Fadi G Lakkis

Fadi G Lakkis, 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts

J. Danska, T. Matozaki, D. Rothstein, 2017, Science Immunology.

Contributes to Medial Immunoprivilege γ Vascular Smooth Muscle Cells by Interferon-Induction of Indoleamine 2 , 3-Dioxygenase in Lakkis

D. Fuchs, J. Pober, G. Tellides, 2007 .

Failure to Induce Neonatal Tolerance in Mice That Lack Both IL-4 and IL-13 but Not in Those That Lack IL-4 Alone1

A. McKenzie, Fadi G Lakkis, B. Konieczny, 2001, The Journal of Immunology.

Those That Lack IL-4 Alone That Lack Both IL-4 and IL-13 but Not in Failure to Induce Neonatal Tolerance in Mice

A. McKenzie, Fadi G Lakkis, B. Konieczny, 2001 .

Dendritic cells and innate immunity in kidney

Fadi G Lakkis, 2015 .

Dendritic Cells and Innate Immunity in Kidney Transplantation

Quan Zhuang, Fadi G Lakkis, 2015, Kidney international.

Antibody-Mediated Rejection of Solid-Organ Allografts.

A. Loupy, G. Chalasani, Fadi G Lakkis, 2018, The New England journal of medicine.

Profound Depletion of Host Conventional Dendritic Cells, Plasmacytoid Dendritic Cells, and B Cells Does Not Prevent Graft-versus-Host Disease Induction

J. McNiff, A. Demetris, D. Rothstein, 2012, The Journal of Immunology.

Mediated by Monocytes An Innate Response to Allogeneic Nonself

N. Rooijen, D. Rothstein, Fadi G Lakkis, 2009 .

Lipoxygenase Products in Normal and Diseased Glomeruli a

K. Badr, Fadi G Lakkis, 1994, Annals of the New York Academy of Sciences.

Tolerance for organ recipients: A clash of paradigms

T. Starzl, Fadi G Lakkis, A. Marcos, 2006, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

CD 4 + CD 25 + regulatory T cells suppress allograft rejection mediated by memory CD 8 + T cells via a CD 30-dependent mechanism

G. Tellides, Z. Dai, Fadi G Lakkis, 2018 .

CD4+CD25+ regulatory T cells suppress allograft rejection mediated by memory CD8+ T cells via a CD30-dependent mechanism.

G. Tellides, Z. Dai, Fadi G Lakkis, 2004, The Journal of clinical investigation.

Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice.

Z. Dai, Fadi G Lakkis, G. H. Ring, 1999, Journal of immunology.

Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.

K. Badr, Fadi G Lakkis, T. Katoh, 1994, Kidney international.

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

J. Morrow, K. Badr, L. Roberts, 1994, The Journal of biological chemistry.

IL-4 is an endogenous inhibitor of neutrophil influx and subsequent pathology in acute antibody-mediated inflammation.

Z. Dai, Fadi G Lakkis, B. Konieczny, 1998, Journal of immunology.

Tertiary Lymphoid Tissues Generate Effector and Memory T Cells That Lead to Allograft Rejection

Fadi G Lakkis, M. Oberbarnscheidt, N. Ruddle, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells 1

G. Tellides, D. Rothstein, Z. Dai, 2005, The Journal of Immunology.

via a CD30-dependent mechanism

G. Tellides, Z. Dai, Fadi G Lakkis, 2004 .

Alloimmune Responses In Vivo CD28-Independent CD8+ T Cell-Mediated CD70 Signaling Is Critical for

A. Sharpe, H. Auchincloss, A. Salama, 2013 .

Langerhans cells are not required for efficient skin graft rejection.

M. Shlomchik, D. Mueller, N. Zhang, 2008, The Journal of investigative dermatology.

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

P. Linsley, Z. Dai, C. Larsen, 1998, Journal of immunology.

Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation

L. Butterfield, D. Metes, A. Thomson, 2016, Front. Immunol..

Transitional B cell cytokines predict renal allograft outcomes

D. Landsittel, A. Cherukuri, A. Salama, 2021, Science Translational Medicine.

Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

P. Linsley, C. Larsen, D. Alexander, 1997, Journal of immunology.

The Allograft Defines the Type of Rejection (Acute versus Chronic) in the Face of an Established Effector Immune Response1

D. Perkins, Z. Dai, G. Chalasani, 2004, The Journal of Immunology.

Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts

E. Rodriguez, R. Margreiter, S. Schneeberger, 2014, Transplant international : official journal of the European Society for Organ Transplantation.

Lymphoid Neogenesis in Murine Cardiac Allografts Undergoing Chronic Rejection

Fadi G Lakkis, N. Ruddle, I. Nasr, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The many shades of macrophages in regulating transplant outcome.

X. Li, Fadi G Lakkis, Shuqiu Chen, 2020, Cellular immunology.

Investigation of Lymphocyte Depletion and Repopulation Using Alemtuzumab (Campath‐1H) in Cynomolgus Monkeys

J. Ijzermans, C. Macedo, D. Metes, 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice.

Fadi G Lakkis, 1998, Journal of the American Society of Nephrology : JASN.

Multiphoton Intravital Microscopy of the Transplanted Mouse Kidney

Simon C Watkins, A. Demetris, D. Rothstein, 2011, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.

A. Demetris, D. Rothstein, G. Chalasani, 2012, Transplant immunology.

Impact of Induction Therapy on Circulating T Follicular Helper Cells and Subsequent Donor-Specific Antibody Formation After Kidney Transplant

D. Landsittel, C. Macedo, D. Metes, 2018, Kidney international reports.

Acute Cellular Rejection with CD20‐Positive Lymphoid Clusters in Kidney Transplant Patients Following Lymphocyte Depletion

Fadi G Lakkis, P. Randhawa, R. Shapiro, 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Immunologic determinants of susceptibility to experimental glomerulonephritis: role of cellular immunity.

Fadi G Lakkis, B. Konieczny, F. Baddoura, 1997, Kidney international.

Immunology: TREG cells in transplantation—a double-edged sword?

Fadi G Lakkis, 2014, Nature Reviews Nephrology.

Acute rejection of vascularized heart allografts in the absence of IFNgamma.

Fadi G Lakkis, B. Konieczny, R. Lowry, 1996, Transplantation.

The role of cytokines, CTLA-4 and costimulation in transplant tolerance and rejection.

Z. Dai, Fadi G Lakkis, 1999, Current opinion in immunology.

Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: implications for long-term allograft acceptance.

Z. Dai, Fadi G Lakkis, B. Konieczny, 1999, Transplantation.

Non-self recognition by monocytes initiates allograft rejection.

D. Rothstein, H. Dai, Fadi G Lakkis, 2014, The Journal of clinical investigation.

Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells.

J. G. van den Berg, Fadi G Lakkis, J. Weening, 2000, Journal of the American Society of Nephrology : JASN.

Interleukin-4 and Interleukin-13 Act on Glomerular Visceral

Fadi G Lakkis, J. Weening, J. Wijdenes, 2000 .

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

A. Demetris, L. Lu, A. Thomson, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Post-transplant repopulation of naïve and memory T cells in blood and lymphoid tissue after alemtuzumab-mediated depletion in heart-transplanted cynomolgus monkeys.

L. Lu, A. Thomson, A. Zahorchak, 2013, Transplant immunology.

Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs

Z. Dai, G. Chalasani, Fadi G Lakkis, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.

Z. Dai, Fadi G Lakkis, B. Konieczny, 1998, Journal of immunology.

Deficient Mice γ Mediated Glomerulonephritis in IFN-Increased Susceptibility to Immunologically Baddoura

Z. Dai, Fadi G Lakkis, F. Baddoura, 1999 .

Innate allorecognition by monocytic cells and its role in graft rejection

X. C. Li, Fadi G Lakkis, X. Li, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Where Is the Alloimmune Response Initiated?

Fadi G Lakkis, 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Essential for Maintaining the CD4, But Not Cutting Edge: Secondary Lymphoid Organs Are

Z. Dai, Fadi G Lakkis, 2001 .

Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue1

D. Rothstein, Z. Dai, C. Larsen, 2005, The Journal of Immunology.

Alloantigen-driven T cell death mediated by Fas ligand and tumor necrosis factor-alpha is not essential for the induction of allograft acceptance.

Z. Dai, Fadi G Lakkis, B. Konieczny, 2000, Transplantation.

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

A. Nakao, Quan Liu, Quan Zhuang, 2016, Nature Communications.

Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation

D. Landsittel, K. Isse, A. Demetris, 2012, Transplantation.

Antibody-Mediated Rejection of Solid-Organ Allografts.

G. Chalasani, Fadi G Lakkis, S. Hariharan, 2018, The New England journal of medicine.

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

D. Rothstein, Songyan Deng, Fadi G Lakkis, 2011, The Journal of Immunology.

Atheroembolic renal disease.

M. Martínez-Maldonado, Fadi G Lakkis, S. Saleem, 1996, Seminars in nephrology.

Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts.

D. Landsittel, H. Dai, Fadi G Lakkis, 2019, The Journal of clinical investigation.

The alloimmune response and effector mechanisms of allograft rejection.

Fadi G Lakkis, A. Arakelov, 2000, Seminars in nephrology.

T-cell migration to vascularized organ allografts

Fadi G Lakkis, J. Walch, 2014, Current opinion in organ transplantation.

Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3

A. Demetris, Fadi G Lakkis, J. Walch, 2011, Transplantation.

The unfinished legacy of liver transplantation: Emphasis on immunology

T. Starzl, Fadi G Lakkis, 2006, Hepatology.

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

Fadi G Lakkis, B. Konieczny, A. Arakelov, 2000, Nature Medicine.

Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death

Fadi G Lakkis, R. Shapiro, K. Ozaki, 2011, Transplant international : official journal of the European Society for Organ Transplantation.

Contribution of Naïve and Memory T‐Cell Populations to the Human Alloimmune Response

C. Macedo, D. Metes, B. Elinoff, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Origin and biology of the allogeneic response.

R. Lechler, Fadi G Lakkis, 2013, Cold Spring Harbor perspectives in medicine.

Antigen Presentation in Transplantation.

M. Alegre, Fadi G Lakkis, A. Morelli, 2016, Trends in immunology.

Allorecognition Triggers Autophagy and Subsequent Necrosis in the Cnidarian Hydractinia symbiolongicarpus

L. Buss, M. Moreno, Fadi G Lakkis, 2012, PloS one.

Memory T Cell Migration

Fadi G Lakkis, Qianqian Zhang, 2015, Front. Immunol..

Genetic diversity of the allodeterminant alr2 in Hydractinia symbiolongicarpus.

Rafael D. Rosengarten, L. Buss, S. Dellaporta, 2011, Molecular biology and evolution.

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

D. Jain, J. McNiff, A. Demetris, 2011, The Journal of Immunology.

Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies.

D. Metes, A. Thomson, A. Humar, 2017, Human immunology.

Getting Down and Dirty: Germ-Exposed Laboratory Mice as a Model of the Adult Human Immune System.

Fadi G Lakkis, M. Oberbarnscheidt, Roger Tieu, 2016, Transplantation.

Direct Antigen Presentation by a Xenograft Induces Immunity Independently of Secondary Lymphoid Organs1

B. Tesar, G. Chalasani, Fadi G Lakkis, 2004, The Journal of Immunology.

Reply to “Confounding factors complicate conclusions in aly model”

Fadi G Lakkis, 2001, Nature Medicine.

Immunologic ignorance of organ allografts

G. Chalasani, Fadi G Lakkis, 2001 .

Memory T cells: a hurdle to immunologic tolerance.

M. Sayegh, Fadi G Lakkis, 2003, Journal of the American Society of Nephrology : JASN.

Janus kinase inhibition for immunosuppression in solid organ transplantation: Is there a role in complex immunologic challenges?

C. Ensor, Fadi G Lakkis, R. Venkataramanan, 2017, Human immunology.

The Fourth International Workshop on Clinical Transplant Tolerance

P. Nickerson, T. Kawai, J. Madsen, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

A brief journey through the immune system.

Fadi G Lakkis, Karim M Yatim, 2015, Clinical journal of the American Society of Nephrology : CJASN.

Journey through the Immune System

Fadi G Lakkis, Karim M Yatim, 2015 .

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

D. Jain, J. McNiff, Jieqing Zhu, 2019, Blood advances.

Resident memory T cells form during persistent antigen exposure leading to allograft rejection

Fadi G Lakkis, M. Oberbarnscheidt, W. Shlomchik, 2021, Science Immunology.

Immunoglobulin-like receptors and the generation of innate immune memory

Fadi G Lakkis, Hossam A. Abdelsamed, Hossam A Abdelsamed, 2022, Immunogenetics.

CD45 ligation expands Tregs by promoting interactions with DCs.

Y. Wan, R. Flavell, C. Rudd, 2014, The Journal of clinical investigation.

In remembrance of things past: memory T cells and transplant rejection

A. Valujskikh, Fadi G Lakkis, 2003, Immunological reviews.

Gene expression analysis in human renal allograft biopsy samples using high-density oligoarray technology.

C. Larsen, E. Akalin, R. Hendrix, 2001, Transplantation.

GENE EXPRESSION ANALYSIS IN HUMAN RENAL ALLOGRAFT BIOPSY SAMPLES USING HIGH-DENSITY

C. Larsen, E. Akalin, R. Hendrix, 2001 .

The innate immune system in transplantation.

Fadi G Lakkis, M. Oberbarnscheidt, D. Zecher, 2011, Seminars in immunology.

PIRs mediate innate myeloid cell memory to nonself MHC molecules

J. Danska, P. Nickerson, M. Shlomchik, 2020, Science.

Evolutionary genetics of the hydroid allodeterminant alr2.

L. Buss, S. Dellaporta, M. Moreno, 2012, Molecular biology and evolution.

Allograft Outcomes in Outbred Mice

A. Demetris, D. Rothstein, Fadi G Lakkis, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus

L. Buss, S. Dellaporta, M. Moreno, 2011, G3: Genes | Genomes | Genetics.

The Dual Role of IL-2 in the Generation and Maintenance of CD8+ Memory T Cells1

Z. Dai, Fadi G Lakkis, B. Konieczny, 2000, The Journal of Immunology.

Anti-inflammatory lymphokine mRNA expression in antibody-induced glomerulonephritis.

Fadi G Lakkis, K. Munger, F. Baddoura, 1996, Kidney international.

Innate allorecognition

Fadi G Lakkis, M. Oberbarnscheidt, 2014, Immunological reviews.

Cognate antigen directs CD8+ T cell migration to vascularized transplants.

D. Rothstein, Fadi G Lakkis, J. Walch, 2013, The Journal of clinical investigation.

Cutting Edge: Perforin Down-Regulates CD4 and CD8 T Cell-Mediated Immune Responses to a Transplanted Organ 1

K. Kokko, Fadi G Lakkis, Y. Inoue, 2003, The Journal of Immunology.

Expression of recombinant rat interleukin-13 (IL-13) and generation of a neutralizing rat IL-13 antiserum.

K. Badr, Fadi G Lakkis, D. Pascual, 1997, Biochemical and biophysical research communications.

Donor‐derived regulatory dendritic cell infusion results in host cell cross‐dressing and T cell subset changes in prospective living donor liver transplant recipients

M. Styn, T. Mohanakumar, C. Macedo, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection.

Fadi G Lakkis, M. Oberbarnscheidt, A. D. Hughes, 2018, Journal of the American Society of Nephrology : JASN.

Cloning of rat interleukin-13 (IL-13) cDNA and analysis of IL-13 gene expression in experimental glomerulonephritis.

Fadi G Lakkis, E. N. Cruet, 1993, Biochemical and biophysical research communications.

IL-2 PROGRAMS ALLOSPECIFIC CD8+ T CELLS FOR ACTIVATION-INDUCED APOPTOSIS WHILE IL-4, IL-7, AND IL-15 PREVENT T CELL DEATH

Z. Dai, Fadi G Lakkis, B. Konieczny, 1999 .

Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool1

Z. Dai, Fadi G Lakkis, 2001, The Journal of Immunology.

An Innate Response to Allogeneic Nonself Mediated by Monocytes1

N. Van Rooijen, D. Rothstein, Fadi G Lakkis, 2009, The Journal of Immunology.

Allorecognition and chimerism in an invertebrate model organism

L. Buss, S. Dellaporta, Fadi G Lakkis, 2008, Organogenesis.

Evolutionary Genetics of the Hydroid Allodeterminant alr2 Research Article

L. Buss, M. Moreno, Fadi G Lakkis, 2012 .

Interleukin 4 receptor targeted cytotoxicity: Genetic construction and in vivo immunosuppressive activity of a diphtheria toxin‐related murine interleukin 4 fusion protein

T. Strom, A. Steele, J. Murphy, 1991, European journal of immunology.

The Immune Response to a Transplanted Organ: An Overview

Fadi G Lakkis, 2012 .

Prospective Multicenter Validation of Human Transitional B cell Cytokines as a Predictive Biomarker in Renal Transplantation

A. Cherukuri, A. Salama, D. Rothstein, 2018, Transplantation.

Breakdown of self-tolerance and the pathogenesis of autoimmunity.

Fadi G Lakkis, G. H. Ring, 1999, Seminars in nephrology.

CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells

C. Rudd, H. Dai, Fadi G Lakkis, 2016, The Journal of Immunology.

The role of self-peptides in direct T cell allorecognition.

Fadi G Lakkis, Hossam A Abdelsamed, 2021, The Journal of clinical investigation.

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

A. Nakao, Quan Liu, Quan Zhuang, 2016, Nature Communications.

Long-Term Effects of Alemtuzumab on Regulatory and Memory T-Cell Subsets in Kidney Transplantation

D. Landsittel, K. Isse, A. Demetris, 2012, Transplantation.

Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts

E. Rodriguez, R. Margreiter, S. Schneeberger, 2014, Transplant international : official journal of the European Society for Organ Transplantation.

Contribution of Naïve and Memory T‐Cell Populations to the Human Alloimmune Response

C. Macedo, D. Metes, B. Elinoff, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Regulatory Dendritic Cell Infusion Prolongs Kidney Allograft Survival in Nonhuman Primates

A. Demetris, A. Thomson, A. Zahorchak, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells

D. Jain, J. McNiff, A. Demetris, 2011, The Journal of Immunology.

Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts.

Z. Dai, Fadi G Lakkis, B. Konieczny, 1999, Transplantation.

Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue1

D. Rothstein, Z. Dai, C. Larsen, 2005, The Journal of Immunology.

Antibody-Mediated Rejection of Solid-Organ Allografts.

G. Chalasani, Fadi G Lakkis, S. Hariharan, 2018, New England Journal of Medicine.

Allograft Outcomes in Outbred Mice

A. Demetris, D. Rothstein, Fadi G Lakkis, 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Leptin — a new hormone of definite interest for the nephrologist

P. Stenvinkel, Fadi G Lakkis, G. H. Ring, 1998 .

Immunotherapy in Transplantation

B. Kaplan, Fadi G Lakkis, G. Burckart, 2010 .