Takumi Watanabe

发表

Molecular design and biological activities of protein-tyrosine phosphatase inhibitors.

K. Umezawa, M. Kawakami, Takumi Watanabe, 2003, Pharmacology & therapeutics.

Structure–Activity Relationship and Rational Design of 3,4-Dephostatin Derivatives as Protein Tyrosine Phosphatase Inhibitors

Y. Umezawa, K. Umezawa, M. Otsuka, 2000 .

Total synthesis of dephostatin, a novel protein tyrosine phosphatase inhibitor

K. Umezawa, M. Otsuka, T. Takeuchi, 1994 .

Catalytic asymmetric total synthesis of (+)-caprazol.

T. Masuda, M. Shibasaki, Takumi Watanabe, 2014, Organic letters.

RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells

K. Ushida, R. Inoue, Takumi Watanabe, 2015, PloS one.

Studies on catalytic enantioselective total synthesis of caprazamycin B: construction of the western zone.

M. Shibasaki, Takumi Watanabe, P. Gopinath, 2012, The Journal of organic chemistry.

Total synthesis of (±)-aglaiastatin, a novel bioactive alkaloid

K. Umezawa, M. Otsuka, T. Takeuchi, 1998 .

Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.

M. Kawada, Takumi Watanabe, Hikaru Abe, 2018, Oncology letters.

Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.

A. Nomoto, M. Kawada, M. Shibasaki, 2013, Organic letters.

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis

N. Takizawa, M. Shibasaki, Takumi Watanabe, 2018, Archives of Virology.

Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin‐like growth factor‐1 secretion by prostate stromal cells

M. Kawada, M. Shibasaki, Takumi Watanabe, 2020, International journal of cancer.

Structure-activity relationship of boronic acid derivatives of tyropeptin: proteasome inhibitors.

Takumi Watanabe, Yoshikazu Takahashi, Y. Akamatsu, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.

Y. Umezawa, Takumi Watanabe, Yoshikazu Takahashi, 2009, Bioorganic & medicinal chemistry letters.

Enzyme-assisted Extraction of Bioactive Phytochemicals from Japanese Peppermint (Mentha arvensis L. cv. 'Hokuto').

N. Ohtsu, Takumi Watanabe, Tai-Ying Chiou, 2020, Journal of oleo science.

Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNFα-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

A. Nomoto, H. Inoue, M. Kawada, 2015, PloS one.

Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.

M. Shibasaki, M. Imoto, Takumi Watanabe, 2012, Organic letters.

NBRI17671, a new antitumor compound, produced by Acremonium sp. CR17671

M. Kawada, Takumi Watanabe, Hikaru Abe, 2010, The Journal of Antibiotics.

Virucidal effect of monogalactosyl diacylglyceride from a green microalga, Coccomyxa sp. KJ, against clinical isolates of SARS‐CoV‐2 as assessed by a plaque assay

T. Akaike, Takumi Watanabe, H. Miyachi, 2021, Journal of clinical laboratory analysis.

Rediscovery of 4‐Trehalosamine as a Biologically Stable, Mass‐Producible, and Chemically Modifiable Trehalose Analog

M. Shibasaki, Takumi Watanabe, C. Hayashi, 2022, Advanced biology.

Diverse Immune Responses to Orally Administered Heat-Killed Cell Preparation of Enterococcus faecalis Strain EC-12 in Murine Immune Tissues

K. Ushida, R. Inoue, Takumi Watanabe, 2009, Bioscience, biotechnology, and biochemistry.

Catalytic Asymmetric Total Synthesis of Leucinostatin A

M. Shibasaki, Takumi Watanabe, Hikaru Abe, 2020, Chemical record.

Structure-activity relationship study of leucinostatin A, a modulator of tumor−stroma interaction

M. Kawada, M. Shibasaki, Takumi Watanabe, 2018, Tetrahedron.

Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction.

M. Kawada, M. Shibasaki, Takumi Watanabe, 2017, Chemistry.

Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2

A. Nomoto, M. Kawada, Takumi Watanabe, 2013, The Journal of Antibiotics.

Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis.

M. Shibasaki, Takumi Watanabe, K. Suenaga, 2017, Chemistry.

Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.

Y. Umezawa, Takumi Watanabe, Yoshikazu Takahashi, 2010, Bioorganic & medicinal chemistry letters.

Anti-Influenza virus effects of Enterococcus faecalis KH2 and Lactobacillus plantarum SNK12 RNA

T. Kawahara, K. Hayashi, Takumi Watanabe, 2020, Bioscience of microbiota, food and health.

Chromatography-free synthesis of Corey's intermediate for Tamiflu

N. Kumagai, M. Shibasaki, Takumi Watanabe, 2014 .

Two approaches toward the formal total synthesis of oseltamivir phosphate (Tamiflu): catalytic enantioselective three-component reaction strategy and L-glutamic acid strategy.

K. Yamatsugu, N. Kumagai, M. Shibasaki, 2013, The Journal of organic chemistry.

Asymmetric conjugate addition reactions of Meldrum's acid derived acceptors employing chiral phosphoramidite ligands.

E. Carreira, Takumi Watanabe, Thomas F Knöpfel, 2003, Organic letters.

Readily available biaryl P,N ligands for asymmetric catalysis.

E. Carreira, Takumi Watanabe, Thomas F Knöpfel, 2004, Angewandte Chemie.

Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis.

M. Shibasaki, Takumi Watanabe, H. Noda, 2023, The Journal of organic chemistry.

Catalytic asymmetric synthesis of CPZEN-45

Toshifumi Takeuchi, M. Shibasaki, Takumi Watanabe, 2016 .

Readily available biaryl P,N ligands for asymmetric catalysis.

E. Carreira, Takumi Watanabe, Thomas F Knöpfel, 2004, Angewandte Chemie.

Catalytic enantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni2-Schiff base catalyst.

M. Shibasaki, Takumi Watanabe, P. Gopinath, 2012, Organic letters.

Catalytic asymmetric synthesis of key intermediate for scytophycin C

M. Shibasaki, Takumi Watanabe, Jin Cui, 2016 .

Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage.

N. Kumagai, M. Shibasaki, Takumi Watanabe, 2018, Chemistry.

Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones

N. Kumagai, M. Shibasaki, Takumi Watanabe, 2020, Chemical science.

Synthesis of caprazamycin B

M. Shibasaki, Takumi Watanabe, P. Gopinath, 2015 .

Concise and Stereodivergent Approach to Chromanone Lactones through Copper-Catalyzed Asymmetric Vinylogous Addition of Siloxyfurans to 2-Ester-Substituted Chromones.

M. Shibasaki, Takumi Watanabe, H. Noda, 2022, Angewandte Chemie.

The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its structurally related derivatives.

Takumi Watanabe, C. Hayashi, Yoshikazu Takahashi, 2010, Bioorganic & medicinal chemistry letters.

Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.

Y. Umezawa, Takumi Watanabe, Yoshikazu Takahashi, 2012, Bioorganic & medicinal chemistry letters.

DNA modifications by the omega-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNA.

T. Matsuda, Takumi Watanabe, Yoshikazu Takahashi, 2010, Chemical research in toxicology.

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.

Kunio Inoue, T. Masuda, Yoshihiko Kobayashi, 2012, Chemistry.

Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.

A. Nomoto, M. Shibasaki, Takumi Watanabe, 2015, Journal of natural products.

Evaluation of the heat-killed and dried cell preparation of Enterococcus faecalis against villous atrophy in early-weaned mice and pigs.

K. Ushida, R. Inoue, Takumi Watanabe, 2011, Animal science journal = Nihon chikusan Gakkaiho.

Androprostamine A: a unique antiprostate cancer agent

M. Kawada, Takumi Watanabe, Hikaru Abe, 2021, The Journal of Antibiotics.

Androprostamine A: a unique antiprostate cancer agent

M. Kawada, Takumi Watanabe, Hikaru Abe, 2021, The Journal of Antibiotics.

Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition.

Y. Fujioka, N. Noda, M. Shibasaki, 2022, Journal of the American Chemical Society.

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2

Takumi Watanabe, I. Momose, 2017, The Journal of Antibiotics.

Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors

A. Nomoto, S. Dan, T. Yamori, 2014, Cancer science.

Synthesis of Androprostamine A and Resormycin.

M. Shibasaki, Takumi Watanabe, Hikaru Abe, 2016, Chemical & pharmaceutical bulletin.

Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity

H. Naganawa, T. Sawa, M. Hamada, 2010, The Journal of Antibiotics.

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

M. Shibuya, M. Kawada, Yoshihiko Kobayashi, 2016, BMC Cancer.

Synthesis and Determination of Absolute Configuration of Lentztrehalose A.

M. Shibasaki, Takumi Watanabe, Ming Zhang, 2015, Chemical and pharmaceutical bulletin.

Oral administration of Enterococcus faecalis EC-12 cell preparation improves villous atrophy after weaning through enhancement of growth factor expression in mice.

K. Ushida, R. Inoue, Takumi Watanabe, 2010, Biomedical research.

Oral Administration of EC-12 Increases the Baseline Gene Expression of Antiviral Cytokine Genes, IFN-γ and TNF-α, in Splenocytes and Mesenteric Lymph Node Cells of Weaning Piglets

K. Ushida, R. Inoue, Takumi Watanabe, 2013, Bioscience of microbiota, food and health.

Structure–activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities

A. Nomoto, M. Kawada, M. Shibasaki, 2013 .

Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460

A. Nomoto, M. Kawada, M. Shibasaki, 2015, The Journal of Antibiotics.

Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells

M. Kawada, Takumi Watanabe, R. Sawa, 2017, The Journal of Antibiotics.

[Boronic Acid as a Promising Class of Chemical Entity for Development of Clinical Medicine for Targeted Therapy of Cancer].

Takumi Watanabe, I. Momose, 2022, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts.

Takumi Watanabe, Yoshikazu Takahashi, K. Hachisuka, 2006, Chemical research in toxicology.

Monotherapy with a novel intervenolin derivative, AS‐1934, is an effective treatment for Helicobacter pylori infection

M. Kawada, M. Shibasaki, Takumi Watanabe, 2018, Helicobacter.

Rapid Induction of an Immune Response in Rat Peyer's Patch after Oral Administration of Enterococcus faecalis Strain EC-12

K. Ushida, R. Inoue, Takumi Watanabe, 2013, Bioscience, biotechnology, and biochemistry.

Physical properties of lactic acid bacteria influence the level of protection against influenza infection in mice

T. Kawahara, Takumi Watanabe, M. Ohwaki, 2021, PloS one.

Enhanced Protection Against Influenza Virus Infection with Dispersion Controlled Lactic Acid Bacteria Powder

T. Kawahara, K. Hayashi, Takumi Watanabe, 2020 .

Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs.

K. Umezawa, T. Watanabe, M. Otsuka, 1995, The Journal of antibiotics.

Total Synthesis of Dephostatin, a Novel Protein Tyrosine Phosphatase Inhibitor.

K. Umezawa, M. Otsuka, T. Takeuchi, 1994 .

Evaluation of the heat-killed and dried cell preparation of Enterococcus faecalis against villous atrophy in early-weaned mice and pigs.

K. Ushida, R. Inoue, Takumi Watanabe, 2011, Animal science journal = Nihon chikusan Gakkaiho.