D. Lorimer

发表

Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator

J. M. Sauder, S. Burley, W. Hendrickson, 2004, The EMBO journal.

Impact of the ΔF508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure*

J. M. Sauder, Xun Zhao, J. Hunt, 2005, Journal of Biological Chemistry.

Structural analysis of a set of proteins resulting from a bacterial genomics project

B. Laubert, J. M. Sauder, K. Gajiwala, 2005, Proteins.

Structural characterization of a GNAT family acetyltransferase from Elizabethkingia anophelis bound to acetyl-CoA reveals a new dimeric interface

J. Forwood, D. Lorimer, T. Edwards, 2021, Scientific reports.

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

P. Myler, B. Sankaran, D. Lorimer, 2018, Acta crystallographica. Section F, Structural biology communications.

Structure of acid deoxyribonuclease

I. Phan, Armando Varela-Ramírez, D. Lorimer, 2017, Nucleic acids research.

Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract.

R. Benya, D. Lorimer, 1996, Biochemical and biophysical research communications.

Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability.

E. Elson, G. Nikčević, D. Lorimer, 1996, The American journal of physiology.

Expression of a mutant myosin light chain that cannot be phosphorylated increases paracellular permeability.

D. Lorimer, P. de Lanerolle, S. Gandhi, 1997, The American journal of physiology.

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

M. Ueffing, N. Janjić, A. Burgin, 2016, Proceedings of the National Academy of Sciences.

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.

P. Myler, E. Saphire, D. Lorimer, 2015, The Journal of infectious diseases.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

A. Wlodawer, A. Gustchina, John H. Dupuis, 2021, bioRxiv.

Company Says It Mapped Part of SARS Virus

E. Liu, J. M. Sauder, S. Burley, 2003 .

Structural characterization of aspartate-semialdehyde dehydrogenase from Pseudomonas aeruginosa and Neisseria gonorrhoeae

P. Myler, J. Forwood, J. Fairman, 2022, Scientific Reports.

Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.

P. Myler, D. Lorimer, B. Staker, 2013, Acta crystallographica. Section F, Structural biology communications.

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Richard D. Taylor, D. Goldberg, A. Cowman, 2022, Journal of medicinal chemistry.

Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

P. Myler, U. Holzgrabe, C. Bond, 2022, The Journal of antimicrobial chemotherapy.

Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease

L. Stewart, D. Lorimer, B. Staker, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

David W. Gray, K. Read, I. Gilbert, 2016, ACS infectious diseases.

Cloning and characterization of a novel human histone deacetylase, HDAC8.

J. Clark, D. Lorimer, J. Buggy, 2000, The Biochemical journal.

Cloning and characterization of a novel human histone deacetylase , HDAC 8

D. Lorimer, J. Buggy, P. Mak, 2022 .

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

P. Myler, W. V. Van Voorhis, D. Lorimer, 2015, Acta crystallographica. Section F, Structural biology communications.

Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1

P. Myler, J. Forwood, D. Lorimer, 2021, Scientific Reports.

Fibroblast Contractility without an Increase in Basal Myosin Light Chain Phosphorylation in Wild Type Cells and Cells Expressing the Catalytic Domain of Myosin Light Chain Kinase (*)

G. Nikčević, R. Paul, D. Lorimer, 1995, The Journal of Biological Chemistry.

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors.

N. V. Sokolova, G. Henkel, D. Lorimer, 2020, ACS medicinal chemistry letters.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

A. Wang, R. Levine, J. Perentesis, 2019, Science Translational Medicine.

Structure and function of a cyanophage-encoded peptide deformylase

Robert A Edwards, Anca M Segall, Forest Rohwer, 2013, The ISME Journal.

Structure of the Reston ebolavirus VP30 C-terminal domain

P. Myler, E. Saphire, R. Kirchdoerfer, 2014, Acta crystallographica. Section F, Structural biology communications.

Solutions of RNA polymerase plus linear wild type E. coli lac DNA fragments contain a mixture of stable P1 and P2 promoter complexes.

A. Revzin, D. Lorimer, 1986, Nucleic acids research.

Gene Composer: database software for protein construct design, codon engineering, and gene synthesis

John Walchli, Lance Stewart, Alex Burgin, 2009, BMC biotechnology.

Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate

P. Myler, D. Lorimer, T. Edwards, 2014, International journal for parasitology. Drugs and drug resistance.

A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins

Nicholas J. Harmer, Thomas E. Edwards, Peter J. Myler, 2013, Antimicrobial Agents and Chemotherapy.

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis

P. Myler, B. Sankaran, L. Stewart, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Toward a structome of Acinetobacter baumannii drug targets

I. Phan, W. V. Van Voorhis, D. Lorimer, 2020, Protein science : a publication of the Protein Society.

Increasing the structural coverage of tuberculosis drug targets.

David Fox, Jan Abendroth, P. Myler, 2015, Tuberculosis.

Specific sequences downstream from -6 are not essential for proper and efficient in vitro utilization of the Escherichia coli lactose promoter.

A. Revzin, D. Lorimer, J. Cao, 1990, Journal of molecular biology.

High-throughput Limited Proteolysis/Mass Spectrometry for Protein Domain Elucidation

Stephen K. Burley, Jeffery B. Bonanno, J. Michael Sauder, 2005, Journal of Structural and Functional Genomics.

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10

Marco Biasini, Victor Seguritan, Forest Rohwer, 2014, Proteins.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors

D. Haft, P. Myler, I. Phan, 2017, Scientific Reports.

Structure of tyrosine aminotransferase from Leishmania infantum

P. Myler, D. Lorimer, T. Edwards, 2014, Acta crystallographica. Section F, Structural biology communications.

New York-Structural GenomiX Research Consortium (NYSGXRC): A Large Scale Center for the Protein Structure Initiative

Stephen K. Burley, Andrej Sali, Mark R. Chance, 2005, Journal of Structural and Functional Genomics.

Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba

P. Myler, D. Kyle, I. Phan, 2020, bioRxiv.

Structures of glyceraldehyde 3‐phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis

P. Myler, O. Soge, K. Hybiske, 2020, Protein science : a publication of the Protein Society.

Crystal structure of chorismate mutase from Burkholderia phymatum.

P. Myler, O. Asojo, D. Lorimer, 2018, Acta crystallographica. Section F, Structural biology communications.

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products

P. Horanyi, D. Lorimer, T. Edwards, 2017, Scientific Reports.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms

P. Myler, B. Sankaran, W. V. Van Voorhis, 2017, Scientific Reports.

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.

P. Myler, C. Lukacs, W. V. Van Voorhis, 2015, Acta crystallographica. Section F, Structural biology communications.

Some of the most interesting CASP11 targets through the eyes of their authors

Victor Seguritan, Thomas S. Peat, Forest Rohwer, 2015, Proteins.

Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site

J. Forwood, D. Lorimer, T. Edwards, 2023, Scientific reports.

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer

John Walchli, Lance Stewart, Alex Burgin, 2009, BMC biotechnology.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

A. Wlodawer, A. Gustchina, R. Yada, 2021, bioRxiv.

Structure of tyrosine aminotransferase from Leishmania infantum

P. Myler, D. Lorimer, T. Edwards, 2014, Acta crystallographica. Section F, Structural biology communications.

Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.

P. Myler, D. Lorimer, B. Staker, 2021, Acta crystallographica. Section F, Structural biology communications.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases

P. Myler, W. V. Voorhis, B. Sankaran, 2015, Journal of Structural and Functional Genomics.

Chapter 3 Myosins

D. Lorimer, P. Lanerolle, 1996 .

Artificial Neural Networks Trained to Detect Viral and Phage Structural Proteins

Victor Seguritan, Peter Salamon, Alex B. Burgin, 2012, PLoS Comput. Biol..