J. Sáez

J. Vayreda, F. Calvo, J. Sáez, 2008, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels

L. Cea, Rosalba Escamilla, J. Sáez, 2017, Shock.

Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells.

J. Sáez, J. Orellana, N. Palacios-Prado, 2006, Toxicology and applied pharmacology.

TNF-α Plus IFN-γ Induce Connexin43 Expression and Formation of Gap Junctions Between Human Monocytes/Macrophages That Enhance Physiological Responses 1

J. Berman, E. Eugenin, M. C. Brañes, 2003, The Journal of Immunology.

Short- and long-term regulation of rat carotid body gap junctions by cAMP. Identification of connexin43, a gap junction subunit.

V. Abudara, J. Sáez, C. Eyzaguirre, 2000, Advances in experimental medicine and biology.

Cells of the carotid body express connexin43 which is up-regulated by cAMP

V. Abudara, J. Sáez, G. Garcés, 1999, Brain Research.

Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions.

A. Nairn, A. Czernik, E. Hertzberg, 1997, Journal of molecular and cellular cardiology.

Regulation of Gap Junctions in Rat Liver during Acute and Chronic CCl4-Induced Liver Injury

E. Hertzberg, E. Eugenin, C. Sáez, 1997 .

Regulation of gap junctions by cell contact and phosphorylation in MDCK cells

E. Hertzberg, J. Sáez, V. Berthoud, 1993 .

Cell-, age- and stage-dependent distribution of connexin43 gap junctions in testes.

J. Sáez, C. Roy, I. P. Tan, 1992, Journal of cell science.

Hepatocyte Gap Junctions: Metabolic Regulation and Possible Role in Liver Metabolism

M. Bennett, D. Spray, J. Sáez, 1990 .

Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization.

K. Schalper, J. Sáez, Helmuth A. Sánchez, 2010, American journal of physiology. Cell physiology.

Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles

L. Cea, Rosalba Escamilla, J. Sáez, 2020, International journal of molecular sciences.

Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+.

E. Hertzberg, J. Sáez, V. Berthoud, 1992, European journal of cell biology.

Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture.

K. Alviña, J. Sáez, Agustín D. Martínez, 2004, Microvascular research.

Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential

K. Schalper, M. Bennett, J. Sáez, 2007, Proceedings of the National Academy of Sciences.

Role of Akt and Ca2+ on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition.

P. Lampe, J. Sáez, S. Lavandero, 2015, Biochimica et biophysica acta.

HIV increases the release of dickkopf‐1 protein from human astrocytes by a Cx43 hemichannel‐dependent mechanism

M. Bennett, J. Berman, S. Morgello, 2014, Journal of neurochemistry.

Superoxide dismutase protects cultured neurons against death by starvation.

D. Spray, M. Bennett, J. Kessler, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles.

Bruno A. Cisterna, J. Sáez, Aníbal A Vargas, 2016, Biochimica et biophysica acta.

TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway

V. Velarde, J. Sáez, J. Orellana, 2021, International journal of molecular sciences.

S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents.

M. Bennett, L. Reuss, J. Sáez, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Influence of cytosolic pH on receptor-mediated endocytosis of asialoorosomucoid.

D. Spray, P. Novikoff, A. Wolkoff, 1988, The American journal of physiology.

TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses.

J. Berman, E. Eugenin, M. C. Brañes, 2003, Journal of immunology.

Gap junctions in cells of the immune system: structure, regulation and possible functional roles.

E. Eugenin, M. C. Brañes, J. Sáez, 2000, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Regulation of Connexin-Based Channels by Fatty Acids

Rodrigo A Acuña, J. Sáez, M. Retamal, 2017, Front. Physiol..

Connexins and glucagon receptors during development of rat hepatic acinus.

J. Sáez, V. Berthoud, V. Iwanij, 1992, The American journal of physiology.

Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.

K. Schalper, J. Sáez, J. Orellana, 2009, Current vascular pharmacology.

Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

V. Velarde, J. Sáez, J. Orellana, 2018, Front. Immunol..

Innexins: Expression, Regulation, and Functions

J. Sáez, J. Vega, I. Barría, 2018, Front. Physiol..

Gap junctions: biochemical properties and functional regulation under physiological and toxicological conditions

E. Hertzberg, D. Spray, J. Sáez, 1990 .

Gap Junctions at the Dendritic Cell-T Cell Interface Are Key Elements for Antigen-Dependent T Cell Activation1

J. Sáez, A. Kalergis, K. Shoji, 2009, The Journal of Immunology.

Determination of synaptic phenotype: insulin and cAMP independently initiate development of electrotonic coupling between cultured sympathetic neurons.

D. Spray, M. Bennett, J. Kessler, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Endogenous pannexin1 channels form functional intercellular cell–cell channels with characteristic voltage-dependent properties

F. González-Nilo, Valeria Márquez-Miranda, J. Sáez, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes

J. Berman, J. Sáez, J. Orellana, 2013, Journal of leukocyte biology.

Isolated liver gap junctions: gating of transjunctional currents is similar to that in intact pairs of rat hepatocytes.

E. Hertzberg, D. Spray, M. Bennett, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications.

A. Moreno, D. Spray, J. Sáez, 1993, Advances in second messenger and phosphoprotein research.

Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation

C. Giaume, A. Koulakoff, Xing Gao, 2019, Glia.

Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro‐inflammatory treatments

M. Cohen-Salmon, C. Giaume, P. Ezan, 2009, Journal of neurochemistry.

Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats

E. Eugenin, M. C. Brañes, J. Sáez, 2002, Brain Research.

On the mechanisms of cell uncoupling induced by a tumor promoter phorbol ester in clone 9 cells, a rat liver epithelial cell line.

E. Hertzberg, M. Rook, J. Sáez, 1993, European journal of cell biology.

Use of antibodies in the analysis of connexin 43 turnover and phosphorylation.

E. Hertzberg, J. Kessler, J. Sáez, 2000, Methods.

Intercellular gap junctional communication is required for an optimal metabolic response of the functional units of liver

J. Sáez, 1997, Hepatology.

Regulation of pannexin and connexin channels and their functional role in skeletal muscles

Bruno A. Cisterna, C. Cardozo, J. Sáez, 2015, Cellular and Molecular Life Sciences.

Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels

J. Sáez, X. Figueroa, M. Riquelme, 2013, Neuropharmacology.

Currently Used Methods for Identification and Characterization of Hemichannels

K. Schalper, J. Sáez, J. Orellana, 2008, Cell communication & adhesion.

Angiotensin II-Induced Mesangial Cell Damage Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels

V. Velarde, J. Sáez, Paola Fernández, 2018, International journal of molecular sciences.

Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro.

E. Eugenin, M. C. Brañes, J. Sáez, 2007, Cellular immunology.

Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators.

E. Eugenin, J. Sáez, M. Pizarro, 2002, American journal of physiology. Gastrointestinal and liver physiology.

, Margarita Pizarro , involvement of Kupffer cells and inflammatory mediators Regulation of hepatic connexins in cholestasis : possible

E. Eugenin, J. Sáez, M. Pizarro, 2002 .

Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species.

K. Schalper, M. Bennett, J. Sáez, 2011, Biochemical and biophysical research communications.

Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway.

J. Sáez, P. Sáez, Agustín D. Martínez, 2013, Biochimica et biophysica acta.

Permeation of Calcium through Purified Connexin 26 Hemichannels*

L. Reuss, J. Sáez, Mariana C. Fiori, 2012, The Journal of Biological Chemistry.

Expression of Connexin43 in mouse Leydig, Sertoli, and germinal cells at different stages of postnatal development

J. Sáez, E. Lamoyi, V. Diaz-sanchez, 2001, The Anatomical record.

Regulation of Smooth Muscle Activity and Gap Junctions by Sexual Hormones in the Rat Oviduct

J. Sáez, M. Villalón, M. Budinich, 1997 .

Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells.

J. Sáez, V. Verselis, J. Orellana, 2009, American journal of physiology. Cell physiology.

Plasma membrane channels formed by connexins: their regulation and functions.

M. C. Brañes, J. Sáez, Agustín D. Martínez, 2003, Physiological reviews.

Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage.

V. Velarde, J. Sáez, J. Orellana, 2020, Biochimica et biophysica acta. Molecular cell research.

Possible Role of Gap Junction Channels and Non-Junctional Channels in the Infection Caused by Trypanosoma cruzi

J. Sáez, J. Vega, I. Barría, 2019, Biology of Trypanosoma cruzi.

Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells

L. Cea, J. Sáez, Aníbal A Vargas, 2014, Front. Cell. Neurosci..

Pannexin 1 channels in skeletal muscles

L. Cea, J. Sáez, Aníbal A Vargas, 2014, Front. Physiol..

Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia

C. Naus, J. Bechberger, J. Sáez, 2013, Neuropharmacology.

The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels

M. V. Bennett, H. Monyer, K. Willecke, 2013, Neuropharmacology.

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

T. Pérez-Acle, Rodrigo A Acuña, R. Araya-Secchi, 2012, Molecular biology of the cell.

Identification of gap junctions in the oviduct and regulation of connexins during development and by sexual hormones.

J. Sáez, M. Villalón, M. Hermoso, 1997, European journal of cell biology.

Connexins and Pannexins in Bone and Skeletal Muscle

Bruno A. Cisterna, L. Plotkin, J. Sáez, 2017, Current Osteoporosis Reports.

The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes

A. Bigot, V. Mouly, J. Bevilacqua, 2016, BMC Cell Biology.

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis

Bruno A. Cisterna, K. Willecke, L. Cea, 2016, Cellular and Molecular Life Sciences.

Functioning of Cx43 Hemichannels Demonstrated by Single Channel Properties

M. Bennett, J. Sáez, J. Contreras, 2003, Cell communication & adhesion.

The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions

E. Rodríguez, J. Sáez, César A González, 1999, Neuroscience Letters.

Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes.

P. Zamorano, J. Sáez, Jorge González, 2018, The American journal of tropical medicine and hygiene.

Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti

T. Pérez-Acle, J. Sáez, Helmuth A. Sánchez, 2023, Frontiers in Cell and Developmental Biology.

Neuronal involvement in muscular atrophy

Bruno A. Cisterna, C. Cardozo, J. Sáez, 2014, Front. Cell. Neurosci..

Connexin-based gap junction hemichannels: gating mechanisms.

Feliksas F. Bukauskas, M. Bennett, J. Sáez, 2005, Biochimica et biophysica acta.

Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue

M. Bennett, J. Sáez, J. Contreras, 2004, Brain Research Reviews.

The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP

E. Brandan, J. Sáez, R. Araya, 2004, Brain Research Reviews.

Gap junction hemichannels in astrocytes of the CNS.

M. Bennett, J. Sáez, J. Contreras, 2003, Acta physiologica Scandinavica.

Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells

J. Sáez, Agustín D. Martínez, M. Guerra, 2014, Front. Cell. Neurosci..

Keratitis-Ichthyosis-Deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43

Tomas Perez-Acle, Oscar Jara, T. Pérez-Acle, 2015, The Journal of investigative dermatology.

Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice

A. Palacios, Marco Fuenzalida, J. Sáez, 2014, Front. Cell. Neurosci..

Gap Junction Intercellular Communication Mediated by Connexin43 in Astrocytes Is Essential for Their Resistance to Oxidative Stress*

C. Naus, J. Bechberger, J. Sáez, 2013, The Journal of Biological Chemistry.

Hemichannels; from the molecule to the function

J. Sáez, M. Retamal, 2014, Front. Physiol..

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

M. Bennett, J. Berman, E. Eugenin, 2012, Journal of Neuroimmune Pharmacology.

Connexins and pannexins in Alzheimer’s disease

C. Naus, C. Giaume, L. Leybaert, 2017, Neuroscience Letters.

ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors

J. Sáez, P. Sáez, A. Lennon-Duménil, 2017, Science Signaling.

Connexin43 is expressed in mouse fetal ovary.

J. Sáez, G. Enders, V. López-Olmos, 2003, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

J. Connor, J. Connor, D. Spray, 1989, Proceedings of the National Academy of Sciences of the United States of America.

C-erbB2/neu Transfection Induces Gap Junctional Communication Incompetence in Glial Cells

J. Trosko, Chia‐cheng Chang, D. Spray, 1996, The Journal of Neuroscience.

Modulation of gap junction channels and hemichannels by growth factors.

K. Schalper, M. Bennett, J. Sáez, 2012, Molecular bioSystems.

Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation

J. Sáez, A. Aguirre, Paloma A Harcha, 2013, Mediators of inflammation.

Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons

Robert H. Brown, D. A. Bosco, F. González-Nilo, 2022, Neuron.

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

M. Bennett, C. Naus, Jean X. Jiang, 2011, Journal of neurochemistry.

Purinergic signaling in tanycytes and its contribution to nutritional sensing

J. Sáez, M. Salgado, M. García-Robles, 2021, Purinergic Signalling.

The FGF2‐induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic‐dependent pathway

C. Farkas, J. Sáez, R. Elizondo-Vega, 2020, Journal of neurochemistry.

Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer

J. Sáez, M. Mesnil, A. Godoy, 2019, Cancers.

Regulation of astrocyte gap junctions by hypoxia–reoxygenation

J. Sáez, Agustín D. Martínez, Juan C Sáez, 2000, Brain Research Reviews.

Carbon tetrachloride at hepatotoxic levels blocks reversibly gap junctions between rat hepatocytes.

D. Spray, M. Bennett, J. Sáez, 1987, Science.

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy

J. Sáez, C. Maturana, C. Bonansco, 2018, Front. Cell. Neurosci..

Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions.

D. Paul, C. Sáez, J. Sáez, 1996, Biology of reproduction.

Gap junctions in the chicken pineal gland

D. Hall, J. Sáez, E. Beyer, 2000, Brain Research.

Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration.

K. Schalper, M. Bennett, C. Giaume, 2009, Antioxidants & redox signaling.

Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland

E. Eugenin, A. Górska, J. Sáez, 2019, Journal of neurochemistry.

Connexin 36 is Expressed in Beta and Connexins 26 and 32 in Acinar Cells at the End of the Secondary Transition of Mouse Pancreatic Development and Increase During Fetal and Perinatal Life

I. Becker, J. Sáez, J. Berumen, 2012, Anatomical record.

Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species

C. Giaume, J. Sáez, J. Orellana, 2020, International journal of molecular sciences.

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

Jean X. Jiang, V. Velarde, J. Sáez, 2012, Glia.

Contribution of non-selective membrane channels and receptors in epilepsy.

J. Sáez, L. Barrio, Yorley Duarte, 2021, Pharmacology & therapeutics.

Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

P. Greengard, A. Nairn, A. Czernik, 1990, European journal of biochemistry.

Glial hemichannels and their involvement in aging and neurodegenerative diseases

C. Giaume, J. Sáez, J. Orellana, 2012, Reviews in the neurosciences.

ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle*

Javiera López, J. Huidobro-Toro, S. Buvinic, 2009, The Journal of Biological Chemistry.

FasL‐triggered death of Jurkat cells requires caspase 8‐induced, ATP‐dependent cross‐talk between fas and the purinergic receptor P2X7

A. Quest, J. Sáez, M. Henríquez, 2013, Journal of cellular physiology.

Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

J. Sáez, P. Sáez, A. Aguirre, 2014, Mediators of inflammation.

Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers

C. Naus, J. Sáez, P. Sáez, 2015, Glia.

Pannexin1 channels act downstream of P2X7 receptors in ATP-induced murine T-cell death

H. Aguila, J. Sáez, P. Sáez, 2014, Channels.

Gap Junctions in Antigen-Presenting Cells

J. Sáez, P. Sáez, Pablo J. Sáez, 2013 .

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

J. Stehberg, J. Sáez, J. Orellana, 2015, Front. Cell. Neurosci..

Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells1

R. Kiessling, D. Mandakovic, J. Sáez, 2007, The Journal of Immunology.

Dendritic Cells Cross-Presentation between Human Melanoma Antigen Transfer and Functional Gap Junctions Facilitate and

R. Kiessling, D. Mandakovic, J. Sáez, 2007 .

Gap Junctions between Leukocyte and Endothelium: Expression of Connexin 43 in Adherent or Activated Leukocytes

J. Sáez, M. Boric, Patricio I. Jara, 1997 .

The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes

A. Bigot, V. Mouly, J. Bevilacqua, 2016, BMC Cell Biology.

Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43

K. Willecke, J. Sáez, D. Eckardt, 2005, Journal of Cell Science.

Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels.

Bruno A. Cisterna, L. Cea, Rosalba Escamilla, 2016, Biochimica et biophysica acta.

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target

C. Naus, C. Giaume, M. Charvériat, 2017, Front. Cell. Neurosci..

From ion channels to cell-to-cell conversations

R. Latorre, J. Sáez, 1997 .

Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins.

J. Sáez, J. Contreras, M. C. Brañes, 2002, Medical science monitor : international medical journal of experimental and clinical research.

Connexin-based channels in astrocytes: how to study their properties.

C. Giaume, V. Abudara, J. Sáez, 2012, Methods in molecular biology.

Normalized Values of 32 p Incorporation Into Human Connexin 43 Under Control Conditions and After Treatment With Staurosporine * or Okadaic Acid *

A. Moreno, G. Fishman, D. Spray, 2005 .

Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

A. Moreno, G. Fishman, D. Spray, 1994, Circulation research.

Involvement of Gap Junction Proteins in Infectious Diseases Caused by Parasites

J. Sáez, Jorge González, J. Vega, 2017 .

Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons

L. Leybaert, G. Bultynck, J. Sáez, 2014, Front. Cell. Neurosci..

Cardiac Myocytes Gap Junctions: Phosphorylation of CX43 through a Protein Kinase C-Dependent Pathway

A. Nairn, A. Czernik, E. Hertzberg, 1997 .

Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice

Jean X. Jiang, J. Sáez, J. Orellana, 2013, PloS one.

Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses.

K. Schalper, J. Sáez, Agustín D. Martínez, 2008, Molecular biology of the cell.

Contribution of large-pore channels to inflammation induced by microorganisms

J. Sáez, Juan Güiza, Camila Gutíerrez, 2023, Frontiers in Cell and Developmental Biology.

Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites

F. González-Nilo, Valeria Márquez-Miranda, J. Sáez, 2021, Journal of cellular physiology.

Rat connexin43: regulation by phosphorylation in heart

A. Nairn, A. Czernik, E. Hertzberg, 1993 .

Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion

M. Bennett, K. Schalper, J. Sáez, 2007, Journal of Membrane Biology.

Glial connexin expression and function in the context of Alzheimer's disease.

C. Giaume, A. Koulakoff, J. Sáez, 2012, Biochimica et biophysica acta.

Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions.

V. Velarde, J. Sáez, J. Orellana, 2011, CNS & neurological disorders drug targets.

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

C. Naus, C. Giaume, J. Sáez, 2010, Molecular and Cellular Neuroscience.

Cx43 Hemichannels and Gap Junction Channels in Astrocytes Are Regulated Oppositely by Proinflammatory Cytokines Released from Activated Microglia

C. Giaume, P. Ezan, J. Sáez, 2007, The Journal of Neuroscience.

Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury

Z. Graham, J. Sáez, J. Hansen, 2023, bioRxiv.

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Bruno A. Cisterna, C. Cardozo, C. Vilos, 2020, Nature Communications.

Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease

C. Giaume, A. Koulakoff, P. Ezan, 2017, Glia.

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy

Bruno A. Cisterna, K. Willecke, C. Cardozo, 2013, Proceedings of the National Academy of Sciences.

Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

Bruno A. Cisterna, L. Cea, J. Sáez, 2012, The Journal of Membrane Biology.

De novo expression of functional connexins 43 and 45 hemichannels increases sarcolemmal permeability of skeletal myofibers during endotoxemia.

L. Cea, Rosalba Escamilla, J. Sáez, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Architecture Discontinuous Conduction in Mouse Bundle Branches Is Caused by Bundle-Branch

H. Jongsma, A. Moreno, D. Gros, 2009 .

Connexin and Pannexin Based Channels in the Nervous System

J. Sáez, B. Nicholson, Juan C. Sáez, 2014 .

Post-transcri ptional events in the expression of gap junctions

D. Laird, J. Sáez, 2000 .

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

M. Bennett, L. Barbeito, V. Abudara, 2010, Proceedings of the National Academy of Sciences.

Connexins as Substrates for Protein Kinases and Phosphoprotein Phosphatases

E. Baéza, J. Sáez, J. Vega, 2012 .

Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels

E. Hertzberg, H. Jongsma, G. Fishman, 1995, Pflügers Archiv.

Regulation of glycogen content in rat pineal gland by norepinephrine

E. Eugenin, C. Sáez, J. Sáez, 1997, Brain Research.

Ca2+ waves are organized among hepatocytes in the intact organ.

M. Fallon, J. Sáez, A. Mennone, 1995, The American journal of physiology.

Pinealocytes in rats: connexin identification and increase in coupling caused by norepinephrine

M. Bennett, R. Dermietzel, J. Sáez, 1991, Brain Research.

ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro

Jean X. Jiang, J. Sáez, P. Sáez, 2013, Mediators of inflammation.

Hunting for connexin hemichannels

L. Leybaert, J. Sáez, 2014, FEBS letters.

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Bruno A. Cisterna, C. Cardozo, C. Vilos, 2020, Nature Communications.

Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures

E. Hertzberg, D. Spray, J. Sáez, 1987, The Journal of cell biology.

Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion.

J. Sáez, M. Boric, P. Jara, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation

F. González-Nilo, Rosalba Escamilla, J. Sáez, 2020, International journal of molecular sciences.

Boldine Prevents Renal Alterations in Diabetic Rats

V. Velarde, J. Sáez, Romina Hernández-Salinas, 2013, Journal of diabetes research.

Christian Giaume (November 1951–July 2019)

L. Roux, C. Naus, L. Venance, 2020, Glia.

Cannabinoids prevent the amyloid β‐induced activation of astroglial hemichannels: A neuroprotective mechanism

C. Giaume, J. Sáez, J. Orellana, 2017, Glia.

Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.

K. Schalper, J. Sáez, J. Orellana, 2012, Advances in experimental medicine and biology.

Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation

L. Cea, J. Sáez, Aníbal A Vargas, 2015, Front. Cell Dev. Biol..

Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells

A. Pastor, Rosalba Escamilla, J. Sáez, 2015, Front. Cell. Neurosci..

Impact of Microglial Activation on Astroglial Connexin Expression and Function in Brain Inflammation

C. Giaume, J. Sáez, M. Retamal, 2013 .

cAMP delays disappearance of gap junctions between pairs of rat hepatocytes in primary culture.

E. Hertzberg, D. Spray, M. Bennett, 1989, The American journal of physiology.

Dear Editor We are submitting the manuscript “Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation” for your consideration for publication in Nitric Oxide

J. Sáez, E. Beyer, M. Shahidullah, 2019 .

Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress

J. Sáez, C. Yi, Lan Xiao, 2021, Advanced science.

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

L. Leybaert, G. Bultynck, J. Stehberg, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Role of calcium permeable channels in dendritic cell migration.

J. Sáez, P. Sáez, A. Lennon-Duménil, 2018, Current opinion in immunology.

Astrocytes as connexin-dependent signaling cells for local blood flow regulation.

J. Sáez, 2008, American journal of physiology. Heart and circulatory physiology.

Colección diplomática del Monasterio de Celanova, 842-1230

J. Sáez, E. Sáez, 1996 .

Long‐term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats

A. Dagnino-Subiabre, J. Sáez, Paola Fernández, 2021, Journal of neuroscience research.

Arachidonic acid-induced dye uncoupling in rat cortical astrocytes is mediated by arachidonic acid byproducts

J. Sáez, Agustín D. Martínez, 1999, Brain Research.

Changes in connexin43, the gap junction protein of astrocytes, during development of the rat pineal gland

J. Sáez, V. Berthoud, 1993, Journal of pineal research.

A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII

F. González-Nilo, E. Chamorro, Valeria Márquez-Miranda, 2021, Proceedings of the National Academy of Sciences.

Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat.

M H Nathanson, J. Anderson, J. Sáez, 1995, The American journal of physiology.

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

M. Bennett, J. Berman, E. Eugenin, 2012, Journal of Neuroimmune Pharmacology.

Intercellular Calcium Signaling in Liver

M. Fallon, J. Sáez, A. Mennone, 1997 .

Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation

J. Sáez, A. Gonzalez-Jamett, Álvaro O. Ardiles, 2023, Biomedicines.

Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation.

J. Bevilacqua, L. Cea, G. Fernández, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Regulation of gap junctions by protein phosphorylation.

J. Sáez, H. González, M. C. Brañes, 1998, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes.

E. Eugenin, C. Sáez, J. Sáez, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes.

E. Eugenin, C. Sáez, J. Sáez, 1998, The American journal of physiology.

Glycosaminoglycans and proteoglycans induce gap junction expression and restore transcription of tissue‐specific mRNAs in primary liver cultures

E. Hertzberg, D. Spray, J. Sáez, 1987, Hepatology.

Modulation of gap junctional conductance in hepatocyte by cyclic amp is protein phosphorylation involved

M. V. Bennett, P. Greengard, A. Nairn, 1985 .

Characterization of a novel water pocket inside the human Cx26 hemichannel structure.

Ruhong Zhou, Seung-Gu Kang, Tien Huynh, 2014, Biophysical journal.

Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II-Induced Renal Damage

V. Velarde, J. Sáez, G. Gómez, 2019, International journal of molecular sciences.