J. Chládek

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Low-dose methotrexate pharmacokinetics and pharmacodynamics in the therapy of severe psoriasis.

M. Šimková, J. Chládek, J. Grim, 2005, Basic & clinical pharmacology & toxicology.

Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.

J. Chládek, O. Pozler, J. Maly, 2010, Journal of Crohn's & colitis.

Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.

J. Chládek, O. Pozler, J. Maly, 2010, Journal of Crohn's & colitis.

Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers

M. Šimková, J. Chládek, J. Vaněčková, 2013, Journal of the European Academy of Dermatology and Venereology : JEADV.

In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma

J. Chládek, J. Martínková, M. Beranek, 2000, European Journal of Clinical Pharmacology.

Alveolar concentration and bronchial flux of nitric oxide: Two linear modeling methods evaluated in children and adolescents with allergic rhinitis and atopic asthma

J. Chládek, J. Chládková, M. Šenkeřík, 2012, Pediatric pulmonology.

Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients

P. Montuschi, P. Barnes, J. Chládek, 2004, Thorax.

Oxidative stress in cystic fibrosis patients with Burkholderia cenocepacia airway colonization: relation of 8-isoprostane concentration in exhaled breath condensate to lung function decline

J. Chládek, L. Fila, A. Grandcourtová, 2014, Folia Microbiologica.

Validation of Nitrite and Nitrate Measurements in Exhaled Breath Condensate

J. Chládek, S. Micuda, J. Chládková, 2006, Respiration.

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

T. Smutny, P. Pávek, J. Chládek, 2017, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Plasmafiltration as an effective method in the removal of circulating pegylated liposomal doxorubicin (PLD) and the reduction of mucocutaneous toxicity during the treatment of advanced platinum-resistant ovarian cancer

J. Chládek, J. Martínková, S. Filip, 2019, Cancer Chemotherapy and Pharmacology.

Steady-state bioequivalence studies of two memantine tablet and oral solution formulations in healthy volunteers

J. Chládek, J. Martínková, S. Micuda, 2008 .

Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment

M. Šimková, J. Chládek, J. Martínková, 1998, European Journal of Clinical Pharmacology.

Activation of p38 MAPK and expression of TGF-β1 in rat colon enterocytes after whole body γ-irradiation

K. Kuča, A. Tichý, E. Novotná, 2012, International journal of radiation biology.

Analysis of exhaled leukotrienes in nonasthmatic adult patients with seasonal allergic rhinitis

J. Chládek, M. Malý, P. Čáp, 2005, Allergy.

No Effect of Phenobarbital Pretreatment of Rats on Methotrexate Pharmacokinetics in the Isolated Liver Perfused in a Single-Pass Way

J. Chládek, J. Martínková, J. Chládková, 2001, Pharmacology.

An in vitro study on methotrexate hydroxylation in rat and human liver.

J. Chládek, J. Martínková, L. Šišpera, 1997, Physiological research.

Analysis of Single-breath Profiles of Exhaled Nitric Oxide in Children with Allergy and Asthma: Guideline-derived Plateau Concentrations Compared to Results of Automatic Evaluation by Two Analyzers

J. Chládek, J. Chládková, Z. Havlínová, 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

Effect of acute acidosis on protein and amino acid metabolism in rats.

J. Chládek, M. Holeček, R. Šafránek, 2003, Clinical nutrition.

In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine.

J. Pejchal, M. Řezáčová, J. Chládek, 2013, Physiological research.

Intra‐individual variability and influence of urine collection period on dextromethorphan metabolic ratios in healthy subjects

J. Chládek, J. Martínková, G. Zimová, 1999, Fundamental & clinical pharmacology.

HPLC determination of arginases inhibitor N-(ω)-hydroxy-nor-L-arginine using core-shell particle column and LC-MS/MS identification of principal metabolite in rat plasma.

M. Nobilis, J. Chládek, M. Hroch, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats.

J. Chládek, M. Holeček, M. Hroch, 2014, General physiology and biophysics.

Exhaled Breath Condensate: Pilot Study of the Method and Initial Experience in Healthy Subjects.

M. Řezáčová, J. Chládek, D. Kohoutová, 2018, Acta medica.

Nitrites and nitrates in exhaled breath condensate in cystic fibrosis: relation to clinical parameters.

J. Chládek, M. Malý, L. Fila, 2013, Bratislavske lekarske listy.

Free 3-nitrotyrosine in exhaled breath condensates of children fails as a marker for oxidative stress in stable cystic fibrosis and asthma.

C. Heizmann, F. Sennhauser, H. Troxler, 2006, Nitric oxide : biology and chemistry.

Nitric oxide and systemic sclerosis.

J. Chládek, T. Soukup, L. Cibičková, 2006, Acta medica.

EFFECT OF ACETYL-L-CARNITINE PRETREATMENT ON RADIATION PNEUMONITIS AND L-ARGININE-NO METABOLIC PATHWAY

K. Kuča, A. Tichý, E. Novotná, 2012 .

The Concentrations of MTX and Folates, and MTHFR Polymorphisms Toxicity in Juvenile Idiopathic Arthritis: Treatment Outcome, Erythrocyte 677TT Genotype Is Associated with Elevated Risk of Methotrexate (MTX)

J. Chládek, P. Doležalová, M. Hroch, 2010 .

Methotrexate bioavailability after oral and subcutaneous dministration in children with juvenile idiopathic arthritis.

J. Chládek, P. Doležalová, J. Chládková, 2009, Clinical and experimental rheumatology.

An improved high‐performance liquid chromatography method for quantification of methotrexate polyglutamates in red blood cells of children with juvenile idiopathic arthritis

J. Chládek, P. Doležalová, M. Hroch, 2009, Biopharmaceutics & drug disposition.

Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide.

J. Chládek, D. Kalfeřt, J. Chládková, 2018, International journal of pediatric otorhinolaryngology.

Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats

J. Chládek, M. Hroch, Z. Havlínová, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

High-dose methotrexate in children with acute lymphoblastic leukemia: 7-hydroxymethotrexate systemic exposure and urinary concentrations at the steady state correlate well with those of methotrexate

J. Chládek, J. Martínková, J. Hak, 2010, Arzneimittelforschung.

Amiodarone modulates pharmacokinetics of low‐dose methotrexate in rats

F. Staud, J. Chládek, J. Martínková, 2008, Biopharmaceutics & drug disposition.

A rat model of early sepsis: relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2.

J. Chládek, J. Martínková, D. Springer, 2012, Biological & pharmaceutical bulletin.

Pharmacokinetics and pharmacodynamics of low-dose methotrexate in the treatment of psoriasis.

M. Šimková, J. Chládek, V. Koudelková, 2002, British journal of clinical pharmacology.

Nitrite in exhaled breath condensate as a marker of nitrossative stress in the airways of patients with asthma, COPD, and idiopathic pulmonary fibrosis

P. Zatloukal, J. Chládek, Vladimír Řihák, 2010, Journal of clinical laboratory analysis.

Early changes in L-arginine-nitric oxide metabolic pathways in response to the whole-body gamma irradiation of rats

A. Tichý, J. Pejchal, J. Vávrová, 2011, International journal of radiation biology.

A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (-6-43)-bis(acetato)amminedichloro(c

Hana Chlubnová, J. Chládek, J. Chládková, 2020 .

A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) and satraplatin (OC-6-43)-bis(acetato)amminedichlo

Hana Chlubnová, J. Chládek, J. Chládková, 2011, Cancer Chemotherapy and Pharmacology.

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats.

F. Staud, J. Chládek, M. Holeček, 2015, American journal of physiology. Renal physiology.

Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity

N. Váňová, J. Chládek, M. Štěrba, 2021, Scientific Reports.

Urinary N‐acetyl‐β‐D‐glucosaminidase activity in healthy children

J. Chládek, Sylvia Skalova, SYLVA SKÁLOVÁ, 2004, Nephrology.

Tolerability and outcomes of kinetically guided therapy with gentamicin in critically ill neonates during the first week of life: an open-label, prospective study.

P. Pokorná, J. Chládek, J. Martínková, 2010, Clinical therapeutics.

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

D. Richardson, D. Kalinowski, J. Chládek, 2015, Oncotarget.

High-performance liquid chromatographic determination of tramadol and its O-desmethylated metabolite in blood plasma. Application to a bioequivalence study in humans.

M. Nobilis, J. Kvetina, F. Perlík, 2002, Journal of chromatography. A.

Erratum to: Kinetically Guided Neoadjuvant Chemoradiotherapy Based on 5-Fluorouracil in Patients with Locally Advanced Rectal Cancer

J. Chládek, J. Grim, J. Martínková, 2015, Clinical Pharmacokinetics.

Pharmacokinetics and Pharmacodynamics of Methotrexate in Non-Neoplastic Diseases

J. Chládek, J. Grim, J. Martínková, 2003, Clinical pharmacokinetics.

Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma

K. Kuča, J. Chládek, M. Hroch, 2013, Journal of applied toxicology : JAT.

The effect of metipranolol and inosine on total hepatic ischemia of rats in vivo.

J. Chládek, J. Martínková, I. Tilšer, 1993, Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove.

High-performance liquid chromatographic assay for the determination of 5-methyltetrahydrofolate in human plasma.

J. Chládek, J. Martínková, L. Šišpera, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart

J. Chládek, M. Štěrba, J. Bureš, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane.

J. Chládek, M. Štěrba, M. Adamcová, 2016, Journal of molecular and cellular cardiology.

Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis.

J. Chládek, P. Doležalová, J. Krijt, 2005, Rheumatology.

Hyaluronidase: its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs.

K. Kuča, D. Jun, J. Chládek, 2013, Toxicology letters.

A pilot study of pharmacokinetically guided dosing of oral methotrexate in the initial phase of psoriasis treatment

M. Šimková, J. Chládek, J. Martínková, 2007, Journal of the European Academy of Dermatology and Venereology : JEADV.

The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis

M. Šimková, J. Chládek, J. Martínková, 2008, European Journal of Clinical Pharmacology.

Oxidative stress in cystic fibrosis patients with Burkholderia cenocepacia airway colonization: relation of 8-isoprostane concentration in exhaled breath condensate to lung function decline

J. Chládek, L. Fila, A. Grandcourtová, 2014, Folia Microbiologica.

Pharmacokinetics of flubendazole and its metabolites in lambs and adult sheep (Ovis aries).

M. Nobilis, L. Skálová, J. Chládek, 2009, Journal of veterinary pharmacology and therapeutics.

Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions

P. Anzenbacher, J. Chládek, J. Martínková, 2004, European Journal of Clinical Pharmacology.

677TT Genotype Is Associated with Elevated Risk of Methotrexate (MTX) Toxicity in Juvenile Idiopathic Arthritis: Treatment Outcome, Erythrocyte Concentrations of MTX and Folates, and MTHFR Polymorphisms

J. Chládek, P. Doležalová, M. Hroch, 2010, The Journal of Rheumatology.

Bioequivalence of two rimantadine tablet formulations in healthy male volunteers after single dose administration.

J. Chládek, J. Martínková, L. Šišpera, 2001, International journal of clinical pharmacology and therapeutics.

Lithium microdialysis and its use for monitoring of stomach and colon submucosal blood perfusion--a pilot study using ischemic preconditioning in rats.

Z. Zadák, J. Chládek, P. Živný, 2006, Acta medica.

Impact of cumulative fluid balance on the pharmacokinetics of extended infusion meropenem in critically ill patients with sepsis

M. Kaška, J. Chládek, J. Martínková, 2021, Critical Care.

CHARLES UNIVERSITY IN PRAGUE FIRST SCHOOL OF MEDICINE Study programme: Human physiology and pathophysiology INTRACELLULAR CONCENTRATION OF METHOTREXATE IN ERYTHROCYTES AND MTHFR POLYMORPHISMS: Possible association with methotrexate efficacy and toxicity in patients with juvenile idiopathic arthritis

J. Chládek, P. Doležalová, J. Tukova, 2011 .

Pharmacokinetics of boldine in control and Mrp2-deficient rats.

J. Chládek, E. Dolezelova, M. Hroch, 2016, Physiological research.

Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC-MS/MS.

J. Chládek, M. Hroch, P. Tomšík, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Glomerular Filtration Rate and Amikacin Clearance During Early Rat Endotoxemia: Comparison with Traditional Endogenous and Exogenous Biomarkers

J. Chládek, E. Dolezelova, D. Springer, 2019, European journal of drug metabolism and pharmacokinetics.

[Renal excretion of methotrexate in an in vivo model in minipigs].

J. Chládek, J. Martínková, L. Šišpera, 2000, Acta medica (Hradec Kralove). Supplementum.

Pharmacokinetics and tissue distribution of platinum in rats following single and multiple oral doses of LA-12 [(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)].

J. Chládek, Frantisek Zák, P. Sova, 2005, International journal of pharmaceutics.

J. Chládek, E. Dolezelova, D. Springer, 2019, European Journal of Drug Metabolism and Pharmacokinetics.

Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients

P. Montuschi, P. Barnes, J. Chládek, 2004, Thorax.