D. Harki

发表

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

N. Krogan, C. Schiffer, R. Harris, 2012, ACS chemical biology.

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

M. Walters, D. Harki, François Grillet, 2020, Journal of medicinal chemistry.

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase*

Blake R. Peterson, Francisco Parra, K. Ng, 2008, Journal of Biological Chemistry.

Cyclic pyrrole-imidazole polyamides targeted to the androgen response element.

J. Phillips, P. Dervan, D. Harki, 2009, Journal of the American Chemical Society.

Solution-phase synthesis of pyrrole-imidazole polyamides.

P. Dervan, D. Harki, D. Chenoweth, 2009, Journal of the American Chemical Society.

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

D. Largaespada, D. Harki, Z. Sachs, 2015, Bioorganic & medicinal chemistry.

Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors.

D. Harki, Daniel A. Harki, Nicholas B Struntz, 2016, ACS chemical biology.

SN-38 Conjugated Gold Nanoparticles Activated by Ewing Sarcoma Specific mRNAs Exhibit In Vitro and In Vivo Efficacy.

D. Harki, David J. Gordon, Jian Tang, 2018, Bioconjugate chemistry.

Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.

Taosheng Chen, D. Harki, W. Pomerantz, 2021, ACS medicinal chemistry letters.

Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement.

A. Pandey, K. Shi, D. Harki, 2020, Angewandte Chemie.

A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells.

K. Klempnauer, D. Harki, M. Yusenko, 2022, Cancer letters.

Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q

R. Harris, M. Carpenter, K. Shi, 2021, Proceedings of the National Academy of Sciences.

Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction.

D. Harki, K. Brummond, Daniel A. Harki, 2016, Organic letters.

A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.

V. Shah, K. Shi, D. Harki, 2022, Journal of medicinal chemistry.

Synthesis of a Universal 5‐Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA‐Dependent RNA Polymerase

C. Cameron, B. Peterson, D. Harki, 2007, Chembiochem : a European journal of chemical biology.

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

D. Harki, H. Aihara, Daniel A. Harki, 2022, Viruses.

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

J. Arnold, C. Cameron, D. Dulin, 2022, bioRxiv.

Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide.

Katy A. Muzikar, P. Dervan, A. Perkins, 2011, Biochemistry.

The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.

R. Harris, Allison M. Land, R. Amaro, 2015, Cell reports.

Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells

R. Harris, W. Brown, D. Young, 2022, mBio.

4-Cyanoindole-2'-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue.

D. Harki, Kellan T. Passow, Kellan T Passow, 2018, Organic letters.

Immunodetection of human topoisomerase I-DNA covalent complexes

K. Flatten, S. Kaufmann, P. Schneider, 2016, Nucleic acids research.

Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.

C. Cameron, B. Peterson, D. Harki, 2006, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.

C. Cameron, Saikat Ghosh, B. Peterson, 2002, Biochemistry.

Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses.

M. Vignuzzi, J. Arnold, C. Cameron, 2021, Molecular cell.

An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir

D. Harki, Daniel A. Harki, R. Moorthy, 2021, RSC advances.

Interfering with nucleotide excision by the coronavirus 3′-to-5′ exoribonuclease

J. Arnold, C. Cameron, D. Dulin, 2022, Nucleic acids research.

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

D. Harki, K. Brummond, Daniel A. Harki, 2017, Journal of medicinal chemistry.

Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.

M. Carpenter, A. Rathore, Ming Li, 2015, Journal of medicinal chemistry.

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

M. Walters, D. Harki, François Grillet, 2020, Journal of medicinal chemistry.

Helenalin Analogues Targeting NF‐κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles

D. Harki, Jacob T. Edwards, Jacob T Edwards, 2018, ChemMedChem.

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

P. Villalta, D. Harki, Daniel A. Harki, 2017, ACS chemical biology.

Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles.

D. Harki, M. E. Olson, Daniel A. Harki, 2016, Tetrahedron letters.

Synthesis of 4‐Cyanoindole Nucleosides, 4‐Cyanoindole‐2ʹ‐Deoxyribonucleoside‐5ʹ‐Triphosphate (4CIN‐TP), and Enzymatic Incorporation of 4CIN‐TP into DNA

S. Sturla, D. Harki, Kellan T Passow, 2020, Current protocols in nucleic acid chemistry.

Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation.

M. Ding, V. Vallyathan, M. Luster, 2000, Cancer research.

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

K. Flatten, S. Kaufmann, Angela L. Perkins, 2016, Organic & biomolecular chemistry.

A redox economical synthesis of bioactive 6,12-guaianolides.

D. Harki, K. Brummond, Daniel A. Harki, 2013, Organic letters.

Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

R. D’Aquila, L. Sutton, G. Jameson, 2019, Chembiochem : a European journal of chemical biology.

Induced copy-back RNA synthesis as a novel therapeutic mechanism against RNA viruses

J. Arnold, C. Cameron, N. Dekker, 2020, bioRxiv.

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.

J. Arnold, C. Cameron, S. Sturla, 2021, Journal of medicinal chemistry.

Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B

M. Carpenter, K. Shi, Ö. Demir, 2019, bioRxiv.

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

G. Jameson, D. Harki, H. Aihara, 2018, Biochemistry.

APOBEC Enzymes as Targets for Virus and Cancer Therapy.

D. Harki, M. E. Olson, Daniel A. Harki, 2017, Cell chemical biology.

Inhibition of Guanosine Monophosphate Synthetase by the Substrate Enantiomer L‐XMP

B. White, D. Harki, M. E. Olson, 2012, Chembiochem : a European journal of chemical biology.

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

Blake R. Peterson, J. Martin Bollinger, David Loakes, 2008, Antimicrobial Agents and Chemotherapy.

Chemical Synthesis of Base-Modified Ribonucleosides as Novel Antiviral Agents

D. Harki, Daniel A. Harki, 2005 .

The current toolbox for APOBEC drug discovery.

M. Carpenter, D. Harki, Daniel A. Harki, 2022, Trends in pharmacological sciences.

Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

N. Levinson, K. Shi, R. Amaro, 2022, bioRxiv.

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Rommie E. Amaro, M. Carpenter, S. Banerjee, 2016, Nature Structural &Molecular Biology.

EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

G. Raj, S. Dehm, D. Harki, 2015, Oncotarget.

Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice.

M. Luster, P. Simeonova, D. Harki, 2003, Environmental health perspectives.

Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery

Dan Wang, D. Harki, Daniel A. Harki, 2012, Drug Delivery and Translational Research.

Parthenolide prodrug LC-1 slows growth of intracranial glioma.

D. Largaespada, D. Harki, J. Ohlfest, 2015, Bioorganic & medicinal chemistry letters.

Lethal Mutagenesis of Picornaviruses with N-6-Modiﬁed Purine Nucleoside Analogues (cid:1) †

C. Cameron, J. Bollinger, E. Smidansky, 2008 .

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

N. Levinson, E. Schönbrunn, V. Chennathukuzhi, 2022, bioRxiv.

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.

N. Mishra, N. Berndt, D. Harki, 2018, Journal of medicinal chemistry.

Small‐Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4‐Amino‐1,2,4‐triazole‐3‐thiol Scaffold

Ming Li, D. Harki, M. E. Olson, 2013, ChemMedChem.

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

C. Ward, R. Raiteri, D. Harki, 2015, Nature Communications.

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

N. Satyamurthy, M. Phelps, P. Dervan, 2008, Proceedings of the National Academy of Sciences.

Determinants of Oligonucleotide Selectivity of APOBEC3B

Rommie E. Amaro, Rommie E Amaro, Jeffrey R Wagner, 2018, J. Chem. Inf. Model..

Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.

D. Harki, A. Harned, Daniel A. Harki, 2012, ACS medicinal chemistry letters.

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers

J. Arnold, C. Cameron, T. van Laar, 2017, Cell Reports.

Recent progress and structural analyses of domain‐selective BET inhibitors

D. Harki, W. Pomerantz, Daniel A. Harki, 2023, Medicinal research reviews.

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

D. Harki, R. Harris, Rayhan G. Biswas, 2023, Research square.

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

D. Harki, Daniel A. Harki, R. Harris, 2023, bioRxiv.

Signatures of Nucleotide A nalog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers Graphical

J. Arnold, C. Cameron, M. Depken, 2017 .

Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery

D. Harki, Daniel A. Harki, Timothy E. Andrews, 2013, Drug Delivery and Translational Research.

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity.

G. Miller, K. Shi, D. Harki, 2021, Journal of medicinal chemistry.

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides.

A. Rathore, Ming Li, Angela L. Perkins, 2017, Journal of molecular biology.