H. Osada

H. Osada, S. Goto, M. Kawatani, 2013, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

Effect of Reveromycin A on Experimental Tooth Movement in OPG−/− Mice

H. Osada, S. Goto, M. Kawatani, 2012, Journal of dental research.

Involvement of disulfide bond formation in the activation of heparanase.

Takehiro Suzuki, N. Dohmae, H. Osada, 2007, Cancer research.

Novel squalene-producing thraustochytrids found in mangrove water

Shunji Takahashi, S. Moriya, H. Osada, 2017, Bioscience, biotechnology, and biochemistry.

Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus

Shunji Takahashi, Yukihiro Asami, Y. Sugimoto, 2009, Chembiochem : a European journal of chemical biology.

Epoxycyclohexenone Inhibits Fas-mediated Apoptosis by Blocking Activation of Pro-caspase-8 in the Death-inducing Signaling Complex*

Yasunobu Miyake, T. Kataoka, H. Kakeya, 2003, The Journal of Biological Chemistry.

Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae.

M. Imoto, H. Osada, N. Watanabe, 2005, The Journal of general and applied microbiology.

Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects?

H. Osada, S. Goto, M. Kawatani, 2021, European journal of orthodontics.

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684

Noriko Ogita, H. Osada, T. Nogawa, 2017, The Journal of Antibiotics.

A cell-based screening to detect inhibitors of BRAF signaling pathway

Yukihiro Asami, H. Koshino, T. Usui, 2009, The Journal of Antibiotics.

Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae

H. Osada, A. Teh, N. Watanabe, 2021, Scientific Reports.

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Y. Murakami, M. Seiki, T. Sakamoto, 2021, Communications Biology.

Exploitation of heparanase inhibitors from microbial metabolites using an efficient visual screening system.

K. Ishida, H. Osada, S. Simizu, 2004, The Journal of antibiotics.

Miclxin, a novel MIC60 inhibitor, induces apoptosis via mitochondrial stress in β-catenin mutant tumor cells.

S. Ishikawa, H. Kakeya, M. Imoto, 2020, ACS chemical biology.

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.

T. Macdonald, H. Kakeya, H. Osada, 2008, Bioorganic & medicinal chemistry.

Identification of a Selective RelA Inhibitor Based on DSE-FRET Screening Methods

Kam Y. J. Zhang, Ashutosh Kumar, Minoru Yoshida, 2020, International journal of molecular sciences.

Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma

I. Endo, Toshio Matsumoto, H. Osada, 2020, Haematologica.

A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell–accelerated fibroblast migration

H. Osada, Y. Kondoh, M. Muroi, 2019, The Journal of Biological Chemistry.

Identification of a small‐molecule ligand of β‐arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells

H. Osada, Y. Kondoh, N. Watanabe, 2018, Cancer medicine.

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

A. Ryo, H. Osada, Y. Futamura, 2019, FEBS letters.

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

Yangrae Cho, Yukihiro Asami, Y. Kwon, 2019, Experimental & Molecular Medicine.

A facile and effective screening method for p21WAF1 promoter activators from microbial metabolites.

L. Nie, H. Kakeya, H. Osada, 2001, The Journal of antibiotics.

Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity.

Hitoshi Nakamoto, H. Osada, Y. Kondoh, 2011, The Biochemical journal.

A novel mitochondrial DnaJ/Hsp40 family protein BIL2 promotes plant growth and resistance against environmental stress in brassinosteroid signaling

K. Ogawa, M. Sakuta, M. Matsui, 2013, Planta.

ATM blocks tunicamycin‐induced endoplasmic reticulum stress

M. Jung, O. Kwon, Long He, 2009, FEBS letters.

KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue.

H. Shibata, C. Ishioka, N. Chiba, 2010, ACS medicinal chemistry letters.

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.

H. Koshino, H. Osada, T. Kudo, 1992, The Journal of antibiotics.

A new biological role of sangivamycin; inhibition of protein kinases.

H. Osada, K. Isono, T. Sonoda, 1989, The Journal of antibiotics.

Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system.

M. Yamasaki, J. Magae, K. Nagai, 1989, The Journal of antibiotics.

ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007

Weiming Zhu, H. Osada, Hongbing Liu, 2005 .

A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine).

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.

H. Koshino, H. Osada, K. Isono, 1992, The Journal of antibiotics.

A new indolocarbazole antibiotic, RK-286D.

M. Satake, H. Koshino, H. Osada, 1992, The Journal of antibiotics.

Brassinosteroids regulate vacuolar morphology in root meristem cells of Arabidopsis thaliana

A. Nakano, K. Shinozaki, M. Sakuta, 2018, Plant signaling & behavior.

An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae

Y. Koyama, H. Osada, M. Kawatani, 2015, The Journal of Antibiotics.

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents.

S. Ōmura, H. Osada, Y. Futamura, 2020, Medicinal chemistry (Shariqah (United Arab Emirates)).

A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.

M. Kimura, I. Yamaguchi, H. Kakeya, 2002, The Biochemical journal.

Osteoclast Inhibitors for Bone Fracture Healing in Mice with High-Turnover Osteoporosis

H. Osada, S. Goto, M. Kawatani, 2020, Journal of Hard Tissue Biology.

Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease

H. Osada, S. Goto, M. Kawatani, 2015, Scientific Reports.

Activation of p38 mitogen‐activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor

M. Tsujimoto, H. Osada, M. Matsumoto, 2000, FEBS letters.

Production of a protein A--lymphotoxin hybrid protein for cancer-targeted therapy.

H. Osada, T. Miki, S. Kato, 1990, Journal of biotechnology.

Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

M. Takagi, N. Imamoto, T. Usui, 2013, ACS chemical biology.

Violaceols Function as Actin Inhibitors Inducing Cell Shape Elongation in Fibroblast Cells

Yukihiro Asami, Jae-Hyuk Jang, O. Kwon, 2012, Bioscience, biotechnology, and biochemistry.

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

H. Osada, S. Simizu, 2000, Nature Cell Biology.

Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay.

N. Kagaya, K. Shin‐ya, H. Kimura, 2019, Journal of biochemistry.

Detection of Cytochrome P450 Substrates by Using a Small‐Molecule Droplet Array on an NADH‐Immobilized Solid Surface

Shunji Takahashi, H. Osada, N. Kanoh, 2011, Chembiochem : a European journal of chemical biology.

Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.

M. Jung, O. Kwon, Long He, 2010, Carcinogenesis.

The Insulin Receptor: A Potential Target of Amarogentin Isolated from Gentiana rigescens Franch That Induces Neurogenesis in PC12 Cells

Minoru Yoshida, H. Osada, Lan Xiang, 2021, Biomedicines.

Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution[S]

Toshihide Kobayashi, H. Osada, R. Ishitsuka, 2011, Journal of Lipid Research.

Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress

R. Watanapokasin, M. Imoto, H. Osada, 2020, Heliyon.

Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells.

H. Zhang, H. Kakeya, H. Osada, 1997, The Journal of antibiotics.

Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L.

T. Usui, H. Osada, J. Kobayashi, 2006, Chemistry & biology.

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists.

M. Sodeoka, D. Hashizume, H. Osada, 2019, Chemistry.

Novel Abscisic Acid Antagonists Identified with Chemical Array Screening

K. Shinozaki, T. Umezawa, H. Osada, 2015, Chembiochem : a European journal of chemical biology.

Genetic safeguard against mycotoxin production and cyclopiazonic acid biosynthesis in Aspergillus oryzae

Y. Koyama, H. Osada, Naoki Kato, 2014 .

Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae

Shunji Takahashi, K. Kitamoto, Y. Koyama, 2011, Chembiochem : a European journal of chemical biology.

Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum.

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2017, Journal of Natural Products.

Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013.

Gil Soo Kim, Young-Soo Hong, Shunji Takahashi, 2016, Journal of natural products.

Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta

J. Ahn, Bo Yeon Kim, M. Na, 2009, Journal of enzyme inhibition and medicinal chemistry.

Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation.

H. Osada, M. Uramoto, K. Isono, 1989, The Journal of antibiotics.

Structure‐Activity Relationships of Terpendole E and Its Natural Derivatives.

H. Hirota, T. Usui, H. Osada, 2017 .

Terpendole E and its Derivative Inhibit STLC‐ and GSK‐1‐Resistant Eg5

H. Hirota, T. Usui, H. Osada, 2014, Chembiochem : a European journal of chemical biology.

Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.

S. Yokoyama, T. Usui, H. Osada, 2006, Toxicology letters.

Actinomycetes, How Fascinating Microorganisms

H. Osada, 1998 .

Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase☆

H. Kakeya, H. Osada, C. Cui, 1997 .

Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice.

H. Osada, S. Goto, M. Kawatani, 2021, Journal of pharmacological sciences.

Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice.

H. Osada, S. Goto, M. Kawatani, 2020, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

S. Ichikawa, T. Eguchi, T. Usui, 2016, Bioscience, biotechnology, and biochemistry.

RECK negatively regulates matrix metalloproteinase-9 transcription.

H. Osada, S. Takagi, S. Simizu, 2009, Cancer research.

Measurement of ATPase Activity of Valosin-containing Protein/p97.

H. Osada, Y. Kondoh, M. Muroi, 2020, Bio-protocol.

Allantopyrone A activates Keap1–Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

H. Osada, Y. Kondoh, M. Muroi, 2016, The Journal of Antibiotics.

Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

M. Watabe, H. Kakeya, H. Osada, 1999, Oncogene.

TU-572, a Potent and Selective CD45 Inhibitor, Suppresses IgE-Mediated Anaphylaxis and Murine Contact Hypersensitivity Reactions

T. Hamaguchi, H. Osada, Masakazu Sato, 2001, International Archives of Allergy and Immunology.

Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase.

A. Saito, H. Osada, T. Sudo, 2008, Chemistry, an Asian journal.

Catenulisporolides, Glycosylated Triene Macrolides from the Chemically Underexploited Actinomycete Catenulispora Species.

Young-Soo Hong, Shunji Takahashi, Jae-Hyuk Jang, 2018, Organic letters.

Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism.

H. Osada, T. Kamakura, T. Motoyama, 2021, Bioscience, biotechnology, and biochemistry.

Fumagillin suppresses HIV‐1 infection of macrophages through the inhibition of Vpr activity

H. Miyoshi, A. Koito, Tomoyuki Yamaguchi, 2006, FEBS letters.

New Abscisic Acid Derivatives Revealed Adequate Regulation of Stomatal, Transcriptional, and Developmental Responses to Conquer Drought.

H. Osada, Y. Kondoh, T. Nakano, 2021, ACS chemical biology.

Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.

T. Sano, T. Usui, K. Kaya, 2001, Journal of natural products.

Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.

H. Osada, N. Watanabe, E. Ong, 2019, Journal of microbiological methods.

Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament.

N. Dohmae, M. Tsuda, T. Usui, 2004, Chemistry & biology.

Special issue: Nucleoside antibiotics, polyoxin and beyond

H. Osada, 2019, The Journal of Antibiotics.

In vivo and in vitro evaluation of novel μ-opioid receptor agonist compounds.

H. Sezutsu, I. Kobayashi, H. Osada, 2015, European journal of pharmacology.

Genome-Wide Maps of Mononucleosomes and Dinucleosomes Containing Hyperacetylated Histones of Aspergillus fumigatus

H. Aburatani, Yutaka Suzuki, H. Nishida, 2010, PloS one.

Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain

H. Hirai, H. Osada, S. Takeda, 2016, Genes to cells : devoted to molecular & cellular mechanisms.

Recently, we isolated epiderstatin1 '2) which inhibits the mitogenic activity induced by epidermal growth factor (EGF) in the culture fluid of Streptomyces pulveraceus subsp. epiderstagenes. Actiketal, a new member

H. Osada, K. Isono, T. Sonoda, 2006 .

Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus.

M. Ubukata, H. Osada, K. Isono, 1992, The Journal of antibiotics.

Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells.

H. Wakasugi, T. Usui, H. Osada, 2007, Anticancer research.

Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

H. Kakeya, H. Osada, K. Isono, 1995, The Journal of antibiotics.

Reveromycin A inhibits antigen receptor-mediated antigen presentation by B lymphoma cells via its effect on intracellular trafficking of the antigen.

Yuriko Tanaka, T. Kakiuchi, T. Uchida, 2002, The Journal of antibiotics.

Biosynthesis of phoslactomycins: cyclohexanecarboxylic acid as the starter unit

K. Reynolds, H. Osada, Y. Sekiyama, 2003 .

Introduction of New Tools for Chemical Biology Research on Microbial Metabolites

H. Osada, 2010, Bioscience, biotechnology, and biochemistry.

Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins.

H. Osada, K. Isono, M. Yoshihama, 1998, The Journal of antibiotics.

Liposidomycin B inhibits in vitro formation of polyprenyl (pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis.

H. Osada, A. Takatsuki, M. Muroi, 1997, The Journal of antibiotics.

Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri.

N. Dohmae, R. Usami, K. Takio, 1996, The Biochemical journal.

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). II. Isolation, physico-chemical properties and structure.

H. Osada, M. Uramoto, K. Isono, 1990, The Journal of antibiotics.

Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin.

J. Magae, H. Osada, K. Isono, 1988, The Journal of antibiotics.

Synthesis and Biological Activity of Aminoacyl Analogs of Ascamycin

M. Ubukata, J. Magae, H. Osada, 1988 .

Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase, in mammalian cell membranes and susceptibility to ascamycin.

H. Osada, K. Isono, 1986, The Journal of antibiotics.

Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri.

H. Osada, K. Isono, 1986, The Biochemical journal.

Synthesis and biological activity of nucleoside antibiotics, ascamycin and its amino acid analogs.

M. Ubukata, H. Osada, K. Isono, 1985, Nucleic acids symposium series.

Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus

Myco Umemura, D. Hagiwara, S. Kawamoto, 2017, PloS one.

Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2.

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013, ACS chemical biology.

Spectomycin B 1 as a Novel SUMOylation Inhibitor That Directly Binds to SUMO E 2

Kam Y. J. Zhang, K. Shin‐ya, Ashutosh Kumar, 2013 .

Asymmetric, stereocontrolled total synthesis of (+) and (−)-spirotryprostatin B via a diastereoselective azomethine ylide [1,3]-dipolar cycloaddition reaction

Robert M. Williams, T. Usui, H. Osada, 2002 .

Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum*

M. Lagarde, P. Greimel, Toshihide Kobayashi, 2012, The Journal of Biological Chemistry.

Nordihydroguaiaretic Acid, of a New Family of Microtubule-stabilizing Agents, Shows Effects Differentiated from Paclitaxel

T. Usui, H. Osada, A. Takatsuki, 2003, Bioscience, biotechnology, and biochemistry.

Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ.

T. Usui, H. Osada, M. Kondoh, 1998, The Journal of antibiotics.

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

M. Sodeoka, H. Hirota, Minoru Yoshida, 2016, Scientific Reports.

A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test

H. Sezutsu, T. Kitamura, O. Kikuchi, 2017, European journal of pharmacology.

Establishment of a Monoclonal Antibody against Human NTCP That Blocks Hepatitis B Virus Infection

K. Chayama, M. Shirouzu, K. Shimotohno, 2022, Journal of virology.

Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field.

Young-Soo Hong, Shunji Takahashi, Jae-Hyuk Jang, 2016, Phytochemistry.

Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells*

Y. Ohta, H. Osada, K. Machida, 2006, Journal of Biological Chemistry.

Molecular Interaction between Cyclophilin D and Adenine Nucleotide Translocase in Cytochrome c Release

H. Osada, K. Machida, 2003, Annals of the New York Academy of Sciences.

A Novel Adenine Nucleotide Translocase Inhibitor, MT-21, Induces Cytochrome c Release by a Mitochondrial Permeability Transition-independent Mechanism*

H. Osada, K. Machida, Y. Hayashi, 2002, The Journal of Biological Chemistry.

Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9.

Takehiro Suzuki, N. Dohmae, A. Masuda, 2012, Experimental cell research.

Kaurene Diterpene Induces Apoptosis in Human Leukemia Cells Partly through a Caspase-8-Dependent Pathway

Y. Asakawa, H. Osada, M. Fujii, 2004, Journal of Pharmacology and Experimental Therapeutics.

Regioselective Synthesis of Benzotriazoles

Yukihiro Asami, K. Rupnik, Jae-Hyuk Jang, 2011 .

3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways.

H. Osada, M. Muroi, Lan Xiang, 2019, Molecular pharmaceutics.

4‐Isoavenaciolide covalently binds and inhibits VHR, a dual‐specificity phosphatase

M. Ubukata, H. Nakayama, K. Takio, 2002, FEBS letters.

Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition.

M. Sodeoka, S. Kidokoro, T. Usui, 2001, Chemistry & biology.

Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis.

Shunji Takahashi, T. Toyomasu, M. Hashimoto, 2009, Bioorganic & medicinal chemistry letters.

Activation of a 36‐kD MBP Kinase, an Active Proteolytic Fragment of MST/Krs Proteins, during Anticancer Drug‐Induced Apoptosis

H. Kakeya, H. Osada, R. Onose, 1999, Annals of the New York Academy of Sciences.

Renal Abnormalities in Mice Caused by Insufficiency of p38α

H. Osada, Yuki Yagasaki, T. Sudo, 2003, Journal of receptor and signal transduction research.

New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006

Gil Soo Kim, Young-Soo Hong, Shunji Takahashi, 2016, Marine drugs.

An experimental study of osteogenesis by autografted dental pulp, periodontal ligament, and bone marrow in vivo.

H. Osada, M. Shimono, T. Shiigai, 1993, The Bulletin of Tokyo Dental College.

Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity.

H. Koshino, H. Kakeya, H. Osada, 2002, The Journal of antibiotics.

Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp.

Yukihiro Asami, H. Kakeya, H. Osada, 2002, Organic letters.

Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols

H. Osada, N. Kanoh, Y. Iwabuchi, 2008 .

Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.

T. Adachi, T. Hamaguchi, H. Osada, 1999, The Journal of antibiotics.

Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1.

A. Saito, H. Osada, T. Sudo, 2007, Journal of biochemistry.

Identification and Characterization of an Inhibitor of Trichothecene 3-O-Acetyltransferase, TRI101, by the Chemical Array Approach

M. Kimura, Tetsuo Kobayashi, Minoru Yoshida, 2013, Bioscience, biotechnology, and biochemistry.

Novel non-peptide inhibitors targeting death receptor-mediated apoptosis.

Yasunobu Miyake, T. Kataoka, H. Kakeya, 2003, Bioorganic & medicinal chemistry letters.

ECH, an Epoxycyclohexenone Derivative That Specifically Inhibits Fas Ligand-Dependent Apoptosis in CTL-Mediated Cytotoxicity1

Yasunobu Miyake, T. Kataoka, H. Kakeya, 2004, The Journal of Immunology.

RKTS-33, an Epoxycyclohexenone Derivative That Specifically Inhibits Fas Ligand-Dependent Apoptosis in CTL-Mediated Cytotoxicity

Yasunobu Miyake, T. Kataoka, H. Kakeya, 2005, Bioscience, biotechnology, and biochemistry.

PC-766B' and PC-766b, 16-membered macrolide angiogenesis inhibitors produced by Nocardia sp. RK97-56

H. Kakeya, H. Osada, A. Takatsuki, 2002 .

Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana

S. Cutler, Y. Makita, M. Matsui, 2016, Plant & cell physiology.

Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies.

H. Osada, Y. Kondoh, T. Nakano, 2019, ACS chemical biology.

High-throughput screening identifies small molecule inhibitors of molecular chaperones.

H. Osada, Y. Kondoh, 2012, Current pharmaceutical design.

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

A. Ryo, F. Kawai, Sam-Yong Park, 2018, Scientific Reports.

Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors.

N. Fujii, H. Ohno, S. Oishi, 2019, Bioconjugate chemistry.

A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo‐Cross‐Linking Beads

H. Osada, Y. Kondoh, Y. Futamura, 2014 .

Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity*

A. Utani, M. Karin, S. Asada, 2002, The Journal of Biological Chemistry.

Bioactivity-guided isolation of neuritogenic triterpenoids from the leaves of Ilex latifolia Thunb.

H. Osada, Xueli Cao, Yu Liu, 2017, Food & function.

Protein tyrosine phosphatase 1B inhibitory activity of 24‐norursane triterpenes isolated from Weigela subsessilis

J. Ahn, Bo Yeon Kim, K. Bae, 2010, Phytotherapy research : PTR.

Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007

H. Osada, H. Kikuchi, T. Nogawa, 2019, The Journal of Antibiotics.

Construction of a potato fraction library for the investigation of functional secondary metabolites

H. Osada, T. Nogawa, Y. Futamura, 2019, Bioscience, biotechnology, and biochemistry.

Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058

Shunji Takahashi, H. Osada, T. Nogawa, 2017, The Journal of Antibiotics.

Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355

Shunji Takahashi, H. Osada, D. Ibrahim, 2016, The Journal of Antibiotics.

Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment.

M. Ubukata, H. Kakeya, H. Osada, 1996, The Journal of antibiotics.

Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.

Young-Soo Hong, H. Hirota, Jae-Hyuk Jang, 2014, Bioorganic & medicinal chemistry letters.

Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74

H. Osada, M. Uramoto, H. Kawasaki, 2013, The Journal of Antibiotics.

Furaquinocins I and J: novel polyketide isoprenoid hybrid compounds from Streptomyces reveromyceticus SN-593

Shunji Takahashi, H. Osada, M. Uramoto, 2011, The Journal of Antibiotics.

Induction of Nectriapyrone Biosynthesis in the Rice Blast Fungus Pyricularia oryzae by Disturbance of the Two‐Component Signal Transduction System

H. Hirota, H. Osada, T. Motoyama, 2019, Chembiochem : a European journal of chemical biology.

Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae

H. Osada, T. Motoyama, C. Yun, 2021, Journal of industrial microbiology & biotechnology.

Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae.

H. Osada, T. Motoyama, C. Yun, 2017, ACS chemical biology.

BPG3 is a novel chloroplast protein that involves the greening of leaves and related to brassinosteroid signaling

M. Sakuta, M. Matsui, T. Asami, 2014, Bioscience, biotechnology, and biochemistry.

Structure-based design of a selective heparanase inhibitor as an antimetastatic agent.

M. Sodeoka, K. Ishida, H. Osada, 2004, Molecular cancer therapeutics.

Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning.

H. Osada, M. Kawatani, N. Kanoh, 2013, Bioconjugate chemistry.

Unique features of the ketosynthase domain in a nonribosomal peptide synthetase–polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1

N. Dohmae, H. Osada, T. Motoyama, 2020, The Journal of Biological Chemistry.

Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion.

H. Waldmann, H. Osada, Slava Ziegler, 2017, Bioorganic & medicinal chemistry.

Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity.

M. Ubukata, H. Kakeya, H. Osada, 1996, The Journal of antibiotics.

Biotransformation of the Mycotoxin, Zearalenone, to a Non-estrogenic Compound by a Fungal Strain of Clonostachys sp.

M. Kimura, I. Yamaguchi, H. Kakeya, 2002, Bioscience, biotechnology, and biochemistry.

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2005, Angewandte Chemie.

Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp.

C. Norbury, L. Nie, T. Beppu, 2001, The Journal of antibiotics.

Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides

J. Porco, H. Kakeya, H. Osada, 2003 .

REDUCTION OF ARYLCARBONYL USING ZINC DUST IN ACETIC ACID

M. Ubukata, H. Osada, B. Rani, 1995 .

Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties.

H. Kakeya, H. Osada, C. Cui, 1996, The Journal of antibiotics.

Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.

M. Ubukata, H. Kakeya, H. Osada, 1995, The Journal of antibiotics.

Tryprostatin A, a specific and novel inhibitor of microtubule assembly.

T. Mayumi, T. Usui, H. Osada, 1998, The Biochemical journal.

Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels–Alderases

Michio Sato, H. Osada, Kenji Watanabe, 2022, Fungal biology and biotechnology.

Fraction Libraries and Genetics as Tools for Natural Product Research: Focus on Decalin-Containing Compounds

H. Osada, J. Lopez, 2019 .

A Hetero Pauson-Khand Reaction of Ketenimines: A New Synthetic Method for γ-Exomethylene-α,β-unsaturated γ-Lactams

Takao Saito, H. Osada, T. Otani, 2010 .

N-linked oligosaccharide processing enzymes as molecular targets for drug discovery

T. Nishio, W. Hakamata, T. Oku, 2006 .

Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors.

H. Kakeya, H. Osada, M. Sato, 1997, Journal of medicinal chemistry.

Isoxazole-4-carboxylic Acid as a Metabolite of Streptomyces sp. and Its Herbicidal Activity

M. Ubukata, S. Sekido, I. Yamaguchi, 1991 .

Total synthesis of (+)-epoxyquinols A and B.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2002, Angewandte Chemie.

Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition.

H Osada, M. Sodeoka, T. Usui, 2001, Journal of medicinal chemistry.

Bitungolides A-F, new polyketides from the Indonesian sponge Theonella cf. swinhoei.

T. Usui, J. Tanaka, H. Osada, 2002, Journal of natural products.

The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2008, Angewandte Chemie.

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.

H. Homma, H. Osada, H. Tomoda, 2015, Bioorganic & medicinal chemistry letters.

Novel Mammalian Cell Cycle Inhibitors, Spirotryprostatins A and B, Produced by Aspergillus fumigatus, Which Inhibit Mammalian Cell Cycle at G2/M Phase

H. Kakeya, H. Osada, C. Cui, 1997 .

Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005.

Young-Soo Hong, Shunji Takahashi, H. Hirota, 2015, Bioorganic & medicinal chemistry letters.

A new cyclic lipopeptide antibiotic, enamidonin.

H. Koshino, H. Osada, K. Isono, 1995, The Journal of antibiotics.

Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus.

H. Kakeya, H. Osada, T. Yano, 1998, The Journal of antibiotics.

In vitro reconstruction of tetronate RK-682 biosynthesis

P. Leadlay, Yuhui Sun, H. Osada, 2009, Nature chemical biology.

Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities

M. Sodeoka, H. Osada, R. Sampe, 1996 .

Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

H. Kakeya, H. Osada, Hui-ping Zhang, 1997 .

Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2-[(4-methylthiopyridin-2-yl)methylsulfinyl]benzimidazole

T. Hamaguchi, H. Osada, Masakazu Sato, 2000 .

Isolation and biological activity of a novel cytokine modulator, cytoxazone.

H. Kakeya, H. Osada, M. Ishizuka, 1998, The Journal of antibiotics.

Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94

H. Hirota, A. Tanaka, H. Osada, 2020, Bioscience, biotechnology, and biochemistry.

Molecular Basis for Two Stereoselective Diels–Alderases that Produce Decalin Skeletons

Y. Sugita, Shunji Takahashi, Suyong Re, 2021, bioRxiv.

Identification of a Molecular Target of a Novel Fungal Metabolite, Pyrrolizilactone, by Phenotypic Profiling Systems

H. Osada, T. Nogawa, M. Kawatani, 2013, Chembiochem : a European journal of chemical biology.

Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus

Shunji Takahashi, H. Koshino, H. Osada, 2013, The Journal of Antibiotics.

Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp.

H. Koshino, H. Kakeya, H. Osada, 1999, The Journal of organic chemistry.

Isolation and biological activity of a novel cytokine modulator, cytoxazone.

H. Kakeya, H. Osada, M. Ishizuka, 1998, The Journal of antibiotics.

RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.

M. Ubukata, H. Osada, T. Kudo, 1995, The Journal of antibiotics.

Isolation and characterization of a new antibiotic, malolactomycin A.

H. Koshino, H. Osada, K. Isono, 1993, The Journal of antibiotics.

Terpeptin, a novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1

H. Osada, K. Arai, K. Kobinata, 1997 .

Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210.

F. Hanaoka, H. Osada, C. Cui, 1997, Bioorganic & medicinal chemistry.

A practical total synthesis of both enantiomers of epoxyquinols A and B

H. Kakeya, H. Osada, Y. Hayashi, 2002 .

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells.

H. Osada, M. Uramoto, T. Nogawa, 2009, Biochemical and biophysical research communications.

Phoslactomycin targets cysteine‐269 of the protein phosphatase 2A catalytic subunit in cells

H. Osada, N. Kanoh, S. Simizu, 2005, FEBS letters.

Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.

M. Inagaki, G. Swarup, G. Marriott, 1999, Journal of biochemistry.

Reduction of Arylcarbonyl Using Zinc Dust in Acetic Acid.

M. Ubukata, H. Osada, B. Rani, 1995 .

Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

Shunji Takahashi, H. Osada, M. Uramoto, 2011, Chembiochem : a European journal of chemical biology.

Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro.

R. Williams, T. Usui, H. Osada, 2000, Bioorganic & medicinal chemistry.

Biochemical Characterization of a Novel Indole Prenyltransferase from Streptomyces sp. SN-593

Y. Sakaki, Shunji Takahashi, A. Toyoda, 2010, Journal of bacteriology.

Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B, and Other Diketopiperazines Produced by Aspergillus fumigatus. Part 2. Physico‐ Chemical Properties and Structures.

H. Kakeya, H. Osada, C. Cui, 1996 .

Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus.

M. Ubukata, H. Kakeya, H. Osada, 1995, The Journal of antibiotics.

Reversal of breast cancer resistance protein–mediated drug resistance by tryprostatin A

A. Herrmann, H. Lage, H. Osada, 2003, International journal of cancer.

Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment

M. Ubukata, H. Kakeya, H. Osada, 1996 .

Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.

H. Kakeya, H. Osada, R. Onose, 2005, The Journal of organic chemistry.

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme

H. Osada, T. Motoyama, C. Yun, 2015, Nature Communications.

Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth.

S. Dan, M. Kawada, H. Osada, 2021, ACS chemical biology.

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.

A. Ganesan, T. Usui, H. Osada, 2000, Journal of medicinal chemistry.

Control of the Stereochemical Course of [4+2] Cycloaddition during trans -Decalin Formation by Fsa2-Family Enzymes

Shunji Takahashi, H. Osada, T. Nogawa, 2018, Angewandte Chemie.

Control of the Stereochemical Course of [4+2] Cycloaddition during trans-Decalin Formation by Fsa2-Family Enzymes.

Shunji Takahashi, H. Osada, T. Nogawa, 2018, Angewandte Chemie.

Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels.

Shunji Takahashi, M. Ihara, K. Matsuda, 2018, ACS chemical biology.

The structure of enopeptins A and B, novel depsipeptide antibiotics

H. Koshino, H. Osada, K. Isono, 1991 .

Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor

Y. Aida, T. Murakami, Masaaki Suzuki, 2015, PLoS ONE.

Discovery of Novel Antiviral Agents Directed Against the Influenza A Virus Nucleoprotein

H. Goto, Y. Aida, Kazunori Yamada, 2012 .

Extracellular phosphorylation of membrane protein modifies theta burst-induced long-term potentiation in CA1 neurons of guinea-pig hippocampal slices

Y. Kuroda, T. Hamaguchi, H. Osada, 1995, Neuroscience Letters.

FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants

T. Demura, K. Shinozaki, Masatomo Kobayashi, 2018, Plant & cell physiology.

Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi

M. Kimura, T. Saito, T. Nishiuchi, 2014, Letters in applied microbiology.

Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua.

Shunji Takahashi, O. Kayser, W. Quax, 2010, Plant & cell physiology.

The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua.

O. Kayser, W. Quax, H. Bouwmeester, 2010, Planta medica.

Separation of proteins by charged ultrafiltration membranes

Shoji Kimura, Shin-ichi Nakao, Toshinori Tsuru, 1988 .

Basic research of the regulation mechanisms of trichothecene production for reduction of the mycotoxin contamination

M. Kimura, H. Osada, Y. Nakajima, 2014 .

Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

H. Osada, R. Pope, Qi-Quan Huang, 2006, Molecular and Cellular Biology.

Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166.

R. Usami, H. Osada, R. Onose, 2001, The Journal of antibiotics.

Structure of malolactomycins A and B, novel 40-membered macrolide antibiotics

H. Koshino, H. Osada, M. Uramoto, 1993 .

Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum.

M. Kimura, Tetsuo Kobayashi, T. Nishiuchi, 2018, ACS chemical biology.

Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases

I. Vetter, H. Waldmann, H. Osada, 2012, Journal of Lipid Research.

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.

Hiroyuki Osada, H. Osada, Satoshi Takagi, 2010, Nature chemical biology.

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

Makoto Muroi, Hiroyuki Osada, Masaya Imoto, 2008, Proceedings of the National Academy of Sciences.

Proteomics-based target identification of natural products affecting cancer metabolism

H. Osada, M. Muroi, 2021, The Journal of Antibiotics.

Improvement of transformation efficiency by strategic circumvention of restriction barriers in Streptomyces griseus.

Shunji Takahashi, Ken-ichi Yoshida, H. Osada, 2011, Journal of microbiology and biotechnology.

Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea.

D. Hashizume, H. Koshino, H. Osada, 2017, Organic letters.

Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

Seung Min Kim, Shunji Takahashi, H. Hirota, 2015 .

Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44

Shunji Takahashi, H. Osada, H. Takagi, 2018, The Journal of Antibiotics.

Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba.

H. Hirota, H. Osada, T. Motoyama, 2012, Chemistry & biology.

Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.

H. Osada, T. Motoyama, 2016, Bioorganic & medicinal chemistry letters.

RK-270A−C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2014, The Journal of Antibiotics.

Productivity and bioactivity of enokipodins A–D of Flammulina rossica and Flammulina velutipes

E. Nagasawa, H. Osada, T. Motoyama, 2020, Bioscience, biotechnology, and biochemistry.

Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.

S. Yokoyama, H. Osada, Y. Kondoh, 2006, Chemistry, an Asian journal.

Synthesis and Characterization of a Novel Protein Tyrosine Phosphatase Inhibitor, 2-(Cyclobutylamino)- N- (2-Furylmethyl)-2-Thioxoacetamide

T. Ishii, T. Hamaguchi, H. Osada, 2005 .

Morphological Changes of Human Myeloid Leukemia K562 Cells by a Protein Phosphatase Inhibitor, Tautomycin

M. Yamasaki, J. Magae, K. Nagai, 1990 .

Rapid screening and identification of cytochalasins by electrospray tandem mass spectrometry.

H. Osada, M. Ueki, P. Stefanowicz, 2002, Journal of mass spectrometry : JMS.

Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

T. Usui, H. Osada, H. Kiyota, 2008, Bioscience, biotechnology, and biochemistry.

Affinity-based target identification for bioactive small molecules

H. Osada, M. Kawatani, 2014 .

Construction and application of a photo-cross-linked chemical array.

H. Osada, Y. Kondoh, Kaori L. Honda, 2015, Methods in molecular biology.

Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics.

H. Osada, N. Kanoh, M. Muroi, 2005, Angewandte Chemie.

Asymmetric total synthesis of pseurotin A.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2003, Organic letters.

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Rachael A Uson-Lopez, H. Osada, Takeshi Shimizu, 2019, The Journal of Antibiotics.

Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library

Shunji Takahashi, H. Osada, D. Ibrahim, 2015, The Journal of Antibiotics.

SYNTHESES AND BIOACTIVITIES OF ACETOPHTHALIDIN AND ITS DERIVATIVES

T. Kitahara, T. Usui, H. Osada, 1998 .

Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B

J. Ahn, H. Osada, H. Ko, 2001, Bioscience, biotechnology, and biochemistry.

Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.

M. Kawada, Ikuko Nagasawa, H. Osada, 2019, Cell chemical biology.

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.

H. Osada, T. Nogawa, M. Kawatani, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Phenotypic screening meets natural products in drug discovery†

H. Osada, Y. Futamura, Kai Yamamoto, 2017, Bioscience, biotechnology, and biochemistry.

Utilization of the Methoxymalonyl-Acyl Carrier Protein Biosynthesis Locus for Cloning of the Tautomycin Biosynthetic Gene Cluster from Streptomyces spiroverticillatus

B. Shen, H. Osada, J. Ju, 2006, Journal of bacteriology.

Respinomycins A1, A2 B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities.

M. Ubukata, H. Osada, T. Kudo, 1993, The Journal of antibiotics.

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2006, Angewandte Chemie.

Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.

H. Ikeda, K. Shin‐ya, Teppei Kawahara, 2019, ACS chemical biology.

The potential of protein disulfide isomerase as a therapeutic drug target.

H. Osada, M. Kawatani, Maola M G Khan, 2011, Oncology research.

Structure–Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array

Y. Nonomura, Yoshikazu Takahashi, H. Osada, 2009, ChemBioChem.

Novel heparan sulfate mimetic compounds as antitumor agents.

K. Ishida, H. Osada, S. Simizu, 2004, Chemistry & biology.

Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase.

T. Kataoka, S. Taketani, H. Osada, 2011, European journal of pharmacology.

Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells.

Y. Ohta, H. Osada, K. Machida, 2009, Archives of biochemistry and biophysics.

Chemical Biology Based on Small Molecule–Protein Interaction

H. Osada, 2009 .

Synthesis of (+)-vinblastine and its analogues.

T. Miyazaki, H. Osada, H. Tokuyama, 2007, Organic letters.

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition*

Hiroyuki Osada, Hisashi Kawasaki, M. Takagi, 2009, Journal of Biological Chemistry.

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Hiroyuki Osada, Tony Hunter, Makoto Taniguchi, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Dephosphorylation of Bcl‐2 by protein phosphatase 2A results in apoptosis resistance

Y. Tamura, H. Osada, S. Simizu, 2004, Cancer science.

Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions

Sheena C. Li, Scott W. Simpkins, C. Myers, 2021, J. Chem. Inf. Model..

Translation of human macrophage activating factor (for glucose consumption) mRNA in Xenopus laevis oocytes.

M. Obinata, H. Osada, S. Natori, 1985, Immunological investigations.

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis.

M. Imoto, H. Osada, M. Kawatani, 2003, Experimental cell research.

Proteomics accelerating the identification of the target molecule of bioactive small molecules.

K. Wierzba, H. Osada, M. Muroi, 2011, Current opinion in chemical biology.

Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.

Makoto Muroi, Sayaka Kazami, Hiroyuki Osada, 2010, Chemistry & biology.

Cell Proliferation and Differentiation

H. Osada, N. Watanabe, 2017 .

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.

H. Schöler, I. Vetter, H. Waldmann, 2016, Cell chemical biology.

Construction of a microbial natural product library for chemical biology studies.

Shunji Takahashi, Hiroyuki Osada, Toshihiko Nogawa, 2012, Current opinion in chemical biology.

Protein Targeting with Small Molecules

H. Osada, 2009 .

Laforin, defective in the progressive myoclonus epilepsy of Lafora type, is a dual-specificity phosphatase associated with polyribosomes.

K. Yamakawa, K. Agarwala, T. Hashikawa, 2000, Human molecular genetics.

The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain.

K. Yamakawa, K. Agarwala, A. Delgado-Escueta, 2003, Human molecular genetics.

Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ

Teruo Hayashi, H. Osada, Y. Kondoh, 2016, Scientific Reports.

MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria.

M. Watabe, H. Osada, K. Machida, 2000, Cancer research.

Bcl‐2 Inhibits Calcineurin‐mediated Fas Ligand Expression in Antitumor Drug‐treated Baby Hamster Kidney Cells

F. Shibasaki, H. Osada, S. Simizu, 2000, Japanese journal of cancer research : Gann.

Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis.

N. Arber, M. Takada, M. Imoto, 2000, Experimental cell research.

Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.

Junko Hashimoto, Shunji Takahashi, Hiroyuki Osada, 2017, Angewandte Chemie.

Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis.

H. Kakeya, H. Osada, R. Onose, 1998, Cancer research.

RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines.

Y. Tamura, H. Osada, S. Takagi, 2005, Cancer research.

Stress meets development in p38 MAP kinase

H. Osada, T. Sudo, M. Maruyama, 2002 .

Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE.

H. Osada, M. Muroi, 2018, Methods in molecular biology.

Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.

Yukihiro Asami, Jae-Hyuk Jang, J. Ahn, 2011, Journal of the American Chemical Society.

Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment

T. Tsuruo, S. Kimura, J. Kuroda, 2010, Cell Death and Differentiation.

Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

H. Osada, M. Uramoto, T. Kamakura, 2020, Journal of antibiotics (Tokyo. 1968).

Synthesis of Grb2 SH2 Domain Proteins for Mirror-Image Screening Systems.

N. Fujii, H. Ohno, T. Noguchi, 2017, Bioconjugate chemistry.

Inhibition of translation by cytotrienin A--a member of the ansamycin family.

J. Pelletier, C. Fraser, F. Robert, 2010, RNA.

Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.

H. Waldmann, H. Osada, B. Wünsch, 2021, Cell chemical biology.

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

H. Waldmann, H. Osada, P. Janning, 2020, Bioscience, biotechnology, and biochemistry.

Development of a Vaccinia H1‐Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate‐Mimicking Core Structure

M. Sodeoka, H. Osada, A. Tsuchiya, 2011, ChemMedChem.

Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions

T. Katagiri, Y. Miyoshi, T. Yoshimaru, 2014, Scientific Reports.

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action

Minoru Yoshida, Chad L. Myers, Hamid Safizadeh, 2017, bioRxiv.

An Overview on the Diversity of Actinomycete Metabolites

H. Osada, 2001 .

Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit*

Shunji Takahashi, Teruo Hayashi, H. Osada, 2015, The Journal of Biological Chemistry.

Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T*

Shunji Takahashi, H. Osada, M. Uramoto, 2014, The Journal of Biological Chemistry.

Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana

K. Shirasu, H. Osada, Y. Noutoshi, 2012, Front. Plant Sci..

Mitochondrial uncoupler exerts a synthetic lethal effect against β‐catenin mutant tumor cells

M. Kawada, M. Imoto, H. Osada, 2017, Cancer science.

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Makoto Muroi, Hiroyuki Osada, H. Osada, 2016, Scientific Reports.

Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways.

Hiroyuki Osada, Tony Hunter, Kazuhiro Ogata, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification of small molecule inhibitors of p27Kip1 ubiquitination by high‐throughput screening

S. Sulaiman, I. Darah, H. Osada, 2013, Cancer science.

Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea.

D. Hashizume, H. Osada, Takeshi Shimizu, 2018, Organic letters.

Cobtorin target analysis reveals that pectin functions in the deposition of cellulose microfibrils in parallel with cortical microtubules.

T. Demura, M. Matsui, N. Kutsuna, 2010, The Plant journal : for cell and molecular biology.

Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.

M. Matsui, N. Kutsuna, H. Osada, 2007, Plant & cell physiology.

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

L. Neckers, S. Soga, J. Trepel, 2008, Proceedings of the National Academy of Sciences.

Identification of Saccharomyces cerevisiae Ribosomal Protein L3 as a Target of Curvularol, a G1-Specific Inhibitor of Mammalian Cells

T. Miyakawa, M. Mizunuma, H. Osada, 2006, Bioscience, biotechnology, and biochemistry.

Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening.

A. Ryo, H. Osada, Takeshi Shimizu, 2016, Biochemical and biophysical research communications.

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a

M. Yoshida, T. Beppu, H. Osada, 1991, The Journal of cell biology.

Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin

J. Nikawa, S. Ishiwata, T. Usui, 2006, EMBO Journal.

A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein

K. Tomii, Y. Aida, Kazunori Yamada, 2015, PLoS pathogens.

Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling.

S. Kimura, H. Osada, M. Kawatani, 2011, Chemistry & biology.

Trends in Bioprobe Research

H. Osada, 2000 .

Expression of heparanase in human tumor cell lines and human head and neck tumors.

K. Ishida, Taka-Aki Sato, H. Osada, 2003, Cancer letters.

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.

A. Ganesan, T. Usui, H. Osada, 2000, Journal of medicinal chemistry.

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Minoru Yoshida, Yoshikazu Ohya, Michael Costanzo, 2018, PLoS Comput. Biol..

Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interaction networks

Minoru Yoshida, Yoshikazu Ohya, Michael Costanzo, 2018 .

Large-scale interpretation of chemical-genetic interaction profiles using a genetic interaction network

Minoru Yoshida, Justin Nelson, Yoshikazu Ohya, 2017, bioRxiv.

Target identification of small molecules based on chemical biology approaches.

Makoto Muroi, Hiroyuki Osada, H. Osada, 2013, Molecular bioSystems.

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.

H. Seimiya, Y. Sugimoto, Minoru Yoshida, 2010, Biochemical and biophysical research communications.

p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression.

H. Osada, T. Sudo, Kayoko Kawai, 2005, Biochemical and biophysical research communications.

CRM646-A and -B, novel fungal metabolites that inhibit heparinase.

W. Oh, H. Koshino, H. Osada, 2000, The Journal of antibiotics.

Inhibition of human telomerase activity by alterperylenol.

H. Kakeya, H. Osada, K. Togashi, 1998, Oncology research.

Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase.

H. Osada, Y. Futamura, M. Muroi, 2016, Natural product reports.

Reveromycin A Inhibits Osteolytic Bone Metastasis of Small-Cell Lung Cancer Cells, SBC-5, through an Antiosteoclastic Activity

S. Sone, S. Yano, H. Osada, 2005, Clinical Cancer Research.

Dissection of two modes of IE1 sub-nuclear localization in baculovirus-infected cells.

H. Osada, S. Matsumoto, Tamio Saito, 2015, Virus research.

A small molecule that induces reactive oxygen species via cellular glutathione depletion.

H. Osada, Y. Kondoh, M. Kawatani, 2014, The Biochemical journal.

Two new triterpenoids from the roots of Pinus densiflora

H. Osada, Y. Futamura, Masabumi Komatsu, 2017, Bioscience, biotechnology, and biochemistry.

Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation

T. Mak, H. Nishina, A. Suzuki, 2021, Cancer science.

Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway

S. He, K. Shirasu, S. Asai, 2020, Nature Communications.

Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues.

J. Hashimoto, H. Ikeda, K. Shin‐ya, 2020, Journal of natural products.

β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593

Shunji Takahashi, Teruo Hayashi, H. Hamamoto, 2020, Scientific Reports.

β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593

Shunji Takahashi, Teruo Hayashi, H. Osada, 2019, Scientific Reports.

Microbial Fraction Library: A Screening Source for Drug Discovery

Toshihiko Nogawa, Julius Adam V. Lopez, Hiroyuki Osada, 2019, Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules.

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

A. Ryo, F. Kawai, Sam-Yong Park, 2018, Scientific Reports.

Identification and structure–activity relationship of purine derivatives as novel MTH1 inhibitors

Kam Y. J. Zhang, Ashutosh Kumar, H. Osada, 2017, Chemical biology & drug design.

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism.

A. Ryo, H. Osada, Y. Futamura, 2016, Biochemical and biophysical research communications.

Small molecules that target phosphorylation dependent protein-protein interaction.

H. Osada, N. Watanabe, 2016, Bioorganic & medicinal chemistry.

Identification of matrix metalloproteinase inhibitors by chemical arrays

N. Taniguchi, Y. Yamaguchi, H. Osada, 2015, Bioscience, biotechnology, and biochemistry.

Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity

H. Osada, T. Nogawa, N. Watanabe, 2015, Bioscience, biotechnology, and biochemistry.

Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules.

H. Osada, A. Wada, Shuta Hara, 2014, Analytical chemistry.

Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library

Shunji Takahashi, H. Osada, M. Uramoto, 2011, The Journal of Antibiotics.

ChemInform Abstract: Furaquinocins I and J: Novel Polyketide Isoprenoid Hybrid Compounds from Streptomyces Reveromyceticus SN-593.

Shunji Takahashi, H. Osada, M. Uramoto, 2011 .

Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.

Shunji Takahashi, H. Osada, M. Uramoto, 2010, Organic letters.

2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

H. Waldmann, T. Förster, H. Osada, 2019, European Journal of Organic Chemistry.

Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity.

N. Dohmae, H. Kakeya, H. Osada, 2005, The Biochemical journal.

Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic

H. Osada, K. Isono, 1985, Antimicrobial Agents and Chemotherapy.

Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis.

B. Shen, H. Osada, J. Ju, 2009, Journal of natural products.

Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator.

Shunji Takahashi, H. Koshino, H. Osada, 2021, Bioscience, biotechnology, and biochemistry.

Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana

R. Shin, T. Miyazaki, J. Y. Moon, 2021, Scientific Reports.

Stereocomplementary Chemoenzymatic Pictet–Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds

S. Panjikar, Hujun Xie, H. Osada, 2019, ACS Catalysis.

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

H. Kakeya, H. Osada, Junichiro Yamaguchi, 2004, Bioorganic & medicinal chemistry letters.

Identification of compounds that augment the lectin-sensitivity of Chinese Hamster Ovary cells.

N. Taniguchi, Tadashi Suzuki, H. Osada, 2012, Biochemical and biophysical research communications.

In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

S. Horinouchi, Minoru Yoshida, Akihisa Matsuyama, 2002, The EMBO journal.

Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces.

M. Nishiyama, T. Fujimura, K. Ishigami, 2016, Nature chemical biology.

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.

T. Usui, H. Osada, Sayaka Kazami, 2010, Bioorganic & medicinal chemistry letters.

Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.

T. Yamori, T. Usui, H. Osada, 2007, Bioorganic & medicinal chemistry letters.

p62 functions as a p38 MAP kinase regulator.

H. Osada, T. Sudo, M. Maruyama, 2000, Biochemical and biophysical research communications.

Identification of Saccharomyces cerevisiae Isoleucyl-tRNA Synthetase as a Target of the G1-specific Inhibitor Reveromycin A*

Hidetoshi Takahashi, D. Hirata, T. Miyakawa, 2002, The Journal of Biological Chemistry.

RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2

Yukihiro Asami, M. Toi, H. Kakeya, 2004 .

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf‐1 activation

L. Neckers, Yukihiro Asami, K. Nishikawa, 2008, Cancer science.

Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR 2 , EGFR , FGFR

K. Nishikawa, T. Usui, H. Kakeya, 2008 .

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

S. Maeda, Y. Ihara, A. Takashima, 2015, Nature Communications.

Iejimalides Show Anti-Osteoclast Activity via V-ATPase Inhibition

T. Usui, H. Osada, J. Kobayashi, 2006, Bioscience, biotechnology, and biochemistry.

Exip, a splicing variant of p38α, participates in interleukin‐1 receptor proximal complex and downregulates NF‐κB pathway

H. Osada, Yuki Yagasaki, T. Sudo, 2004 .

Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway.

H. Osada, Yuki Yagasaki, T. Sudo, 2004, FEBS letters.

A new trichostatin derivative, trichostatin RK, from Streptomyces sp. RK98-A74.

R. Usami, H. Osada, M. Ueki, 2001, The Journal of antibiotics.

Lindersin B from Lindernia crustacea induces neuritogenesis by activation of tyrosine kinase A/phosphatidylinositol 3 kinase/extracellular signal-regulated kinase signaling pathway.

H. Osada, Lan Xiang, J. Qi, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Cell cycle arrest and antitumor activity of pironetin and its derivatives.

K. Tsuchiya, K. Nishikawa, S. Kobayashi, 1998, Cancer letters.

[Development of new antitumor reagents which block the cell cycle progression].

H. Osada, 1997, Gan to kagaku ryoho. Cancer & chemotherapy.

Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.

N. Watanabe, H. Hama, H. Osada, 2002, Biochemical and biophysical research communications.

Immunolocalization of p38 MAP kinase in mouse brain

Bingren Hu, T. Shiga, Y. Kasuya, 2000, Brain Research.

Secretion of Heparanase Protein Is Regulated by Glycosylation in Human Tumor Cell Lines*

K. Ishida, H. Osada, S. Simizu, 2004, Journal of Biological Chemistry.

The Anticancer Natural Product Pironetin Selectively Targets Lys352 of α-Tubulin

K. Nishikawa, H. Watanabe, H. Nakayama, 2004 .

Formation and Dissociation of the BSS1 Protein Complex Regulates Plant Development via Brassinosteroid Signaling[OPEN]

H. Kawaide, M. Matsui, T. Asami, 2015, Plant Cell.

Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations

Y. Goto, M. Shirouzu, Minoru Yoshida, 2020, Nature Chemical Biology.

SPR imaging of photo-cross-linked small-molecule arrays on gold.

Kazuki Inamori, Motoki Kyo, Hiroyuki Osada, 2006, Analytical chemistry.

RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening

Shunji Takahashi, H. Koshino, H. Osada, 2014, The Journal of Antibiotics.

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

C. Walsh, S. Garneau‐Tsodikova, F. Schroeder, 2006, Chemistry & biology.

Enzymatic Generation of the Antimetabolite γ,γ-Dichloroaminobutyrate by NRPS and Mononuclear Iron Halogenase Action in a Streptomycete

C. Walsh, S. Garneau‐Tsodikova, F. Schroeder, 2006 .

Hot springs and cool natural products.

H. Kwon, Minoru Yoshida, M. Imoto, 2008, Nature chemical biology.

Detection of oxygen addition peaks for terpendole E and related indole–diterpene alkaloids in a positive-mode ESI-MS

H. Hirota, Shunya Takahashi, H. Koshino, 2014, Journal of mass spectrometry : JMS.

Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase.

H. Hirota, H. Osada, H. Kiyota, 2021, Bioscience, biotechnology, and biochemistry.

Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus.

H. Osada, T. Kamakura, T. Motoyama, 2021, Bioscience, biotechnology, and biochemistry.

Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy.

H. Osada, N. Watanabe, 2012, Current drug targets.

New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.

H. Osada, K. Isono, H. Takahashi, 1998, The Journal of antibiotics.

Sparoxomycins Al and A 2 , NewInducers of the Flat Reversion of NRKCells Transformed by Temperature Sensitive Rons Sarcoma Virus I . Taxonomy of the Producing Organism , Fermentation and Biological Activity

M. Ubukata, H. Kakeya, H. Osada, 2006 .

New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.

M. Ubukata, H. Osada, K. Isono, 1998, The Journal of antibiotics.

Isolation and Biological Properties of a New Cell Cycle Inhibitor, Curvularol, Isolated from Curvularia sp. RK97-F166.

K. Horikoshi, R. Usami, H. Osada, 2001 .

RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2016, Journal of antibiotics (Tokyo. 1968).

Indomethacin Induction of Metamorphosis from the Asexual Stage to Sexual Stage in the Moon Jellyfish, Aurelia aurita

H. Osada, J. Shoji, Tamio Saito, 2012, Bioscience, biotechnology, and biochemistry.

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

J. Hashimoto, I. Kozone, H. Ikeda, 2017, Scientific Reports.

Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2021, Journal of microbiology and biotechnology.

New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties.

H. Osada, K. Isono, T. Yano, 1990, Agricultural and biological chemistry.

Rapid screening method for inhibitors of protein kinase C.

H Osada, J. Magae, H. Osada, 1988, The Journal of antibiotics.

The phosphorylation status and anti‐apoptotic activity of Bcl‐2 are regulated by ERK and protein phosphatase 2A on the mitochondria

Y. Tamura, H. Osada, S. Simizu, 2004, FEBS letters.

Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods.

H. Osada, M. Kawatani, Y. Futamura, 2015, Journal of medicinal chemistry.

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

B. Shen, F. Hoffmann, H. Osada, 2010, Journal of the American Chemical Society.

Effect of Reveromycin A on Experimental Tooth Movement in OPG−/− Mice

H. Osada, S. Goto, M. Kawatani, 2012, Journal of dental research.

Intramolecular [2+2+2] cycloaddition of bis(propargylphenyl)carbodiimides: synthesis of L-shaped π-extended compounds with pyrrolo[1,2-a][1,8]naphthyridine corner units.

R. Sakamoto, Takao Saito, K. Tamao, 2013, Chemical communications.

A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.

Shunji Takahashi, H. Hirota, Jae-Hyuk Jang, 2015, Biochemical and biophysical research communications.

A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units

Shunji Takahashi, Hiroyuki Osada, Shiou-Chuan Tsai, 2016, Nature Communications.

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters

K. Umezawa, H. Osada, M. Kawatani, 2016, FEBS letters.

Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway

H. Osada, M. Kawatani, Xueli Cao, 2015, Molecular Pharmacology.

Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.

H. Inui, H. Osada, Y. Kondoh, 2020, Environmental pollution.

RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group.

R. Usami, H. Kakeya, H. Osada, 1997, Journal of natural products.

A novel mitochondrial DnaJ/Hsp40 family protein BIL2 promotes plant growth and resistance against environmental stress in brassinosteroid signaling

K. Ogawa, M. Sakuta, M. Matsui, 2013, Planta.

CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells

Y. Hata, H. Nishina, K. Nakahama, 2021, The Journal of biological chemistry.

Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

M. Seki, K. Noguchi, H. Osada, 2020, Scientific Reports.

RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. II. Physico-chemical properties and structure elucidation.

M. Ubukata, H. Osada, T. Morita, 1995, The Journal of antibiotics.

Small-Molecule Microarrays as Tools for Facilitating Chemical Genomics : Recent Advances

H. Osada, N. Kanoh, 2006 .

Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity.

H. Koshino, H. Osada, K. Isono, 1991, The Journal of antibiotics.

Aturanosides A and B, Glycosylated Anthraquinones with Antiangiogenic Activity from a Soil-Derived Streptomyces Species.

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2018, Journal of natural products.

Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.

Shinya Oishi, Hiroyuki Osada, Masato Kaneda, 2013, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents.

K. Ishida, H. Osada, S. Simizu, 2004, Bioorganic & medicinal chemistry letters.

Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation

A. Nakano, K. Shinozaki, M. Sakuta, 2017, Scientific Reports.

A Point Mutation in ftmD Blocks the Fumitremorgin Biosynthetic Pathway in Aspergillus fumigatus Strain Af293

Shunji Takahashi, H. Osada, Naoki Kato, 2013, Bioscience, biotechnology and biochemistry.

Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase.

H. Osada, M. Muroi, N. Lai, 2008, Experimental cell research.

Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility.

A. Simeonov, A. Napper, T. Lundbäck, 2014, Assay and drug development technologies.

Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium.

H. Osada, Zhonghua Ma, T. Nishikawa, 2018, Angewandte Chemie.

Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening

N. Fujii, H. Ohno, T. Noguchi, 2017 .

Heparanase as a molecular target of cancer chemotherapy

K. Ishida, H. Osada, S. Simizu, 2004, Cancer science.

Kerriamycin B inhibits protein SUMOylation

Minoru Yoshida, Hiroyuki Osada, Hisashi Kawasaki, 2009, The Journal of Antibiotics.

Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.

H. Osada, M. Kawatani, Takeshi Shimizu, 2011, ACS chemical biology.

Identification of Protein–Small Molecule Interactions by Chemical Array

H. Osada, S. Simizu, 2012 .

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

M. Kuwano, M. Ono, A. Fotovati, 2008, Cancer science.

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

H. Osada, M. Kawatani, S. Simizu, 2008, Bioscience, biotechnology, and biochemistry.

Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction.

N. Fujii, H. Ohno, T. Noguchi, 2017, Bioorganic & medicinal chemistry letters.

Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons

Y. Iwayama, T. Yoshikawa, H. Osada, 2021, Translational Psychiatry.

ZHD-0501, a Novel Naturally Occurring Staurosporine Analogue from Actinomadura sp. 007.

Weiming Zhu, H. Osada, Hongbing Liu, 2005 .

Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs.

Jae-Hyuk Jang, J. Ahn, H. Osada, 2018, Journal of microbiology and biotechnology.

Eighth Korea–Japan Chemical Biology symposium: chemical biology notes from a small island

Shunji Takahashi, Jae-Hyuk Jang, J. Ahn, 2016, The Journal of Antibiotics.

Screening of a virtual mirror-image library of natural products.

N. Fujii, H. Ohno, T. Noguchi, 2016, Chemical communications.

First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry.

M. Nakata, H. Kakeya, H. Osada, 2005, The Journal of organic chemistry.

Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor.

Yukihiro Asami, H. Kakeya, H. Osada, 2002, Journal of the American Chemical Society.

Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

T. Usui, H. Kakeya, H. Osada, 2008, The Journal of Antibiotics.

Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth.

M. Kawada, D. Hashizume, H. Osada, 2021, ACS chemical biology.

Synthesis of pironetin and related analogs: studies on structure-activity relationships as tubulin assembly inhibitors.

T. Kitahara, T. Usui, H. Osada, 2000, The Journal of antibiotics.

Proteomic profiling reveals that collismycin A is an iron chelator

Y. Igarashi, H. Osada, M. Kawatani, 2016, Scientific Reports.

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

Minoru Yoshida, H. Kakeya, H. Osada, 2015, The Journal of Antibiotics.

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

Y. Aida, H. Osada, M. Yokoyama, 2017, Virology.

Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice

Young‐Tae Chang, H. Osada, M. Muroi, 2019, Journal of cellular and molecular medicine.

A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells

Minoru Yoshida, N. Kudo, H. Osada, 2020, Bioscience, biotechnology, and biochemistry.

Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.

M. Uesugi, Hayato Nakagawa, R. Sakamoto, 2021, Cell chemical biology.

Chembiomolecular Science

M. Iino, M. Shibasaki, H. Osada, 2013, Springer Japan.

Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.

H. Kakeya, H. Osada, Hui-ping Zhang, 1998 .

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Sheena C. Li, Scott W. Simpkins, C. Myers, 2019, Nature Protocols.

Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis

Shunji Takahashi, Y. Koyama, H. Osada, 2016, Scientific Reports.

Metabolic pathway prediction based on inclusive relation between cyclic substructures

Shigehiko Kanaya, Aki Hirai, Md. Altaf-Ul-Amin, 2009 .

Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

H. Osada, M. Uramoto, T. Kamakura, 2020, The Journal of Antibiotics.

Glaziovianin A, a New Isoflavone, from the Leaves of Ateleia Glaziovianna and Its Cytotoxic Activity Against Human Cancer Cells.

T. Yamori, T. Usui, H. Osada, 2007 .

Actin Stress Fiber Retraction and Aggresome Formation Is a Common Cellular Response to Actin Toxins

T. Usui, H. Osada, Sayaka Kazami, 2011, Bioscience, biotechnology and biochemistry.

Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry.

H. Osada, Y. Kondoh, M. Muroi, 2020, Bio-protocol.

Cleavable linker for photo-cross-linked small-molecule affinity matrix.

H. Osada, N. Kanoh, Y. Iwabuchi, 2010, Bioconjugate chemistry.

Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR.

K. Nishikawa, T. Usui, H. Kakeya, 2008, Oncology Research.

Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening

Jiang Li, K. Semba, H. Osada, 2023, The Journal of biological chemistry.

Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.

M. Sekine, Takuma Sasaki, K. Okada, 2004, The Journal of organic chemistry.

Formation and Dissociation of the BSS1 Protein Complex Regulates Plant Development via Brassinosteroid Signaling[OPEN]

H. Kawaide, M. Matsui, T. Asami, 2015, Plant Cell.

Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete

Kenji Watanabe, Y. Tsunematsu, H. Osada, 2020, The Journal of Antibiotics.

Development and application of bioprobes for Mammalian cell cycle analyses.

H. Osada, 2003, Current medicinal chemistry.

Boron‐Based Inhibitors of Acyl Protein Thioesterases 1 and 2

K. Mikoshiba, I. Vetter, H. Waldmann, 2013, Chembiochem : a European journal of chemical biology.

A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme.

J. Ahn, Bo Yeon Kim, H. Oh, 2004, Planta medica.

Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.

Hidetoshi Takahashi, H. Koshino, H. Osada, 1992, Journal of antibiotics (Tokyo. 1968).

Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.

H. Osada, M. Kawatani, Takeshi Shimizu, 2012, Chemistry & biology.

Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593.

Shunji Takahashi, J. Chappell, H. Osada, 2017, ACS synthetic biology.

Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus.

H. Kakeya, H. Osada, K. Isono, 1995, The Journal of antibiotics.

Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments

Minoru Yoshida, Henry N. Ward, Raamesh Deshpande, 2019, Nature Protocols.

On‐Chip Fragment‐Based Approach for Discovery of High‐Affinity Bivalent Inhibitors

K. Ishida, H. Osada, S. Simizu, 2009, Chembiochem : a European journal of chemical biology.

Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae.

H. Osada, T. Motoyama, C. Yun, 2017, ACS chemical biology.

Structure–Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array

Y. Nonomura, Yoshikazu Takahashi, H. Osada, 2009, Chembiochem : a European journal of chemical biology.

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

M. Kuwano, M. Ono, A. Fotovati, 2008, Cancer science.

Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. II. Isolation, physico-chemical properties and structure elucidation.

M. Ubukata, H. Osada, M. Uramoto, 1996, Journal of antibiotics (Tokyo. 1968).

Sparoxomycins A1 and A2, New Inducers of the Flat Reversion of NRK Cells Transformed by Temperature Sensitive Rous Sarcoma Virus. Part 2. Isolation, Physico-Chemical Properties and Structure Elucidation.

M. Ubukata, H. Osada, M. Uramoto, 1996 .

Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6.

Seung Min Kim, Y. Kwon, Gun-Hee Kim, 2021, ACS chemical biology.

BPG3 is a novel chloroplast protein that involves the greening of leaves and related to brassinosteroid signaling

M. Sakuta, M. Matsui, T. Asami, 2014, Bioscience, biotechnology, and biochemistry.

Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase.

A. Saito, H. Osada, T. Sudo, 2008, Chemistry, an Asian journal.

Genome-wide maps of mono- and di-nucleosomes of Aspergillus fumigatus

Hiroyuki Aburatani, Hiroyuki Osada, Hiromi Nishida, 2009, Bioinform..

The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin.

K. Nishikawa, H. Nakayama, K. Takio, 2004, Chemistry & biology.

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.

H. Osada, S. Takagi, S. Simizu, 2010, Nature chemical biology.

The application of the chemical array for biological study.

H. Osada, S. Simizu, Isao Miyazaki, 2010, Methods in molecular biology.

Privileged biorenewable secologanin-based diversity-oriented synthesis for pseudo-natural alkaloids: uncovering novel neuroprotective and antimalarial frameworks.

H. Osada, Y. Futamura, H. Zou, 2021, ChemSusChem.

Anti-angiogenesis effects induced by octaminomycins A and B against HUVECs.

Jae-Hyuk Jang, J. Ahn, H. Osada, 2018, Journal of microbiology and biotechnology.