S. Caccia

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S. Caccia, 1998, Clinical pharmacokinetics.

Brain uptake and distribution of the potential memory enhancer CL 275,838 and its main metabolites in rats: relationship between brain concentrations and in vitro potencies on neurotransmitter mechanisms

A. Cagnotto, M. Skorupska, S. Caccia, 1994, Psychopharmacology.

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

M. Gobbi, S. Garattini, E. Frittoli, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs

S. Garattini, E. Frittoli, A. Codegoni, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Mode of action of tiaspirone on the central cholinergic system

S. Garattini, S. Consolo, S. Caccia, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

M. Gobbi, S. Garattini, E. Frittoli, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

AM 580 , a Stable Benzoic Derivative of Retinoic Acid , Has Powerful and Selective Cyto-Differentiating Effects on Acute Promyelocytic Leukemia Cells

M. Calzi, T. Barbui, S. Caccia, 2002 .

Brain‐to‐blood partition and in vivo inhibition of 5‐hydroxytryptamine reuptake and quipazine‐mediated behaviour of nefazodone and its main active metabolites in rodents

L. Cervo, S. Caccia, A. Nacca, 1998, British journal of pharmacology.

Acid‐catalysed Hydrolysis and Benzodiazepine‐like Properties of 5‐(Dialkylamino)‐ and 5‐(Alkylthio)‐substituted 8‐Chloro‐6‐phenyl‐6H‐[1,2,4]triazolo[4,3‐a][1,5]benzodiazepines in Mice

A. Cagnotto, S. Caccia, M. Ghia, 1998, The Journal of pharmacy and pharmacology.

AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.

T. Barbui, S. Caccia, A. Rambaldi, 1996, Blood.

The effects of single and repeated anorectic doses of 5‐hydroxytryptamine uptake inhibitors on indole levels in rat brain

S. Garattini, A. Codegoni, S. Caccia, 1993, British journal of pharmacology.

Anorectic activity of fluoxetine and norfluoxetine in mice, rats and guinea‐pigs

S. Garattini, A. Codegoni, S. Caccia, 1992, The Journal of pharmacy and pharmacology.

Anorectic Activity of Fluoxetine and Norfluoxetine in Rats: Relationship Between Brain Concentrations and In‐vitro Potencies on Monoaminergic Mechanisms

S. Garattini, E. Frittoli, S. Caccia, 1992, The Journal of pharmacy and pharmacology.

Predicting the Clinical Relevance of Drug Interactions From Pre-Approval Studies

S. Garattini, A. Nobili, S. Caccia, 2009, Drug safety.

Targeting thalamic nuclei is not sufficient for the full anti-absence action of ethosuximide in a rat model of absence epilepsy

Vincenzo Crunelli, V. Crunelli, N. Leresche, 2003, Epilepsy Research.

In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: Insights into the mechanisms of pharmacoresistance

E. Oby, C. Baumgartner, A. Vezzani, 2006, Brain Research.

Antipsychotic drug toxicology in children

M. Bonati, S. Caccia, A. Clavenna, 2011, Expert opinion on drug metabolism & toxicology.

Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations.

S. Garattini, S. Caccia, R. Samanin, 1989, European journal of pharmacology.

A new generation of antipsychotics: pharmacology and clinical utility of cariprazine in schizophrenia

A. Nobili, S. Caccia, L. Pasina, 2013, Therapeutics and clinical risk management.

Kinetics and distribution of the β‐adrenergic agonist salbutamol in rat brain

S. Caccia, M. Fong, 1984 .

Kinetics and distribution of the beta-adrenergic agonist salbutamol in rat brain.

S. Caccia, M. Fong, 1984, The Journal of pharmacy and pharmacology.

In vivo and in vitro interaction of flunarizine with d-fenfluramine serotonergic effects

M. Gobbi, E. Frittoli, S. Caccia, 1996, Pharmacology Biochemistry and Behavior.

U PREGULATION OF M ULTIDRUG R ESISTANCE T RANSPORTERS IN THE E PILEPTIC B RAIN

R. Fanelli, S. Caccia, R. Bagnati, 2002 .

Effect ofd-fenfluramine on the indole contents of the rat brain after treatment with different inducers of cytochrome P450 isoenzymes

S. Garattini, S. Caccia, A. Bergami, 1995, Psychopharmacology.

Hepatic microsomal metabolism of the potential memory-enhancing agent, CL 275,838, to its desbenzyl derivative.

P. Marini, F. de Palma, S. Caccia, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Disposition of d-fenfluramine in lean and obese rats

S. Garattini, S. Caccia, G. Guiso, 1988, Appetite.

The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide

L. Polito, G. Forloni, M. Salmona, 2009, Journal of neurochemistry.

Liquid chromatographic assay for riluzole in mouse plasma and central nervous system tissues.

S. Caccia, M. Čolović, E. Zennaro, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

E. Novellino, M. Hamon, R. Budriesi, 2009, Journal of medicinal chemistry.

N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed.

S. Caccia, 2007, Current drug metabolism.

CYP3A-INDUCING EFFECT OF HYPERFORIN AND DERIVATIVES IN RODENTS

A. Mangolini, L. Cantoni, S. Caccia, 2005 .

Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse.

A. Mangolini, L. Cantoni, S. Caccia, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development

A. Vezzani, F. Noe, G. Battaglia, 2006, Neurobiology of Disease.

Design, synthesis, and structure-activity relationship of N-arylnaphthylamine derivatives as amyloid aggregation inhibitors.

R. Di Santo, R. Costi, S. Caccia, 2012, Journal of medicinal chemistry.

Interspecies and interstrain studies on the increased susceptibility to metrazol-induced convulsions in animals given aspartame.

M. Salmona, L. Diomede, M. Romano, 1991, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

(—)‐m‐Chlorophenyl‐piperazine, a central 5‐hydroxytryptamine agonist, is a metabolite of trazodone

S. Garattini, S. Caccia, R. Samanin, 1981, The Journal of pharmacy and pharmacology.

1-Aryl-piperazine as active metabolites of drugs with an aryl-piperazine side-chain

S. Garattini, S. Caccia, M. Fong, 1985 .

Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).

S. Garattini, S. Caccia, R. Reginato, 1983, Arzneimittel-Forschung.

Species differences in the kinetics and metabolism of fenfluramine isomers.

S. Garattini, M. Rocchetti, S. Caccia, 1982, Archives internationales de pharmacodynamie et de therapie.

Benzodiazepines: Relationship between pharmacological activity in the rat and in vivo receptor binding

S. Garattini, S. Caccia, T. Mennini, 1982, Pharmacology Biochemistry and Behavior.

Identification and quantitation of 1-(2-pyrimidinyl)piperazine, an active metabolite of the anxiolytic agent buspirone, in rat plasma and brain.

S. Garattini, M. Muglia, S. Caccia, 1982, Journal of chromatography.

Antileptazol activity and kinetics of clobazam and N-desmethyl-clobazam in the guinea-pig.

S. Garattini, S. Caccia, G. Guiso, 1981, Archives internationales de pharmacodynamie et de therapie.

Relationship between camazepam, N‐methyl‐oxazepam and oxazepam brain concentrations and antileptazol effect in the rat

S. Garattini, S. Caccia, M. Ballabio, 1981, The Journal of pharmacy and pharmacology.

Determination of plasma and brain concentrations of trazodone and its metabolite, 1-m-chlorophenylpiperazine, by gas-liquid chromatography.

R. Fanelli, S. Caccia, G. Guiso, 1981, Journal of chromatography.

Brain concentrations of clobazam and N‐desmethylclobazam and antileptazol activity

S. Garattini, S. Caccia, G. Guiso, 1980, The Journal of pharmacy and pharmacology.

Further studies on brain concentrations of amphetamine and its metabolites in strains of mice showing different sensitivity to pharmacological effects of amphetamine

S. Caccia, A. Jori, 1975, The Journal of pharmacy and pharmacology.

The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).

S. Garattini, S. Caccia, G. Bianchi, 1988, European journal of pharmacology.

Effect of tyrosine on the potentiation by aspartame and phenylalanine of metrazol-induced convulsions in rats.

M. Salmona, L. Diomede, M. Romano, 1991, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame.

M. Salmona, L. Diomede, M. Romano, 1990, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Reciprocal interaction of 5‐hydroxytryptamine and cholecystokinin in the control of feeding patterns in rats

S. Caccia, R. Samanin, G. Grignaschi, 1993, British journal of pharmacology.

Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

E. Lacivita, M. Leopoldo, F. Berardi, 2008, Journal of medicinal chemistry.

THE 1-(2,3-DICHLOROPHENYL)-PIPERAZINE-TO-ARIPIPRAZOLE RATIO AT STEADY STATE IN RATS AND SCHIZOPHRENIC PATIENTS

G. Campiani, S. Butini, S. Caccia, 2006 .

Plasma concentrations of trazodone and 1‐(3‐chlorophenyl)piperazine in man after a single oral dose of trazodone

S. Garattini, S. Caccia, M. Fong, 1982, The Journal of pharmacy and pharmacology.

Stereoselective disposition of fenfluramine enantiomers in the rat.

S. Caccia, A. Jori, P. de Ponte, 1978, Xenobiotica; the fate of foreign compounds in biological systems.

Differences in the availability of d- and l-enantiomers after administration of racemic amphetamine to rats.

S. Caccia, A. Jori, P. de Ponte, 1978, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given d- and dl-fenfluramine for 15 days

S. Garattini, S. Caccia, I. Conforti, 2004, European Journal of Clinical Pharmacology.

5-HT2B/2C but not 5-HT2A receptor subtypes modulate the impulse flow dependent release of DA in the rat nucleus accumbens and striatum: Studies with morphine and amphetamine

U. Spampinato, G. Porras, S. Caccia, 2000, European Neuropsychopharmacology.

Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts

L. Cervo, S. Caccia, P. Morazzoni, 2002, Psychopharmacology.

Single‐Dose Safety and Pharmacokinetics of a Potential Cognition‐Enhancing Compound, CL 275,838, in Healthy Volunteers

P. Tiraboschi, S. Caccia, M. Tettamanti, 1993, Journal of clinical pharmacology.

1‐m‐Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole

S. Garattini, S. Caccia, M. Fong, 1982, The Journal of pharmacy and pharmacology.

Reciprocal interaction of5-hydroxytryptam ine and cholecystokinin inthecontrol offeeding patterns inrats

S. Caccia, R. Samanin, G. Grignaschi, 1993 .

Blockade by trazodone of naloxone‐precipitated jumping in morphine‐dependent rats: correlation with brain levels of m‐chlorophenylpiperazine

L. Cervo, S. Caccia, R. Samanin, 1981, The Journal of pharmacy and pharmacology.

Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism.

S. Caccia, 2005, Current drug metabolism.

Diazepam increases membrane fluidity of rat hippocampus synaptosomes

S. Garattini, M. Salmona, S. Caccia, 1984, FEBS letters.

Serotonin Transmission and Food Intake

S. Garattini, S. Caccia, R. Samanin, 1990 .

Effect of piribedil and its metabolite, S584, on brain lipid peroxidation in vitro and in vivo.

R. Bellasio, S. Caccia, G. Guiso, 1997, European journal of pharmacology.

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

S. Garattini, S. Caccia, G. Guiso, 1992, Neuropharmacology.

Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.

A. Bergamini, E. Novellino, G. Greco, 1999, Journal of medicinal chemistry.

New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update.

S. Caccia, 2002, Current opinion in investigational drugs.

Determination of the retinobenzoic acid derivative Am580 in rat plasma by high-performance liquid chromatography.

S. Caccia, E. Garattini, G. Guiso, 1995, Journal of chromatography. B, Biomedical applications.

The Use of Pharmacokinetics in the Assessment of Dexfenfluramine Safety

S. Caccia, B. Campbell, B. Dard‐Brunelle, 1996 .

Determination of orally administered all-trans-retinoic acid in human plasma by high-performance liquid chromatography.

S. Caccia, A. Biondi, A. Rambaldi, 1994, Journal of chromatography. B, Biomedical applications.

Pharmacokinetic and pharmacodynamic significance of antidepressant drug metabolites.

S. Garattini, S. Caccia, 1992, Pharmacological research.

Interaction of (+)‐amphetamine with cerebral dopaminergic neurones in two strains of mice, that show different temperature responses to this drug

S. Garattini, S. Caccia, A. Jori, 1973, British journal of pharmacology.

Biotransformation of Post-Clozapine Antipsychotics

S. Caccia, 2000 .

Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.

A. Vezzani, S. Caccia, R. Samanin, 1989, The Journal of pharmacology and experimental therapeutics.

Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.

E. Novellino, G. Greco, M. Hamon, 1999, Journal of medicinal chemistry.

Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.

M. Hamon, S. Consolo, G. Campiani, 1997, Journal of medicinal chemistry.

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.

E. Novellino, S. Parapini, D. Taramelli, 2012, Journal of medicinal chemistry.

Optimized Synthesis of AMPA Receptor Antagonist ZK 187638 and Neurobehavioral Activity in a Mouse Model of Neuronal Ceroid Lipofuscinosis

M. Bonomi, S. Caccia, L. Carvelli, 2006, ChemMedChem.

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.

E. Novellino, G. Forloni, M. Brindisi, 2011, Organic & biomolecular chemistry.

Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.

E Novellino, A. Bergamini, E. Novellino, 2001, Journal of medicinal chemistry.

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

E. Novellino, M. Hamon, R. Budriesi, 2009, Journal of medicinal chemistry.

The effect of the spin trapping agent α-phenyl-n-tert-butyl nitrone on dexfenfluramine-induced serotonin depletion in rat brain.

S. Caccia, A. Bergami, C. Fracasso, 1997, Environmental toxicology and pharmacology.

Studies on the Susceptibility to Convulsions in Animals Receiving Abuse Doses of Aspartame

S. Garattini, M. Salmona, A. Vezzani, 1988 .

Interaction of the Anticonvulsants, Denzimol and Nafimidone, with Liver Cytochrome P450 in the Rat

M. Salmona, S. Caccia, C. Fracasso, 1988, The Journal of pharmacy and pharmacology.

Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat

L. Conforti, S. Caccia, I. Conti, 1986, The Journal of pharmacy and pharmacology.

Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques

John J. Wright, R. Olsen, S. Garattini, 1987, Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques.

Pharmacokinetics and metabolism update for some recent antipsychotics

S. Caccia, 2011, Expert opinion on drug metabolism & toxicology.

Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats.

P. Ghezzi, S. Garattini, S. Caccia, 1982, Toxicology Letters.

Separation of Beta Adrenoceptor Antagonist Enantiomers by High Resolution Capillary Gas Chromatography

R. Fanelli, C. Chiabrando, S. Caccia, 1978 .

A Mouse Model of Familial ALS Has Increased CNS Levels of Endogenous Ubiquinol9/10 and Does Not Benefit from Exogenous Administration of Ubiquinol10

E. Beghi, M. Gobbi, S. Pozzi, 2013, PloS one.

Pyroglutamate kinetics and neurotoxicity studies in mice.

P. Ghezzi, S. Garattini, M. Salmona, 1983, Toxicology letters.

Plasma pyroglutamic acid levels after oral administration of monosodium glutamate to human volunteers.

P. Ghezzi, S. Garattini, M. Salmona, 1983, Toxicology letters.

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

M. Gobbi, L. Verotta, L. Cervo, 1999, Naunyn-Schmiedeberg's Archives of Pharmacology.

Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat

S. Garattini, S. Caccia, C. Fracasso, 2005, Psychopharmacology.

Biotransformation of post-clozapine antipsychotics: pharmacological implications.

S. Caccia, 2000, Clinical pharmacokinetics.

Propranolol does not alter flutoprazepam kinetics and metabolism in the rat

S. Caccia, I. Conti, S. Sarati, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice.

A. Nobili, S. Caccia, L. Pasina, 2013, European journal of internal medicine.

Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin.

L. Cervo, E. Calcagno, S. Caccia, 2008, European journal of pharmacology.

Safety and Pharmacokinetics of Atypical Antipsychotics in Children and Adolescents

S. Caccia, 2013, Pediatric Drugs.

Effects of chronic treatment with escitalopram or citalopram on extracellular 5‐HT in the prefrontal cortex of rats: role of 5‐HT1A receptors

S. Caccia, C. Fracasso, R. Invernizzi, 2004, British journal of pharmacology.

A Pilot Study on Brain‐to‐Plasma Partition of 10,11‐Dyhydro‐10‐hydroxy‐5H‐dibenzo(b,f)azepine‐5‐carboxamide and MDR1 Brain Expression in Epilepsy Patients Not Responding to Oxcarbazepine

C. Baumgartner, A. Vezzani, D. Janigro, 2005, Epilepsia.

Limbic Seizures Induce P-Glycoprotein in Rodent Brain: Functional Implications for Pharmacoresistance

E. Aronica, J. Gorter, R. Fanelli, 2002, The Journal of Neuroscience.

The Stereoselective Targeting of a Specific Enzyme-Substrate Complex Is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(−)-PPO464

A. Bergamini, F. Baldanti, G. Campiani, 2001, The Journal of Biological Chemistry.

Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis‐like disease

B. Seilheimer, C. Bendotti, S. Caccia, 2006, Journal of neuroscience research.

Lipophilicity and disposition of 1-aryl-piperazines in the rat.

S. Caccia, R. Urso, I. Conti, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

1‐(ℴo‐Methoxyphenyl)piperazine is a metabolite of drugs bearing a methoxyphenylpiperazine side‐chain

E. Benfenati, S. Caccia, F. D. Vedova, 1987, The Journal of pharmacy and pharmacology.

Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice.

L. Cervo, E. Calcagno, S. Caccia, 2009, The international journal of neuropsychopharmacology.

Disposition of (-)-fenfluramine and its active metabolite, (-)-norfenfluramine in rat: a single dose-proportionality study.

S. Garattini, S. Caccia, G. Guiso, 1988, Xenobiotica; the fate of foreign compounds in biological systems.

Species differences in clobazam metabolism and antileptazol effect

S. Garattini, S. Caccia, R. Samanin, 1980, The Journal of pharmacy and pharmacology.

Dopamine-N-methyl-D-aspartate interactions in the modulation of locomotor activity and memory consolidation in mice.

S. Cabib, A. Oliverio, A. Mele, 1996, European journal of pharmacology.

Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats

S. Garattini, S. Caccia, G. Bianchi, 1989, European Journal of Drug Metabolism and Pharmacokinetics.

Ionization constants and partition coefficients of 1‐arylpiperazine derivatives

S. Caccia, R. Urso, M. Fong, 1985, The Journal of pharmacy and pharmacology.

In‐vivo metabolism in the rat and mouse of antrafenine to 1‐ m‐trifluoromethylphenylpiperazine

S. Caccia, I. Conti, A. Notarnicola, 1985, The Journal of pharmacy and pharmacology.

Ionization constants and lipophilicity of 1-arylpiperazines investigated by reversed-phase high-performance liquid chromatography

L. Aarons, S. Caccia, R. Urso, 1985 .

Disposition of the psychotropic drugs buspirone, MJ-13805 and piribedil, and of their common active metabolite 1-(2-pyrimidinyl)-piperazine in the rat.

S. Caccia, G. Guiso, M. Fong, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

Identification and quantitation of 1-arylpiperazines, metabolites resulting from side-chain cleavage of (4-substituted aryl-1-piperazinyl)alkyl heterocyclic derivatives in rat plasma and brain.

E. Benfenati, S. Caccia, M. Fong, 1984, Journal of chromatography.

Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats

L. Cervo, S. Caccia, M. Čolović, 2005, Pharmacology Biochemistry and Behavior.

The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT2A and 5-HT2C receptor subtypes and significance of the haloperidol dose used

U. Spampinato, P. Deurwaerdère, S. Caccia, 2000, Neuropharmacology.

Pseudodementia in the elderly: Differential diagnosis and treatment.

S. Garattini, S. Caccia, T. Mennini, 1982 .

Comparison of the plasma levels of fenfluramine in rats after a toxic dose and in man after a maximal therapeutic dose

S. Garattini, S. Caccia, 1979 .

Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.

M. Hamon, S. Consolo, G. Campiani, 1997, Journal of medicinal chemistry.

Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: Synthesis and Biological Evaluation of Novel Quinoxalinylethylpyridylthioureas as Potent Antiviral Agents

A. Bergamini, E. Novellino, G. Greco, 2000, Antiviral chemistry & chemotherapy.

Genotype-Dependent Activity of Tryptophan Hydroxylase-2 Determines the Response to Citalopram in a Mouse Model of Depression

G. Forloni, L. Cervo, E. Calcagno, 2005, The Journal of Neuroscience.

Progress in assessing the role of serotonin in the control of food intake.

S. Garattini, S. Caccia, R. Samanin, 1988, Clinical neuropharmacology.

Formation of Active Metabolites of Psychotropic Drugs

S. Garattini, S. Caccia, 1990 .

Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat.

S. Caccia, M. Čolović, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Clinical Pharmacokinetics of Oral Buspirone in Patients with Impaired Renal Function

S. Garattini, S. Caccia, R. Mayol, 1988, Clinical pharmacokinetics.

Citalopram‐induced hypophagia is enhanced by blockade of 5‐HT1A receptors: role of 5‐HT2C receptors

S. Caccia, R. Samanin, G. Grignaschi, 1998, British journal of pharmacology.

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor

E. Lacivita, M. Leopoldo, F. Berardi, 2010, Neuroscience Letters.

5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum

U. Spampinato, E. Esposito, V. Matteo, 2002, Neuropsychopharmacology.

Species differences in phenazeram kinetics and metabolism

S. Garattini, S. Caccia, V. Zherdev, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Chronic treatment with reboxetine by osmotic pumps facilitates its effect on extracellular noradrenaline and may desensitize α2‐adrenoceptors in the prefrontal cortex

S. Caccia, R. Samanin, C. Fracasso, 2001, British journal of pharmacology.

Pharmacokinetics of fenfluramine enantiomers in man

S. Caccia, M. Ballabio, P. D. Ponte, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Kinetics of fenfluramine isomers in the rat

S. Garattini, S. Caccia, G. Guiso, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Progress report on the anorexia induced by drugs believed to mimic some of the effects of serotonin on the central nervous system.

S. Garattini, A. Codegoni, S. Caccia, 1992, The American journal of clinical nutrition.

Significance of Fenfluramine Neurotoxicity: A Kinetic Approach

S. Garattini, S. Caccia, 1990 .

Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms

S. Garattini, S. Caccia, T. Mennini, 2004, Psychopharmacology.

A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR 5-METHOXY-3-[N-(4-(4-FLUORO-PHENYL)-4-OXOBUTYL)-1,2,5,6-TETRAHYDROPYRIDIN-3-YL-METHYL]-1H-INDOLE (BIMG 80), A POTENTIAL ANTIPSYCHOTIC AGENT, AND ITS APPLICATION IN BRAIN-TO-PLASMA DISTRIBUTION STUDIES IN THE RAT

S. Caccia, A. Ceci, C. Fracasso, 1999 .

Critical appraisal of lurasidone in the management of schizophrenia

A. Nobili, S. Caccia, L. Pasina, 2012, Neuropsychiatric disease and treatment.

Effect of aspartame on seizures in various models of experimental epilepsy.

S. Garattini, M. Salmona, A. Vezzani, 1988, Toxicology and applied pharmacology.

Prevention of Inappropriate Prescribing in Hospitalized Older Patients Using a Computerized Prescription Support System (INTERcheck®)

Andrea Remuzzi, Alessandra Marengoni, A. Remuzzi, 2013, Drugs & Aging.

Effect of dimethylamino-2-ethoxyimino-2-adamantane (CM 54903), a non-polar dimethylaminoethanol analog, on brain regional cholinergic neurochemical parameters.

S. Garattini, H. Ladinsky, S. Consolo, 1982, Biochemical pharmacology.

Mechanism of action of anxiolytic drugs.

S. Garattini, S. Caccia, T. Mennini, 1987, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Disposition and metabolism of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in the rat.

S. Garattini, M. Muglia, S. Caccia, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

1-(2-Pyrimidinyl)-piperazine as active metabolite of buspirone in man and rat.

S. Garattini, S. Caccia, I. Conti, 1986, Pharmacology.

Liquid chromatography-tandem mass spectrometry of I3,II8-biapigenin, the major biflavone in Hypericum perforatum extracts.

S. Caccia, M. Čolović, 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Notes on kinetics and metabolism of benzodiazepines

S. Garattini, S. Caccia, T. Mennini, 1981 .

Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin

M. Gobbi, L. Pirona, A. Riva, 2005, European Neuropsychopharmacology.

Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of d-fenfluramine in the rat

S. Garattini, C. Bendotti, S. Caccia, 1989, Neuropharmacology.

Depletion and time-course of recovery of brain serotonin after repeated subcutaneous dexfenfluramine in the mouse. A comparison with the rat

S. Garattini, S. Caccia, A. Bergami, 1995, Neuropharmacology.

The role of d-norfenfluramine in the indole-depleting effect of d-fenfluramine in the rat.

S. Garattini, S. Caccia, M. Anelli, 1993, European journal of pharmacology.

Effect of escalating doses of d-fenfluramine on the content of indoles in brain

S. Garattini, S. Caccia, M. Anelli, 1992, Neuropharmacology.

Single- and multiple-dose kinetics of d-fenfluramine in rats given anorectic and toxic doses.

S. Garattini, S. Caccia, M. Anelli, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Carbonic anhydrase activators. The selective serotonin reuptake inhibitors fluoxetine, sertraline and citalopram are strong activators of isozymes I and II.

C. Supuran, A. Casini, A. Scozzafava, 2003, Bioorganic & medicinal chemistry letters.

Simultaneous determination of the propranolol enantiomers in biological samples by gas--liquid chromatography.

S. Caccia, G. Guiso, M. Ballabio, 1979, Journal of chromatography.

Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem.

S. Garattini, S. Caccia, A. Jori, 1977, European journal of pharmacology.

Single and multiple dose pharmacokinetics of etizolam in healthy subjects

S. Garattini, S. Caccia, S. Confalonieri, 1991, European Journal of Clinical Pharmacology.

Liquid chromatography of the potential memory-enhancing agent CL 275,838 and its main metabolites, using a post-column photochemical reactor and fluorimetric detection.

P. Marini, S. Caccia, S. Confalonieri, 1992, Journal of chromatography.

The Pharmacokinetics of a Potential Memory-Enhancing Compound, CL 275 838, in Fasted and Fed Volunteers

S. Caccia, S. Confalonieri, G. Guiso, 1992 .

High-performance liquid chromatographic method for the determination of a potential memory-enhancing compound (CL 275,838) and its desbenzyl metabolite in rat plasma or serum.

S. Caccia, S. Confalonieri, G. Guiso, 1991, Journal of chromatography.

New atypical antipsychotics for schizophrenia: iloperidone

A. Nobili, S. Caccia, L. Pasina, 2010, Drug design, development and therapy.

Effects of intracerebroventricular administration of d-fenfluramine and d-norfenfluramine, as a single injection or 2-HR infusion, on serotonin in brain: Relationship to concentrations of drugs in brain

S. Garattini, S. Caccia, R. Samanin, 1991, Neuropharmacology.

Selective storage of p-hydroxy-d-amphetamine in the dopaminergic nerve terminals.

S. Garattini, S. Caccia, A. Jori, 1979, Biochemical pharmacology.

Neuropharmacological Effects of Low and High Doses of Repeated Oral Dexfenfluramine in Rats: A Comparison with Fluoxetine

S. Garattini, S. Caccia, A. Bergami, 1997, Pharmacology Biochemistry and Behavior.

Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain

M. Gobbi, S. Caccia, A. Bergami, 1996, Neuroscience Letters.

Determination of piribedil and its basic metabolites in plasma by high-performance liquid chromatography.

S. Caccia, G. Guiso, R. Spinelli, 1991, Journal of chromatography.

Solid-phase extraction of piribedil and its metabolites from plasma and urine without and after deconjugation, by high performance liquid chromatography

S. Caccia, S. Sarati, 1992, European Journal of Drug Metabolism and Pharmacokinetics.

Kinetics of piribedil and effects on dopamine metabolism: hepatic biotransformation is not a determinant of its dopaminergic action in rats

S. Garattini, S. Caccia, G. Guiso, 2005, Psychopharmacology.

St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects.

M. Gobbi, S. Caccia, 2009, Current drug metabolism.

Does ethyl‐β‐carboline‐3‐carboxylate interact with mouse brain benzodiazepine receptors in vivo?

S. Garattini, S. Caccia, T. Mennini, 1982, The Journal of pharmacy and pharmacology.

Further studies on the mechanism of serotonin-dependent anorexia in rats

C. Bendotti, E. Borroni, S. Caccia, 2004, Psychopharmacology.

Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse.

S. Caccia, C. Fracasso, M. Čolović, 2008, Drug Metabolism Letters.

Hyperforin in St . John ’ s Wort ’ s Central Effects : What is the Mechanism of Action ?

M. Gobbi, S. Caccia, 2010 .

Orally Administered Ranitidine Plasma Concentrations before and after Biliopancreatic Diversion in Morbidly Obese Patients

S. Caccia, M. Cossu, M. Ruggiu, 1999, Obesity surgery.

Determination of ranitidine in rat plasma and brain by high-performance liquid chromatography.

S. Caccia, G. Guiso, C. Fracasso, 1987, Journal of Chromatography A.

Pharmacokinetics of Isosorbide Dinitrate in Healthy Volunteers After 24‐Hour Intravenous Infusion

R. Latini, R. Urso, S. Caccia, 1997, Journal of clinical pharmacology.

Multiple‐Dose Pharmacokinetics and Safety of a Potential Memory‐Enhancing Compound, CL 275,838, in Healthy Male Volunteers

P. Tiraboschi, S. Caccia, M. Tettamanti, 1994, Journal of clinical pharmacology.

Liquid chromatographic determination of the potential memory enhancing agent CL 275,838 using a post-column photolysis and fluorimetric detection

S. Caccia, G. Guiso, S. Gherardi, 1992 .

Formation of active metabolites of psychotropic drugs. An updated review of their significance.

S. Garattini, S. Caccia, 1990, Clinical pharmacokinetics.

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.

E. Novellino, V. Yardley, S. Croft, 2009, Journal of medicinal chemistry.

Isocratic reversed-phase liquid chromatography of all-trans-retinoic acid and its major metabolites in new potential supplementary test systems for developmental toxicology.

S. Caccia, G. Guiso, B. Dimitrova, 1996, Journal of chromatography. B, Biomedical applications.

Recombinant tumor necrosis factor reduces hepatic drug metabolism in vivo in the rat.

P. Ghezzi, M. Bianchi, S. Caccia, 1988, Journal of biological response modifiers.

Distribution and localization of p-hydroxy-d-amphetamine in rat brain.

S. Garattini, S. Caccia, G. Guiso, 1978, European journal of pharmacology.

Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors.

T. Suhara, E. Lacivita, M. Leopoldo, 2010, Journal of medicinal chemistry.

High-performance liquid chromatography measurement of hyperforin and its reduced derivatives in rodent plasma.

S. Caccia, P. Morazzoni, C. Fracasso, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Gas—liquid chromatographic determination of clobazam and N-desmethylclobazam in plasma

S. Caccia, G. Guiso, M. Ballabio, 1979 .

Distribution of the methylpiperazinopyridobenzoxazepine derivative JL13, a potential antipsychotic, in rat brain

S. Caccia, G. Guiso, 2001, The Journal of pharmacy and pharmacology.

Effects of chronic treatment with di-(2-ethylhexyl) phthalate on rat liver microsomal activities.

M. Salmona, E. Zuccato, S. Caccia, 1980, Toxicology letters.

Progress report on the anorectic effects of dexfenfluramine, fluoxetine and sertraline.

S. Garattini, S. Caccia, A. Bizzi, 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Oral kinetics of dexfenfluramine and dexnorfenfluramine in non-human primates.

S Garattini, S. Garattini, S. Caccia, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Brain Uptake and Acute Indole‐depleting Effect of Dexfenfluramine in Squirrel Monkeys after a High‐dose Regimen

S. Garattini, S. Caccia, A. Bergami, 1995 .

Brain levels of tofizopam in the rat and relationship with benzodiazepine receptors

S. Garattini, S. Caccia, T. Mennini, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological activities of clobazam and diazepam in the rat: relation to drug brain levels.

M. Carli, S. Garattini, S. Caccia, 1980, Archives internationales de pharmacodynamie et de therapie.

Quantitative analysis of minaprine and some of its metabolites with application to kinetic studies in rats.

E. Benfenati, S. Caccia, M. Fong, 1983, Journal of chromatography.

Distribution of amphetamine and its hydroxylated metabolites in various areas of the rat brain

S. Caccia, A. Jori, 1974, The Journal of pharmacy and pharmacology.

Notes on buspirone's mechanisms of action.

S. Garattini, S. Caccia, T. Mennini, 1982, The Journal of clinical psychiatry.

Identification and Quantitative Determination of 2,3,7,8-Tetrachlorodibenzo-para-Dioxin in Animals From a Contaminated Area

R. Fanelli, S. Garattini, G. Tognoni, 1978 .

Pharmacological and Biochemical Studies on Benzodiazepines

S. Garattini, S. Caccia, T. Mennini, 1981 .

Persistent Excitability Changes in the Piriform Cortex of the Isolated Guinea‐pig Brain after Transient Exposure to Bicuculline

M. Curtis, M. Forti, G. Biella, 1997, The European journal of neuroscience.

Kinetic and pharmacological studies on estazolam in mice and man.

S. Garattini, S. Caccia, R. Urso, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

S. Garattini, S. Caccia, R. Samanin, 2010, European Journal of Drug Metabolism and Pharmacokinetics.