A. Guse

发表

Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose

M. Hohenegger, B. Potter, G. Mayr, 1999, Nature.

Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by T Cell Receptor/CD3 Complex Stimulation

G. Dupont, A. Guse, Diana Gil, 2022, Frontiers in Molecular Biosciences.

Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells

B. Potter, Mark P Thomas, A. Guse, 2012, Journal of medicinal chemistry.

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.

A. Galione, B. Potter, A. Guse, 2008, Journal of medicinal chemistry.

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP

Insa M. A. Wolf, F. Koch-Nolte, A. Guse, 2019, Purinergic Signalling.

Trifluoromethylated cyclic-ADP-ribose mimic: synthesis of 8-trifluoromethyl-N(1)-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine-5',5''-cyclic pyrophosphate (8-CF(3)-cIDPRE) and its calcium release activity in T cells.

Zhenjun Yang, A. Guse, T. Kirchberger, 2010, Organic & biomolecular chemistry.

Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.

C. Elling, G. Mayr, M. Nalaskowski, 2008, The Biochemical journal.

T-cell receptor-mediated metabolism of inositol polyphosphates in Jurkat T-lymphocytes. Identification of a D-myo-inositol 1,2,3,4,6-pentakisphosphate-2-phosphomonoesterase activity, a D-myo-inositol 1,3,4,5,6-pentakisphosphate-1/3-phosphatase activity and a D/L-myo-inositol 1,2,4,5,6-pentakisphosph

F. Emmrich, A. Guse, 1991, The Journal of biological chemistry.

Mass changes of inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate during cell cycle progression in rat thymocytes.

F. Emmrich, K. Brand, A. Guse, 1993, The Journal of biological chemistry.

Adriamycin inhibits inositol 1,4,5-trisphosphate 3-kinase activity in vitro and blocks formation of inositol 1,3,4,5-tetrakisphosphate in stimulated Jurkat T-lymphocytes. Does inositol 1,3,4,5-tetrakisphosphate play a role in Ca(2+)-entry?

F. Emmrich, A. Guse, C. P. da Silva, 1994, The Journal of biological chemistry.

ApoE Regulates Corticospinal Neuronal Survival Through ApoER2

J. Heeren, A. Guse, F. Farsian, 2013 .

P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signaling milliseconds after T cell activation

Insa M. A. Wolf, H. Mittrücker, F. Koch-Nolte, 2022, Science advances.

Nicotinic Acid Adenine Dinucleotide 2'-Phosphate (NAADP) Binding Proteins in T-Lymphocytes.

J. Marchant, A. Guse, K. Weber, 2012, Messenger.

PrPc capping in T cells promotes its association with the lipid raft proteins reggie‐1 and reggie‐2 and leads to signal transduction

H. Plattner, A. Guse, D. Legler, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation

D. Lodygin, Insa M. A. Wolf, S. Feske, 2018, Science Signaling.

Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

L. Sturla, E. Zocchi, A. De Flora, 2021, Nutrients.

CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues.

H. Mittrücker, L. Sturla, E. Zocchi, 2020, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

C. Lohr, F. Koch-Nolte, J. Heeren, 2019, Biochemical Society transactions.

Full focus on calcium

J. Parys, A. Guse, 2019, Science Signaling.

NAD derived second messengers: Role in spontaneous diastolic Ca(2+) transients in murine cardiac myocytes.

A. Guse, R. Fliegert, D. Warszta, 2014, DNA repair.

Pharmacological activation of the ryanodine receptor in Jurkat T‐lymphocytes

M. Hohenegger, B. Potter, G. Mayr, 1999, British journal of pharmacology.

Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies.

M. Hafner, S. Dübel, Werner Müller, 2009, Journal of immunological methods.

Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR).

A. Guse, 2004, Current medicinal chemistry.

Inhibition of alpha 1-adrenoceptor-mediated inositol phosphate accumulation in cultured cardiac myocytes by cyclic AMP-generating compounds.

A. Guse, I. Berg, G. Gercken, 1991, Journal of molecular and cellular cardiology.

Emerging Roles of NAD+ and Its Metabolites in Cell Signaling

F. Koch-Nolte, M. Ziegler, A. Guse, 2009, Science Signaling.

CD83 Modulates B Cell Function In Vitro: Increased IL-10 and Reduced Ig Secretion by CD83Tg B Cells

F. Koch-Nolte, A. Guse, B. Fleischer, 2007, PloS one.

Ca2+ signaling in T-lymphocytes.

A. Guse, 1998, Critical reviews in immunology.

Carbamoylcholine-induced accumulation of inositol mono-, bis-, tris- and tetrakisphosphates in isolated cardiac myocytes from adult rats.

A. Guse, I. Berg, G. Gercken, 1989, Biochimica et biophysica acta.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Degradation by Alkaline Phosphatase*

A. Guse, R. Fliegert, Frederike Schmid, 2012, The Journal of Biological Chemistry.

P2X7 is expressed on human innate‐like T lymphocytes and mediates susceptibility to ATP‐induced cell death

F. Koch-Nolte, A. Guse, T. Magnus, 2022, European journal of immunology.

Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes.

G. Mayr, A. Guse, B. Bröker, 1997, Journal of immunology.

Concept and evaluation of the integrated seminars during pre-clinical studies ( " Medicine I " ) at Hamburg Medical School

S. Harendza, A. Guse, J. Schultz, 2007 .

Design, Synthesis, and Chemical and Biological Properties of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose.

T. Hirokawa, S. Shuto, B. Potter, 2014, Messenger.

Membrane-Permeable Octanoyloxybenzyl-Masked cNMPs As Novel Tools for Non-Invasive Cell Assays

A. Guse, V. Nikolaev, C. Meier, 2018, Molecules.

Determination of inositol polyphosphates from human T-lymphocyte cell lines by anion-exchange high-performance liquid chromatography and post-column derivatization.

F. Emmrich, A. Guse, 1992, Journal of chromatography.

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP): novel regulators of Ca2+-signaling and cell function.

A. Guse, 2002, Current molecular medicine.

NAADP Mobilizes Calcium from the Endoplasmic Reticular Ca2+ Store in T-lymphocytes*

A. Guse, T. Kirchberger, M. Steen, 2007, Journal of Biological Chemistry.

Preincubation with anti‐CD4 influences activation of human T cells by subsequent co‐cross‐linking of CD4 with CD3

F. Emmrich, A. Guse, A. Tsygankov, 1993, Journal of leukocyte biology.

Running Head: 2ʹ-Deoxy-ADPR is an endogenous superagonist of TRPM2

A. Guse, M. Flato, Christelle Moreau, 2017 .

NAADP: A Universal Ca2+ Trigger

A. Guse, Hon Cheung Lee, 2008, Science Signaling.

NAD degradation and regulation of CD38 expression by human monocytes/macrophages.

S. Hauschildt, A. Guse, A. Ogilvie, 2001, European journal of biochemistry.

Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose.

B. Potter, A. Guse, G. Wagner, 2005, The Journal of organic chemistry.

Second Messenger Function of Nicotinic Acid Adenine Dinucleotide Phosphate Revealed by an Improved Enzymatic Cycling Assay*

S. Bruhn, A. Guse, A. Gasser, 2006, Journal of Biological Chemistry.

TRPM2 activation: Paradigm shifted?

A. Guse, R. Fliegert, Hans T Hölzer, 2018, Cell calcium.

Intracellular Ca2+ pools in Jurkat T-lymphocytes.

F. Emmrich, A. Guse, E. Roth, 1993, The Biochemical journal.

The 2021 FASEB science research conference on NAD metabolism and signaling

D. Corda, D. Sinclair, M. Freichel, 2021, Aging.

CD38: A NAADP degrading enzyme

H. Mittrücker, S. Bruhn, A. Guse, 2011, FEBS letters.

Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice

H. Mittrücker, L. Sturla, A. De Flora, 2022, Cells.

Ectocellular CD38‐catalyzed synthesis and intracellular Ca2+‐signalling activity of cyclic ADP‐ribose in T‐lymphocytes are not functionally related

G. Mayr, F. Malavasi, A. Guse, 1998, FEBS letters.

Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.

F. Emmrich, B. Potter, G. Mayr, 1995, Journal of immunology.

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation

K. Krause, D. Lodygin, A. Bowie, 2021, Science Signaling.

Design and Synthesis of Cyclic ADP-4-Thioribose as a Stable Equivalent of Cyclic ADP-Ribose, a Calcium Ion-Mobilizing Second Messenger**

T. Hirokawa, S. Shuto, B. Potter, 2013, Angewandte Chemie.

Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic-ribose, a Ca2+-mobilizing agent selectively active in T cells

S. Shuto, A. Matsuda, B. Potter, 2008 .

Design and synthesis of 4″,6″-unsaturated cyclic ADP-carbocyclic ribose as a Ca 2+ -mobilizing agent

S. Shuto, A. Matsuda, B. Potter, 2008 .

Novel nucleobase-simplified cyclic ADP-ribose analogue: A concise synthesis and Ca(2+)-mobilizing activity in T-lymphocytes.

L. Zhang, Zhenjun Yang, Lihe Zhang, 2010, Organic & biomolecular chemistry.

Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp+) Is an Essential Regulator of T-Lymphocyte Ca2+-Signaling

B. Potter, G. Mayr, A. Guse, 2000, The Journal of cell biology.

Inositol Phosphate Accumnlation in Cultured Cardiac Myocytes by Cyclic AMP-Generating Compounds

A. Guse, I. Berg, 1991 .

Synthesis of stable and cell-type selective analogues of cyclic ADP-ribose, a Ca(2+)-mobilizing second messenger. Structure--activity relationship of the N1-ribose moiety.

S. Shuto, A. Matsuda, B. Potter, 2005, Journal of the American Chemical Society.

Amplification and propagation of pacemaker Ca2+ signals by cyclic ADP-ribose and the type 3 ryanodine receptor in T cells

B. Potter, Zhenjun Yang, L. Zhang, 2004, Journal of Cell Science.

The Calcium-Sensing Receptor Stabilizes Podocyte Function in Proteinuric Humans and Mice.

Markus M. Rinschen, Victor G. Puelles, Wiebke Sachs, 2022, Kidney international.

2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: Identification of a new and potent inhibitor

B. Potter, A. Flügel, F. Odoardi, 2021, Biochimica et biophysica acta. Molecular cell research.

High-Resolution Calcium Imaging Method for Local Calcium Signaling.

Insa M. A. Wolf, A. Guse, Björn-Philipp Diercks, 2019, Methods in molecular biology.

Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations.

A. Guse, Björn-Philipp Diercks, R. Fliegert, 2017, Biochimica et biophysica acta. Molecular cell research.

Frontrunners of T cell activation: Initial, localized Ca 2+ signals mediated by NAADP and the

Insa M. A. Wolf, H. Mittrücker, D. Lodygin, 2016 .

Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor

Insa M. A. Wolf, H. Mittrücker, D. Lodygin, 2015, Science Signaling.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation*♦

M. Hohenegger, B. Potter, S. Bruhn, 2013, The Journal of Biological Chemistry.

NAADP MEDIATED CALCIUM SIGNALLING AND ARRHYTHMIAS IN THE HEART EVOKED BY β-ADRENERGIC STIMULATION

B. Potter, Martin, S. Bruhn, 2013 .

Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b

K. Cornils, J. Schwarz, G. Glassmeier, 2007, The FEBS journal.

Analysis of subcellular calcium signals in T-lymphocytes.

G. Mayr, F. Koch-Nolte, A. Guse, 2003, Cellular signalling.

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

J. Izbicki, R. Flavell, Babett Steglich, 2020, Nature Communications.

Unique properties of the capacitative Ca(2+)-entry antagonist LU 52396: its inhibitory activity depends on the activation state of the cells.

G. Mayr, A. Guse, K. Schweitzer, 1997, Cell calcium.

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

M. Meyer-Hermann, E. Hernández-Vargas, A. Guse, 2013, Front. Immunol..

Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling

A. Guse, I. Ernst, R. Fliegert, 2013, Front. Immunol..

Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger.

A. Guse, 1999, Cellular signalling.

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

B. Potter, A. Guse, Christelle Moreau, 2013, Journal of medicinal chemistry.

Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction1

A. Guse, Guixiu Shi, F. Lund, 2007, The Journal of Immunology.

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

B. Potter, A. Guse, M. Flato, 2017, Nature chemical biology.

Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor† †This paper is part of an Organic & Biomolecular Chemistry web theme issue on chemical biology.

A. Galione, B. Potter, A. Guse, 2010, Organic & biomolecular chemistry.

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

B. Potter, A. Guse, Joanna M. Watt, 2019, The Journal of organic chemistry.

First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist.

B. Potter, A. Guse, G. Wagner, 2003, Chemical communications.

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

A. Guse, R. Fliegert, W. M. Riekehr, 2020, Frontiers in Immunology.

Ca2+ Entry Induced by Cyclic ADP-ribose in Intact T-Lymphocytes*

G. Mayr, B. Potter, A. Guse, 1997, The Journal of Biological Chemistry.

Knock-down of the Type 3 Ryanodine Receptor Impairs Sustained Ca2+ Signaling via the T Cell Receptor/CD3 Complex*

G. Mayr, A. Guse, K. Weber, 2002, The Journal of Biological Chemistry.

A structural overview of the ion channels of the TRPM family.

Juan Du, A. Guse, Wei Lü, 2019, Cell calcium.

TRPM2 Is Not Required for T-Cell Activation and Differentiation

H. Mittrücker, S. Menzel, F. Koch-Nolte, 2022, Frontiers in Immunology.

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

H. Mittrücker, T. Bedke, N. Gagliani, 2021, Cells.

Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by the Interplay Between ORAI1 and InsP3 Receptors

G. Dupont, A. Guse, Diana Gil, 2021, Frontiers in Immunology.

Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)‐dependent calcium signalling

A. Guse, Björn-Philipp Diercks, 2018, The Journal of physiology.

Ca2+ Microdomains in T-Lymphocytes

Insa M. A. Wolf, A. Guse, 2017, Front. Oncol..

Ca(2+) microdomains, NAADP and type 1 ryanodine receptor in cell activation.

Insa M. A. Wolf, A. Guse, 2016, Biochimica et biophysica acta.

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

M. Hohenegger, B. Potter, A. Flügel, 2009, Proceedings of the National Academy of Sciences.

Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR)

A. Guse, 2005, The FEBS journal.

Activation of T Cell Calcium Influx by the Second Messenger ADP-ribose*

N. Oppenheimer, J. Schwarz, G. Glassmeier, 2006, Journal of Biological Chemistry.

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Francis J. Huber, J Wagner, J. Izbicki, 2023, Immunity.

Cyclic ADP-ribose

A. Guse, 2000, Journal of Molecular Medicine.

Enzymology of Ca2+-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

A. Guse, 2023, Cells.

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

B. Potter, Mark P Thomas, A. Guse, 2017, The Biochemical journal.

Second Messenger Signaling: Multiple Receptors for NAADP

A. Guse, 2009, Current Biology.

Activation of the P2X7 ion channel by soluble and covalently bound ligands

M. Seman, N. Schwarz, F. Koch-Nolte, 2009, Purinergic Signalling.

TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer

J. Izbicki, R. Flavell, Babett Steglich, 2020, Nature Communications.

Immortalization of human T cell clones by Herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors.

F. Emmrich, B. Fleckenstein, I. Müller-Fleckenstein, 1993, Journal of immunology.

High Metabolic Function and Resilience of NKG2A-Educated NK Cells

M. Altfeld, G. Martrus, A. Guse, 2020, Frontiers in Immunology.

IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

G. Sauter, R. Simon, J. Izbicki, 2020, Gastroenterology.

Basic Principles of Science in Medical Education—Development and Implementation of a Two Week Introductory Track

H. Dubben, L. Kriston, A. Guse, 2016 .

Human CD4 modulation in vivo induced by antibody treatment.

F. Emmrich, G. Burmester, J. Kalden, 1993, Clinical immunology and immunopathology.

Unexpected players for local calcium signals: STIM and ORAI proteins

A. Guse, Björn-Philipp Diercks, 2020 .

Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors.

A. Guse, Björn-Philipp Diercks, Diana C Gil Montoya, 2021, Pharmacology & therapeutics.

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

B. Potter, A. Guse, Joanna M. Watt, 2020, RSC advances.

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

B. Potter, C. Cordiglieri, A. Guse, 2018, Scientific Reports.

Stimulation of Local Cytosolic Calcium Release by Photothermal Heating for Studying Intra‐ and Intercellular Calcium Waves

W. Parak, Dingcheng Zhu, N. Feliu, 2021, Advanced materials.

Hormonal Control of ADP-ribosyl Cyclase Activity in Pancreatic Acinar Cells from Rats*

E. Krause, A. Guse, I. Schulz, 2003, Journal of Biological Chemistry.

Differential mentorship for medical students: development, implementation and initial evaluation

M. Bullinger, A. Guse, C. Petersen-Ewert, 2012 .

Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7*

F. Di Virgilio, E. Jacchetti, A. Schenone, 2010, The Journal of Biological Chemistry.

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

B. Potter, A. Flügel, F. Odoardi, 2009, The Biochemical journal.

Intracellular Ca(2+) release mechanisms: multiple pathways having multiple functions within the same cell type?

A. Guse, C. Silva, C. P. da Silva, 2000, Biochimica et biophysica acta.

Back from the Dormant Stage: Second Messenger Cyclic ADP-Ribose Essential for Toxoplasma gondii Pathogenicity

A. Guse, 2008, Science Signaling.

Phosphatidylinositol hydrolysis and an increase in Ca2+ concentration in the signal-transduction process triggered by murine Fc gamma RIII are not required for protein kinase C translocation.

J. Altrichter, A. Guse, M. Daëron, 1995, European journal of biochemistry.

Digital Health meets Hamburg integrated medical degree program iMED: concept and introduction of the new interdisciplinary 2nd track Digital Health

René Werner, Maike Henningsen, Rüdiger Schmitz, 2020, GMS journal for medical education.

Metabolism of inositol phosphates in alpha 1-adrenoceptor-stimulated and homogenized cardiac myocytes of adult rats.

A. Guse, I. Berg, G. Gercken, 1989, Biochemical Journal.

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation.

W. Kiess, A. Guse, I. Berg, 1992, Endocrinology.

Inositol tetrakisphosphates as second messengers induce Ca(++)-dependent chloride currents in Xenopus laevis oocytes.

W. Meyerhof, J. Schwarz, A. Guse, 1991, Biochemical and biophysical research communications.

ADP‐ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site

M. Seman, N. Schwarz, A. Guse, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Beta1-integrins mediate Ca2+-signalling and T cell spreading via divergent pathways.

G. Mayr, A. Guse, H. Schöttelndreier, 1999, Cellular signalling.

The Ca2+-Mobilizing Second Messenger Cyclic ADP-Ribose

A. Guse, 2000 .

Ca2+ release via ryanodine receptors and Ca2+ entry: major mechanisms in NAADP-mediated Ca2+ signaling in T-lymphocytes.

A. Guse, M. Langhorst, N. Schwarzmann, 2004, Cellular signalling.

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system

B. Potter, D. Schild, A. Flügel, 2010, Brain : a journal of neurology.

Regulation of calcium signalling by adenine-based second messengers.

A. Guse, A. Gasser, R. Fliegert, 2007, Biochemical Society transactions.

NAADP: From Discovery to Mechanism

A. Guse, T. Walseth, 2021, Frontiers in Immunology.

HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation

D. Lodygin, H. Schlüter, A. Flügel, 2021, Science Signaling.

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

M. Freichel, V. Tsvilovskyy, A. Guse, 2020, Frontiers in Cell and Developmental Biology.

NAADP Signaling: New Kids on the Block

A. Guse, 2022, Cells.

Linking NAADP to Ion Channel Activity: A Unifying Hypothesis

A. Guse, 2012, Science Signaling.

2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca2+ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis

B. Potter, F. Odoardi, A. Guse, 2023, Biochimica et biophysica acta. Molecular cell research.

Calcium mobilizing second messengers derived from NAD.

A. Guse, 2015, Biochimica et biophysica acta.

Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors

E. Zocchi, A. De Flora, S. Bruzzone, 2003, The Journal of cell biology.

Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation.

B. Potter, A. Flügel, F. Odoardi, 2015, Messenger.

N-terminal tagging of two-pore channels interferes with NAADP action.

A. Guse, 2013, The Biochemical journal.

Functional Ryanodine Receptor Expression Is Required for NAADP-mediated Local Ca2+ Signaling in T-lymphocytes*

Andreas H. Guse, A. Guse, Werner Dammermann, 2005, Journal of Biological Chemistry.

Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography.

B. Potter, G. Mayr, A. Guse, 1998, Journal of chromatography. B, Biomedical sciences and applications.

1-(5-phospho-beta-D-ribosyl)2'-phosphoadenosine 5'-phosphate cyclic anhydride induced Ca2+ release in human T-cell lines.

B. Potter, G. Mayr, A. Guse, 1997, European journal of biochemistry.

Culturing and patch clamping of Jurkat T cells and neurons on Al2O3 coated nanowire arrays of altered morphology

R. Blick, M. Borgström, C. Ronning, 2019, RSC advances.

NAD binding by human CD38 analyzed by Trp189 fluorescence.

A. Guse, R. Fliegert, Anette Rosche, 2019, Biochimica et biophysica acta. Molecular cell research.

Exploring the value and role of integrated supportive science courses in the reformed medical curriculum iMED: a mixed methods study

A. Guse, S. Sehner, T. Tilling, 2016, BMC medical education.

The Hamburg integrated medical degree program iMED

A. Guse, S. Mohr, Jelka Meyer, 2019, GMS journal for medical education.

Synthesis of cyclic adenosine 5 ¢-diphosphate ribose analogues : a C 2 ¢ endo / syn “ southern ” ribose conformation underlies activity at the sea urchin cADPR receptor †

A. Galione, B. Potter, A. Guse, 2010 .

Ca2+-Signalling in Human T-Lymphocytes

B. Potter, G. Mayr, A. Guse, 1997 .

Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

A. Nicke, N. Schwarz, F. Koch-Nolte, 2012, PloS one.

A two-week interprofessional teamwork simulation with real cardiac patients

H. Grahn, A. Guse, S. Mohr, 2020, Journal of Interprofessional Education & Practice.

Ultra-fast cell counters based on microtubular waveguides

R. Blick, Insa M. A. Wolf, A. Guse, 2017, Scientific Reports.

Cellular effects and metabolic stability of N1‐cyclic inosine diphosphoribose and its derivatives

B. Potter, A. Flügel, C. Cordiglieri, 2006, British journal of pharmacology.

Small Molecule Antagonists of NAADP-Induced Ca2+ Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

B. Potter, A. Flügel, C. Cordiglieri, 2018, Scientific Reports.

Tuning TPC2.

A. Guse, 2022, Cell Calcium.

The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation

A. Guse, 2002 .

25 Years of Collaboration with A Genius: Deciphering Adenine Nucleotide Ca2+ Mobilizing Second Messengers Together with Professor Barry Potter

A. Guse, 2020, Molecules.

Transient Tyrosine Phosphorylation of Human Ryanodine Receptor upon T Cell Stimulation*

G. Mayr, A. Guse, A. Tsygankov, 2001, The Journal of Biological Chemistry.

Regulation of cADP-ribose-induced Ca2+ Release by Mg2+ and Inorganic Phosphate*

B. Potter, G. Mayr, A. Guse, 1996, The Journal of Biological Chemistry.

Adhesion to laminin-1 and collagen IV induces the formation of Ca2+ microdomains that sensitize mouse T cells for activation

G. Dupont, S. Huber, A. Guse, 2023, Science Signaling.

A Minimal Structural Analogue of Cyclic ADP-ribose

L. Zhang, Zhenjun Yang, Hongwei Jin, 2005, Journal of Biological Chemistry.

Mechanisms involved in α6β1-integrin-mediated Ca2+ signalling

Andreas H. Guse, B. Potter, G. Mayr, 2001 .

Complex inositol polyphosphate response induced by co-cross-linking of CD4 and Fc gamma receptors in the human monocytoid cell line U937.

F. Emmrich, A. Guse, B. Bröker, 1992, Journal of immunology.

Vicinal thiols are involved in inositol 1,2,3,5,6-pentakisphosphate 5-phosphatase activity from fetal calf thymus.

C. Schultz, G. Mayr, A. Guse, 1997, Biochemical and biophysical research communications.

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity.

N. Oppenheimer, S. Shuto, A. Matsuda, 2002, Biochemistry.

Assay for ADP-ribosyl cyclase by reverse-phase high-performance liquid chromatography.

G. Mayr, A. Guse, K. Schweitzer, 2001, Analytical biochemistry.

Non-radioactive, isomer-specific inositol phosphate mass determinations: high-performance liquid chromatography-micro-metal-dye detection strongly improves speed and sensitivity of analyses from cells and micro-enzyme assays.

G. Mayr, A. Guse, K. Weber, 1995, Journal of chromatography. B, Biomedical applications.

cADPR Does Not Activate TRPM2

H. Tidow, A. Guse, R. Fliegert, 2022, International journal of molecular sciences.

Determination of intracellular concentrations of the TRPM2 agonist ADP-ribose by reversed-phase HPLC.

A. Guse, A. Gasser, 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR).

A. Guse, 2004, Current molecular medicine.

A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.

L. Zhang, Zhenjun Yang, A. Guse, 2011, Chemical communications.

Synthesis and biological evaluation of novel membrane-permeant cyclic ADP-ribose mimics: N1-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine 5',5''-cyclicpyrophosphate (cIDPRE) and 8-substituted derivatives.

L. Zhang, Zhenjun Yang, L. Zhang, 2004, Journal of medicinal chemistry.

Mechanisms involved in alpha6beta1-integrin-mediated Ca(2+) signalling.

B. Potter, G. Mayr, A. Guse, 2001, Cellular signalling.

Measuring CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) activity by reverse-phase HPLC.

A. Guse, T. Kirchberger, 2013, Cold Spring Harbor protocols.

Synthesis and Metabolism of the myo‐Inositol Pentakisphosphates

C. Schultz, G. Mayr, A. Guse, 1997 .

Ca2+ release and Ca2+ entry induced by rapid cytosolic alkalinization in Jurkat T-lymphocytes.

F. Emmrich, A. Guse, E. Roth, 1994, The Biochemical journal.

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

G. Adam, F. Malavasi, S. Menzel, 2017, Scientific Reports.

Effects of Mentoring Speed Dating as an Innovative Matching Tool in Undergraduate Medical Education: A Mixed Methods Study

A. Guse, Jenni Guse, I. Heinen, 2016, PloS one.

Short-term dietary changes can result in mucosal and systemic immune depression

E. Elinav, O. Kretz, K. Lassen, 2023, Nature Immunology.

Purification and analytical characterization of an anti-CD4 monoclonal antibody for human therapy.

F. Emmrich, A. Guse, H. Schulze-Koops, 1994, Journal of chromatography. A.

T cell Ca2+ microdomains through the lens of computational modeling

A. Guse, Björn-Philipp Diercks, Diana C. Gil Montoya, 2023, Frontiers in immunology.

Time-Dependent Image Restoration of Low-SNR Live-Cell Ca2 Fluorescence Microscopy Data

C. Lohr, A. Guse, C. Gee, 2021, International journal of molecular sciences.

Integration of nicotinic acid adenine dinucleotide phosphate (NAADP)‐dependent calcium signalling

A. Guse, Björn-Philipp Diercks, 2018, The Journal of physiology.

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

A. Konnerth, B. Sakmann, P. Jonas, 1990, Pflügers Archiv.

NAADP: A Universal Ca2+ Trigger

A. Guse, Hon Cheung Lee, Hon-cheung Lee, 2008, Science Signaling.

The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice

G. Damonte, H. Mittrücker, L. Sturla, 2023, Frontiers in endocrinology.

2′-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca2+ concentrations

A. Guse, R. Fliegert, Anette Rosche, 2024, Frontiers in immunology.

2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

B. Potter, A. Guse, M. Flato, 2017, Nature chemical biology.

Structural determinants for N1/N7 cyclization of nicotinamide hypoxanthine 5'-dinucleotide (NHD+) derivatives by ADP-ribosyl cyclase from aplysia californica: Ca2+-mobilizing activity of 8-substituted cyclic inosine 5'-diphosphoribose analogues in T-lymphocytes.

B. Potter, A. Guse, K. Weber, 2006, Journal of medicinal chemistry.

Generation and characterization of antagonistic anti-human CD39 nanobodies

A. Guse, B. Rissiek, A. Rissiek, 2024, Frontiers in immunology.

Opus: University of Bath Online Publication Store Design, Synthesis, and Chemical and Biological Properties of Cyclic Adp-4-thioribose as a Stable Equivalent of Cyclic Adp-ribose

T. Hirokawa, S. Shuto, B. Potter, 2022 .