Nicole Merten

发表

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

G. Milligan, E. Kostenis, K. Mohr, 2010, Nature Biotechnology.

Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

Daniel Schulz, Evi Kostenis, Michel Gillard, 2013, Science Signaling.

GPC receptors and not ligands decide the binding mode in neuropeptide Y multireceptor/multiligand system.

A. Beck‐Sickinger, Nicole Merten, D. Lindner, 2008, Biochemistry.

Molecular ligand-receptor interaction of the NPY/PP peptide family.

A. Beck‐Sickinger, Nicole Merten, 2006, EXS.

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40*

Evi Kostenis, Trond Ulven, Manuel Grundmann, 2011, The Journal of Biological Chemistry.

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

E. Kostenis, A. Bond, S. Ullrich, 2008, Journal of medicinal chemistry.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

E. Kostenis, K. Mohr, Q. Lu, 2018, Cell chemical biology.

Lack of Evidence for AT1R/B2R Heterodimerization in COS-7, HEK293, and NIH3T3 Cells

T. Walther, D. Weiner, E. Kostenis, 2009, Journal of Biological Chemistry.

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

K. Kristiansen, E. Kostenis, S. Ullrich, 2010, ACS medicinal chemistry letters.

Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2.

M. C. Nielsen, E. Kostenis, K. Mohr, 2007, Bioorganic & medicinal chemistry letters.

Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs.

E. Kostenis, B. Odermatt, K. Monk, 2022, Cell chemical biology.

The Third Intracellular Loop Stabilizes the Inactive State of the Neuropeptide Y1 Receptor*

P. Light, W. Colmers, A. Beck‐Sickinger, 2008, Journal of Biological Chemistry.

How Carvedilol activates β2-adrenoceptors

Victor Jun Yu Lim, P. Kolb, D. Malan, 2022, Nature Communications.

Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.

B. Fleischmann, E. Kostenis, B. Nieswandt, 2020, Molecular cell.

Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.

B. Fleischmann, E. Kostenis, B. Nieswandt, 2020, Molecular cell.

Lack of beta-arrestin signaling in the absence of active G proteins

J. Wess, C. Hoffmann, E. Kostenis, 2018, Nature Communications.

The experimental power of FR900359 to study Gq-regulated biological processes

H. Dohlman, C. Müller, M. Hesse, 2015, Nature Communications.

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes

E. Kostenis, K. Mohr, R. Schröder, 2017, Molecular Pharmacology.

An experimental strategy to probe Gq contribution to signal transduction in living cells

C. Müller, E. Kostenis, A. Inoue, 2021, The Journal of biological chemistry.

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

E. Kostenis, Nicole Merten, E. Busch-Nentwich, 2019, Nature Communications.

The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules*

E. Kostenis, Nicole Merten, Stephanie Hennen, 2015, The Journal of Biological Chemistry.

A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs

E. Kostenis, Nicole Merten, M. Schiedel, 2021, Angewandte Chemie.

DECONVOLUTION OF COMPLEX G PROTEIN-COUPLED RECEPTOR SIGNALING IN LIVE CELLS : TAKING ADVANTAGE OF THE RESOLVING POWER OF DYNAMIC MASS REDISTRIBUTION TECHNOLOGY

G. Milligan, E. Kostenis, K. Mohr, 2010 .

Receptor Subtype-specific Docking of Asp6.59 with C-terminal Arginine Residues in Y Receptor Ligands*

T. Schöneberg, A. Beck‐Sickinger, Nicole Merten, 2007, Journal of Biological Chemistry.

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαi and Downstream Signaling Cascade Activation*

L. Pardo, J. M. Mathiesen, E. Kostenis, 2009, Journal of Biological Chemistry.

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

U. Holzgrabe, C. Hoffmann, E. Kostenis, 2012, Nature Communications.

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

G. Milligan, E. Kostenis, K. Mohr, 2011, Nature Protocols.

Biosynthetic Studies on Acetosellin and Structure Elucidation of a New Acetosellin Derivative

M. Gütschow, I. Arslan, T. Schneider, 2017, Planta Medica.

Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

E. Kostenis, Nicole Merten, E. Busch-Nentwich, 2019, Nature Communications.

Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2

E. Kostenis, F. Hansen, Nicole Merten, 2023, Journal of medicinal chemistry.

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40*

E. Kostenis, H. Sauerwein, S. Ullrich, 2011, The Journal of Biological Chemistry.