T. Otani

发表

New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: taxonomy, fermentation, isolation, structural elucidation and biological properties.

Y. Sugimoto, Y. Yamada, Y. Aoyagi, 2000, The Journal of antibiotics.

Structure of cypemycin, a new peptide antibiotic

S. Ōmura, Ken‐ichiro Yoshida, T. Otani, 1994 .

Isolation, structure determination and biological activities of a novel antifungal antibiotic, S-632-C, closely related to glutarimide antibiotics.

K. Suzukake-Tsuchiya, M. Hori, T. Otani, 1993, The Journal of antibiotics.

Structure and cycloaromatization of a novel enediyne, C-1027 chromophore

T. Otani, Y. Minami, R. Azuma, 1993 .

Inhibition of anchorage-independent growth of tumor cells by IT-62-B, a new anthracycline.

M. Hori, T. Otani, S. Ikeno, 1997, The Journal of antibiotics.

A new antibiotic, cypemycin. Taxonomy, fermentation, isolation and biological characteristics.

S. Ōmura, M. Hayashi, Y. Takahashi, 1993, The Journal of antibiotics.

New antibiotics 4181-A and B from Streptomyces griseus; taxonomy, fermentation, isolation and characterization.

Y. Yamada, T. Otani, C. Q. Qi, 1988, The Journal of antibiotics.

New Cdc25B Tyrosine Phosphatase Inhibitors, Nocardiones A and B, Produced by Nocardia sp. TP‐A0248: Taxonomy, Fermentation, Isolation, Structural Elucidation and Biological Properties.

Y. Sugimoto, Y. Aoyagi, Yuji Yamada, 2000 .

Structure of an aromatization product of C-1027 chromophore

Ken‐ichiro Yoshida, T. Otani, Y. Minami, 1993 .

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.

Y. Sugimoto, K. Wierzba, T. Otani, 1990, The Journal of antibiotics.

MJ347-81F4 A & B, novel antibiotics from Amycolatopsis sp.: taxonomic characteristics, fermentation, and antimicrobial activity.

T. Takeuchi, M. Hamada, M. Hori, 1998, The Journal of antibiotics.

TOC-39, a novel parenteral broad-spectrum cephalosporin with excellent activity against methicillin-resistant Staphylococcus aureus

K. Hiramatsu, T. Otani, H. Hanaki, 1995, Antimicrobial agents and chemotherapy.

Novel triene-beta-lactone antibiotics, oxazolomycin derivative and its isomer, produced by Streptomyces sp. KSM-2690.

S. Ito, H. Hori, T. Otani, 2000, The Journal of antibiotics.

Conformation studies on and assessment by spectral analysis of the protein-chromophore interaction of the macromolecular antitumor antibiotic C-1027.

T. Otani, 1993, The Journal of antibiotics.

Discovery of methyl-2-(2'-hydroxyphenyl)-2-oxazoline-4-carboxylate as a secondary metabolite from Actinomadura sp.

T. Takeuchi, M. Hamada, T. Otani, 1997, The Journal of antibiotics.

Aminopeptidase activity of an antitumor antibiotic, C-1027.

T. Aoyagi, Y. Moriya, M. Hori, 1992, The Journal of antibiotics.

A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.

Y. Yamada, T. Otani, Y. Minami, 1988, The Journal of antibiotics.

A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties.

T. Otani, Y. Minami, T. Marunaka, 1988, The Journal of antibiotics.

A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.

H. Saito, Y. Yamada, T. Otani, 1989, The Journal of antibiotics.

Isolation and characterization of non-protein chromophore and its degradation product from antibiotic C-1027.

T. Otani, Y. Minami, K. Yoshida, 1991, The Journal of antibiotics.

Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore.

T. Tanaka, T. Otani, M. Hirama, 2001, Journal of molecular biology.

DNA Homology Between Chromoprotein Antibiotic Producers

M. Hamada, M. Hori, T. Otani, 1993 .

Synthesis and absolute stereochemistry of the aminosugar moiety of antibiotic C-1027 chromophore

T. Ishii, Ken‐ichiro Yoshida, T. Otani, 1993 .

New metabolites, tetrahydrofuran lignans, produced by Streptomyces sp. IT-44.

T. Otani, H. Hayashi, H. Matsumoto, 1994, The Journal of antibiotics.

Antitumor enediyne chromoprotein C-1027: mechanistic investigation of the chromophore-mediated self-decomposition pathway.

T. Otani, F. Hosoi, M. Inoue, 2006, Journal of the American Chemical Society.

Remarkable kinetic solvent isotope effect on the cycloaromatization of C-1027 chromophore, a 9-membered enediyne, and the thermochemistry

Ken‐ichiro Yoshida, T. Otani, M. Hirama, 1994 .

Absolute configuration of C-1027 chromophore

M. Ishiguro, Ken‐ichiro Yoshida, T. Otani, 1996 .

TAXONOMY , FERMENTATION , ISOLATION AND CHARACTERIZATION

Yuji Yamada, T. Otani, H. Matsumoto, 2006 .

Cloning and nucleotide sequencing of the antitumor antibiotic C-1027 apoprotein gene.

M. Hamada, M. Hori, T. Otani, 1992, Bioscience, biotechnology, and biochemistry.

IT‐143‐A and B, Novel Piericidin‐Group Antibiotics Produced by Streptomyces sp.

Ken‐ichiro Yoshida, T. Otani, Toru Sasaki, 1997 .

IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp.

T. Otani, T. Sasaki, K. Yoshida, 1996, The Journal of antibiotics.

A new anthracycline antibiotic, IT-62-B, converts the morphology of ras-transformed cells back to normal: taxonomy, fermentation, isolation, structure elucidation and biological characterization.

T. Otani, H. Matsumoto, T. Sasaki, 1997, The Journal of antibiotics.

C-1027-AG, a selective antagonist of the macromolecular antitumor antibiotic C-1027.

T. Otani, Y. Minami, T. Marunaka, 1988, Journal of antibiotics (Tokyo. 1968).

C-1027 enediyne chromophore: presence of another active form and its chemical structure.

T. Otani, T. Sasaki, Y. Minami, 1999, Journal of antibiotics (Tokyo. 1968).

Structure-activity relationships between linkage style at the C-3 position and nuclear analogues of C(7)-hydroxyminoaminothiazol cephalosporins against methicillin-resistantStaphylococcus aureus

K. Hiramatsu, T. Otani, H. Hanaki, 1996 .

The Benzoxazolinate of C-1027 Confers Intercalative DNA Binding

P. Dedon, T. Otani, Li Yu, 1995 .

Purification and primary structure of C-1027-AG, a selective antagonist of antitumor antibiotic C-1027, from Streptomyces globisporus.

T. Otani, T. Shimazu, T. Yasuhara, 1991, Agricultural and biological chemistry.

INTERACTION OF C-1027 CHROMOPHORE WITH D(DTATAC)2 : A BINDING MODEL BASED ON NMR EXPERIMENTS

Y. Okuno, T. Iwashita, Y. Sugiura, 1996 .