Akbar Ali

发表

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

N. Krogan, C. Schiffer, R. Harris, 2012, ACS chemical biology.

Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration

Bracken M. King, B. Tidor, C. Schiffer, 2013, Journal of chemical theory and computation.

Dengue Virus NS 2 B / NS 3 Protease Inhibitors Exploiting the Prime Side Authors

C. Schiffer, Akbar Ali, Kuan-Hung Lin, 2017 .

Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side

C. Schiffer, Akbar Ali, Kuan-Hung Lin, 2017, Journal of Virology.

HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands to Optimize Hydrogen Bonding in the Substrate Envelope.

Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali, 2019, Journal of medicinal chemistry.

Identification of Flavopiridol Analogues that Selectively Inhibit Positive Transcription Elongation Factor (P‐TEFb) and Block HIV‐1 Replication

T. Rana, M. Stevenson, Akbar Ali, 2009, Chembiochem : a European journal of chemical biology.

Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

Shuntai Zhou, C. Schiffer, R. Swanstrom, 2019, bioRxiv.

Structural Adaptation of Darunavir Analogs Against Primary Resistance Mutations in HIV-1 Protease

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, bioRxiv.

Inhibiting HTLV-1 Protease: A Viable Antiviral Target.

C. Schiffer, E. Nalivaika, M. Somasundaran, 2021, ACS chemical biology.

Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition.

Akbar Ali, L. Stern, Digamber Rane, 2022, ACS chemical biology.

Isolation and Seroprevalence of Avian Infectious Bronchitis Virus Serotypes in Pakistan

N. Siddique, Akbar Ali, A. Rahim, 2018 .

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates

Jesse J. Lipp, K. Shokat, T. Rana, 2016, Genes & development.

The value of molecular stratification for CEBPA DM and NPM1 MUT FLT3 WT genotypes in older patients with acute myeloid leukaemia

R. Hills, D. Linch, Akbar Ali, 2015, British journal of haematology.

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.

C. Schiffer, E. Nalivaika, Akbar Ali, 2021, Chemical reviews.

In ovo vaccination against avian influenza virus subtype H9N2.

N. Siddique, Akbar Ali, S. Yasmeen, 2015 .

Synthesis and Structure–Activity Relationship Studies of HIV‐1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication

T. Rana, M. Stevenson, Akbar Ali, 2012, ChemMedChem.

P-TEFb Kinase Complex Phosphorylates Histone H1 to Regulate Expression of Cellular and HIV-1 Genes*

T. Rana, Akbar Ali, H. Cao, 2010, The Journal of Biological Chemistry.

A REVERSE TRANSCRIPTION - POLYMERASE CHAIN REACTION FOR THE DETECTION OF PNEUMOVIRUSES

Akbar Ali, D. Reynolds, 1999 .

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

Hong Cao, Christos J. Petropoulos, Celia A. Schiffer, 2012, PLoS pathogens.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance.

C. Schiffer, Akbar Ali, Adam K. Hedger, 2022, Journal of molecular biology.

Deciphering the Molecular Mechanism of HCV Protease Inhibitor Fluorination as a General Approach to Avoid Drug Resistance

C. Schiffer, E. Chan, Akbar Ali, 2021, bioRxiv.

Discovery of Quinoxaline-Based P1-P3 Macrocyclic NS3/4A Protease Inhibitors with Potent Activity against Drug-Resistant Hepatitis C Virus Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2021, Journal of medicinal chemistry.

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

C. Schiffer, Akbar Ali, Adam K. Hedger, 2020, mBio.

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir [preprint]

C. Schiffer, Akbar Ali, M. Henes, 2020 .

Molecular and structural mechanism of pan-genotypic HCV NS3/4A protease inhibition by glecaprevir

C. Schiffer, Akbar Ali, Nese Kurt-Yilmaz, 2019, bioRxiv.

Molecular Mechanism of Resistance in a Clinically Significant Double-Mutant Variant of HCV NS3/4A Protease.

C. Schiffer, C. Petropoulos, Wei Huang, 2018, Structure.

Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.

C. Schiffer, C. Petropoulos, Wei Huang, 2018, ACS medicinal chemistry letters.

Hepatitis C Virus NS3/4A Protease Inhibitors Incorporating Flexible P2 Quinoxalines Target Drug Resistant Viral Variants.

Wei Huang, Akbar Ali, Celia A Schiffer, 2017, Journal of medicinal chemistry.

Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease.

C. Schiffer, Akbar Ali, Kristina L. Prachanronarong, 2016, Journal of the American Chemical Society.

Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.

C. Schiffer, Cihan Aydın, Akbar Ali, 2016, ACS chemical biology.

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Akbar Ali, Kelin Li, Alicia M. Hanson, 2015, ACS chemical biology.

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

C. Schiffer, Akbar Ali, Djadé I. Soumana, 2014, ACS chemical biology.

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

Hong Cao, Bruce Tidor, Nese Kurt Yilmaz, 2013, Chemistry & biology.

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.

C. Schiffer, C. Petropoulos, Cihan Aydın, 2013, ACS chemical biology.

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

C. Schiffer, W. Royer, Akbar Ali, 2010, Proceedings of the National Academy of Sciences.

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Michael K. Gilson, Hong Cao, Bruce Tidor, 2010, Journal of Virology.

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2010, Journal of medicinal chemistry.

Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2007, Journal of medicinal chemistry.

Comparison between Haemaglutination Test and Polymerase Chain Reaction for Diagnosis of Canine Parvovirus Infection

H. Ullah, S. Umar, M. Shah, 2015 .

Small-molecule inhibition of HIV-1 Vif

Hong Cao, Akbar Ali, Tariq M Rana, 2008, Nature Biotechnology.

Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

P. Kaufman, Akbar Ali, H. Cao, 2013, Proceedings of the National Academy of Sciences.

Discovery of a Small Molecule Tat-trans-Activation-responsive RNA Antagonist That Potently Inhibits Human Immunodeficiency Virus-1 Replication*

Hong Cao, Akbar Ali, Yueh-Hsin Ping, 2003, Journal of Biological Chemistry.

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1.

Jennifer E. Golden, Samantha A Bender, Akbar Ali, 2019, Journal of medicinal chemistry.

Dissecting RNA-interference pathway with small molecules.

T. Rana, Akbar Ali, H. Cao, 2005, Chemistry & biology.

Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells.

T. Rana, Akbar Ali, H. Cao, 2004, Chemistry & biology.

ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification

R. Hills, D. Linch, Akbar Ali, 2014, Leukemia & lymphoma.

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

C. Schiffer, J. Lee, E. Nalivaika, 2021, Viruses.

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Hong Cao, Bruce Tidor, Celia A. Schiffer, 2013, ACS chemical biology.

Frequency of NPM1 Mutations in Pakistani Acute Myeloid Leukemia Patients

A. Shakoori, Akbar Ali, R. Gale, 2013 .

Frequency of NPM 1 Mutations in Pakistani Acute Myeloid Leukemia Patients

A. Shakoori, Akbar Ali, M. K. Siddique, 2013 .

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.

Akbar Ali, Celia A Schiffer, Tariq M Rana, 2006, Journal of medicinal chemistry.

Phenotypic heterogeneity and evidence of a founder effect associated with G6PC3 mutations in patients with severe congenital neutropenia

A. Shakoori, A. Segal, D. Linch, 2012, British journal of haematology.

Robust against Drug Resistance HIV-1 Protease Inhibitors Designed To Be Hypothesis: Structural Analysis of Novel Evaluating the Substrate-Envelope

B. Tidor, M. Gilson, C. Schiffer, 2014 .

Molecular Basis for Drug Resistance in HIV-1 Protease

Celia A. Schiffer, Kelly M. Thayer, Akbar Ali, 2010, Viruses.

Pfcrt Gene in Plasmodium falciparum Field Isolates from Muzaffargarh, Pakistan

Akbar Ali, H. Bilal, A. Tanveer, 2015, Journal of arthropod-borne diseases.

Antimicrobial Resistance Pattern of Uropathogens Isolated from Rafha Central Hospital, Rafha, Kingdom of Saudi Arabia

Akbar Ali, 2018, Journal of Pure and Applied Microbiology.

Different immunogenic peptides of pseudorabies virus detected by sera prepared in different animal species

Akbar Ali, M. Azmi, I. Eljalii, 2003 .

Detection of Toxoplasma gondii by Loop-mediated Isothermal Amplification in Blood and Urine Samples from Women in Saudi Arabia

Y. Lau, Akbar Ali, M. Lai, 2020 .

Design of Mutation‐resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis

Hong Cao, Bruce Tidor, Michael K Gilson, 2007, Chemical biology & drug design.

Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.

B. Tidor, C. Schiffer, T. Rana, 2012, Journal of medicinal chemistry.

Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.

C. Schiffer, E. Nalivaika, Akbar Ali, 2018, ACS infectious diseases.

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Hong Cao, Bruce Tidor, Michael K Gilson, 2008, Journal of the American Chemical Society.

HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2023, European journal of medicinal chemistry.

Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere.

C. Schiffer, R. Swanstrom, E. Nalivaika, 2020, Journal of medicinal chemistry.

Additivity in the analysis and design of HIV protease inhibitors.

Bruce Tidor, Michael K Gilson, Akbar Ali, 2009, Journal of medicinal chemistry.

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

C. Schiffer, T. Rana, S. Anjum, 2010, Journal of medicinal chemistry.

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

N. Krogan, C. Schiffer, M. Carpenter, 2012, ACS chemical biology.

Molecular and structural mechanism of pan-genotypic HCV NS3/ Molecular and structural mechanism of pan-genotypic HCV NS3/ 4A protease inhibition by glecaprevir [preprint] 4A protease inhibition by glecaprevir [preprint] us you.

C. Schiffer, Akbar Ali, M. Henes, 2022 .

Role of Mannheimia (Pasteurella) haemolytica in severe respiratory tract infection in commercial poultry in Pakistan.

N. Siddique, A. Ghafar, Akbar Ali, 2015 .

Detection of FLT3/TKD and IDH1 Mutations in Pakistani Acute Myeloid Leukemia Patients by Denaturing HPLC

A. Shakoori, Akbar Ali, R. Gale, 2017, Journal of cellular biochemistry.

Frequency of FLT3/ITD Mutations in Pakistani Acute Myeloid Leukemia Patients

A. Shakoori, Akbar Ali, M. K. Siddique, 2013 .

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.

C. Schiffer, C. Petropoulos, Wei Huang, 2013, ACS chemical biology.

Isolation and sequence analysis of reassortant low pathogenic avian influenza virus H4N6 from duck and chicken in live bird markets from Pakistan.

N. Siddique, Akbar Ali, F. Rashid, 2016 .

Allosteric quinoxaline-based inhibitors of the flavivirus NS2B/NS3 protease.

C. Schiffer, E. Nalivaika, Akbar Ali, 2022, Bioorganic chemistry.