B. de Costa

发表

Identification of a GBR12935 homolog, LR1111, which is over 4,000‐fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters

K. Rice, R. Rothman, H. Xu, 1993, Synapse.

Cannabinoid receptor localization in brain.

M. Herkenham, K. Rice, M. Johnson, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.

K. Rice, M. Johnson, L. Melvin, 1993, The Journal of pharmacology and experimental therapeutics.

Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter.

M. Reith, K. Rice, B. de Costa, 1992, European journal of pharmacology.

Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.

W. Bowen, M. Friedman, B. de Costa, 2001, European journal of pharmacology.

Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats

B. de Costa, R. Matsumoto, Thuy Tran, 1998, Psychopharmacology.

Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogues.

M. Rogawski, K. Rice, B. de Costa, 1990, Journal of Medicinal Chemistry.

Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.

P. Contreras, W. Bowen, K. Rice, 1990, Journal of medicinal chemistry.

[3H]1‐[2‐(2‐thienyl)cyclohexyl]piperidine labels two high‐affinity binding sites in human cortex: Further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex

K. Rice, M. Heyes, R. Rothman, 1991, Synapse.

Sigma receptors: biology and function.

W. Bowen, J. Walker, K. Rice, 1990, Pharmacological reviews.

Subchronic administration of N-[2-(3,4-dichlorophenyl) ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) alters sigma 1 receptor binding.

A. Zambon, B. de Costa, A. Kanthasamy, 1997, European journal of pharmacology.

Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.

W. Bowen, L. Radesca, B. de Costa, 1992, Journal of medicinal chemistry.

Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands.

W. Bowen, L. Radesca, B. de Costa, 1991, Journal of medicinal chemistry.

Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism.

W. Bowen, B. de Costa, D. Truong, 1995, European journal of pharmacology.

Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.

B. de Costa, M. Eldefrawi, L. Raymon, 1993, Journal of Medicinal Chemistry.

Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys.

J. Woods, S. Negus, E. Butelman, 1993, The Journal of pharmacology and experimental therapeutics.

GBR12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat.

K. Rice, R. Rothman, Rice Kc, 1994, The Journal of pharmacology and experimental therapeutics.

Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.

J. Cadet, K. Rice, F. Carroll, 1994, Journal of Pharmacology and Experimental Therapeutics.

Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.

K. Rice, F. Carroll, R. Rothman, 1993, Life sciences.

Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.

J. Cadet, K. Rice, F. Carroll, 1994, The Journal of pharmacology and experimental therapeutics.

Labelling of diazepam-sensitive and -insensitive benzodiazepine receptors with [3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine 3-carboxylate (ZG-63).

P. Skolnick, B. de Costa, G. Wong, 1993, European Journal of Pharmacology.

Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.

W. Bowen, J. Linders, C. Dominguez, 1993, Journal of medicinal chemistry.

Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).

K. Rice, R. Rothman, C. Dersch, 2000, Journal of medicinal chemistry.

Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).

K. Rice, R. Rothman, C. Dersch, 1996, Journal of medicinal chemistry.

Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.

W. Bowen, C. Dominguez, L. Radesca, 1992, Journal of medicinal chemistry.

Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

P. Skolnick, C. Dominguez, K. Rice, 1993, Journal of medicinal chemistry.

Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.

H. Mosberg, J. Woods, S. Comer, 1993, The Journal of pharmacology and experimental therapeutics.

Selective antagonism by naltrindole of the antinociceptive effects of the delta opioid agonist cyclic[D-penicillamine2-D-penicillamine5]enkephalin in the rat.

B. de Costa, D. Hammond, M. Rafferty, 1991, The Journal of pharmacology and experimental therapeutics.

Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites.

B. de Costa, M. Eldefrawi, L. Raymon, 1993, Journal of medicinal chemistry.

Synthesis of an affinity ligand (‘UPHIT’) for in vivo acylation of the κ‐opioid receptor

K. Rice, R. Rothman, B. de Costa, 1989 .

Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells

E. Rojas, P. Skolnick, H. Pollard, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Site-specific acylation of GABA-gated Cl- channels: effects on 36Cl- uptake.

P. Skolnick, K. Rice, B. de Costa, 1991, European journal of pharmacology.

Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.

A. Mahboubi, K. Rice, R. Rothman, 1991, Molecular pharmacology.

A practical approach for repositioning flipped venous access ports.

B. de Costa, K. Dickey, L. Greenwood, 2000, Journal of vascular and interventional radiology : JVIR.

Selective and enantiospecific acylation of kappa opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexy l] benzeneacetamide. Demonstration of kappa receptor heterogeneity.

K. Rice, R. Rothman, B. de Costa, 1989, Journal of medicinal chemistry.

Differential binding of opioid peptides and other drugs to two subtypes of opioid delta ncx binding sites in mouse brain: further evidence for delta receptor heterogeneity.

K. Rice, R. Rothman, B. de Costa, 1993, Peptides.

Apparent affinity of opioid antagonists in morphine-treated rhesus monkeys discriminating between saline and naltrexone.

K. Rice, J. Woods, B. de Costa, 1990, The Journal of pharmacology and experimental therapeutics.

Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.

F. Porreca, B. de Costa, K. Rice, 1991, The Journal of pharmacology and experimental therapeutics.

Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes.

K. Rice, J. Woods, R. Rothman, 1989, European journal of pharmacology.

Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.

W. Bowen, J. Walker, K. Rice, 1989, FEBS letters.

Synthesis and evaluation of optically pure [3H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

W. Bowen, K. Rice, B. de Costa, 1989 .

Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.

H. Mosberg, J. Woods, S. Comer, 1993, The Journal of pharmacology and experimental therapeutics.

Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.

W. Bowen, C. George, J. Walker, 1989, Journal of medicinal chemistry.

Differential antagonism of bremazocine- and U69,593-induced antinociception by quadazocine: further functional evidence of opioid kappa receptor multiplicity in the mouse.

F. Porreca, B. de Costa, R. Haaseth, 1993, The Journal of pharmacology and experimental therapeutics.

Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid mu, delta, kappa 1, kappa 2a, or kappa 2b receptors.

K. Rice, R. Raffa, R. Rothman, 1994, Peptides.

Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity.

W. Bowen, B. de Costa, R. Matsumoto, 1999, European journal of pharmacology.

N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice.

J. Miller, W. Bowen, B. de Costa, 2001, European journal of pharmacology.

Selective labeling of kappa 2 opioid receptors in rat brain by [125I]IOXY: interaction of opioid peptides and other drugs with multiple kappa 2a binding sites.

K. Rice, R. Rothman, B. de Costa, 1993, Peptides.

Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex.

J. Holaday, J. Long, A. Mahboubi, 1991, Synapse.

Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-

K. Berman, C. George, M. Iadarola, 1992, Journal of medicinal chemistry.

Synthesis of N,N'-substituted piperazine and homopiperazine derivatives with polyamine-like actions at N-methyl-D-aspartate receptors.

P. Skolnick, B. de Costa, G. Li, 1995, Journal of medicinal chemistry.

meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore.

P. Skolnick, K. Rice, B. de Costa, 1989, Molecular pharmacology.

Sigma receptors and signal transduction: negative modulation of signaling through phosphoinositide-linked receptor systems.

W. Bowen, K. Rice, B. de Costa, 1993, NIDA research monograph.

Characterization of the enantiomers of cis-N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)cyclohexylamine (BD737 and BD738): novel compounds with high affinity, selectivity and biological efficacy at sigma receptors.

W. Bowen, J. Walker, K. Rice, 1992, The Journal of pharmacology and experimental therapeutics.

A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.

W. Bowen, C. Dominguez, B. de Costa, 1994, Journal of medicinal chemistry.