabetes Mellitus

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2014, Medical science monitor : international medical journal of experimental and clinical research.

Active vitamin D possesses beneficial effects on the interaction between muscle and bone.

S. Yano, I. Kanazawa, Ken-ichiro Tanaka, 2014, Biochemical and biophysical research communications.

Higher Serum Uric Acid is a Risk Factor of Reduced Muscle Mass in Men with Type 2 Diabetes Mellitus.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2018, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Bone Mineral Density Is not Sensitive Enough to Assess the Risk of Vertebral Fractures in Type 2 Diabetic Women

T. Sugimoto, Masahiro Yamamoto, M. Yamauchi, 2007, Calcified Tissue International.

Metabolic Disorders, Osteoporosis and Fracture Risk in Asia: A Systematic Review.

R. Burge, T. Sugimoto, A. Brnabic, 2014, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

Baseline atherosclerosis parameter could assess the risk of bone loss during pioglitazone treatment in type 2 diabetes mellitus

S. Yano, I. Kanazawa, T. Sugimoto, 2010, Osteoporosis International.

Expression of parathyroid hormone‐related protein (PTHrP) in multiple myeloma

R. Kitazawa, S. Maeda, S. Kitazawa, 2002, Pathology international.

Osteoblast AMP-activated protein kinase regulates glucose metabolism and bone mass in adult mice.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, Biochemical and biophysical research communications.

Decreased Serum Insulin-like Growth Factor-I is a Risk Factor for Non-vertebral Fractures in Diabetic Postmenopausal Women

I. Kanazawa, T. Sugimoto, H. Miyake, 2017, Internal medicine.

T. Sugimoto, M. Yamauchi, 2015, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

[112th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: Emerging Comorbidities of Diabetes Mellitus: Osteoporosis].

T. Sugimoto, 2015, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2013, Biochemical and biophysical research communications.

Trial to predict malignancy of affected parathyroid glands in primary hyperparathyroidism.

K. Chihara, H. Sowa, T. Sugimoto, 2003, Endocrine journal.

Carboxyl-terminal parathyroid hormone fragments stimulate type-1 procollagen and insulin-like growth factor-binding protein-5 mRNA expression in osteoblastic UMR-106 cells.

K. Chihara, H. Kaji, T. Sugimoto, 1998, Endocrine journal.

Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity.

K. Chihara, M. Fukase, H. Kaji, 1994, Endocrinology.

Interleukin-1beta stimulates transendothelial mobilization of human peripheral blood mononuclear cells with a potential to differentiate into osteoclasts in the presence of osteoblasts.

R. Kitazawa, K. Chihara, H. Kaji, 2001, Endocrine journal.

Prospective short-term effects of glucocorticoid treatment on glucose and lipid metabolism in Japanese.

S. Kawano, T. Sugimoto, H. Kaji, 2010, Internal medicine.

Effect of adenosine and adenosine analogs on [14C]aminopyrine accumulation by rabbit parietal cells

H. Mutoh, A. Terano, T. Sugimoto, 1989, Digestive Diseases and Sciences.

The action of GH/IGF-I/IGFBP in osteoblasts and osteoclasts.

K. Chihara, T. Sugimoto, 1997, Hormone research.

IGF-I mediates the stimulatory effect of high calcium concentration on osteoblastic cell proliferation.

K. Chihara, M. Fukase, T. Sugimoto, 1994, The American journal of physiology.

Testosterone Increases Osteoprotegerin mRNA Expression in Mouse Osteoblast Cells

K. Chihara, H. Kaji, T. Sugimoto, 2004, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Effect of ascorbic acid deficiency on calcium metabolism in bone of rat with hereditary defect in L-ascorbic acid biosynthesis

T. Fujita, M. Fukase, T. Sugimoto, 1989, Journal of Bone and Mineral Metabolism.

Hypophosphatemia induced by intravenous administration of saccharated ferric oxide: another form of FGF23-related hypophosphatemia.

T. Fujita, T. Sugimoto, S. Fukumoto, 2009, Bone.

Constitutive c‐fos expression in osteoblastic MC3T3‐E1 cells stimulates osteoclast maturation and osteoclastic bone resorption

H. Kaji, K. Chihara, T. Sugimoto, 1994, Clinical and experimental immunology.

Constitutive expression of c-fos gene inhibits type 1 collagen synthesis in transfected osteoblasts.

T. Sugimoto, S. Shiozawa, T. Fujita, 1992, Biochemical and biophysical research communications.

Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Inhibition of the mevalonate pathway rescues the dexamethasone-induced suppression of the mineralization in osteoblasts via enhancing bone morphogenetic protein-2 signal.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, American journal of physiology. Endocrinology and metabolism.

Association of polymorphic alleles of the calcium‐sensing receptor gene with the clinical severity of primary hyperparathyroidism

K. Chihara, S. Yano, T. Sugimoto, 2001, Clinical endocrinology.

FAM5C is a soluble osteoblast differentiation factor linking muscle to bone.

S. Seino, Ken-ichiro Tanaka, T. Sugimoto, 2012, Biochemical and biophysical research communications.

Retinoic acid induces osteoclast-like cell formation by directly acting on hemopoietic blast cells and stimulates osteopontin mRNA expression in isolated osteoclasts.

K. Chihara, M. Fukase, H. Kaji, 1995, Life sciences.

Combined effects of dexamethasone and 1,25-dihydroxyvitamin D3 on parathyroid hormone secretion in cultured bovine parathyroid cells.

E. Slatopolsky, J. Morrissey, T. Sugimoto, 1989, Endocrinology.

Endothelin 1 hydrolysis by rat kidney membranes

K. Chihara, M. Fukase, T. Sugimoto, 1992, FEBS letters.

Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor

K. Chihara, T. Sugimoto, H. Kaji, 2001, FEBS letters.

Effect of ipriflavone on bone mineral content in osteoporotic patients

R. Kitazawa, T. Fujita, M. Fukase, 2006, Journal of Bone and Mineral Metabolism.

Vitamin D status affects osteopenia in postmenopausal patients with primary hyperparathyroidism.

K. Chihara, T. Sugimoto, H. Kaji, 2008, Endocrine journal.

A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.

M. Fukunaga, Toshitaka Nakamura, Y. Tanigawara, 2005, The Journal of clinical endocrinology and metabolism.

Late-onset isolated adrenocorticotropic hormone deficiency caused by nivolumab: a case report

Ayumu Takeno, I. Kanazawa, T. Sugimoto, 2019, BMC Endocrine Disorders.

Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases in Japan: prevalence, biochemical data and treatment.

I. Endo, Toshio Matsumoto, K. Ozono, 2015, Endocrine journal.

Osteosarcoma in a pregnant patient with McCune-Albright syndrome.

R. Kitazawa, S. Yano, R. Maruyama, 2009, Bone.

Glucose uptake inhibition decreases expressions of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteocalcin in osteocytic MLO-Y4-A2 cells.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, American journal of physiology. Endocrinology and metabolism.

Lack of cooperation between physicians and dentists during osteoporosis treatment may increase fractures and osteonecrosis of the jaw

A. Taguchi, T. Sugimoto, M. Shiraki, 2016, Current medical research and opinion.

Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw

T. Yoneda, A. Taguchi, T. Shibahara, 2016, Journal of Bone and Mineral Metabolism.

MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy

S. Yano, T. Tsukamoto, T. Sugimoto, 2007, Clinical and Experimental Nephrology.

Hypercalcemia associated with eosinophilic myocarditis in a patient undergoing maintenance hemodialysis.

K. Tanabe, S. Yano, Ken-ichiro Tanaka, 2012, Internal medicine.

Effects of high concentrations of glucose on PTH secretion in parathyroid cells.

E. Slatopolsky, J. Morrissey, T. Sugimoto, 1990, Kidney international.

Pathogenesis and diagnostic criteria for rickets and osteomalacia—proposal by an expert panel supported by the Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research, and the Japan Endocrine Society

Toshio Matsumoto, K. Ozono, Y. Takeuchi, 2015, Journal of Bone and Mineral Metabolism.

A Case of Primary Hyperparathyroidism with Marked Pancreatic Calcification

T. Fujita, Y. Yoshimoto, M. Fukase, 1984 .

Acute-onset hypomagnesemia-induced hypocalcemia caused by the refractoriness of bones and renal tubules to parathyroid hormone

S. Yano, T. Sugimoto, Toru Yamaguchi, 2011, Journal of Bone and Mineral Metabolism.

Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism.

M. Inaba, Y. Nishizawa, Y. Imanishi, 2006, European journal of endocrinology.

Vitamin D Receptor Genotype Bone Loss in Japanese Patients Hyperparathyroidism Is Associated with Cort with Primary ica

K. Chihara, T. Sugimoto, Tatsuya Kobayashi, 2006 .

Parathyroid hormone gene polymorphisms in primary hyperparathyroidism

K. Chihara, T. Sugimoto, T. Kobayashi, 1999, Clinical endocrinology.

Vitamin D receptor genotype is associated with cortical bone loss in Japanese patients with primary hyperparathyroidism.

K. Chihara, T. Sugimoto, T. Kobayashi, 1998, Endocrine journal.

Rosuvastatin increased serum osteocalcin levels independent of its serum cholesterol-lowering effect in patients with type 2 diabetes and hypercholesterolemia.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2009, Internal medicine.

Short title: Osteocalcin and Atherosclerosis

S. Yano, I. Kanazawa, T. Sugimoto, 2008 .

Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression.

S. Yano, I. Kanazawa, T. Sugimoto, 2010, Endocrine journal.

Statin Suppresses Apoptosis in Osteoblastic Cells: Role of Transforming Growth Factor-β-Smad3 Pathway

K. Chihara, H. Sowa, T. Sugimoto, 2008, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Osteoblast AMP-Activated Protein Kinase Regulates Postnatal Skeletal Development in Male Mice

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, Endocrinology.

Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2011, Metabolism: clinical and experimental.

Cross talk of dual‐signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells

K. Chihara, M. Fukase, T. Sugimoto, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH‐related peptide in osteoblastic osteosarcoma cells: Role of Na+/H+ exchange

M. Fukase, T. Fujita, T. Sugimoto, 1992, Journal of cellular physiology.

The direct involvement of cAMP-dependent protein kinase in the regulation of collagen synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblast-like osteosarcoma cells (UMR-106).

K. Chihara, M. Fukase, T. Sugimoto, 1992, Biochemical and biophysical research communications.

The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone.

M. Fukase, H. Kaji, T. Sugimoto, 1992, Biochemical and biophysical research communications.

The activation of cAMP-dependent protein kinase is directly linked to the inhibition of osteoblast proliferation (UMR-106) by parathyroid hormone-related protein.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Biochemical and biophysical research communications.

The activation of cAMP-dependent protein kinase is directly linked to the regulation of osteoblast proliferation (UMR-106) by parathyroid hormone.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Biochemical and biophysical research communications.

Pathogenesis and diagnostic criteria for rickets and osteomalacia - proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society.

Toshio Matsumoto, K. Ozono, Y. Takeuchi, 2015, Endocrine journal.

Activation of AMP-activated protein kinase decreases receptor activator of NF-κB ligand expression and increases sclerostin expression by inhibiting the mevalonate pathway in osteocytic MLO-Y4 cells.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2016, Biochemical and biophysical research communications.

Comparisons of serum sclerostin levels among patients with postmenopausal osteoporosis, primary hyperparathyroidism and osteomalacia.

S. Seino, Y. Imanishi, T. Sugimoto, 2011, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: potential therapeutic targets for glucocorticoid-induced osteoporosis.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Biochemical and biophysical research communications.

Sequential therapy with once-weekly teriparatide injection followed by alendronate versus monotherapy with alendronate alone in patients at high risk of osteoporotic fracture: final results of the Japanese Osteoporosis Intervention Trial-05

T. Sone, Toshitaka Nakamura, Shiro Tanaka, 2022, Osteoporosis International.

Inhibition of adenosine monophosphate-activated protein kinase suppresses bone morphogenetic protein-2-induced mineralization of osteoblasts via Smad-independent mechanisms.

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, Endocrine journal.

Association of Urinary Pentosidine Levels With the Risk of Fractures in Patients With Severe Osteoporosis: The Japanese Osteoporosis Intervention Trial‐05 (JOINT‐05)

T. Sone, Toshitaka Nakamura, Shiro Tanaka, 2022, JBMR plus.

A case of magnesium deficiency associated with insufficient parathyroid hormone action and severe osteoporosis.

S. Yano, I. Kanazawa, T. Sugimoto, 2007, Endocrine journal.

Association of n-3 Polyunsaturated Fatty Acid Intake with Bone Mineral Density in Postmenopausal Women

T. Sugimoto, Toru Yamaguchi, M. Yamauchi, 2013, Calcified Tissue International.

Growth Hormone in Bone Remodeling

K. Chihara, T. Sugimoto, 1997 .

Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene

R. Kitazawa, S. Kitazawa, K. Chihara, 2006, Endocrine.

Changes in quality of life in patients with postmenopausal osteoporosis receiving weekly bisphosphonate treatment: a 2-year multicenter study in Japan

Toshitaka Nakamura, H. Hagino, T. Sugimoto, 2019, Journal of Bone and Mineral Metabolism.

Clinical and biochemical presentation of primary hyperparathyroidism in Kansai district of Japan.

K. Chihara, T. Sugimoto, T. Kobayashi, 1997, Endocrine journal.

Visceral fat accumulation is associated with increased plasma sphingosine-1-phosphate levels in type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Sayuri Tanaka, 2018, Diabetes research and clinical practice.

Low density lipoprotein-cholesterol levels affect vertebral fracture risk in female patients with primary hyperparathyroidism.

T. Sugimoto, T. Sugimoto, H. Kaji, 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Age-Dependent Changes in Bone Mineral Density and Body Composition in Middle-aged and Elderly Women: Role of Growth Hormone, Insulin-like Growth Factor-I and Insulin-like Growth Factor-binding Protein-3

K. Chihara, T. Sugimoto, 1996 .

Phloretin Promotes Adipogenesis via Mitogen-Activated Protein Kinase Pathways in Mouse Marrow Stromal ST2 Cells

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, International journal of molecular sciences.

Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas.

R. Kitazawa, S. Maeda, S. Kitazawa, 2003, European journal of endocrinology.

Statins modulate the levels of osteoprotegerin/receptor activator of NFkappaB ligand mRNA in mouse bone-cell cultures.

K. Chihara, T. Sugimoto, M. Kanatani, 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Vitamin D-mediated hypercalcemia in multicentric Castleman’s disease

S. Yano, R. Maruyama, I. Kanazawa, 2015, Journal of Bone and Mineral Metabolism.

Enzymological and cellular mechanisms of parathyroid hormone degradation by the kidney

K. Chihara, M. Fukase, T. Sugimoto, 1994, Journal of Bone and Mineral Metabolism.

Meprin is predominantly involved in parathyroid hormone degradation by the microvillar membranes of rat kidney.

K. Chihara, N. Katunuma, M. Fukase, 1994, Life sciences.

Involvement ofc-fos gene in the regulation of osteoblast proliferation and osteoclast differentiation by parathyroid hormone and parathyroid hormone-related protein

K. Chihara, M. Fukase, T. Sugimoto, 1994, Journal of Bone and Mineral Metabolism.

Stimulatory effect of carboxyl-terminal parathyroid hormone fragments on osteoclast-like cell formation and osteoclastic activity

K. Chihara, M. Fukase, T. Sugimoto, 1994, Journal of Bone and Mineral Metabolism.

Estrogen blocks parathyroid hormone (PTH)-stimulated osteoclast-like cell formation by selectively affecting PTH-responsive cyclic adenosine monophosphate pathway.

K. Chihara, H. Kaji, T. Sugimoto, 1996, Endocrinology.

Carboxyl-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation.

K. Chihara, M. Fukase, H. Kaji, 1995, Endocrinology.

Second messenger signaling of c‐fos gene induction by parathyroid hormone (PTH) and PTH‐related peptide in osteoblastic osteosarcoma cells: Its role in osteoblast proliferation and osteoclast‐like cell formation

K. Chihara, M. Fukase, T. Sugimoto, 1994, Journal of cellular physiology.

Cross‐talk of parathyroid hormone‐responsive dual signal transduction systems in osteoblastic osteosarcoma cells: Its role in PTH‐induced homologous desensitization of intracellular calcium response

K. Chihara, M. Fukase, T. Sugimoto, 1994, Journal of cellular physiology.

Second messenger signaling of PTH- and PTHRP-stimulated osteoclast-like cell formation from hemopoietic blast cells.

K. Chihara, M. Fukase, H. Kaji, 1993, The American journal of physiology.

Interaction of parathyroid hormone‐related peptide‐responsive dual signal transduction systems in osteoblastic osteosarcoma cells: Role in PTHrP‐induced homologous desensitization

K. Chihara, M. Fukase, T. Sugimoto, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Regulation of cytosolic pH in bovine parathyroid cells: effect of fluoride.

R. Civitelli, E. Slatopolsky, J. Morrissey, 1989, Endocrinology.

Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus.

I. Kanazawa, M. Yokomoto-Umakoshi, T. Sugimoto, 2017, Endocrine journal.

Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes.

S. Yano, T. Sugimoto, Toru Yamaguchi, 2008, The Journal of clinical endocrinology and metabolism.

Role of increase in intracellular calcium in PTH-induced homologous desensitization in UMR-106 cells.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Biochemical and biophysical research communications.

Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells.

R. Kitazawa, S. Seino, T. Komori, 2012, Bone.

Insulin-Like Growth Factor-I Protects Against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2019, Calcified Tissue International.

Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.

K. Chihara, M. Fukase, T. Sugimoto, 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Role of Dual Signal Transduction Systems in the Stimulation of Bone Resorption by Parathyroid Hormone-Related Peptide

K. Chihara, M. Fukase, H. Kaji, 1993, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

The Association Between Osteocalcin and Chronic Inflammation in Patients with Type 2 Diabetes Mellitus

I. Kanazawa, T. Sugimoto, Sayuri Tanaka, 2018, Calcified Tissue International.

Sibling Cases of Multiple Endocrine Neoplasia Type 1 (MEN1) Appearing in a Family with Epilepsy

I. Kanazawa, T. Sugimoto, M. Sohmiya, 2006 .

Possible involvement of vitamin D and calcium-sensing receptors in the regulation of parathyroid cell proliferation in a patient under hemodialysis

R. Kitazawa, S. Maeda, S. Kitazawa, 2000 .

Effect of 1,25-dihydroxyvitamin D3 on cytosolic calcium in dispersed parathyroid cells.

E. Slatopolsky, J. Morrissey, T. Sugimoto, 1988, Kidney international.

Low skeletal muscle mass is associated with the risk of all-cause mortality in patients with type 2 diabetes mellitus

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2019, Therapeutic advances in endocrinology and metabolism.

Treatment of osteopenia secondary to primary hyperparathyroidism.

K. Chihara, T. Sugimoto, T. Yamaguchi, 2000, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Renal Phosphate Reabsorption is Correlated with the Increase in Lumbar Bone Mineral Density in Patients Receiving Once-Weekly Teriparatide

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2015, Calcified Tissue International.

Bisphosphonate-related osteonecrosis of the jaw: position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral

T. Yoneda, A. Taguchi, H. Hagino, 2010, Journal of Bone and Mineral Metabolism.

Improved peripheral cortical bone geometry after surgical treatment of primary hyperparathyroidism in postmenopausal women.

T. Sugimoto, M. Yamauchi, H. Kaji, 2008, The Journal of clinical endocrinology and metabolism.

Association of Polymorphic Alleles of the Calcium-Sensing Receptor Gene with Parathyroid Hormone Secretion in Hemodialysis Patients

K. Chihara, S. Yano, T. Sugimoto, 2000, Nephron.

Familial Hypocalciuric Hypercalcemia Caused by an R648stop Mutation in the Calcium‐Sensing Receptor Gene

E. Brown, K. Chihara, S. Yano, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prediction of bone mass change after parathyroidectomy in patients with primary hyperparathyroidism.

K. Chihara, T. Sugimoto, Toru Yamaguchi, 2000, The Journal of clinical endocrinology and metabolism.

Efficacy and Safety of Risedronate in Osteoporosis Subjects with Comorbid Diabetes, Hypertension, and/or Dyslipidemia: A Post Hoc Analysis of Phase III Trials Conducted in Japan

Y. Nishizawa, T. Sugimoto, R. Okazaki, 2015, Calcified Tissue International.

Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2015, Calcified Tissue International.

A case of primary hyperparathyroidism with marked changes in bone mineral density and geometry after parathyroidectomy

K. Chihara, T. Sugimoto, H. Kaji, 2006, Journal of Bone and Mineral Metabolism.

Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts.

K. Chihara, M. Fukase, H. Kaji, 1994, Endocrinology.

Acromegaly associated with monoclonal gammopathy of undetermined significance (MGUS).

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2006, Endocrine journal.

Age‐ and gender‐related changes in body composition in Japanese subjects

M. Fukase, T. Fujita, T. Sugimoto, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The combination of high glucose and advanced glycation end-products (AGEs) inhibits the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced increase in the receptor for AGEs.

S. Yano, T. Sugimoto, Toru Yamaguchi, 2007, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation.

K. Chihara, H. Kaji, T. Sugimoto, 1996, Endocrinology.

Effect of parathyroidectomy on bone mineral density in hemodialysis patients with secondary hyperparathyroidism: possible usefulness of preoperative determination of parathyroid hormone level for prediction of bone regain.

K. Chihara, S. Yano, H. Kaji, 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Osteoporosis and vertebral fracture are associated with deterioration of activities of daily living and quality of life in patients with type 2 diabetes mellitus

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, Journal of Bone and Mineral Metabolism.

Association of Bone Mineral Density, Bone Turnover Markers, and Vertebral Fractures with All-Cause Mortality in Type 2 Diabetes Mellitus

I. Kanazawa, T. Sugimoto, H. Miyake, 2017, Calcified Tissue International.

Effect of 17 β -estradiol on the proliferation of osteoblastic MC3T3-E1 cells via human monocytes

M. Fukase, T. Fujita, T. Sugimoto, 1991 .

BMP/Wnt antagonists are upregulated by dexamethasone in osteoblasts and reversed by alendronate and PTH: Potential therapeutic targets for glucocorticoid-induced osteoporosis

S. Yano, I. Kanazawa, T. Sugimoto, 2009 .

Smad7 inhibits differentiation and mineralization of mouse osteoblastic cells.

S. Seino, G. Hendy, T. Sugimoto, 2012, Endocrine journal.

Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells.

K. Chihara, T. Sugimoto, Toru Yamaguchi, 2005, American journal of physiology. Endocrinology and metabolism.

The Calcium-sensing Receptor (CaR) is Involved in Strontium Ranelate-induced Osteoblast Differentiation and Mineralization

S. Yano, T. Sugimoto, Toru Yamaguchi, 2010, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[Calcium homeostasis and diabetes mellitus].

T. Sugimoto, Toru Yamaguchi, 2006, Clinical calcium.

Bazedoxifene Ameliorates Homocysteine-Induced Apoptosis via NADPH Oxidase-Interleukin 1β and 6 Pathway in Osteocyte-like Cells

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2019, Calcified Tissue International.

Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women.

K. Chihara, T. Sugimoto, Tohru Yamaguchi, 2002, Endocrine journal.

Effect of 1,25-dihydroxyvitamin D3 on phospholipid metabolism in cultured bovine parathyroid cells.

E. Slatopolsky, J. Morrissey, T. Sugimoto, 1988, Endocrinology.

Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture.

M. Fukunaga, E. Itoi, Y. Ohashi, 2014, Clinical therapeutics.

Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage*

Toru Yamaguchi, Kohei Miyazono, Hiroshi Kaji, 2003, Journal of Biological Chemistry.

Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women.

T. Sugimoto, Toru Yamaguchi, M. Yamauchi, 2010, Clinical nutrition.

Plasma lipids and osteoporosis in postmenopausal women.

Toru Yamaguchi, Kazuo Chihara, K. Chihara, 2002, Endocrine journal.

Asian variant of intravascular large B cell lymphoma causes patients to frequently develop the syndrome of inappropriate antidiuretic hormone secretion

T. Sugimoto, Masahiro Yamamoto, M. Inoue, 2011, Annals of Hematology.

Skeletal responsiveness to parathyroid hormone in pseudohypoparathyroidism.

K. Chihara, H. Kaji, T. Sugimoto, 2001, European journal of endocrinology.

Association of osteoglycin and FAM5C with bone turnover markers, bone mineral density, and vertebral fractures in postmenopausal women with type 2 diabetes mellitus.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2017, Bone.

Graves’ disease and vertebral fracture: Possible pathogenic link in postmenopausal women

M. Notsu, T. Sugimoto, M. Yamauchi, 2020, Clinical endocrinology.

Altered parathyroid hormone- or calcitonin-stimulated adenosine 3′,5′-monophosphate release by isolated perfused bone from glucocorticoid-treated rats

T. Fujita, M. Fukase, T. Sugimoto, 1986, Calcified Tissue International.

The Presence and Severity of Vertebral Fractures is Associated with the Presence of Esophageal Hiatal Hernia in Postmenopausal Women

K. Chihara, S. Yano, T. Sugimoto, 2002, Osteoporosis International.

Advanced Glycation End Products (AGEs), but not High Glucose, Inhibit the Osteoblastic Differentiation of Mouse Stromal ST2 Cells Through the Suppression of Osterix Expression, and Inhibit Cell Growth and Increasing Cell Apoptosis

S. Yano, Ken-ichiro Tanaka, M. Notsu, 2012, Calcified Tissue International.

Serum Osteocalcin/Bone-Specific Alkaline Phosphatase Ratio Is a Predictor for the Presence of Vertebral Fractures in Men with Type 2 Diabetes

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Calcified Tissue International.

Diagnostic criteria for primary osteoporosis: year 2012 revision

T. Tomomitsu, T. Sone, M. Fukunaga, 2013, Journal of Bone and Mineral Metabolism.

Marked and sustained increase in bone mineral density after parathyroidectomy in patients with primary hyperparathyroidism; a six‐year longitudinal study with or without parathyroidectomy in a Japanese population

K. Chihara, H. Sowa, T. Sugimoto, 2004, Clinical endocrinology.

[Progress in diagnosis and therapy: Hypercalcemia due to primary hyperparathyroidism].

T. Sugimoto, 2007, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

Evaluation of changes in bone density and biochemical parameters after parathyroidectomy in primary hyperparathyroidism.

K. Chihara, T. Sugimoto, T. Yamaguchi, 2000, Endocrine journal.

Phorbol ester induces desensitization of PTH-stimulated cyclic AMP production by decreasing the PTH receptor binding in UMR-106 cells.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Biochemical and biophysical research communications.

A pregnant woman with an autonomously functioning thyroid nodule: a case report

M. Notsu, T. Sugimoto, M. Yamauchi, 2020, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Cloning of mouse diastrophic dysplasia sulfate transporter gene induced during osteoblast differentiation by bone morphogenetic protein-2.

K. Chihara, M. Fukase, K. Saijoh, 1997, Gene.

Causes and differential diagnosis of hypocalcemia--recommendation proposed by expert panel supported by ministry of health, labour and welfare, Japan.

I. Endo, Hiroyuki Tanaka, Toshio Matsumoto, 2008, Endocrine journal.

Menin Inactivation Leads to Loss of Transforming Growth Factor β Inhibition of Parathyroid Cell Proliferation and Parathyroid Hormone Secretion

R. Kitazawa, S. Kitazawa, K. Chihara, 2004, Cancer Research.

Primary Aldosteronism as a Risk Factor for Vertebral Fracture

M. Notsu, T. Sugimoto, Masahiro Yamamoto, 2017, The Journal of clinical endocrinology and metabolism.

A randomized, double-blind, placebo-controlled study of once weekly elcatonin in primary postmenopausal osteoporosis

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2018, Current medical research and opinion.

Role of Osteoglycin in the Linkage between Muscle and Bone*

S. Seino, Ken-ichiro Tanaka, T. Sugimoto, 2012, The Journal of Biological Chemistry.

Involvement of dual signal transduction systems in the stimulation of osteoclast-like cell formation by parathyroid hormone and parathyroid hormone-related peptide.

K. Chihara, M. Fukase, H. Kaji, 1993, Biochemical and biophysical research communications.

Menin Suppresses Osteoblast Differentiation by Antagonizing the AP-1 Factor, JunD*

K. Chihara, G. Hendy, H. Sowa, 2005, Journal of Biological Chemistry.

Relationships between dimethylarginine and the presence of vertebral fractures in type 2 diabetes mellitus

T. Nabika, S. Yano, I. Kanazawa, 2010, Clinical endocrinology.

Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary

Naoto Endo, Hajime Orimo, Takao Suzuki, 2012, Archives of Osteoporosis.

Serum DHEA-S level is associated with the presence of atherosclerosis in postmenopausal women with type 2 diabetes mellitus.

S. Yano, I. Kanazawa, T. Sugimoto, 2008, Endocrine journal.

Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk.

T. Sone, M. Fukunaga, H. Yoshikawa, 2012, The Journal of clinical endocrinology and metabolism.

Clinical Trials Express: Fracture Risk Reduction With Denosumab in Japanese Postmenopausal Women and Men With Osteoporosis: Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

Sakae Tanaka, T. Sone, M. Fukunaga, 2014, The Journal of clinical endocrinology and metabolism.

Successful reduction of ACTH secretion in a case of intractable Cushing's disease with pituitary Crooke's cell adenoma by combined modality therapy including temozolomide.

S. Yamada, Ayumu Takeno, I. Kanazawa, 2019, Endocrine journal.

Activations of ERK1/2 and JNK by Transforming Growth Factor β Negatively Regulate Smad3-induced Alkaline Phosphatase Activity and Mineralization in Mouse Osteoblastic Cells*

K. Chihara, H. Sowa, T. Sugimoto, 2002, The Journal of Biological Chemistry.

Elevated sclerostin levels are associated with vertebral fractures in patients with type 2 diabetes mellitus.

T. Sugimoto, Masahiro Yamamoto, M. Yamauchi, 2013, The Journal of clinical endocrinology and metabolism.

Partial improvement of anterior pituitary deficiency following steroid treatment in a patient with neurosarcoidosis accompanied by central diabetes insipidus.

Ken-ichiro Tanaka, T. Sugimoto, Toru Yamaguchi, 2012, Internal medicine.

Relationships between serum adiponectin levels versus bone mineral density, bone metabolic markers, and vertebral fractures in type 2 diabetes mellitus.

S. Yano, I. Kanazawa, T. Sugimoto, 2008, European journal of endocrinology.

Management manual for cancer treatment-induced bone loss (CTIBL): position statement of the JSBMR

T. Yoneda, T. Taguchi, S. Horie, 2020, Journal of Bone and Mineral Metabolism.

Calcitonin directly acts on mouse osteoblastic MC3T3-E1 cells to stimulate mRNA expression of c-fos, insulin-like growth factor-1 and osteoblastic phenotypes (type 1 collagen and osteocalcin).

K. Chihara, M. Fukase, K. Saijoh, 1994, Biochemical and biophysical research communications.

Internal Tandem Duplication Mutations in FLT3 Gene Augment Chemotaxis to Cxcl12 Protein by Blocking the Down-regulation of the Rho-associated Kinase via the Cxcl12/Cxcr4 Signaling Axis*

T. Taketani, T. Sugimoto, S. Fukuda, 2014, The Journal of Biological Chemistry.

Risk Factors for Hip Fracture in Hemodialysis Patients

K. Chihara, S. Yano, T. Sugimoto, 2002, American Journal of Nephrology.

A case of membranous nephropathy associated with chronic sinusitis.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Journal of nephrology.

Impaired parathyroid hormone-stimulated adenosine 3',5'-monophosphate release by isolated perfused bones obtained from vitamin D-deficient rats.

Y. Yoshimoto, M. Fukase, T. Fujita, 1986, Endocrinology.

Bone metabolism and fracture risk in type 2 diabetes mellitus.

T. Sugimoto, Toru Yamaguchi, 2012, BoneKEy reports.

Osteocalcin secretion Osteoporosis Fracture Osteocalcin Adiponectin Osteocalcin Adiponectin secretion Fat accumulation Insulin resistance Diabetes mellitus Atherosclerosis Cardiovascular disease Adiponectin

T. Sugimoto, Toru Yamaguchi, 2012 .

Bone metabolism and fracture risk in type 2 diabetes mellitus [Review].

T. Sugimoto, Toru Yamaguchi, 2011, Endocrine journal.

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2009, Diabetes Care.

Diabetic Patients Have an Increased Risk of Vertebral Fractures Independent of BMD or Diabetic Complications

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Effects of ascorbic acid on alkaline phosphatase activity and hormone responsiveness in the osteoblastic osteosarcoma cell line UMR-106

T. Fujita, M. Fukase, T. Sugimoto, 1986, Calcified Tissue International.

Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes.

S. Yano, I. Kanazawa, T. Sugimoto, 2009, Bone.

Functional giant parathyroid cyst with high concentration of CA19-9 in cystic fluid.

R. Kitazawa, K. Chihara, H. Sowa, 2003, Endocrine journal.

Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2016, Diabetes research and clinical practice.

Overweight and underweight are risk factors for vertebral fractures in patients with type 2 diabetes mellitus

Ayumu Takeno, I. Kanazawa, Ken-ichiro Tanaka, 2018, Journal of Bone and Mineral Metabolism.

Involvement of the Osteoinductive Factors, Tmem119 and BMP-2, and the ER Stress Response PERK–eIF2α–ATF4 Pathway in the Commitment of Myoblastic into Osteoblastic Cells

G. Hendy, I. Kanazawa, Ken-ichiro Tanaka, 2014, Calcified Tissue International.

Increased low-density lipoprotein cholesterol level is associated with non-vertebral fractures in postmenopausal women

Ken-ichiro Tanaka, T. Sugimoto, Toru Yamaguchi, 2015, Endocrine.

Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism.

K. Chihara, T. Sugimoto, T. Kobayashi, 2000, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2009, Osteoporosis International.

Which Is a Better Skeletal Muscle Mass Index for the Evaluation of Physical Abilities: The Present Height or Maximum Height?

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2020, Internal medicine.

Additive effects of parathyroid hormone and calcitonin on adenosine 3',5'-monophosphate release in newly established perfusion system of rat femur.

Y. Yoshimoto, M. Fukase, T. Fujita, 1985, Endocrinology.

Primary pulmonary squamous cell carcinoma associated with elevated IL-6, leukocytosis, hypercalcemia, phagocytosis, reactive lymphadenopathy and glomerular mesangial cell proliferation via the production of PTH-rP and G-CSF.

T. Sugimoto, Toru Yamaguchi, Y. Yamane, 2008, Internal medicine.

Biologic activities of parathyroid hormone (1-34) and parathyroid hormone-related peptide (1-34) in isolated perfused rat femur.

E. Slatopolsky, T. Sugimoto, K. Martin, 1992, The Journal of laboratory and clinical medicine.

Discordance between Prevalent Vertebral Fracture and Vertebral Strength Estimated by the Finite Element Method Based on Quantitative Computed Tomography in Patients with Type 2 Diabetes Mellitus

T. Sugimoto, Masahiro Yamamoto, Nobuaki Kiyohara, 2015, PloS one.

Role of Parathyroid Hormone in Bone Fragility of Postmenopausal Women with Vitamin D Insufficiency

T. Sugimoto, Toru Yamaguchi, M. Yamauchi, 2011, Calcified Tissue International.

Relationship Between Changes in Serum Levels of Intact Parathyroid Hormone and Sclerostin After a Single Dose of Zoledronic Acid: Results of a Phase 1 Pharmacokinetic Study

Toshitaka Nakamura, T. Sugimoto, M. Shiraki, 2021, Calcified tissue international.

Efficacy of denosumab co-administered with vitamin D and Ca by baseline vitamin D status

Toshitaka Nakamura, Makiko Kobayashi, Toshio Matsumoto, 2020, Journal of Bone and Mineral Metabolism.

Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis

S. Yano, Y. Kinoshita, T. Sugimoto, 2011, Geriatrics & gerontology international.

Design of a pragmatic approach to evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures

M. Fukunaga, E. Itoi, Y. Ohashi, 2011, Journal of Bone and Mineral Metabolism.

Multiple vertebral fractures are associated with refractory reflux esophagitis in postmenopausal women

K. Chihara, T. Sugimoto, Toru Yamaguchi, 2004, Journal of Bone and Mineral Metabolism.

Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus

T. Nabika, S. Yano, I. Kanazawa, 2011, Clinical endocrinology.

Fracture risk is increased by the complication of hypertension and treatment with calcium channel blockers in postmenopausal women with type 2 diabetes

S. Yano, Ken-ichiro Tanaka, T. Sugimoto, 2013, Journal of Bone and Mineral Metabolism.

Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells.

Toru Yamaguchi, I. Kanazawa, Ken-ichiro Tanaka, 2015, Biochemical and biophysical research communications.

Study of twice-weekly injections of Teriparatide by comparing efficacy with once-weekly injections in osteoporosis patients: the TWICE study

M. Ito, T. Sone, M. Fukunaga, 2019, Osteoporosis International.

Effects of Serum from a Fibrodysplasia Ossificans Progressiva Patient on Osteoblastic Cells

T. Sugimoto, A. Kawara, T. Katagiri, 2012 .

Evaluation of Changes in Parameters after Parathy Hyperparathyroidism Bone Density roidectomy in and Bioc Primary h emica

K. Chihara, T. Sugimoto, Toru, 2006 .

S. Yano, Ken-ichiro Tanaka, M. Notsu, 2012, Calcified Tissue International.

High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation

T. Oono, Ayumu Takeno, I. Kanazawa, 2020, Diabetology International.

Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus

T. Sugimoto, Masahiro Yamamoto, M. Yamauchi, 2019, PloS one.

A scoring assessment tool for the risk of vertebral fractures in patients with type 2 diabetes mellitus.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2019, Bone.

Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2018, Osteoporosis International.

The mechanism of bone fragility in diabetes mellitus

I. Kanazawa, T. Sugimoto, 2017 .

1,25-Dihydroxyvitamin D3 control of free cytosolic Ca2+ in the kidney

T. Fujita, M. Fukase, T. Sugimoto, 1990, Journal of Bone and Mineral Metabolism.

Intestinal Absorption of Phosphate

K. Chihara, T. Sugimoto, T. Yamaguchi, 2002 .

Vertebral fracture risk after once-weekly teriparatide injections: follow-up study of Teriparatide Once-Weekly Efficacy Research (TOWER) trial

T. Sone, M. Fukunaga, Toshitaka Nakamura, 2013, Current medical research and opinion.

Serum dipeptidyl peptidase‐4 is associated with multiple vertebral fractures in type 2 diabetes mellitus

I. Kanazawa, M. Notsu, T. Sugimoto, 2016, Clinical endocrinology.

Acute suppurative thyroiditis caused by thyroid papillary carcinoma in the right thyroid lobe of a healthy woman

R. Maruyama, M. Notsu, T. Sugimoto, 2018, Thyroid Research.

Albuminuria Increases All-Cause Mortality in Japanese Patients with Type 2 Diabetes Mellitus

I. Kanazawa, T. Sugimoto, H. Miyake, 2018, Journal of clinical medicine.

Efficacy and safety of once-monthly risedronate in osteoporosis subjects with mild-to-moderate chronic kidney disease: a post hoc subgroup analysis of a phase III trial in Japan

T. Shigematsu, T. Sugimoto, D. Inoue, 2018, Journal of Bone and Mineral Metabolism.

Three-year denosumab treatment in postmenopausal Japanese women and men with osteoporosis: results from a 1-year open-label extension of the Denosumab Fracture Intervention Randomized Placebo Controlled Trial (DIRECT)

Sakae Tanaka, M. Ito, T. Sone, 2015, Osteoporosis International.

Direct involvement of cAMP-dependent protein kinase in the regulation of alkaline phosphatase activity by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic UMR-106 cells.

K. Chihara, M. Fukase, T. Sugimoto, 1994, Biochemical and biophysical research communications.

Acute Phase Reactions After Intravenous Infusion of Zoledronic Acid in Japanese Patients with Osteoporosis: Sub-analyses of the Phase III ZONE Study

Toshitaka Nakamura, Y. Takeuchi, T. Sugimoto, 2021, Calcified Tissue International.

Relationship Between Bone Mineral Density and Risk of Vertebral Fractures with Denosumab Treatment in Japanese Postmenopausal Women and Men with Osteoporosis

Toshitaka Nakamura, Toshio Matsumoto, S. Matsui, 2020, Calcified Tissue International.

Changes in bone mineral density, bone turnover markers, and vertebral fracture risk reduction with once weekly teriparatide

Toshitaka Nakamura, Shiro Tanaka, T. Sugimoto, 2014, Current medical research and opinion.

Quantitative ultrasound and vertebral fractures in patients with type 2 diabetes

S. Yano, Eri Nitta, I. Kanazawa, 2011, Journal of Bone and Mineral Metabolism.

Papillary thyroid carcinoma is a risk factor for severe osteoporosis

M. Notsu, T. Sugimoto, M. Yamauchi, 2019, Journal of Bone and Mineral Metabolism.

Design of a randomized trial of teriparatide followed by alendronate: Japanese Osteoporosis Intervention Trial-05 (JOINT-05)

Shiro Tanaka, H. Hagino, T. Sugimoto, 2020, Journal of Bone and Mineral Metabolism.

Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, T. Yamaguchi, 2011, Osteoporosis International.

Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus

S. Yano, I. Kanazawa, T. Sugimoto, 2007, Osteoporosis International.

Dose–response study of denosumab on bone mineral density and bone turnover markers in Japanese postmenopausal women with osteoporosis

Toshitaka Nakamura, T. Sugimoto, M. Shiraki, 2012, Osteoporosis International.

The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure.

S. Yano, I. Kanazawa, T. Sugimoto, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Advanced Glycation End Products-induced Vascular Calcification is Mediated by Oxidative Stress: Functional Roles of NAD(P)H-oxidase

S. Yano, T. Sugimoto, M. Morita, 2012, Hormone and Metabolic Research.

Protein kinase C is involved in PTH-induced homologous desensitization by directly affecting PTH receptor in the osteoblastic osteosarcoma cells.

M. Fukase, T. Fujita, T. Sugimoto, 1991, Endocrinology.

Purification of meprin from human kidney and its role in parathyroid hormone degradation.

K. Chihara, M. Fukase, H. Kido, 1994, Biological chemistry Hoppe-Seyler.

Nerve conduction velocity is negatively associated with intima-media thickness and brachial-ankle pulse wave velocity in men with type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, Sayuri Tanaka, 2018, PloS one.

Defective O-glycosylation due to a novel homozygous S129P mutation is associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis.

H. Jüppner, T. Sugimoto, A. Miyauchi, 2009, The Journal of clinical endocrinology and metabolism.

Phase II/III, randomized, double-blind, parallel-group study of monthly delayed-release versus daily immediate-release risedronate tablets in Japanese patients with involutional osteoporosis

Sakae Tanaka, T. Sone, H. Hagino, 2019, Journal of Bone and Mineral Metabolism.

Successful treatment of hyperphosphatemic tumoral calcinosis with long-term acetazolamide.

K. Chihara, M. Fukase, T. Fujita, 1995, Bone.

Treatment responses with once-weekly teriparatide therapy for osteoporosis

T. Sugimoto, M. Shiraki, T. Nakamura, 2016, Osteoporosis International.

FGF-23 is a circulating factor that is elevated in oncogenic osteomalacia and X-linked hypophosphatemic rickets.

K. White, M. Econs, J. Lavigne, 2002 .

Effects of bazedoxifene on bone mineral density, bone turnover, and safety in postmenopausal japanese women with osteoporosis

A. Chines, T. Sugimoto, G. Constantine, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Prehypertension increases the risk of atherosclerosis in drug-naïve Japanese patients with type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, 2018, PloS one.

Protein kinase C is crucial for the stimulation of sodium-dependent phosphate transport by parathyroid hormone-related peptide in osteoblast-like cells.

K. Chihara, M. Fukase, T. Sugimoto, 1994, Biochemical and biophysical research communications.

Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, T. Yamaguchi, 2011, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Higher Serum Uric Acid is a Risk Factor of Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes Mellitus.

I. Kanazawa, Ken-ichiro Tanaka, M. Notsu, 2018, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes.

H. Bokura, S. Yamaguchi, A. Nagai, 2011, Diabetes research and clinical practice.

Role of interleukin-6 and prostaglandins in the effect of monocyte-conditioned medium on osteoclast formation.

K. Chihara, M. Fukase, T. Sugimoto, 1994, The American journal of physiology.

Effect of 1,25-dihydroxyvitamin D3 on the proliferation of osteoblastic MC3T3-E1 cells by modulating the release of local regulators from monocytes.

K. Chihara, M. Fukase, T. Sugimoto, 1993, Biochemical and biophysical research communications.

A Paranasal Tumor Associated With Tumor‐Induced Osteomalacia

T. Sugimoto, M. Yamauchi, A. Miyauchi, 2006, The Laryngoscope.

Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX

J. Kanis, E. McCloskey, H. Johansson, 2015, Osteoporosis International.

Effects of Treatment With Risedronate and Alfacalcidol on Progression of Atherosclerosis in Postmenopausal Women With Type 2 Diabetes Mellitus Accompanied With Osteoporosis

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2010, The American journal of the medical sciences.

Association of n-3 Polyunsaturated Fatty Acid Intake with Bone Mineral Density in Postmenopausal Women

T. Sugimoto, Toru Yamaguchi, M. Yamauchi, 2013, Calcified Tissue International.

[Bone diseases caused by impaired glucose and lipid metabolism].

I. Kanazawa, T. Sugimoto, 2013, Clinical calcium.

Characterization of a chymotrypsin-like hydrolytic activity in the opossum kidney cell.

K. Chihara, M. Fukase, T. Sugimoto, 1994, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Decreased PTH levels accompanied by low bone formation are associated with vertebral fractures in postmenopausal women with type 2 diabetes.

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2012, The Journal of clinical endocrinology and metabolism.

Xanthinuria type I with a novel mutation of xanthine dehydrogenase.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2015, American Journal of the Medical Sciences.

[Anti-RANKL monoclonal antibody Denosumab (AMG162)].

T. Sugimoto, 2011, Clinical calcium.

Potential hippocampal region atrophy in diabetes mellitus type 2: a voxel-based morphometry VSRAD study

T. Sugimoto, H. Kitagaki, A. Wada, 2010, Japanese Journal of Radiology.

Combination of Obesity with Hyperglycemia is a Risk Factor for the Presence of Vertebral Fractures in Type 2 Diabetic Men

S. Yano, I. Kanazawa, T. Sugimoto, 2008, Calcified Tissue International.

Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2010, Journal of Bone and Mineral Metabolism.

One-hour post-load hyperglycemia by 75g oral glucose tolerance test as a novel risk factor of atherosclerosis.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2014, Endocrine journal.

Bone metabolism and fracture risk in type 2 diabetes mellitus.

T. Sugimoto, Toru Yamaguchi, 2012, BoneKEy reports.

Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus.

I. Kanazawa, T. Sugimoto, Toru Yamaguchi, 2010, Metabolism: clinical and experimental.

Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2016, Diabetes research and clinical practice.

Diabetic Patients Have an Increased Risk of Vertebral Fractures Independent of BMD or Diabetic Complications

T. Sugimoto, Toru Yamaguchi, Masahiro Yamamoto, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Efficacy of once-weekly and twice-weekly injections of teriparatide by patient characteristics: A post hoc analysis of the TWICE study

T. Sugimoto, T. Uzawa, Takeshi Yoshimura, 2021, Osteoporosis and sarcopenia.

24-Month Open-Label Teriparatide Once-Weekly Efficacy Research Trial Examining Bone Mineral Density in Subjects with Primary Osteoporosis and High Fracture Risk

T. Sone, M. Fukunaga, H. Yoshikawa, 2017, Advances in Therapy.

Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells.

I. Kanazawa, Ken-ichiro Tanaka, T. Sugimoto, 2015, Biochemical and biophysical research communications.

Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes.

H. Bokura, S. Yamaguchi, A. Nagai, 2011, Diabetes research and clinical practice.

Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells.

K. Chihara, T. Sugimoto, Toru Yamaguchi, 2005, American Journal of Physiology. Endocrinology and Metabolism.