G. Thoma

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Targeting the CXCR4–CXCL12 Axis Mobilizes Autologous Hematopoietic Stem Cells and Prolongs Islet Allograft Survival via Programmed Death Ligand 1

S. Rodig, R. Abdi, M. Jurewicz, 2011, The Journal of Immunology.

Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus‐induced mouse model

J. Pfeilschifter, G. Thoma, H. Zerwes, 2011, Clinical and experimental immunology.

Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.

M. Streiff, G. Thoma, H. Zerwes, 2008, Bioorganic & medicinal chemistry letters.

Removal of anti-Galalpha1,3Gal xenoantibodies with an injectable polymer.

E. Persohn, M. Streiff, G. Thoma, 2002, The Journal of clinical investigation.

Removal of anti-Galα1,3Gal xenoantibodies with an injectable polymer

E. Persohn, M. Streiff, G. Thoma, 2002 .

Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin.

W. Jahnke, B. Ernst, G. Thoma, 2001, Angewandte Chemie.

Targeting CLA/E‐selectin interactions prevents CCR4‐mediated recruitment of human Th2 memory cells to human skin in vivo

T. Biedermann, J. Vries, G. Thoma, 2002, European journal of immunology.

Polymers carrying sLex‐mimetics are superior inhibitors of E‐selectin‐dependent leukocyte rolling in vivo

G. Thoma, P. Hellewell, K. Norman, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

vivo P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in

F. Kolbinger, A. Pockley, G. Thoma, 2013 .

Nanomolar E-selectin inhibitors: 700-fold potentiation of affinity by multivalent ligand presentation.

G. Thoma, J. Patton, J. Magnani, 2001, Journal of the American Chemical Society.

Versatile Functionalization of Polylysine: Synthesis, Characterization, and Use of Neoglycoconjugates

B. Ernst, G. Thoma, J. Patton, 1999 .

Novel glycodendrimers self-assemble to nanoparticles which function as polyvalent ligands in vitro and in vivo.

N. Voelcker, M. Streiff, G. Thoma, 2002, Angewandte Chemie.

Drug discovery strategies for novel leukotriene A4 hydrolase inhibitors

G. Thoma, H. Otto, C. Loesche, 2021, Expert opinion on drug discovery.

This information is current as via Programmed Death Ligand 1 Cells and Prolongs Islet Allograft Survival Mobilizes Autologous Hematopoietic Stem CXCL12 Axis - Targeting the CXCR4

S. Rodig, R. Abdi, M. Jurewicz, 2012 .

Synthesis and characterization of polyaspartic acid-carbohydrate conjugates: Multivalent sialyl lewis

B. Ernst, G. Thoma, R. Duthaler, 1997 .

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood.

M. Streiff, G. Thoma, J. Kovarik, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.

G. Thoma, J. Patton, J. Magnani, 2001, Bioorganic & medicinal chemistry letters.

A Readily Available, Highly Potent E-Selectin Antagonist.

W. Jahnke, G. Thoma, J. Patton, 2001, Angewandte Chemie.

Radical Cyclization Reactions

B. Giese, G. Thoma, K. Kulicke, 1996 .

Synthesis of Oligosaccharide-Polylysine Conjugates: A Well Characterized Sialyl Lewisa Polymer for ELISA

B. Ernst, G. Thoma, J. Magnani, 1997 .

Group Transfer Addition-Reactions of Methyl(Phenylseleno)Malononitrile to Alkenes

G. Thoma, D. Curran, E. Eichenberger, 1994 .

1,2-Asymmetric Induction in Reactions of Nonconjugated Acyclic Radicals: A New Model for Highly Selective Atom-Transfer Reactions of Alkyl-Substituted Radicals.

B. Giese, F. Wetterich, W. Damm, 1993 .

Additions of malononitrile radicals to alkenes: new examples of 1,2-asymmetric induction in iodine and phenylselenium transfer reactions

G. Thoma, D. Curran, 1992 .

Mechanistic studies of atom transfer addition reactions of iodomalononitriles to alkenes. 1,2-asymmetric induction in an iodine atom transfer reaction.

G. Thoma, D. Curran, 1991 .

Synthesis of a Sialyl Lewis x Mimic with Fixed Carboxylic Acid Group: Chemical Approach toward the Elucidation of the Bioactive Conformation of Sialyl Lewis x.

G. Thoma, R. Duthaler, F. Schwarzenbach, 1996, The Journal of organic chemistry.

C ? C Bond Formation via Carbon‐Centered Radicals Generated from Dicarbonyl(η5‐cyclopentadienyl) organoiron Complexes

B. Giese, G. Thoma, 1991 .

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.

Trixie Wagner, Jiri Kovarik, M. Streiff, 2008, Journal of medicinal chemistry.

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Trixie Wagner, Wolfgang Blum, M. Streiff, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of a Sialyl Lewis x Mimic with Fixed Carboxylic Acid Group: Chemical Approach toward the Elucidation of the Bioactive Conformation of Sialyl Lewis x.

G. Thoma, R. Duthaler, F. Schwarzenbach, 1996, The Journal of organic chemistry.

Photolytic Reactions of (o-Allylbenzyl)dicarbonyl(η5-cyclopentadienyl)iron

B. Giese, G. Thoma, 1992 .

Dimeric Metal Complexes as Mediators for Radical C ? C Bond-Forming Reactions

B. Giese, G. Thoma, 1991 .

Selective inhibitors of the Janus kinase Jak3--Are they effective?

G. Thoma, H. Zerwes, Peter Drückes, 2014, Bioorganic & medicinal chemistry letters.

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.

I. Behrmann, G. Thoma, H. Zerwes, 2011, Chemistry & biology.

Discovery and profiling of a selective and efficacious Syk inhibitor.

Eric Vangrevelinghe, E. Vangrevelinghe, Christian C. Lee, 2015, Journal of medicinal chemistry.

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.

K E Norman, F. Kolbinger, A. Pockley, 2000, Blood.

Generation and synthetic use of alkyl radicals with [CpFe(CO)2]2 as mediator

B. Giese, G. Thoma, 1989 .

Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.

Eric Vangrevelinghe, E. Vangrevelinghe, R. Falchetto, 2011, Journal of medicinal chemistry.

Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: a novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo.

N. Voelcker, C. Masson, M. Streiff, 2005, Chemistry.

The Chemokine Receptor Cxcr3 Is Not Essential for Acute Cardiac Allograft Rejection in Mice and Rats

M. Streiff, G. Wieczorek, M. Hofmann, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

K. Azzaoui, R. Wolf, P. Loetscher, 2021, Journal of medicinal chemistry.

Syk inhibitors with high potency in presence of blood.

Jianwei Che, E. Vangrevelinghe, Christian C. Lee, 2014, Bioorganic & medicinal chemistry letters.

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

E. Vangrevelinghe, Christian C. Lee, G. Thoma, 2015, Bioorganic & medicinal chemistry letters.

P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo

A. Graham Pockley, Matthew J. Cotter, F. Kolbinger, 2000 .

Simplified sialyl Lewisx analogues with improved E-selectin inhibition

G. Thoma, F. Schwarzenbach, 2003 .

Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.

G. Thoma, H. Zerwes, P. Rudewicz, 2023, Journal of medicinal chemistry.

Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.

E. Vangrevelinghe, G. Thoma, H. Zerwes, 2023, Journal of medicinal chemistry.