C. Hrycyna

发表

Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers.

A. Bhatia, H. Schäfer, C. Hrycyna, 2005, Biochemistry.

Gene Expression and Detection

I. Pastan, M. Gottesman, C. Kimchi-Sarfaty, 2003 .

Competency-Based Reforms of the Undergraduate Biology Curriculum: Integrating the Physical and Biological Sciences

Katerina V. Thompson, Michael S. Gaines, W. LaCourse, 2013, CBE life sciences education.

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.

S. Michaelis, A. Rusiñol, C. Hrycyna, 2005, The Biochemical journal.

Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro.

S. Clarke, C. Hrycyna, 1992, The Journal of biological chemistry.

Biochemical, cellular, and pharmacological aspects of the multidrug transporter.

I. Pastan, M. Gottesman, M. Ramachandra, 1999, Annual review of pharmacology and toxicology.

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

T. Litman, S. Bates, R. Robey, 2001, Cancer research.

Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.

Daxi Sun, J. Schuetz, M. Adachi, 2007, Cancer research.

Purine Analogue Drug Cytotoxicity and Tissue Distribution Substrate Overlap between Mrp 4 and Abcg 2 / Bcrp Affects

J. Schuetz, M. Adachi, C. Stewart, 2007 .

Functional reconstitution of the integral membrane enzyme, isoprenylcysteine carboxyl methyltransferase, in synthetic bolalipid membrane vesicles.

D. Thompson, C. Hrycyna, Wilma Febo-Ayala, 2006, Biochemistry.

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

S. Young, Sandy Chang, D. Andres, 2012, Journal of Lipid Research.

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells*

S. Young, C. Coffinier, D. Andres, 2008, Journal of Biological Chemistry.

Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.

F. Sharom, C. Hrycyna, J. Chmielewski, 2014, ACS chemical neuroscience.

Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator.

D. Thompson, C. Hrycyna, S. Haldar, 2005, Bioconjugate chemistry.

Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.

C. Hrycyna, Jerrin Kuriakose, J. Chmielewski, 2012, Bioorganic & medicinal chemistry letters.

Methyltransferase‐like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

Yaohui Nie, S. Kuang, W. Tao, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice

Yaohui Nie, S. Kuang, W. Tao, 2019, The Journal of Biological Chemistry.

Dual Modulation of Human P-Glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier.

C. Hrycyna, J. Chmielewski, Allison M. Lange, 2017, Molecular pharmaceutics.

Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.

S. Clarke, C. Hrycyna, 1990, Molecular and cellular biology.

Inhibition of P-Glycoprotein-Mediated Paclitaxel Resistance by Reversibly Linked Quinine Homodimers

C. Hrycyna, J. Chmielewski, M. M. Pires, 2009, Molecular Pharmacology.

Inhibition of P-Glycoprotein-Mediated Taxol Resistance by Reversibly-Linked Quinine Homodimers

C. Hrycyna, J. Chmielewski, M. M. Pires, 2008 .

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.

I. Pastan, M. Gottesman, M. Ramachandra, 1998, Biochemistry.

Homodimers of the Antiviral Abacavir as Modulators of P-glycoprotein Transport in Cell Culture: Probing Tether Length.

C. Hrycyna, J. Chmielewski, Dana Emmert, 2013, MedChemComm.

Tools for eradicating HIV in the brain: prodrug dimeric inhibitors of P-gp.

C. Hrycyna, J. Chmielewski, 2012, Therapeutic delivery.

Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity

Qigui Yu, J. Lan, C. Hrycyna, 2019, Journal of medicinal chemistry.

Yeast STE14 methyltransferase, expressed as TrpE-STE14 fusion protein in Escherichia coli, for in vitro carboxylmethylation of prenylated polypeptides.

P. Backlund, S. Michaelis, C. Hrycyna, 1995, Methods in enzymology.

Chapter 4 – Biochemical and Biological Functions of Isoprenylcysteine Carboxyl Methyltransferase

C. Hrycyna, M. Philips, Helen R Court, 2011 .

Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter

E. Rojas, I. Kopin, C. Hrycyna, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways.

S. Clarke, C. Hrycyna, M. C. Yang, 1994, Biochemistry.

Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers.

C. Hrycyna, J. Chmielewski, D. Davis, 2012, Journal of the American Chemical Society.

Effect of combination of suboptimal concentrations of P‐glycoprotein blockers on the proliferation of MDR1 gene expressing cells

P. S. Pine, C. Hrycyna, T. Licht, 1996, International journal of cancer.

Genetic analysis of the multidrug transporter.

I. Pastan, M. Gottesman, U. Germann, 1995, Annual review of genetics.

Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.

R. Gibbs, Daniel D Macdougall, C. Hrycyna, 2006, Bioorganic & medicinal chemistry letters.

Therapeutic intervention based on protein prenylation and associated modifications

Herbert Waldmann, F. Tamanoi, M. Gelb, 2006, Nature chemical biology.

Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors.

R. Gibbs, C. Hrycyna, Kalub Hahne, 2011, Bioorganic & medicinal chemistry letters.

Identification of a novel nanomolar inhibitor of hIcmt via a carboxylate replacement approach

R. Gibbs, C. Hrycyna, Jiao Song, 2012 .

Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes.

R. Gibbs, M. Distefano, C. Hrycyna, 2012, Biochemical and biophysical research communications.

Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.

R. Gibbs, C. Hrycyna, Liza Shrestha, 2012, Bioorganic & medicinal chemistry.

The Isoprenoid Substrate Specificity of Isoprenylcysteine Carboxylmethyltransferase

R. Gibbs, C. Hrycyna, Jessica L Anderson, 2005, Journal of Biological Chemistry.

Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation.

James L. Hougland, Taysir K. Bader, M. Distefano, 2022, ACS chemical biology.

Diazirine-Containing Photoactivatable Isoprenoid: Synthesis and Application in Studies with Isoprenylcysteine Carboxyl Methyltransferase

M. Distefano, M. Strom, C. Hrycyna, 2014, The Journal of organic chemistry.

Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.

R. Gibbs, C. Hrycyna, Jessica L Anderson, 2005, Bioorganic & medicinal chemistry letters.

The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors

C. Hrycyna, J. Chmielewski, J. Goebel, 2021, Cancer drug resistance.

Selectable Markers for Gene Therapy

I. Pastan, M. Gottesman, C. Kimchi-Sarfaty, 2008 .

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.

I. Pastan, M. Ramachandra, S. Ambudkar, 1996, Molecular biology of the cell.

Selectable Markers for Gene Therapy 2

I. Pastan, M. Gottesman, C. Kimchi-Sarfaty, 2003 .

9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing.

C. Hrycyna, Jessica L Anderson, 2006, The Enzymes.

Modification of eukaryotic signaling proteins by C-terminal methylation reactions.

S. Clarke, C. Hrycyna, 1993, Pharmacology & therapeutics.

Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A

C. Hrycyna, Karin F K Ejendal, Christine A Hrycyna, 2005, Molecular Pharmacology.

The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding

C. Hrycyna, Karin F K Ejendal, Christine A Hrycyna, 2006, Protein science : a publication of the Protein Society.

[3H]dexamethasone binding to plasma membrane-enriched fractions from liver of nonadrenalectomized rats.

R. Smith, F. Quelle, C. Hrycyna, 1988, Endocrinology.

Recombinant Synthesis of Human ABCG2 Expressed in the Yeast Saccharomyces cerevisiae: an Experimental Methodological Study

C. Hrycyna, M. Wiese, A. Jacobs, 2011, The protein journal.

Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function.

M. Gottesman, C. Hrycyna, 1998, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.

Célia Baroux, Ueli Grossniklaus, Markus Geisler, 2005, The Plant journal : for cell and molecular biology.

Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.

C. Hrycyna, Karin F K Ejendal, Karin F Ejendal, 2002, Current protein & peptide science.

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C‐terminal methylation of a‐factor and RAS proteins.

S. Clarke, S. Michaelis, C. Hrycyna, 1991, The EMBO journal.

Bivalent probes of the human multidrug transporter P-glycoprotein.

C. Hrycyna, J. Chmielewski, M. M. Pires, 2006, Biochemistry.

N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.

C. Hrycyna, N. K. Diop, 2005, Biochemistry.

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability

Eric D. Spear, E. Carpenter, S. Michaelis, 2018, Disease Models & Mechanisms.

ZMPSTE24 Missense Mutations that Cause Progeroid Diseases Decrease Prelamin A Cleavage Activity, Protein Stability, or Both

Eric D. Spear, E. Carpenter, S. Michaelis, 2017, bioRxiv.

A Protease for the Ages

S. Michaelis, C. Hrycyna, Susan Michaelis, 2013, Science.

Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.

J. Barrowman, S. Michaelis, C. Hrycyna, 2012, Human molecular genetics.

Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.

C. Hrycyna, J. Chmielewski, M. M. Pires, 2009, Biochemical and biophysical research communications.

Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.

C. Hrycyna, C A Hrycyna, 2001, Seminars in cell & developmental biology.

Functional Characterization of Glycosylation-Deficient Human P-Glycoprotein Using A Vaccinia Virus Expression System

M. Ramachandra, S. Ambudkar, C. Hrycyna, 2000, The Journal of Membrane Biology.

P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.

I. Pastan, J. Yewdell, J. Bennink, 1998, Cancer research.

Chapter 9 - Inhibitors of Postprenylation CAAX Processing Enzymes

R. Gibbs, C. Hrycyna, J. Bergman, 2011 .

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

S. Young, C. Coffinier, Sandy Chang, 2007, Proceedings of the National Academy of Sciences.

a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

M. Distefano, J. Becker, E. Ganusova, 2017, Bioconjugate chemistry.

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

F. Martinon, M. Quadroni, A. Tardivel, 2016, Proceedings of the National Academy of Sciences.

HIV-protease inhibitors block the enzymatic activity of purified Ste24p.

S. Young, C. Coffinier, L. Fong, 2008, Biochemical and biophysical research communications.

Purification, Functional Reconstitution, and Characterization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxylmethyltransferase Ste14p*♦

S. Michaelis, C. Hrycyna, Hilary Frase, 2005, Journal of Biological Chemistry.

Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae.

S. Clarke, C. Hrycyna, 1993, Biochemistry.

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.

K. Kirk, Adele M. Lehane, Rowena E. Martin, 2014, ACS chemical biology.

Transmembrane inhibitors of P-glycoprotein, an ABC transporter.

M. Gottesman, S. Tarasov, N. Tarasova, 2005, Journal of medicinal chemistry.

A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases.

D. Thompson, S. Leffler, C. Hrycyna, 2005, Biochemical and biophysical research communications.

Design and Evaluation of a One-Semester General Chemistry Course for Undergraduate Life Science Majors

M. Towns, C. Hrycyna, J. Chmielewski, 2018 .

Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.

R. Gibbs, C. Hrycyna, J. Bergman, 2011, Bioorganic & medicinal chemistry letters.

Both ATP sites of human P-glycoprotein are essential but not symmetric.

I. Pastan, M. Ramachandra, P. Cheng, 1999, Biochemistry.

Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.

I. Pastan, M. Ramachandra, C. Hrycyna, 1998, Methods in enzymology.

Dual inhibitors of the human blood-brain barrier drug efflux transporters P-glycoprotein and ABCG2 based on the antiviral azidothymidine.

C. Hrycyna, J. Chmielewski, Hilda A. Namanja-Magliano, 2017, Bioorganic & medicinal chemistry.

Functional Oligomerization of the Saccharomyces cerevisiae Isoprenylcysteine Carboxyl Methyltransferase, Ste14p

C. Hrycyna, Kalub Hahne, A. Griggs, 2010, The Journal of Biological Chemistry.

Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.

Kyle V. Butler, C. Hrycyna, Jian Jin, 2016, MedChemComm.

S-Farnesyl-Thiopropionic Acid (FTPA) Triazoles as Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase.

R. Gibbs, C. Hrycyna, Jiao Song, 2012, ACS medicinal chemistry letters.

Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.

A. Murphy, A. Müller, U. Grossniklaus, 2005 .

Mechanism of Action of Human P-glycoprotein ATPase Activity

I. Pastan, M. Gottesman, P. Pedersen, 1998, The Journal of Biological Chemistry.