T. Takita

发表

Oxanosine, a novel nucleoside from actinomycetes.

H. Naganawa, T. Takeuchi, M. Hamada, 1981, The Journal of antibiotics.

Immunological involvement in pulmonary fibrosis induced by peplomycin.

T. Takita, H. Umezawa, A. Matsuda, 1985, The Journal of antibiotics.

Chemistry of bleomycin. XXV. Reductive methylation of bleomycin, a chemical proof for the presence of the free secondary amine in bleomycin.

H. Naganawa, T. Takita, H. Umezawa, 1980, The Journal of antibiotics.

Coriolin, a new Basidiomycetes antibiotic.

T. Takeuchi, T. Takita, H. Iinuma, 1969, The Journal of antibiotics.

Letter: Absolute configuration of coriolin, a sesquiterpene antibiotic from Coriolus consors.

T. Takita, H. Umezawa, H. Nakamura, 1974, The Journal of antibiotics.

An X‐ray study of ilamycin B1, a cyclic heptapeptide antibiotic

Y. Iitaka, T. Takita, H. Nakamura, 1974 .

Novel antifungal antibiotics octacosamicins A and B. II. The structure elucidation using various NMR spectroscopic methods.

Y. Takahashi, H. Naganawa, T. Takeuchi, 1988, The Journal of antibiotics.

The X-ray structure determination of oxanosine.

N. Shimada, N. Yagisawa, T. Takita, 1981, The Journal of antibiotics.

A NEW ANTIBIOTIC, FORMYCIN.

T. Takita, H. Umezawa, M. Hori, 1964, The Journal of antibiotics.

The structure of pepstatin.

T. Aoyagi, T. Takeuchi, T. Takita, 1970, The Journal of antibiotics.

Chemistry of bleomycin. XVIII. carbon-13 NMR studies.

H. Naganawa, T. Takita, H. Umezawa, 1977, The Journal of antibiotics.

THE STRUCTURES OF ILAMYCIN AND ILAMYCIN B2.

H. Naganawa, T. Takita, H. Umezawa, 1964, The Journal of antibiotics.

Effect of oxygen concentration on pulmonary fibrosis caused by peplomycin in mice.

T. Takita, H. Umezawa, A. Matsuda, 1984, The Journal of antibiotics.

The structure of the sulfur-containing chromophore of phleomycin, and chemical transformation of phleomycin to bleomycin.

T. Takita, Y. Muraoka, A. Fujii, 1972, The Journal of antibiotics.

Assessment of the anti-diabetic activity of deoxyspergualin in low-dose streptozotocin-induced diabetic mice.

Teruya Nakamura, T. Takeuchi, T. Takita, 1988, The Journal of antibiotics.

Inhibition of tyrosine hydroxylase, a Fe(II)-stimulated monooxygenase, by bleomycin.

T. Takeuchi, T. Takita, H. Umezawa, 1980, The Journal of antibiotics.

Chemistry of bleomycin. XXII. Interaction of bleomycin with nucleic acids, preferential binding to guanine base and electrostatic effect of the terminal amine.

H. Naganawa, T. Takita, H. Umezawa, 1978, The Journal of antibiotics.

Biological activities of deoxyspergualin in autoimmune disease mice.

Teruya Nakamura, F. Abe, T. Takeuchi, 1988, The Journal of antibiotics.

Effect of spergualin in autoimmune disease mice.

F. Abe, T. Takeuchi, T. Takita, 1987, The Journal of antibiotics.

Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities.

H. Naganawa, T. Takeuchi, M. Hamada, 1988, The Journal of antibiotics.

Inhibition of infectivity of human immunodeficiency virus by a novel nucleoside, oxetanocin, and related compounds

T. Takeuchi, N. Shimada, T. Takita, 1989, Antimicrobial Agents and Chemotherapy.

A new antibiotic indisocin and N-methylindisocin.

Y. Takahashi, H. Naganawa, T. Takeuchi, 1987, The Journal of antibiotics.

Facile and practical synthesis of optically pure 1 d - chiro -inositol from myo -inositol

T. Takeuchi, T. Takita, Yoshiaki Takahashi, 2001 .

A study of the secondary structure of ilamycin B1 by 300 MHz proton magnetic resonance

T. Takita, L. Cary, M. Ohnishi, 1971, FEBS letters.

Synthesis of carbocyclic nucleosides: synthesis of (±)-2,2-bis(hydroxymethyl)cyclopropyl nucleosides

T. Takita, S. Nishiyama, S. Yamamura, 1992 .

Biosyntheses of new bleomycins.

N. Shimada, T. Takita, H. Umezawa, 1974, The Journal of antibiotics.

PREPARATION OF BLEOMYGINIG ACID: HYDROLYSIS OF BLEOMFYGIN B2 BY A FUSARIUM AGYLAGMATINE AMIDOHYDROLASE

T. Takita, H. Umezawa, A. Fujii, 1973 .

Synthesis of Oxetanocin, Novel Nucleoside Containing an Oxetane Ring and its Carbocyclic Analogues

T. Takita, S. Niitsuma, Y. Ichikawa, 1992 .

Inhibition of infectivity of human immunodeficiency virus by oxetanocin.

T. Takeuchi, N. Shimada, T. Takita, 1987, The Journal of antibiotics.

Oxetanocin, a novel nucleoside from bacteria.

N. Shimada, T. Takita, A. Fujii, 1986, The Journal of antibiotics.

DNA-bleomycin interaction: Nucleotide sequence-specific binding and cleavage of DNA by bleomycin

Y. Sugiura, M. Otsuka, M. Ohno, 1984 .

Chemistry of bleomycin. XX. The X-ray structure determination of P-3A Cu(II)-complex a biosynthetic intermediate of bleomycin.

T. Takita, H. Umezawa, H. Nakamura, 1978, The Journal of antibiotics.

The bleomycins: Antitumor copper-binding antibiotics

T. Takita, H. Umezawa, 1980 .

The structure of antrimycin.

H. Naganawa, N. Shimada, T. Takita, 1981, The Journal of antibiotics.

COMPLEXES: IMPLICATIONS FOR IRON-BINDING SITE AND ROLE OF THE SUGAR PORTION IN BLEOMYCIN ANTIBIOTICS

Y. Umezawa, Y. Sugiura, T. Takita, 2006 .

THE ABSOLUTE STRUCTURE OF ORYZOXYMYCIN

H. Naganawa, T. Takita, H. Umezawa, 1974 .

The structures of oryzoxymycin and its dimerization product.

H. Naganawa, T. Takita, S. Takahashi, 1972, The Journal of antibiotics.

The X-ray structure determination of oxetanocin.

N. Shimada, T. Takita, H. Nakamura, 1986, The Journal of antibiotics.

Redox potential of the active bleomycin-Fe(III) complex by cyclic voltammetry

T. Takita, K. Ishizu, K. Miyoshi, 1988 .

Electrochemical and ESR studies on Cu(II) complexes of bleomycin and its related compounds.

Y. Sugiura, T. Takita, H. Umezawa, 1981, The Journal of antibiotics.

An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen.

T. Takita, H. Umezawa, K. Takahashi, 1981, The Journal of antibiotics.

Chemistry of bleomycin. XXIII. Natural abundance 15N-NMR spectroscopic evidence for the structure of bleomycin.

W. Hull, H. Naganawa, T. Takita, 1979, The Journal of antibiotics.

Chemistry of bleomycin. XXI. Metal-complex of bleomycin and its implication for the mechanism of bleomycin action.

T. Takita, H. Umezawa, Y. Iitaka, 1978, The Journal of antibiotics.

Chemistry of bleomycin. XIX Revised structures of bleomycin and phleomycin.

Y. Umezawa, H. Naganawa, T. Takita, 1978, The Journal of antibiotics.

Chemistry of bleomycin. IV. The structure of amine component II of bleomycin A2.

T. Takita, H. Umezawa, Y. Muraoka, 1970, The Journal of antibiotics.

Chemical studies on bleomycins. I. The acid hydrolysis products of bleomycin A2.

T. Takita, H. Umezawa, Y. Muraoka, 1968, The Journal of antibiotics.

Oxetanocin-oxetanose chemistry : lewis acid promoted glycosidations of the D-erythrooxetanose derivatives

T. Takita, S. Nishiyama, S. Yamamura, 1992 .

A total synthesis of oxetanocin, a novel nucleoside with an oxetane ring

T. Takita, S. Nishiyama, S. Yamamura, 1988 .

Studies on the total synthesis of oxetanocin; II. Total synthesis if oxetanocin

T. Takita, Kuniki Kato, S. Niitsuma, 1987 .

The chemistry of bleomycin. IX. The structures of bleomycin and phleomycin.

T. Takita, Y. Muraoka, A. Fujii, 1972, The Journal of antibiotics.

The chemistry of bleomycin. II the molecular and crystal structure of a sulfur-containing chromophoric amino acid

T. Takita, H. Umezawa, Y. Iitaka, 1968 .

CHEMISTRY OF BLEOMYGIN. III THE SUGAR MOIETIES OF BLEOMYGIN A2

T. Takita, H. Umezawa, S. Omoto, 1969 .

Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase B.

T. Aoyagi, T. Takita, H. Suda, 1977, Journal of medicinal chemistry.

Chemistry of bleomycin. XXVII. Cleomycin, a new family of bleomycin-phleomycin group.

H. Naganawa, T. Takita, H. Umezawa, 1980, The Journal of antibiotics.

Synthesis of cleonine, amino(1-hydroxycyclopropyl)acetic acid, a novel amino acid contained in cleomycin

T. Takita, H. Umezawa, Kuniki Kato, 1980 .

Vanoxonin, a new inhibitor of thymidylate synthetase. III. Inhibition of thymidylate synthetase by vanoxonin-vanadium complex.

T. Takeuchi, K. Isshiki, T. Takita, 1985, The Journal of antibiotics.

Derivatives of oxetanocin: oxetanocins H, X and G, and 2-aminooxetanocin A.

T. Nishikiori, N. Shimada, T. Takita, 1987, The Journal of antibiotics.

Preparation of trans-3-(hydroxymethyl)-2-vinyloxetane via allyloxycarbanion-mediated carbon–carbon bond formation in allyl glycidyl ether

T. Takita, Kuniki Kato, S. Niitsuma, 1988 .

Studies on the total synthesis of oxetanocin; I. The first synthesis of a nucleoside having oxetanosyl-N-glycoside

T. Takita, Kuniki Kato, S. Niitsuma, 1987 .

Synthesis and antiviral activity of oxetanocin derivatives

N. Shimada, T. Takita, S. Hasegawa, 1991 .

Synthetic studies on oxetanocin analogs: synthesis of oxetanosyl C-nucleoside, 2-deoxy-2-hydroxymethyl-β-D-erythrooxetanosyl maleimide

T. Takita, S. Nishiyama, S. Yamamura, 1991 .

A facile synthesis of 2-deoxy-2-hydroxymethyl-β-D-erythrofuranosyl nucleosides from 9-(2-deoxy-2-hydroxymethyl-β-D-erythrooxetanosyl)adenine by a novel ring expansion accompanying transglycosidation

H. Naganawa, T. Takita, S. Nishiyama, 1989 .

Synthetic studies on oxetanocin, a novel nucleoside with an oxetane ring synthesis of some chiral D-oxetanosyl acylates

T. Takita, S. Nishiyama, S. Yamamura, 1988 .

A facile enantioselective synthesis of (1R, 2R, 3S)-1-amino-2,3-bishydroxymethylcyclobutane derivatives, a key synthetic intermediate of carbocyclic oxetanocins

T. Takita, S. Nishiyama, Y. Ogino, 1992 .

The structure of a glyoxalase I inhibitor and its chemical reactivity with SH-compounds.

T. Takeuchi, T. Takita, H. Umezawa, 1975, The Journal of antibiotics.

Synthesis of p-hydroxyubenimex.

T. Aoyagi, T. Takita, H. Umezawa, 1987, The Journal of antibiotics.

Stereoselective synthesis of (2s,3s,4r)-4-amino-3-hydroxy-2-methyl-pentanoic acid, an amino acid constituent of bleomycin, by aldold condensation)☆

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Total synthesis of deglyco-bleomycin A2

Y. Umezawa, M. Otsuka, M. Ohno, 1981 .

Glycocinnasperimicin D, a new member of glycocinnamolyspermidine antibiotic.

M. Nishida, H. Naganawa, T. Takeuchi, 1985, The Journal of antibiotics.

Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria.

T. Aoyagi, T. Takeuchi, M. Hamada, 1983, The Journal of antibiotics.

The structure of bestatin.

T. Aoyagi, T. Takita, H. Umezawa, 1976, The Journal of antibiotics.

Inhibition of dopamine-beta-hydroxylase, A copper enzyme, by bleomycin.

T. Takeuchi, T. Takita, H. Umezawa, 1980, The Journal of antibiotics.

The nature of thiol-compounds which trap cuprous ion reductively liberated from bleomycin-Cu(II) in cells.

T. Takita, H. Umezawa, K. Takahashi, 1987, The Journal of antibiotics.

Effects of o-phenanthroline, 2,2'-dipyridyl and neocuproine on the activities of bleomycin to inhibit DNA synthesis and growth of cultured cells.

T. Takita, H. Umezawa, K. Takahashi, 1986, The Journal of antibiotics.

Purification of bleomycins.

Y. Suhara, T. Takita, H. Umezawa, 1966, The Journal of antibiotics.

Lipid peroxidation by bleomycin-iron complexes in vitro.

T Takita, H Umezawa, T. Takita, 1985, The Journal of antibiotics.

Chemistry of bleomycin. XVI epi-bleomycin.

T. Takita, H. Umezawa, M. Kunishima, 1976, The Journal of antibiotics.

A facile total synthesis of oxanosine, a novel nucleoside antibiotic

N. Shimada, N. Yagisawa, T. Takita, 1983 .

Mode of action of oxanosine, a novel nucleoside antibiotic.

T. Takeuchi, N. Shimada, N. Yagisawa, 1982, The Journal of antibiotics.

X-ray structure determination of (2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoic acid, a new amino acid component of bestatin.

T. Aoyagi, T. Takita, H. Umezawa, 1976, The Journal of antibiotics.

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONS OF BESTATIN ANALOGS, INHIBITORS OF AMINOPEPTIDASE B

T. Aoyagi, T. Takita, H. Umezawa, 1977 .

Liblomycin, a new analogue of bleomycin.

T. Takeuchi, T. Takita, H. Umezawa, 1987, Cancer treatment reviews.

CHEMICAL AND BIOLOGICAL MODIFICATION OF BLEOMYCIN, AN ANTITUMOR ANTIBIOTIC

T. Takita, K. Maeda, 1980 .

Kijimicin, a polyether antibiotic.

Y. Takahashi, H. Naganawa, T. Takeuchi, 1990, The Journal of antibiotics.

The structure of hidamicin, a polyether antibiotic.

Y. Takahashi, H. Naganawa, T. Takeuchi, 1989, The Journal of antibiotics.

Chemistry of bleomycin. VII. Synthesis of -amino- -(4-amino-6-carboxy-5-methylpyrimidin-2-yl)-propionic acid, an amine component of bleomycin.

T. Takita, H. Umezawa, Y. Muraoka, 1972, The Journal of antibiotics.

The structure of the guanido amino acid moiety of viomycin.

T. Takita, K. Maeda, 1968, The Journal of antibiotics.

Synthetic analogues and biosynthetic intermediates of bleomycin. Metal-binding, dioxygen interaction, and implication for the role of functional groups in bleomycin action mechanism.

T. Suzuki, Y. Sugiura, M. Otsuka, 1983, The Journal of biological chemistry.

Crystal and molecular structures of 44-homooligomycin B

T. Nishikiori, N. Shimada, T. Takita, 1991 .

Suppression of experimental allergic encephalomyelitis in guinea pigs by spergualin and 15-deoxyspergualin.

F. Abe, T. Takeuchi, T. Takita, 1987, The Journal of antibiotics.

Activation of bleomycin-Fe(III) by bleomycin-Cu(II) and cysteine.

T. Takita, H. Umezawa, K. Takahashi, 1987, The Journal of antibiotics.

Total synthesis of the disaccharide of bleomycin, 2-0-(α-D-mannopyranosyl)-L-gulopyranose

T. Takita, H. Umezawa, T. Miyake, 1981 .

Synthesis of 3-deazaoxanosines, C-nucleoside isosteres of oxanosine

T. Takita, H. Umezawa, Kuniki Kato, 1985 .

Total synthesis of bleomycin A21)

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

The chemistry of bleomycin. 8. The structure of the sugar moiety of bleomycin A 2 .

T. Takita, H. Umezawa, S. Omoto, 1972, Journal of antibiotics (Tokyo. 1968).

The chemical synthesis of bestatin.

T. Aoyagi, T. Takita, H. Umezawa, 1976, The Journal of antibiotics.

Identification of an antibiotic produced by S. galbus, n. sp. with streptomycin.

T. Takita, H. Umezawa, Y. Okami, 1959, Journal of antibiotics (Tokyo. 1968).

CHEMISTRY OF BLEOMYCIN. XII

T. Takita, H. Umezawa, S. Omoto, 1973 .

Synthesis of the pyrimidine moiety of bleomycin

Y. Umezawa, M. Otsuka, M. Ohno, 1980 .

Chemistry of bleomycin. VI. Selective cleavage of bleomycin A 2 by N-bromosuccinimide.

T. Takita, H. Umezawa, Y. Muraoka, 1972, The Journal of antibiotics.

CHEMICAL STUDIES ON BLEOMYCINS. I

T. Takita, H. Umezawa, Y. Muraoka, 1968 .

An improved, practical synthesis of the derivatives of 1-O-acetyl-2- deoxy-2-hydroxymethyl-D-erythrooxetanose, a key sugar moiety for the synthesis of oxetanosyl-N-glycoside

T. Takita, S. Nishiyama, S. Yamamura, 1990 .

8''-Hydroxypactamycin and 7-deoxypactamycin, new members of the pactamycin group.

H. Naganawa, T. Takeuchi, K. Isshiki, 1986, The Journal of antibiotics.

Regio- and stereo-specific synthesis of threo-3-amino-2-hydroxy-acids, novel amino-acids contained in aminopeptidase inhibitors of microbial origin.

T. Takita, H. Umezawa, K. Kato, 1980, Journal of the Chemical Society. Perkin transactions 1.

HYDROXYPEPSTATIN, A NEW PEPSTATIN PRODUCED BY STREPTOMYCES

T. Aoyagi, H. Naganawa, T. Takeuchi, 1973 .

Letter: X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin.

T. Takita, H. Umezawa, H. Nakamura, 1973, The Journal of antibiotics.

SYNTHESIS OF 4-AMINO-3 HYDROXY-6-METHYLHEPTANOIG ACID, AN AMINE COMPONENT OF PEPSTATIN

T. Takita, H. Umezawa, H. Morishima, 1973 .

New pepstatins, pepstatins B and C, and pepstanone A, produced by streptomyces.

H. Iizuka, T. Takita, T. Miyano, 1972, The Journal of antibiotics.

Chemical modification of oxanosine. I. Synthesis and biological properties of 2'-deoxyoxanosine.

M. Hamada, N. Shimada, N. Yagisawa, 1984, The Journal of antibiotics.

Revised Structure and Stereochemistry of Coriolins

H. Naganawa, T. Takita, H. Umezawa, 1971 .

Interspecific transfer and expression of melanin gene(s) on cosmids in Streptomyces strains

T. Takita, T. Morino, Hideo Takahashi, 1988, Applied Microbiology and Biotechnology.

The structure of coriolin, a new sesquiterpene antibiotic

T. Takita, H. Umezawa, H. Iinuma, 1969 .

Minor congeners of antrimycin: application of secondary ion mass spectrometry (SIMS) to structure determination.

T Takita, H Umezawa, H. Naganawa, 1982, The Journal of antibiotics.

Synthesis of Carbocyclic Nucleosides: Synthesis of (.+‐.)‐2,2‐Bis( hydroxymethyl)cyclopropyl Nucleosides.

T. Takita, S. Nishiyama, S. Yamamura, 1993 .

Syntheses of 2,2-bishydroxymethylcyclopropyl adenine and uracil, novel carbocyclic nucleosides

T. Takita, S. Nishiyama, S. Yamamura, 1991 .

Effects of deoxyspergualin on hematopoiesis: studies of murine hematopoietic progenitor cell and peripheral blood cell levels.

F. Abe, T. Takeuchi, T. Takita, 1989, The Journal of antibiotics.

RETRO-SYNTHETIC MANIPULATION OF BLEOMYCINS

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Different Sensitivity to Bleomycin-Induced Pulmonary Fibrosis among Various Strains of Mice

Katsutoshi Takahashi, T. Takita, H. Umezawa, 1987 .

Carbon-13 NMR assignment of peplomycin.

H. Naganawa, T. Takita, Y. Muraoka, 1989, Journal of antibiotics (Tokyo. 1968).

TOTAL SYNTHESIS OF BLEOMYCIN A2

Y. Umezawa, M. Otsuka, M. Ohno, 1982 .

Antrimycin, a new peptide antibiotic.

T Takeuchi, T Takita, H Umezawa, 1981, The Journal of antibiotics.

METHYLSPINAZARIN AND DIHYDROMETHYLSPINAZARIN, GATEGHOL-O-METHYL TRANSFERASE INHIBITORS PRODUCED BY STREPTOMYCES

T. Takeuchi, T. Sawa, T. Takita, 1973 .

The structure of dihydroviomycidine.

T. Takita, K. Maeda, 1969, The Journal of antibiotics.

The structures of coriolin B and C.

T. Takita, H. Umezawa, H. Iinuma, 1970, Tetrahedron letters.

The structure of elastatinal, an elastase inhibitor of microbial origin.

T. Aoyagi, T. Takeuchi, T. Takita, 1975, The Journal of antibiotics.

Neopyrrolomycin, a new chlorinated phenylpyrrole antibiotic.

Y. Takahashi, H. Naganawa, M. Hamada, 1990, The Journal of antibiotics.

CHEMISTRY OF BLEOMYCIN. XI

T. Takita, H. Umezawa, A. Fujii, 1973 .

Oxanosine, a novel nucleoside from actinomycetes.

H. Naganawa, T. Takeuchi, M. Hamada, 1981, Nucleic acids symposium series.

Production by actinomycetes of (S,S)-N,N'-ethylenediamine-disuccinic acid, an inhibitor of phospholipase C.

T. Aoyagi, T. Nishikiori, H. Naganawa, 1984, The Journal of antibiotics.

CHEMISTRY OF BLEOMYCIN. XXVIII

Y. Umezawa, H. Naganawa, T. Takita, 1981 .

Chemistry of bleomycin. XXVIII. Preparation of deglycobleomycin by mild acid hydrolysis of bleomycin.

Y. Umezawa, H. Naganawa, T. Takita, 1981, The Journal of antibiotics.

The structure of arphamenines A and B.

T. Aoyagi, H. Naganawa, T. Takita, 1983, The Journal of antibiotics.

Molecular and crystal structure of viomycidine.

T. Takita, H. Nakamura, S. Omoto, 1969, Journal of antibiotics (Tokyo. 1968).

Biosynthesis and Chemical Synthesis of Bleomycin

T. Takita, Y. Muraoka, 1991 .

THE CHEMISTRY OF BLEOMYGIN. X

T. Takita, H. Umezawa, Y. Iitaka, 1973 .

Bleomycin Antibiotics: Metal Complexes and Their Biological Action

Y. Sugiura, T. Takita, H. Umezawa, 1986 .

Syntheses of Bestatin and Its Analogues and their Bioactivity

T. Takita, H. Umezawa, 1980 .